Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I6V3_LEIIN

TriTrypDb:

LINF_310025000

Length:

375

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I6V3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6V3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	144	148	PF00656	0.638
CLV_NRD_NRD_1	123	125	PF00675	0.637
CLV_NRD_NRD_1	128	130	PF00675	0.623
CLV_NRD_NRD_1	173	175	PF00675	0.627
CLV_NRD_NRD_1	189	191	PF00675	0.689
CLV_NRD_NRD_1	353	355	PF00675	0.585
CLV_NRD_NRD_1	360	362	PF00675	0.621
CLV_NRD_NRD_1	84	86	PF00675	0.580
CLV_NRD_NRD_1	88	90	PF00675	0.561
CLV_PCSK_KEX2_1	123	125	PF00082	0.637
CLV_PCSK_KEX2_1	128	130	PF00082	0.623
CLV_PCSK_KEX2_1	189	191	PF00082	0.569
CLV_PCSK_KEX2_1	269	271	PF00082	0.624
CLV_PCSK_KEX2_1	353	355	PF00082	0.585
CLV_PCSK_KEX2_1	360	362	PF00082	0.621
CLV_PCSK_KEX2_1	84	86	PF00082	0.580
CLV_PCSK_KEX2_1	88	90	PF00082	0.561
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.717
CLV_PCSK_PC7_1	124	130	PF00082	0.671
CLV_PCSK_PC7_1	185	191	PF00082	0.609
CLV_PCSK_PC7_1	84	90	PF00082	0.528
CLV_PCSK_SKI1_1	100	104	PF00082	0.594
CLV_PCSK_SKI1_1	257	261	PF00082	0.696
CLV_PCSK_SKI1_1	313	317	PF00082	0.808
CLV_PCSK_SKI1_1	354	358	PF00082	0.593
CLV_PCSK_SKI1_1	84	88	PF00082	0.706
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.781
DOC_MAPK_gen_1	100	108	PF00069	0.594
DOC_MAPK_gen_1	84	94	PF00069	0.548
DOC_MAPK_MEF2A_6	88	96	PF00069	0.609
DOC_PP2B_LxvP_1	108	111	PF13499	0.669
DOC_PP4_FxxP_1	326	329	PF00568	0.682
DOC_PP4_FxxP_1	71	74	PF00568	0.600
DOC_USP7_MATH_1	148	152	PF00917	0.646
DOC_USP7_MATH_1	8	12	PF00917	0.738
DOC_USP7_UBL2_3	309	313	PF12436	0.784
DOC_WW_Pin1_4	19	24	PF00397	0.737
DOC_WW_Pin1_4	191	196	PF00397	0.632
DOC_WW_Pin1_4	220	225	PF00397	0.742
DOC_WW_Pin1_4	314	319	PF00397	0.811
DOC_WW_Pin1_4	38	43	PF00397	0.788
DOC_WW_Pin1_4	4	9	PF00397	0.639
DOC_WW_Pin1_4	59	64	PF00397	0.757
DOC_WW_Pin1_4	72	77	PF00397	0.572
LIG_14-3-3_CanoR_1	123	127	PF00244	0.674
LIG_14-3-3_CanoR_1	263	267	PF00244	0.553
LIG_14-3-3_CanoR_1	360	368	PF00244	0.639
LIG_14-3-3_CanoR_1	88	96	PF00244	0.570
LIG_Actin_WH2_2	73	90	PF00022	0.538
LIG_BIR_II_1	1	5	PF00653	0.787
LIG_BIR_III_3	1	5	PF00653	0.787
LIG_FHA_1	19	25	PF00498	0.759
LIG_FHA_1	245	251	PF00498	0.595
LIG_FHA_1	274	280	PF00498	0.744
LIG_FHA_1	285	291	PF00498	0.586
LIG_FHA_1	59	65	PF00498	0.698
LIG_FHA_1	8	14	PF00498	0.709
LIG_FHA_2	171	177	PF00498	0.608
LIG_FHA_2	287	293	PF00498	0.759
LIG_FHA_2	332	338	PF00498	0.694
LIG_FHA_2	360	366	PF00498	0.635
LIG_Integrin_RGD_1	164	166	PF01839	0.766
LIG_LIR_Apic_2	323	329	PF02991	0.688
LIG_LIR_Apic_2	365	371	PF02991	0.640
LIG_LIR_Apic_2	68	74	PF02991	0.610
LIG_LIR_Gen_1	213	224	PF02991	0.689
LIG_LIR_Gen_1	334	343	PF02991	0.608
LIG_LIR_Nem_3	334	338	PF02991	0.607
LIG_PCNA_PIPBox_1	80	89	PF02747	0.652
LIG_Pex14_2	168	172	PF04695	0.749
LIG_SH2_CRK	368	372	PF00017	0.643
LIG_SH2_STAT5	187	190	PF00017	0.636
LIG_SH2_STAT5	255	258	PF00017	0.661
LIG_SH3_1	192	198	PF00018	0.728
LIG_SH3_3	103	109	PF00018	0.665
LIG_SH3_3	11	17	PF00018	0.673
LIG_SH3_3	157	163	PF00018	0.650
LIG_SH3_3	192	198	PF00018	0.630
LIG_SH3_3	2	8	PF00018	0.670
LIG_SH3_3	226	232	PF00018	0.715
LIG_SH3_3	275	281	PF00018	0.655
LIG_SH3_3	321	327	PF00018	0.643
LIG_SH3_3	41	47	PF00018	0.780
LIG_SUMO_SIM_anti_2	104	109	PF11976	0.711
LIG_SUMO_SIM_par_1	341	346	PF11976	0.692
MOD_CDC14_SPxK_1	22	25	PF00782	0.779
MOD_CDK_SPxK_1	19	25	PF00069	0.783
MOD_CK1_1	18	24	PF00069	0.770
MOD_CK1_1	298	304	PF00069	0.754
MOD_CK1_1	31	37	PF00069	0.726
MOD_CK1_1	317	323	PF00069	0.528
MOD_CK1_1	55	61	PF00069	0.711
MOD_CK1_1	7	13	PF00069	0.707
MOD_CK1_1	75	81	PF00069	0.570
MOD_CK2_1	132	138	PF00069	0.739
MOD_CK2_1	170	176	PF00069	0.576
MOD_CK2_1	286	292	PF00069	0.760
MOD_CK2_1	359	365	PF00069	0.631
MOD_GlcNHglycan	150	153	PF01048	0.661
MOD_GlcNHglycan	155	159	PF01048	0.567
MOD_GlcNHglycan	297	300	PF01048	0.714
MOD_GlcNHglycan	35	38	PF01048	0.678
MOD_GlcNHglycan	57	60	PF01048	0.724
MOD_GlcNHglycan	77	80	PF01048	0.687
MOD_GSK3_1	12	19	PF00069	0.694
MOD_GSK3_1	28	35	PF00069	0.534
MOD_GSK3_1	291	298	PF00069	0.674
MOD_GSK3_1	316	323	PF00069	0.706
MOD_GSK3_1	4	11	PF00069	0.788
MOD_GSK3_1	55	62	PF00069	0.767
MOD_LATS_1	359	365	PF00433	0.631
MOD_NEK2_1	132	137	PF00069	0.661
MOD_NEK2_1	168	173	PF00069	0.741
MOD_NEK2_1	293	298	PF00069	0.675
MOD_NEK2_1	87	92	PF00069	0.619
MOD_NEK2_2	255	260	PF00069	0.696
MOD_PIKK_1	8	14	PF00454	0.653
MOD_PK_1	88	94	PF00069	0.532
MOD_PKA_1	88	94	PF00069	0.532
MOD_PKA_2	122	128	PF00069	0.675
MOD_PKA_2	262	268	PF00069	0.598
MOD_PKA_2	359	365	PF00069	0.662
MOD_PKA_2	87	93	PF00069	0.600
MOD_Plk_1	168	174	PF00069	0.685
MOD_Plk_1	28	34	PF00069	0.700
MOD_Plk_4	262	268	PF00069	0.657
MOD_Plk_4	88	94	PF00069	0.567
MOD_ProDKin_1	19	25	PF00069	0.738
MOD_ProDKin_1	191	197	PF00069	0.626
MOD_ProDKin_1	220	226	PF00069	0.741
MOD_ProDKin_1	314	320	PF00069	0.809
MOD_ProDKin_1	38	44	PF00069	0.784
MOD_ProDKin_1	4	10	PF00069	0.639
MOD_ProDKin_1	59	65	PF00069	0.758
MOD_ProDKin_1	72	78	PF00069	0.564
TRG_DiLeu_BaLyEn_6	339	344	PF01217	0.710
TRG_ENDOCYTIC_2	335	338	PF00928	0.703
TRG_ER_diArg_1	127	129	PF00400	0.633
TRG_ER_diArg_1	188	190	PF00400	0.715
TRG_ER_diArg_1	83	85	PF00400	0.569
TRG_ER_diArg_1	87	89	PF00400	0.562
TRG_NES_CRM1_1	254	268	PF08389	0.686
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.590
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4V3	Leptomonas seymouri	40%	92%
A0A3Q8ISN5	Leishmania donovani	99%	100%
E9B1X6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q686	Leishmania major	87%	100%