Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I6W0_LEIIN

TriTrypDb:

LINF_310026300

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4I6W0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6W0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.716
CLV_NRD_NRD_1	12	14	PF00675	0.622
CLV_NRD_NRD_1	142	144	PF00675	0.496
CLV_NRD_NRD_1	83	85	PF00675	0.436
CLV_NRD_NRD_1	91	93	PF00675	0.469
CLV_PCSK_KEX2_1	142	144	PF00082	0.496
CLV_PCSK_KEX2_1	222	224	PF00082	0.482
CLV_PCSK_KEX2_1	85	87	PF00082	0.445
CLV_PCSK_KEX2_1	91	93	PF00082	0.474
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.482
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.445
CLV_PCSK_SKI1_1	91	95	PF00082	0.546
DEG_Nend_Nbox_1	1	3	PF02207	0.444
DEG_SPOP_SBC_1	153	157	PF00917	0.608
DEG_SPOP_SBC_1	33	37	PF00917	0.481
DOC_MAPK_gen_1	167	175	PF00069	0.627
DOC_MAPK_RevD_3	72	86	PF00069	0.498
DOC_PP2B_PxIxI_1	111	117	PF00149	0.709
DOC_PP4_FxxP_1	188	191	PF00568	0.701
DOC_USP7_MATH_1	153	157	PF00917	0.654
DOC_USP7_MATH_1	191	195	PF00917	0.737
DOC_USP7_MATH_1	47	51	PF00917	0.532
DOC_USP7_MATH_1	95	99	PF00917	0.694
DOC_USP7_MATH_2	235	241	PF00917	0.679
DOC_WW_Pin1_4	145	150	PF00397	0.672
DOC_WW_Pin1_4	231	236	PF00397	0.698
DOC_WW_Pin1_4	25	30	PF00397	0.496
DOC_WW_Pin1_4	43	48	PF00397	0.475
LIG_14-3-3_CanoR_1	13	22	PF00244	0.474
LIG_14-3-3_CanoR_1	154	159	PF00244	0.679
LIG_14-3-3_CanoR_1	174	179	PF00244	0.607
LIG_14-3-3_CanoR_1	25	29	PF00244	0.464
LIG_14-3-3_CanoR_1	51	59	PF00244	0.389
LIG_14-3-3_CanoR_1	84	94	PF00244	0.675
LIG_BIR_III_2	179	183	PF00653	0.673
LIG_BRCT_BRCA1_1	64	68	PF00533	0.303
LIG_EH_1	185	189	PF12763	0.692
LIG_FHA_1	170	176	PF00498	0.727
LIG_FHA_1	34	40	PF00498	0.514
LIG_FHA_2	128	134	PF00498	0.695
LIG_FHA_2	13	19	PF00498	0.474
LIG_FHA_2	85	91	PF00498	0.649
LIG_LIR_Nem_3	218	224	PF02991	0.694
LIG_LIR_Nem_3	65	70	PF02991	0.303
LIG_MLH1_MIPbox_1	64	68	PF16413	0.303
LIG_Pex14_2	4	8	PF04695	0.441
LIG_SH2_CRK	232	236	PF00017	0.720
LIG_SH2_NCK_1	124	128	PF00017	0.762
LIG_SH2_PTP2	6	9	PF00017	0.458
LIG_SH2_STAT5	11	14	PF00017	0.470
LIG_SH2_STAT5	6	9	PF00017	0.472
LIG_SH2_STAT5	79	82	PF00017	0.648
LIG_SH3_3	181	187	PF00018	0.675
LIG_TRAF2_1	134	137	PF00917	0.720
LIG_TRAF2_1	235	238	PF00917	0.732
LIG_TRAF2_1	87	90	PF00917	0.648
MOD_CK1_1	103	109	PF00069	0.680
MOD_CK1_1	125	131	PF00069	0.767
MOD_CK1_1	156	162	PF00069	0.647
MOD_CK1_1	189	195	PF00069	0.734
MOD_CK1_1	42	48	PF00069	0.508
MOD_CK1_1	50	56	PF00069	0.414
MOD_CK1_1	58	64	PF00069	0.238
MOD_CK2_1	127	133	PF00069	0.740
MOD_CK2_1	18	24	PF00069	0.511
MOD_CK2_1	190	196	PF00069	0.744
MOD_CK2_1	231	237	PF00069	0.700
MOD_CK2_1	84	90	PF00069	0.641
MOD_DYRK1A_RPxSP_1	25	29	PF00069	0.458
MOD_GlcNHglycan	103	106	PF01048	0.495
MOD_GlcNHglycan	124	127	PF01048	0.509
MOD_GlcNHglycan	227	230	PF01048	0.514
MOD_GlcNHglycan	39	42	PF01048	0.720
MOD_GlcNHglycan	64	67	PF01048	0.300
MOD_GlcNHglycan	97	100	PF01048	0.507
MOD_GSK3_1	127	134	PF00069	0.701
MOD_GSK3_1	14	21	PF00069	0.511
MOD_GSK3_1	152	159	PF00069	0.677
MOD_GSK3_1	186	193	PF00069	0.686
MOD_GSK3_1	24	31	PF00069	0.466
MOD_GSK3_1	33	40	PF00069	0.440
MOD_GSK3_1	43	50	PF00069	0.399
MOD_GSK3_1	58	65	PF00069	0.242
MOD_GSK3_1	95	102	PF00069	0.703
MOD_N-GLC_1	37	42	PF02516	0.695
MOD_NEK2_1	122	127	PF00069	0.775
MOD_NEK2_1	230	235	PF00069	0.740
MOD_NEK2_1	39	44	PF00069	0.519
MOD_NEK2_1	55	60	PF00069	0.238
MOD_NEK2_1	62	67	PF00069	0.312
MOD_NEK2_1	68	73	PF00069	0.300
MOD_PIKK_1	127	133	PF00454	0.673
MOD_PK_1	154	160	PF00069	0.593
MOD_PKA_1	84	90	PF00069	0.659
MOD_PKA_2	100	106	PF00069	0.643
MOD_PKA_2	12	18	PF00069	0.460
MOD_PKA_2	153	159	PF00069	0.627
MOD_PKA_2	24	30	PF00069	0.463
MOD_PKA_2	50	56	PF00069	0.426
MOD_PKA_2	85	91	PF00069	0.668
MOD_PKB_1	167	175	PF00069	0.660
MOD_Plk_1	169	175	PF00069	0.670
MOD_Plk_1	217	223	PF00069	0.663
MOD_Plk_2-3	18	24	PF00069	0.488
MOD_Plk_4	55	61	PF00069	0.320
MOD_ProDKin_1	145	151	PF00069	0.675
MOD_ProDKin_1	231	237	PF00069	0.702
MOD_ProDKin_1	25	31	PF00069	0.494
MOD_ProDKin_1	43	49	PF00069	0.472
TRG_DiLeu_BaEn_4	136	142	PF01217	0.678
TRG_DiLeu_BaEn_4	89	95	PF01217	0.683
TRG_DiLeu_BaLyEn_6	210	215	PF01217	0.682
TRG_ENDOCYTIC_2	77	80	PF00928	0.651
TRG_ER_diArg_1	141	143	PF00400	0.682
TRG_ER_diArg_1	164	167	PF00400	0.704
TRG_ER_diArg_1	83	86	PF00400	0.640
TRG_ER_diArg_1	91	93	PF00400	0.669
TRG_NLS_MonoExtC_3	83	89	PF00514	0.635
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	213	218	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	92	97	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFE3	Leishmania donovani	100%	100%
E9AIU6	Leishmania braziliensis	55%	100%
E9B1Y4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q676	Leishmania major	79%	98%