LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Putative dihydrouridine synthase (Dus)

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative dihydrouridine synthase (Dus)
Gene product:
dihydrouridine synthase (Dus) - putative
Species:
Leishmania infantum
UniProt:
A4I6W8_LEIIN
TriTrypDb:
LINF_310027100
Length:
660

Annotations

Annotations by Jardim et al.

Pyrimidine metabolism, dihydrouridine synthase (Dus)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A4I6W8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6W8

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 10
GO:0003824 catalytic activity 1 10
GO:0005488 binding 1 10
GO:0016491 oxidoreductase activity 2 10
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3 10
GO:0017150 tRNA dihydrouridine synthase activity 5 10
GO:0036094 small molecule binding 2 10
GO:0043167 ion binding 2 10
GO:0043168 anion binding 3 10
GO:0050660 flavin adenine dinucleotide binding 4 10
GO:0097159 organic cyclic compound binding 2 10
GO:0106413 dihydrouridine synthase activity 4 10
GO:0140098 catalytic activity, acting on RNA 3 10
GO:0140101 catalytic activity, acting on a tRNA 4 10
GO:0140640 catalytic activity, acting on a nucleic acid 2 10
GO:1901265 nucleoside phosphate binding 3 10
GO:1901363 heterocyclic compound binding 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 76 80 PF00656 0.442
CLV_NRD_NRD_1 296 298 PF00675 0.236
CLV_NRD_NRD_1 32 34 PF00675 0.588
CLV_NRD_NRD_1 421 423 PF00675 0.233
CLV_NRD_NRD_1 58 60 PF00675 0.405
CLV_NRD_NRD_1 623 625 PF00675 0.440
CLV_NRD_NRD_1 88 90 PF00675 0.751
CLV_PCSK_KEX2_1 296 298 PF00082 0.236
CLV_PCSK_KEX2_1 32 34 PF00082 0.588
CLV_PCSK_KEX2_1 345 347 PF00082 0.479
CLV_PCSK_KEX2_1 421 423 PF00082 0.249
CLV_PCSK_KEX2_1 623 625 PF00082 0.447
CLV_PCSK_KEX2_1 88 90 PF00082 0.751
CLV_PCSK_PC1ET2_1 345 347 PF00082 0.479
CLV_PCSK_PC7_1 84 90 PF00082 0.555
CLV_PCSK_SKI1_1 22 26 PF00082 0.433
CLV_PCSK_SKI1_1 33 37 PF00082 0.456
CLV_PCSK_SKI1_1 375 379 PF00082 0.420
CLV_PCSK_SKI1_1 405 409 PF00082 0.259
CLV_PCSK_SKI1_1 424 428 PF00082 0.259
CLV_PCSK_SKI1_1 88 92 PF00082 0.491
DEG_APCC_DBOX_1 532 540 PF00400 0.499
DOC_ANK_TNKS_1 623 630 PF00023 0.447
DOC_CYCLIN_yCln2_LP_2 322 328 PF00134 0.433
DOC_MAPK_gen_1 547 556 PF00069 0.553
DOC_MAPK_gen_1 641 649 PF00069 0.504
DOC_MAPK_MEF2A_6 505 513 PF00069 0.418
DOC_PP2B_LxvP_1 322 325 PF13499 0.433
DOC_PP4_FxxP_1 333 336 PF00568 0.499
DOC_PP4_FxxP_1 470 473 PF00568 0.433
DOC_SPAK_OSR1_1 232 236 PF12202 0.352
DOC_USP7_MATH_1 20 24 PF00917 0.401
DOC_USP7_MATH_1 367 371 PF00917 0.632
DOC_USP7_MATH_1 568 572 PF00917 0.604
DOC_USP7_MATH_1 595 599 PF00917 0.548
DOC_USP7_UBL2_3 639 643 PF12436 0.562
DOC_WW_Pin1_4 139 144 PF00397 0.416
DOC_WW_Pin1_4 176 181 PF00397 0.514
DOC_WW_Pin1_4 63 68 PF00397 0.487
LIG_14-3-3_CanoR_1 22 27 PF00244 0.416
LIG_14-3-3_CanoR_1 490 498 PF00244 0.499
LIG_14-3-3_CanoR_1 623 628 PF00244 0.469
LIG_BIR_II_1 1 5 PF00653 0.415
LIG_BIR_III_4 425 429 PF00653 0.443
LIG_FHA_1 140 146 PF00498 0.499
LIG_FHA_1 206 212 PF00498 0.448
LIG_FHA_1 315 321 PF00498 0.516
LIG_FHA_1 325 331 PF00498 0.526
LIG_FHA_1 428 434 PF00498 0.529
LIG_FHA_1 494 500 PF00498 0.534
LIG_FHA_1 89 95 PF00498 0.559
LIG_FHA_2 367 373 PF00498 0.549
LIG_FHA_2 439 445 PF00498 0.427
LIG_FHA_2 450 456 PF00498 0.436
LIG_FHA_2 544 550 PF00498 0.670
LIG_FHA_2 74 80 PF00498 0.402
LIG_FHA_2 93 99 PF00498 0.432
LIG_GBD_Chelix_1 314 322 PF00786 0.329
LIG_Integrin_isoDGR_2 30 32 PF01839 0.442
LIG_LIR_Gen_1 158 166 PF02991 0.520
LIG_LIR_Gen_1 306 315 PF02991 0.416
LIG_LIR_Gen_1 383 393 PF02991 0.325
LIG_LIR_Gen_1 441 449 PF02991 0.416
LIG_LIR_Nem_3 125 131 PF02991 0.416
LIG_LIR_Nem_3 158 163 PF02991 0.519
LIG_LIR_Nem_3 306 311 PF02991 0.416
LIG_LIR_Nem_3 441 445 PF02991 0.416
LIG_LIR_Nem_3 9 14 PF02991 0.378
LIG_PDZ_Class_2 655 660 PF00595 0.589
LIG_Pex14_1 503 507 PF04695 0.499
LIG_Pex14_2 519 523 PF04695 0.459
LIG_SH2_CRK 11 15 PF00017 0.366
LIG_SH2_CRK 61 65 PF00017 0.437
LIG_SH2_NCK_1 61 65 PF00017 0.398
LIG_SH2_SRC 442 445 PF00017 0.499
LIG_SH2_STAP1 386 390 PF00017 0.416
LIG_SH2_STAP1 442 446 PF00017 0.499
LIG_SH2_STAT5 141 144 PF00017 0.433
LIG_SH2_STAT5 28 31 PF00017 0.380
LIG_SH3_2 476 481 PF14604 0.499
LIG_SH3_3 160 166 PF00018 0.396
LIG_SH3_3 208 214 PF00018 0.444
LIG_SH3_3 253 259 PF00018 0.561
LIG_SH3_3 470 476 PF00018 0.433
LIG_SH3_3 61 67 PF00018 0.498
LIG_SUMO_SIM_anti_2 379 386 PF11976 0.420
LIG_SUMO_SIM_par_1 614 620 PF11976 0.350
LIG_SUMO_SIM_par_1 645 652 PF11976 0.439
LIG_TRAF2_1 165 168 PF00917 0.385
LIG_TRAF2_1 356 359 PF00917 0.588
LIG_TRAF2_1 642 645 PF00917 0.542
LIG_WRC_WIRS_1 300 305 PF05994 0.433
MOD_CDK_SPxxK_3 63 70 PF00069 0.408
MOD_CK1_1 176 182 PF00069 0.564
MOD_CK1_1 471 477 PF00069 0.439
MOD_CK2_1 265 271 PF00069 0.664
MOD_CK2_1 366 372 PF00069 0.553
MOD_CK2_1 449 455 PF00069 0.459
MOD_CK2_1 528 534 PF00069 0.443
MOD_CK2_1 543 549 PF00069 0.562
MOD_CK2_1 92 98 PF00069 0.522
MOD_CMANNOS 50 53 PF00535 0.327
MOD_Cter_Amidation 30 33 PF01082 0.434
MOD_GlcNHglycan 109 112 PF01048 0.395
MOD_GlcNHglycan 246 249 PF01048 0.583
MOD_GlcNHglycan 353 356 PF01048 0.447
MOD_GlcNHglycan 47 50 PF01048 0.534
MOD_GlcNHglycan 491 494 PF01048 0.295
MOD_GlcNHglycan 541 544 PF01048 0.344
MOD_GlcNHglycan 551 554 PF01048 0.591
MOD_GlcNHglycan 574 577 PF01048 0.710
MOD_GlcNHglycan 583 589 PF01048 0.515
MOD_GlcNHglycan 599 602 PF01048 0.315
MOD_GlcNHglycan 633 636 PF01048 0.680
MOD_GlcNHglycan 79 83 PF01048 0.644
MOD_GSK3_1 135 142 PF00069 0.430
MOD_GSK3_1 155 162 PF00069 0.519
MOD_GSK3_1 246 253 PF00069 0.545
MOD_GSK3_1 310 317 PF00069 0.499
MOD_GSK3_1 347 354 PF00069 0.613
MOD_GSK3_1 41 48 PF00069 0.525
MOD_GSK3_1 489 496 PF00069 0.511
MOD_GSK3_1 539 546 PF00069 0.440
MOD_GSK3_1 568 575 PF00069 0.722
MOD_GSK3_1 595 602 PF00069 0.467
MOD_GSK3_1 73 80 PF00069 0.531
MOD_GSK3_1 88 95 PF00069 0.526
MOD_N-GLC_1 350 355 PF02516 0.425
MOD_NEK2_1 106 111 PF00069 0.447
MOD_NEK2_1 173 178 PF00069 0.430
MOD_NEK2_1 310 315 PF00069 0.488
MOD_NEK2_1 427 432 PF00069 0.432
MOD_NEK2_1 449 454 PF00069 0.416
MOD_NEK2_1 528 533 PF00069 0.515
MOD_NEK2_1 539 544 PF00069 0.523
MOD_NEK2_1 73 78 PF00069 0.514
MOD_NEK2_2 189 194 PF00069 0.575
MOD_PIKK_1 471 477 PF00454 0.529
MOD_PK_1 623 629 PF00069 0.414
MOD_PKA_1 623 629 PF00069 0.414
MOD_PKA_1 88 94 PF00069 0.478
MOD_PKA_2 489 495 PF00069 0.463
MOD_PKA_2 623 629 PF00069 0.478
MOD_PKA_2 88 94 PF00069 0.478
MOD_Plk_1 173 179 PF00069 0.345
MOD_Plk_1 33 39 PF00069 0.496
MOD_Plk_1 569 575 PF00069 0.556
MOD_Plk_1 73 79 PF00069 0.476
MOD_Plk_4 223 229 PF00069 0.286
MOD_Plk_4 299 305 PF00069 0.433
MOD_Plk_4 310 316 PF00069 0.499
MOD_Plk_4 380 386 PF00069 0.419
MOD_ProDKin_1 139 145 PF00069 0.416
MOD_ProDKin_1 176 182 PF00069 0.526
MOD_ProDKin_1 63 69 PF00069 0.484
MOD_SUMO_for_1 642 645 PF00179 0.542
MOD_SUMO_rev_2 16 21 PF00179 0.256
MOD_SUMO_rev_2 162 172 PF00179 0.422
MOD_SUMO_rev_2 461 470 PF00179 0.499
TRG_DiLeu_BaEn_1 306 311 PF01217 0.421
TRG_DiLeu_BaEn_4 534 540 PF01217 0.471
TRG_DiLeu_BaEn_4 651 657 PF01217 0.461
TRG_DiLeu_BaLyEn_6 459 464 PF01217 0.433
TRG_ENDOCYTIC_2 11 14 PF00928 0.364
TRG_ENDOCYTIC_2 141 144 PF00928 0.416
TRG_ENDOCYTIC_2 300 303 PF00928 0.433
TRG_ENDOCYTIC_2 386 389 PF00928 0.416
TRG_ENDOCYTIC_2 442 445 PF00928 0.499
TRG_ENDOCYTIC_2 61 64 PF00928 0.449
TRG_ER_diArg_1 420 422 PF00400 0.433
TRG_ER_diArg_1 87 89 PF00400 0.565
TRG_NES_CRM1_1 309 323 PF08389 0.431
TRG_Pf-PMV_PEXEL_1 12 16 PF00026 0.472
TRG_Pf-PMV_PEXEL_1 129 134 PF00026 0.299
TRG_Pf-PMV_PEXEL_1 388 392 PF00026 0.299

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HS31 Leptomonas seymouri 60% 100%
A0A0S4JUA9 Bodo saltans 38% 100%
A0A3Q8ICM1 Leishmania donovani 100% 100%
A4HJH5 Leishmania braziliensis 79% 100%
C9ZWQ2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
E9B1Z2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q669 Leishmania major 92% 100%
Q8C2P3 Mus musculus 32% 100%
V5D2B4 Trypanosoma cruzi 41% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS