Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I6V4_LEIIN

TriTrypDb:

LINF_310025100

Length:

1094

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4I6V4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6V4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	63	67	PF00656	0.687
CLV_C14_Caspase3-7	759	763	PF00656	0.750
CLV_C14_Caspase3-7	848	852	PF00656	0.756
CLV_NRD_NRD_1	1005	1007	PF00675	0.455
CLV_NRD_NRD_1	1089	1091	PF00675	0.450
CLV_NRD_NRD_1	757	759	PF00675	0.562
CLV_NRD_NRD_1	834	836	PF00675	0.546
CLV_NRD_NRD_1	997	999	PF00675	0.509
CLV_PCSK_FUR_1	1003	1007	PF00082	0.421
CLV_PCSK_KEX2_1	1005	1007	PF00082	0.496
CLV_PCSK_KEX2_1	1091	1093	PF00082	0.432
CLV_PCSK_KEX2_1	205	207	PF00082	0.705
CLV_PCSK_KEX2_1	229	231	PF00082	0.660
CLV_PCSK_KEX2_1	757	759	PF00082	0.562
CLV_PCSK_KEX2_1	833	835	PF00082	0.551
CLV_PCSK_PC1ET2_1	1091	1093	PF00082	0.432
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.705
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.660
CLV_PCSK_PC7_1	830	836	PF00082	0.489
CLV_PCSK_SKI1_1	1014	1018	PF00082	0.362
CLV_PCSK_SKI1_1	193	197	PF00082	0.695
CLV_PCSK_SKI1_1	246	250	PF00082	0.684
CLV_PCSK_SKI1_1	382	386	PF00082	0.727
CLV_PCSK_SKI1_1	394	398	PF00082	0.706
CLV_PCSK_SKI1_1	599	603	PF00082	0.462
CLV_PCSK_SKI1_1	824	828	PF00082	0.543
DEG_APCC_DBOX_1	591	599	PF00400	0.660
DEG_ODPH_VHL_1	86	97	PF01847	0.734
DEG_SCF_FBW7_1	8	13	PF00400	0.740
DEG_SCF_FBW7_2	687	693	PF00400	0.659
DEG_SIAH_1	124	132	PF03145	0.696
DEG_SPOP_SBC_1	812	816	PF00917	0.731
DOC_ANK_TNKS_1	61	68	PF00023	0.685
DOC_ANK_TNKS_1	757	764	PF00023	0.755
DOC_CKS1_1	180	185	PF01111	0.581
DOC_CKS1_1	687	692	PF01111	0.670
DOC_CYCLIN_yCln2_LP_2	146	152	PF00134	0.682
DOC_CYCLIN_yCln2_LP_2	703	706	PF00134	0.740
DOC_MAPK_gen_1	1003	1011	PF00069	0.628
DOC_MAPK_gen_1	1044	1051	PF00069	0.492
DOC_MAPK_gen_1	156	166	PF00069	0.534
DOC_MAPK_gen_1	596	604	PF00069	0.648
DOC_MAPK_MEF2A_6	159	168	PF00069	0.534
DOC_MAPK_RevD_3	1076	1091	PF00069	0.380
DOC_MAPK_RevD_3	821	835	PF00069	0.684
DOC_PP1_RVXF_1	1012	1018	PF00149	0.476
DOC_PP2B_LxvP_1	146	149	PF13499	0.742
DOC_PP2B_LxvP_1	349	352	PF13499	0.587
DOC_PP2B_LxvP_1	69	72	PF13499	0.737
DOC_PP2B_LxvP_1	702	705	PF13499	0.744
DOC_PP4_FxxP_1	180	183	PF00568	0.595
DOC_USP7_MATH_1	1069	1073	PF00917	0.388
DOC_USP7_MATH_1	15	19	PF00917	0.655
DOC_USP7_MATH_1	268	272	PF00917	0.480
DOC_USP7_MATH_1	302	306	PF00917	0.519
DOC_USP7_MATH_1	419	423	PF00917	0.489
DOC_USP7_MATH_1	500	504	PF00917	0.565
DOC_USP7_MATH_1	716	720	PF00917	0.758
DOC_USP7_MATH_1	78	82	PF00917	0.832
DOC_USP7_MATH_1	800	804	PF00917	0.731
DOC_USP7_MATH_1	901	905	PF00917	0.741
DOC_USP7_MATH_1	929	933	PF00917	0.713
DOC_USP7_MATH_1	950	954	PF00917	0.707
DOC_USP7_MATH_1	974	978	PF00917	0.719
DOC_USP7_MATH_1	997	1001	PF00917	0.640
DOC_WW_Pin1_4	13	18	PF00397	0.705
DOC_WW_Pin1_4	150	155	PF00397	0.714
DOC_WW_Pin1_4	179	184	PF00397	0.576
DOC_WW_Pin1_4	220	225	PF00397	0.476
DOC_WW_Pin1_4	307	312	PF00397	0.618
DOC_WW_Pin1_4	4	9	PF00397	0.758
DOC_WW_Pin1_4	481	486	PF00397	0.512
DOC_WW_Pin1_4	492	497	PF00397	0.492
DOC_WW_Pin1_4	558	563	PF00397	0.519
DOC_WW_Pin1_4	658	663	PF00397	0.756
DOC_WW_Pin1_4	686	691	PF00397	0.741
DOC_WW_Pin1_4	733	738	PF00397	0.750
DOC_WW_Pin1_4	796	801	PF00397	0.741
DOC_WW_Pin1_4	81	86	PF00397	0.762
DOC_WW_Pin1_4	895	900	PF00397	0.734
DOC_WW_Pin1_4	981	986	PF00397	0.699
LIG_14-3-3_CanoR_1	193	201	PF00244	0.476
LIG_14-3-3_CanoR_1	267	276	PF00244	0.487
LIG_14-3-3_CanoR_1	301	311	PF00244	0.550
LIG_14-3-3_CanoR_1	502	512	PF00244	0.461
LIG_14-3-3_CanoR_1	529	536	PF00244	0.452
LIG_14-3-3_CanoR_1	548	558	PF00244	0.398
LIG_14-3-3_CanoR_1	787	796	PF00244	0.747
LIG_14-3-3_CanoR_1	824	829	PF00244	0.744
LIG_14-3-3_CanoR_1	926	934	PF00244	0.735
LIG_14-3-3_CanoR_1	996	1002	PF00244	0.671
LIG_AP2alpha_1	256	260	PF02296	0.496
LIG_APCC_ABBA_1	566	571	PF00400	0.388
LIG_BIR_II_1	1	5	PF00653	0.754
LIG_BIR_III_2	659	663	PF00653	0.741
LIG_BIR_III_4	356	360	PF00653	0.587
LIG_BIR_III_4	851	855	PF00653	0.753
LIG_Clathr_ClatBox_1	902	906	PF01394	0.741
LIG_CSL_BTD_1	868	871	PF09270	0.696
LIG_eIF4E_1	161	167	PF01652	0.388
LIG_EVH1_1	148	152	PF00568	0.682
LIG_FHA_1	1023	1029	PF00498	0.323
LIG_FHA_1	131	137	PF00498	0.713
LIG_FHA_1	184	190	PF00498	0.476
LIG_FHA_1	281	287	PF00498	0.490
LIG_FHA_1	403	409	PF00498	0.506
LIG_FHA_1	575	581	PF00498	0.361
LIG_FHA_1	789	795	PF00498	0.716
LIG_FHA_1	800	806	PF00498	0.697
LIG_FHA_1	839	845	PF00498	0.778
LIG_FHA_1	987	993	PF00498	0.657
LIG_FHA_2	1054	1060	PF00498	0.450
LIG_FHA_2	442	448	PF00498	0.488
LIG_FHA_2	459	465	PF00498	0.342
LIG_FHA_2	514	520	PF00498	0.526
LIG_FHA_2	654	660	PF00498	0.692
LIG_FHA_2	7	13	PF00498	0.740
LIG_FHA_2	941	947	PF00498	0.806
LIG_KLC1_Yacidic_2	740	745	PF13176	0.693
LIG_LIR_Apic_2	179	183	PF02991	0.384
LIG_LIR_Apic_2	740	746	PF02991	0.769
LIG_LIR_Apic_2	977	981	PF02991	0.794
LIG_LIR_Gen_1	1000	1009	PF02991	0.652
LIG_LIR_Gen_1	160	170	PF02991	0.388
LIG_LIR_Gen_1	217	227	PF02991	0.477
LIG_LIR_Gen_1	272	281	PF02991	0.519
LIG_LIR_Gen_1	571	580	PF02991	0.388
LIG_LIR_Nem_3	1000	1004	PF02991	0.659
LIG_LIR_Nem_3	160	165	PF02991	0.388
LIG_LIR_Nem_3	179	184	PF02991	0.397
LIG_LIR_Nem_3	217	222	PF02991	0.476
LIG_LIR_Nem_3	261	265	PF02991	0.482
LIG_LIR_Nem_3	272	278	PF02991	0.436
LIG_LIR_Nem_3	454	458	PF02991	0.508
LIG_LIR_Nem_3	473	479	PF02991	0.368
LIG_LIR_Nem_3	571	576	PF02991	0.388
LIG_MAD2	382	390	PF02301	0.503
LIG_NRBOX	1011	1017	PF00104	0.615
LIG_Pex14_2	256	260	PF04695	0.496
LIG_Pex14_2	569	573	PF04695	0.388
LIG_SH2_CRK	1001	1005	PF00017	0.644
LIG_SH2_CRK	162	166	PF00017	0.384
LIG_SH2_CRK	455	459	PF00017	0.497
LIG_SH2_NCK_1	1018	1022	PF00017	0.307
LIG_SH2_NCK_1	44	48	PF00017	0.698
LIG_SH2_PTP2	275	278	PF00017	0.527
LIG_SH2_PTP2	477	480	PF00017	0.499
LIG_SH2_PTP2	978	981	PF00017	0.706
LIG_SH2_SRC	455	458	PF00017	0.488
LIG_SH2_SRC	708	711	PF00017	0.671
LIG_SH2_SRC	743	746	PF00017	0.692
LIG_SH2_STAP1	1018	1022	PF00017	0.283
LIG_SH2_STAP1	162	166	PF00017	0.307
LIG_SH2_STAT3	39	42	PF00017	0.726
LIG_SH2_STAT3	614	617	PF00017	0.668
LIG_SH2_STAT5	1001	1004	PF00017	0.638
LIG_SH2_STAT5	1061	1064	PF00017	0.462
LIG_SH2_STAT5	275	278	PF00017	0.527
LIG_SH2_STAT5	424	427	PF00017	0.497
LIG_SH2_STAT5	465	468	PF00017	0.452
LIG_SH2_STAT5	477	480	PF00017	0.418
LIG_SH2_STAT5	743	746	PF00017	0.769
LIG_SH2_STAT5	796	799	PF00017	0.746
LIG_SH2_STAT5	978	981	PF00017	0.706
LIG_SH3_2	151	156	PF14604	0.709
LIG_SH3_2	497	502	PF14604	0.473
LIG_SH3_2	88	93	PF14604	0.731
LIG_SH3_3	122	128	PF00018	0.742
LIG_SH3_3	146	152	PF00018	0.734
LIG_SH3_3	195	201	PF00018	0.475
LIG_SH3_3	306	312	PF00018	0.542
LIG_SH3_3	476	482	PF00018	0.500
LIG_SH3_3	494	500	PF00018	0.445
LIG_SH3_3	514	520	PF00018	0.525
LIG_SH3_3	538	544	PF00018	0.528
LIG_SH3_3	629	635	PF00018	0.755
LIG_SH3_3	669	675	PF00018	0.755
LIG_SH3_3	684	690	PF00018	0.673
LIG_SH3_3	761	767	PF00018	0.744
LIG_SH3_3	79	85	PF00018	0.805
LIG_SH3_3	868	874	PF00018	0.758
LIG_SH3_3	894	900	PF00018	0.743
LIG_SH3_3	907	913	PF00018	0.722
LIG_SH3_3	94	100	PF00018	0.653
LIG_SUMO_SIM_anti_2	1066	1072	PF11976	0.315
LIG_SUMO_SIM_anti_2	563	569	PF11976	0.334
LIG_SUMO_SIM_par_1	1079	1085	PF11976	0.306
LIG_SUMO_SIM_par_1	576	581	PF11976	0.303
LIG_TRAF2_1	943	946	PF00917	0.750
LIG_TRFH_1	742	746	PF08558	0.770
LIG_TYR_ITIM	475	480	PF00017	0.382
LIG_TYR_ITSM	158	165	PF00017	0.476
LIG_UBA3_1	992	999	PF00899	0.654
LIG_WRC_WIRS_1	177	182	PF05994	0.388
LIG_WW_1	705	708	PF00397	0.688
LIG_WW_3	671	675	PF00397	0.716
MOD_CDC14_SPxK_1	153	156	PF00782	0.697
MOD_CDC14_SPxK_1	499	502	PF00782	0.466
MOD_CDK_SPxK_1	150	156	PF00069	0.714
MOD_CDK_SPxK_1	496	502	PF00069	0.474
MOD_CDK_SPxxK_3	481	488	PF00069	0.506
MOD_CDK_SPxxK_3	86	93	PF00069	0.667
MOD_CDK_SPxxK_3	981	988	PF00069	0.670
MOD_CK1_1	1039	1045	PF00069	0.492
MOD_CK1_1	179	185	PF00069	0.573
MOD_CK1_1	18	24	PF00069	0.669
MOD_CK1_1	2	8	PF00069	0.755
MOD_CK1_1	223	229	PF00069	0.476
MOD_CK1_1	25	31	PF00069	0.703
MOD_CK1_1	271	277	PF00069	0.504
MOD_CK1_1	324	330	PF00069	0.596
MOD_CK1_1	426	432	PF00069	0.441
MOD_CK1_1	495	501	PF00069	0.551
MOD_CK1_1	503	509	PF00069	0.444
MOD_CK1_1	661	667	PF00069	0.768
MOD_CK1_1	692	698	PF00069	0.761
MOD_CK1_1	736	742	PF00069	0.759
MOD_CK1_1	788	794	PF00069	0.747
MOD_CK1_1	799	805	PF00069	0.669
MOD_CK1_1	81	87	PF00069	0.783
MOD_CK1_1	915	921	PF00069	0.741
MOD_CK1_1	937	943	PF00069	0.784
MOD_CK2_1	458	464	PF00069	0.467
MOD_CK2_1	513	519	PF00069	0.531
MOD_CK2_1	929	935	PF00069	0.819
MOD_CK2_1	940	946	PF00069	0.737
MOD_CK2_1	958	964	PF00069	0.630
MOD_CK2_1	981	987	PF00069	0.670
MOD_Cter_Amidation	831	834	PF01082	0.544
MOD_GlcNHglycan	1038	1041	PF01048	0.672
MOD_GlcNHglycan	216	219	PF01048	0.654
MOD_GlcNHglycan	241	244	PF01048	0.669
MOD_GlcNHglycan	262	265	PF01048	0.680
MOD_GlcNHglycan	323	326	PF01048	0.835
MOD_GlcNHglycan	420	424	PF01048	0.687
MOD_GlcNHglycan	437	440	PF01048	0.584
MOD_GlcNHglycan	503	506	PF01048	0.783
MOD_GlcNHglycan	551	554	PF01048	0.708
MOD_GlcNHglycan	562	565	PF01048	0.568
MOD_GlcNHglycan	693	697	PF01048	0.546
MOD_GlcNHglycan	718	721	PF01048	0.570
MOD_GlcNHglycan	815	818	PF01048	0.527
MOD_GlcNHglycan	858	861	PF01048	0.513
MOD_GlcNHglycan	939	942	PF01048	0.606
MOD_GSK3_1	179	186	PF00069	0.559
MOD_GSK3_1	18	25	PF00069	0.683
MOD_GSK3_1	189	196	PF00069	0.417
MOD_GSK3_1	2	9	PF00069	0.740
MOD_GSK3_1	204	211	PF00069	0.393
MOD_GSK3_1	400	407	PF00069	0.489
MOD_GSK3_1	419	426	PF00069	0.371
MOD_GSK3_1	431	438	PF00069	0.460
MOD_GSK3_1	492	499	PF00069	0.551
MOD_GSK3_1	574	581	PF00069	0.280
MOD_GSK3_1	661	668	PF00069	0.757
MOD_GSK3_1	682	689	PF00069	0.680
MOD_GSK3_1	711	718	PF00069	0.742
MOD_GSK3_1	788	795	PF00069	0.746
MOD_GSK3_1	796	803	PF00069	0.692
MOD_GSK3_1	807	814	PF00069	0.621
MOD_GSK3_1	936	943	PF00069	0.854
MOD_GSK3_1	958	965	PF00069	0.754
MOD_N-GLC_1	1063	1068	PF02516	0.630
MOD_N-GLC_1	18	23	PF02516	0.571
MOD_N-GLC_1	189	194	PF02516	0.695
MOD_N-GLC_1	330	335	PF02516	0.702
MOD_N-GLC_1	376	381	PF02516	0.738
MOD_N-GLC_1	411	416	PF02516	0.682
MOD_N-GLC_1	824	829	PF02516	0.544
MOD_NEK2_1	1031	1036	PF00069	0.372
MOD_NEK2_1	1063	1068	PF00069	0.442
MOD_NEK2_1	1071	1076	PF00069	0.323
MOD_NEK2_1	176	181	PF00069	0.384
MOD_NEK2_1	189	194	PF00069	0.405
MOD_NEK2_1	214	219	PF00069	0.474
MOD_NEK2_1	22	27	PF00069	0.641
MOD_NEK2_1	260	265	PF00069	0.482
MOD_NEK2_1	289	294	PF00069	0.529
MOD_NEK2_1	3	8	PF00069	0.758
MOD_NEK2_1	385	390	PF00069	0.561
MOD_NEK2_1	411	416	PF00069	0.508
MOD_NEK2_1	528	533	PF00069	0.489
MOD_NEK2_1	574	579	PF00069	0.361
MOD_NEK2_1	663	668	PF00069	0.774
MOD_NEK2_1	677	682	PF00069	0.686
MOD_NEK2_1	694	699	PF00069	0.709
MOD_NEK2_1	922	927	PF00069	0.741
MOD_NEK2_1	934	939	PF00069	0.748
MOD_NEK2_2	513	518	PF00069	0.468
MOD_PIKK_1	677	683	PF00454	0.752
MOD_PIKK_1	927	933	PF00454	0.735
MOD_PK_1	819	825	PF00069	0.733
MOD_PKA_2	268	274	PF00069	0.483
MOD_PKA_2	501	507	PF00069	0.495
MOD_PKA_2	528	534	PF00069	0.450
MOD_PKA_2	786	792	PF00069	0.743
MOD_PKA_2	838	844	PF00069	0.776
MOD_PKA_2	997	1003	PF00069	0.679
MOD_PKB_1	267	275	PF00069	0.468
MOD_PKB_1	785	793	PF00069	0.743
MOD_Plk_1	1063	1069	PF00069	0.430
MOD_Plk_1	18	24	PF00069	0.770
MOD_Plk_1	376	382	PF00069	0.538
MOD_Plk_1	411	417	PF00069	0.481
MOD_Plk_1	419	425	PF00069	0.431
MOD_Plk_1	513	519	PF00069	0.513
MOD_Plk_1	604	610	PF00069	0.650
MOD_Plk_1	807	813	PF00069	0.730
MOD_Plk_1	819	825	PF00069	0.664
MOD_Plk_1	986	992	PF00069	0.656
MOD_Plk_2-3	1055	1061	PF00069	0.447
MOD_Plk_4	132	138	PF00069	0.711
MOD_Plk_4	176	182	PF00069	0.388
MOD_Plk_4	18	24	PF00069	0.770
MOD_Plk_4	223	229	PF00069	0.476
MOD_Plk_4	271	277	PF00069	0.504
MOD_Plk_4	412	418	PF00069	0.521
MOD_Plk_4	574	580	PF00069	0.361
MOD_Plk_4	800	806	PF00069	0.729
MOD_Plk_4	865	871	PF00069	0.682
MOD_Plk_4	929	935	PF00069	0.760
MOD_Plk_4	974	980	PF00069	0.700
MOD_ProDKin_1	13	19	PF00069	0.706
MOD_ProDKin_1	150	156	PF00069	0.714
MOD_ProDKin_1	179	185	PF00069	0.573
MOD_ProDKin_1	220	226	PF00069	0.477
MOD_ProDKin_1	307	313	PF00069	0.621
MOD_ProDKin_1	4	10	PF00069	0.757
MOD_ProDKin_1	481	487	PF00069	0.512
MOD_ProDKin_1	492	498	PF00069	0.493
MOD_ProDKin_1	558	564	PF00069	0.512
MOD_ProDKin_1	658	664	PF00069	0.756
MOD_ProDKin_1	686	692	PF00069	0.739
MOD_ProDKin_1	733	739	PF00069	0.751
MOD_ProDKin_1	796	802	PF00069	0.740
MOD_ProDKin_1	81	87	PF00069	0.760
MOD_ProDKin_1	895	901	PF00069	0.734
MOD_ProDKin_1	981	987	PF00069	0.694
MOD_SUMO_rev_2	1085	1093	PF00179	0.532
MOD_SUMO_rev_2	441	451	PF00179	0.490
TRG_DiLeu_BaEn_1	571	576	PF01217	0.388
TRG_DiLeu_BaLyEn_6	90	95	PF01217	0.683
TRG_ENDOCYTIC_2	1001	1004	PF00928	0.657
TRG_ENDOCYTIC_2	161	164	PF00928	0.388
TRG_ENDOCYTIC_2	219	222	PF00928	0.484
TRG_ENDOCYTIC_2	262	265	PF00928	0.480
TRG_ENDOCYTIC_2	275	278	PF00928	0.439
TRG_ENDOCYTIC_2	455	458	PF00928	0.508
TRG_ENDOCYTIC_2	476	479	PF00928	0.493
TRG_ER_diArg_1	1003	1006	PF00400	0.583
TRG_ER_diArg_1	1090	1093	PF00400	0.633
TRG_ER_diArg_1	267	270	PF00400	0.455
TRG_ER_diArg_1	756	758	PF00400	0.758
TRG_ER_diArg_1	833	835	PF00400	0.751
TRG_ER_diArg_1	995	998	PF00400	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4J6	Leishmania donovani	99%	100%
E9B1X7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	93%
Q4Q685	Leishmania major	88%	100%