LeishMANIAdb
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Putative dihydroceramide synthase

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative dihydroceramide synthase
Gene product:
Sphingosine N-acyltransferase - putative
Species:
Leishmania infantum
UniProt:
A4I6V5_LEIIN
TriTrypDb:
LINF_310025200
Length:
461

Annotations

Annotations by Jardim et al.

Phospholipid biosynthesis, dihydroceramide synthase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0016020 membrane 2 14
GO:0110165 cellular anatomical entity 1 14
GO:0005783 endoplasmic reticulum 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Phosphorylation

Promastigote: 393

Expansion

Sequence features

A4I6V5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6V5

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 14
GO:0006643 membrane lipid metabolic process 4 14
GO:0006665 sphingolipid metabolic process 4 14
GO:0006672 ceramide metabolic process 4 14
GO:0006807 nitrogen compound metabolic process 2 14
GO:0008152 metabolic process 1 14
GO:0008610 lipid biosynthetic process 4 14
GO:0009058 biosynthetic process 2 14
GO:0009987 cellular process 1 14
GO:0030148 sphingolipid biosynthetic process 5 14
GO:0034641 cellular nitrogen compound metabolic process 3 14
GO:0043603 amide metabolic process 3 14
GO:0043604 amide biosynthetic process 4 14
GO:0044237 cellular metabolic process 2 14
GO:0044238 primary metabolic process 2 14
GO:0044249 cellular biosynthetic process 3 14
GO:0044255 cellular lipid metabolic process 3 14
GO:0044271 cellular nitrogen compound biosynthetic process 4 14
GO:0046467 membrane lipid biosynthetic process 4 14
GO:0046513 ceramide biosynthetic process 5 14
GO:0071704 organic substance metabolic process 2 14
GO:1901564 organonitrogen compound metabolic process 3 14
GO:1901566 organonitrogen compound biosynthetic process 4 14
GO:1901576 organic substance biosynthetic process 3 14
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 14
GO:0016410 N-acyltransferase activity 5 14
GO:0016740 transferase activity 2 14
GO:0016746 acyltransferase activity 3 14
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 14
GO:0050291 sphingosine N-acyltransferase activity 6 14

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 246 252 PF00089 0.544
CLV_NRD_NRD_1 137 139 PF00675 0.296
CLV_NRD_NRD_1 281 283 PF00675 0.261
CLV_NRD_NRD_1 284 286 PF00675 0.253
CLV_NRD_NRD_1 298 300 PF00675 0.257
CLV_NRD_NRD_1 35 37 PF00675 0.588
CLV_NRD_NRD_1 453 455 PF00675 0.570
CLV_NRD_NRD_1 458 460 PF00675 0.567
CLV_PCSK_FUR_1 282 286 PF00082 0.189
CLV_PCSK_KEX2_1 127 129 PF00082 0.365
CLV_PCSK_KEX2_1 221 223 PF00082 0.230
CLV_PCSK_KEX2_1 281 283 PF00082 0.270
CLV_PCSK_KEX2_1 284 286 PF00082 0.271
CLV_PCSK_KEX2_1 35 37 PF00082 0.623
CLV_PCSK_KEX2_1 453 455 PF00082 0.571
CLV_PCSK_KEX2_1 458 460 PF00082 0.569
CLV_PCSK_PC1ET2_1 127 129 PF00082 0.335
CLV_PCSK_PC1ET2_1 221 223 PF00082 0.247
CLV_PCSK_PC1ET2_1 458 460 PF00082 0.473
CLV_PCSK_PC7_1 454 460 PF00082 0.475
CLV_PCSK_SKI1_1 140 144 PF00082 0.360
CLV_PCSK_SKI1_1 218 222 PF00082 0.313
CLV_PCSK_SKI1_1 300 304 PF00082 0.289
CLV_PCSK_SKI1_1 408 412 PF00082 0.509
DOC_ANK_TNKS_1 10 17 PF00023 0.302
DOC_CYCLIN_yCln2_LP_2 185 191 PF00134 0.344
DOC_MAPK_gen_1 136 144 PF00069 0.490
DOC_MAPK_MEF2A_6 143 152 PF00069 0.473
DOC_PP2B_LxvP_1 183 186 PF13499 0.333
DOC_PP2B_LxvP_1 25 28 PF13499 0.344
DOC_PP4_FxxP_1 171 174 PF00568 0.238
DOC_SPAK_OSR1_1 104 108 PF12202 0.538
DOC_USP7_MATH_1 18 22 PF00917 0.401
DOC_USP7_MATH_1 431 435 PF00917 0.681
DOC_USP7_MATH_1 436 440 PF00917 0.664
DOC_USP7_UBL2_3 139 143 PF12436 0.585
DOC_USP7_UBL2_3 296 300 PF12436 0.561
DOC_WW_Pin1_4 131 136 PF00397 0.592
DOC_WW_Pin1_4 14 19 PF00397 0.396
DOC_WW_Pin1_4 340 345 PF00397 0.333
LIG_14-3-3_CanoR_1 128 134 PF00244 0.636
LIG_14-3-3_CanoR_1 299 303 PF00244 0.556
LIG_14-3-3_CanoR_1 305 313 PF00244 0.535
LIG_14-3-3_CanoR_1 35 39 PF00244 0.415
LIG_14-3-3_CanoR_1 4 12 PF00244 0.397
LIG_14-3-3_CanoR_1 42 46 PF00244 0.355
LIG_Actin_WH2_2 373 391 PF00022 0.559
LIG_BIR_II_1 1 5 PF00653 0.361
LIG_BRCT_BRCA1_1 156 160 PF00533 0.278
LIG_Clathr_ClatBox_1 213 217 PF01394 0.426
LIG_EH1_1 230 238 PF00400 0.325
LIG_FHA_1 232 238 PF00498 0.270
LIG_FHA_1 7 13 PF00498 0.424
LIG_GBD_Chelix_1 356 364 PF00786 0.327
LIG_LIR_Gen_1 100 109 PF02991 0.576
LIG_LIR_Gen_1 17 27 PF02991 0.371
LIG_LIR_Gen_1 44 55 PF02991 0.337
LIG_LIR_Nem_3 100 105 PF02991 0.609
LIG_LIR_Nem_3 157 163 PF02991 0.301
LIG_LIR_Nem_3 167 173 PF02991 0.219
LIG_LIR_Nem_3 17 22 PF02991 0.350
LIG_LIR_Nem_3 223 228 PF02991 0.464
LIG_LIR_Nem_3 247 253 PF02991 0.239
LIG_LIR_Nem_3 321 327 PF02991 0.286
LIG_LIR_Nem_3 44 50 PF02991 0.303
LIG_LIR_Nem_3 52 57 PF02991 0.321
LIG_LYPXL_S_1 81 85 PF13949 0.295
LIG_LYPXL_yS_3 82 85 PF13949 0.295
LIG_NRBOX 355 361 PF00104 0.267
LIG_Pex14_1 149 153 PF04695 0.291
LIG_Pex14_1 354 358 PF04695 0.383
LIG_Pex14_2 320 324 PF04695 0.296
LIG_REV1ctd_RIR_1 322 332 PF16727 0.295
LIG_SH2_CRK 108 112 PF00017 0.578
LIG_SH2_CRK 19 23 PF00017 0.350
LIG_SH2_CRK 330 334 PF00017 0.343
LIG_SH2_NCK_1 189 193 PF00017 0.344
LIG_SH2_STAP1 19 23 PF00017 0.438
LIG_SH2_STAT3 162 165 PF00017 0.278
LIG_SH2_STAT3 273 276 PF00017 0.544
LIG_SH2_STAT5 154 157 PF00017 0.277
LIG_SH2_STAT5 163 166 PF00017 0.252
LIG_SH2_STAT5 206 209 PF00017 0.319
LIG_SH2_STAT5 253 256 PF00017 0.286
LIG_SH2_STAT5 26 29 PF00017 0.418
LIG_SH2_STAT5 330 333 PF00017 0.381
LIG_SH2_STAT5 96 99 PF00017 0.542
LIG_SH3_3 185 191 PF00018 0.231
LIG_SH3_3 77 83 PF00018 0.397
LIG_SUMO_SIM_anti_2 234 242 PF11976 0.293
LIG_SUMO_SIM_anti_2 74 79 PF11976 0.290
LIG_SUMO_SIM_par_1 234 242 PF11976 0.313
LIG_SUMO_SIM_par_1 261 268 PF11976 0.302
LIG_SUMO_SIM_par_1 373 379 PF11976 0.413
LIG_TRAF2_1 191 194 PF00917 0.330
LIG_TRAF2_1 418 421 PF00917 0.765
LIG_TYR_ITIM 80 85 PF00017 0.414
LIG_UBA3_1 213 221 PF00899 0.343
MOD_CDK_SPK_2 131 136 PF00069 0.553
MOD_CDK_SPK_2 340 345 PF00069 0.250
MOD_CDK_SPxxK_3 131 138 PF00069 0.513
MOD_CDK_SPxxK_3 340 347 PF00069 0.333
MOD_CK1_1 309 315 PF00069 0.451
MOD_CK1_1 34 40 PF00069 0.384
MOD_CK1_1 439 445 PF00069 0.772
MOD_CK1_1 6 12 PF00069 0.420
MOD_CK2_1 18 24 PF00069 0.363
MOD_CK2_1 390 396 PF00069 0.648
MOD_CK2_1 406 412 PF00069 0.646
MOD_Cter_Amidation 125 128 PF01082 0.423
MOD_GlcNHglycan 124 127 PF01048 0.450
MOD_GlcNHglycan 5 8 PF01048 0.472
MOD_GlcNHglycan 51 54 PF01048 0.561
MOD_GlcNHglycan 68 71 PF01048 0.556
MOD_GSK3_1 110 117 PF00069 0.635
MOD_GSK3_1 14 21 PF00069 0.384
MOD_GSK3_1 263 270 PF00069 0.398
MOD_GSK3_1 336 343 PF00069 0.300
MOD_GSK3_1 37 44 PF00069 0.377
MOD_GSK3_1 396 403 PF00069 0.700
MOD_GSK3_1 406 413 PF00069 0.691
MOD_GSK3_1 436 443 PF00069 0.779
MOD_GSK3_1 444 451 PF00069 0.798
MOD_GSK3_1 45 52 PF00069 0.364
MOD_LATS_1 406 412 PF00433 0.631
MOD_N-GLC_1 31 36 PF02516 0.587
MOD_N-GLC_1 448 453 PF02516 0.504
MOD_N-GLC_1 45 50 PF02516 0.462
MOD_N-GLC_2 314 316 PF02516 0.383
MOD_NEK2_1 148 153 PF00069 0.395
MOD_NEK2_1 155 160 PF00069 0.414
MOD_NEK2_1 265 270 PF00069 0.291
MOD_NEK2_1 378 383 PF00069 0.570
MOD_NEK2_1 410 415 PF00069 0.693
MOD_NEK2_1 440 445 PF00069 0.781
MOD_NEK2_1 73 78 PF00069 0.238
MOD_NEK2_2 336 341 PF00069 0.298
MOD_PIKK_1 448 454 PF00454 0.750
MOD_PKA_1 284 290 PF00069 0.389
MOD_PKA_1 453 459 PF00069 0.710
MOD_PKA_2 284 290 PF00069 0.554
MOD_PKA_2 292 298 PF00069 0.540
MOD_PKA_2 3 9 PF00069 0.321
MOD_PKA_2 34 40 PF00069 0.450
MOD_PKA_2 41 47 PF00069 0.398
MOD_PKA_2 431 437 PF00069 0.646
MOD_PKA_2 453 459 PF00069 0.710
MOD_PKB_1 282 290 PF00069 0.433
MOD_Plk_1 177 183 PF00069 0.348
MOD_Plk_1 309 315 PF00069 0.473
MOD_Plk_1 73 79 PF00069 0.248
MOD_Plk_2-3 390 396 PF00069 0.589
MOD_Plk_4 148 154 PF00069 0.325
MOD_Plk_4 209 215 PF00069 0.323
MOD_Plk_4 232 238 PF00069 0.362
MOD_Plk_4 298 304 PF00069 0.492
MOD_Plk_4 73 79 PF00069 0.264
MOD_ProDKin_1 131 137 PF00069 0.587
MOD_ProDKin_1 14 20 PF00069 0.405
MOD_ProDKin_1 340 346 PF00069 0.333
MOD_SUMO_rev_2 420 425 PF00179 0.608
TRG_ENDOCYTIC_2 108 111 PF00928 0.489
TRG_ENDOCYTIC_2 19 22 PF00928 0.358
TRG_ENDOCYTIC_2 253 256 PF00928 0.307
TRG_ENDOCYTIC_2 370 373 PF00928 0.368
TRG_ENDOCYTIC_2 82 85 PF00928 0.418
TRG_ENDOCYTIC_2 86 89 PF00928 0.396
TRG_ER_diArg_1 135 138 PF00400 0.503
TRG_NLS_Bipartite_1 127 142 PF00514 0.438
TRG_NLS_MonoExtN_4 135 142 PF00514 0.526
TRG_Pf-PMV_PEXEL_1 408 412 PF00026 0.430
TRG_Pf-PMV_PEXEL_1 95 100 PF00026 0.387

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2N8 Leptomonas seymouri 64% 100%
A0A0S4JEY3 Bodo saltans 32% 100%
A0A0S4JIF9 Bodo saltans 34% 100%
A0A1X0NPU5 Trypanosomatidae 46% 100%
A0A1X0NPY1 Trypanosomatidae 46% 100%
A0A3S7X4J5 Leishmania donovani 99% 100%
A0A422MNN3 Trypanosoma rangeli 46% 100%
A4HJG0 Leishmania braziliensis 70% 100%
C9ZMC0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
C9ZWR6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9B1X8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4Q684 Leishmania major 96% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS