LeishMANIAdb
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Nucleosome assembly protein-like protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nucleosome assembly protein-like protein
Gene product:
nucleosome assembly protein-like protein
Species:
Leishmania infantum
UniProt:
A4I6V2_LEIIN
TriTrypDb:
LINF_310024900
Length:
403

Annotations

Annotations by Jardim et al.

Histone/chromosome structure, Nucleosome assembly -like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043231 intracellular membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 12
GO:0000785 chromatin 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I6V2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6V2

Function

Biological processes
Term Name Level Count
GO:0006325 chromatin organization 4 12
GO:0006334 nucleosome assembly 7 12
GO:0006338 chromatin remodeling 5 12
GO:0009987 cellular process 1 12
GO:0016043 cellular component organization 3 12
GO:0022607 cellular component assembly 4 12
GO:0034728 nucleosome organization 6 12
GO:0043933 protein-containing complex organization 4 12
GO:0065003 protein-containing complex assembly 5 12
GO:0065004 protein-DNA complex assembly 6 12
GO:0071824 protein-DNA complex subunit organization 5 12
GO:0071840 cellular component organization or biogenesis 2 12
Molecular functions
Term Name Level Count
GO:0003682 chromatin binding 2 1
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0042393 histone binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 13 17 PF00656 0.699
CLV_C14_Caspase3-7 347 351 PF00656 0.711
CLV_NRD_NRD_1 40 42 PF00675 0.243
CLV_NRD_NRD_1 80 82 PF00675 0.302
CLV_PCSK_KEX2_1 39 41 PF00082 0.280
CLV_PCSK_SKI1_1 119 123 PF00082 0.273
CLV_PCSK_SKI1_1 169 173 PF00082 0.236
CLV_PCSK_SKI1_1 192 196 PF00082 0.334
CLV_PCSK_SKI1_1 240 244 PF00082 0.241
CLV_PCSK_SKI1_1 315 319 PF00082 0.277
CLV_PCSK_SKI1_1 89 93 PF00082 0.254
DEG_APCC_DBOX_1 168 176 PF00400 0.446
DOC_ANK_TNKS_1 179 186 PF00023 0.482
DOC_MAPK_gen_1 167 175 PF00069 0.456
DOC_MAPK_gen_1 236 246 PF00069 0.472
DOC_MAPK_gen_1 252 261 PF00069 0.363
DOC_MAPK_MEF2A_6 239 246 PF00069 0.500
DOC_PP1_RVXF_1 117 124 PF00149 0.482
DOC_PP1_RVXF_1 190 196 PF00149 0.477
DOC_PP4_FxxP_1 123 126 PF00568 0.482
DOC_PP4_FxxP_1 274 277 PF00568 0.437
DOC_USP7_MATH_1 140 144 PF00917 0.505
DOC_USP7_MATH_1 159 163 PF00917 0.519
DOC_USP7_MATH_1 20 24 PF00917 0.709
DOC_USP7_MATH_1 267 271 PF00917 0.530
DOC_USP7_MATH_1 363 367 PF00917 0.704
DOC_USP7_UBL2_3 118 122 PF12436 0.495
DOC_USP7_UBL2_3 236 240 PF12436 0.452
DOC_USP7_UBL2_3 250 254 PF12436 0.394
DOC_WW_Pin1_4 138 143 PF00397 0.511
DOC_WW_Pin1_4 195 200 PF00397 0.502
DOC_WW_Pin1_4 273 278 PF00397 0.529
DOC_WW_Pin1_4 377 382 PF00397 0.655
LIG_14-3-3_CanoR_1 98 108 PF00244 0.556
LIG_BIR_III_2 113 117 PF00653 0.532
LIG_CaM_IQ_9 42 58 PF13499 0.529
LIG_eIF4E_1 43 49 PF01652 0.446
LIG_FHA_1 224 230 PF00498 0.520
LIG_FHA_1 241 247 PF00498 0.350
LIG_FHA_1 307 313 PF00498 0.520
LIG_FHA_2 104 110 PF00498 0.529
LIG_FHA_2 11 17 PF00498 0.648
LIG_FHA_2 163 169 PF00498 0.435
LIG_FHA_2 174 180 PF00498 0.437
LIG_FHA_2 212 218 PF00498 0.483
LIG_FHA_2 326 332 PF00498 0.550
LIG_FHA_2 33 39 PF00498 0.461
LIG_FHA_2 90 96 PF00498 0.445
LIG_LIR_Gen_1 269 280 PF02991 0.437
LIG_LIR_Nem_3 269 275 PF02991 0.437
LIG_LIR_Nem_3 366 371 PF02991 0.674
LIG_LIR_Nem_3 51 55 PF02991 0.460
LIG_NRBOX 44 50 PF00104 0.446
LIG_PCNA_PIPBox_1 46 55 PF02747 0.532
LIG_PCNA_yPIPBox_3 39 53 PF02747 0.417
LIG_Pex14_2 271 275 PF04695 0.434
LIG_SH2_STAT3 43 46 PF00017 0.529
LIG_SH2_STAT5 202 205 PF00017 0.438
LIG_SH2_STAT5 320 323 PF00017 0.446
LIG_SH3_2 105 110 PF14604 0.532
LIG_SH3_3 102 108 PF00018 0.548
LIG_SH3_3 274 280 PF00018 0.530
LIG_SUMO_SIM_anti_2 26 33 PF11976 0.541
LIG_SUMO_SIM_par_1 26 33 PF11976 0.502
LIG_TRAF2_1 396 399 PF00917 0.705
LIG_TRAF2_1 92 95 PF00917 0.460
MOD_CDK_SPxxK_3 377 384 PF00069 0.659
MOD_CK1_1 15 21 PF00069 0.711
MOD_CK1_1 162 168 PF00069 0.429
MOD_CK2_1 152 158 PF00069 0.510
MOD_CK2_1 173 179 PF00069 0.549
MOD_CK2_1 18 24 PF00069 0.653
MOD_CK2_1 195 201 PF00069 0.509
MOD_CK2_1 32 38 PF00069 0.342
MOD_CK2_1 325 331 PF00069 0.510
MOD_CK2_1 338 344 PF00069 0.652
MOD_CK2_1 348 354 PF00069 0.667
MOD_CK2_1 89 95 PF00069 0.445
MOD_GlcNHglycan 132 135 PF01048 0.338
MOD_GlcNHglycan 142 145 PF01048 0.324
MOD_GSK3_1 15 22 PF00069 0.700
MOD_GSK3_1 99 106 PF00069 0.448
MOD_N-GLC_1 204 209 PF02516 0.299
MOD_N-GLC_1 240 245 PF02516 0.246
MOD_N-GLC_2 68 70 PF02516 0.332
MOD_NEK2_1 149 154 PF00069 0.434
MOD_NEK2_1 242 247 PF00069 0.532
MOD_NEK2_2 267 272 PF00069 0.529
MOD_PIKK_1 306 312 PF00454 0.532
MOD_PKA_2 223 229 PF00069 0.543
MOD_Plk_1 204 210 PF00069 0.499
MOD_Plk_1 240 246 PF00069 0.445
MOD_Plk_1 32 38 PF00069 0.441
MOD_Plk_2-3 211 217 PF00069 0.488
MOD_Plk_2-3 346 352 PF00069 0.693
MOD_Plk_4 159 165 PF00069 0.443
MOD_Plk_4 267 273 PF00069 0.434
MOD_ProDKin_1 138 144 PF00069 0.511
MOD_ProDKin_1 195 201 PF00069 0.502
MOD_ProDKin_1 273 279 PF00069 0.529
MOD_ProDKin_1 377 383 PF00069 0.655
TRG_ENDOCYTIC_2 52 55 PF00928 0.446
TRG_ER_diArg_1 372 375 PF00400 0.695
TRG_ER_diArg_1 39 41 PF00400 0.371
TRG_ER_diArg_1 55 58 PF00400 0.529
TRG_NES_CRM1_1 26 38 PF08389 0.433
TRG_NLS_Bipartite_1 239 253 PF00514 0.529
TRG_NLS_MonoExtN_4 247 253 PF00514 0.434
TRG_Pf-PMV_PEXEL_1 330 334 PF00026 0.534
TRG_Pf-PMV_PEXEL_1 89 93 PF00026 0.250

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1J2 Leptomonas seymouri 32% 100%
A0A0N1IJI7 Leptomonas seymouri 68% 99%
A0A0S4J1L1 Bodo saltans 41% 98%
A0A1X0NTY9 Trypanosomatidae 42% 93%
A0A3Q8IA70 Leishmania donovani 33% 100%
A0A3R7KHX6 Trypanosoma rangeli 42% 93%
A0A3R7KRI5 Trypanosoma rangeli 29% 100%
A0A3S7X4M4 Leishmania donovani 100% 100%
A4HA02 Leishmania braziliensis 34% 100%
A4HJF7 Leishmania braziliensis 84% 100%
A4HY66 Leishmania infantum 31% 100%
A6H767 Bos taurus 34% 100%
B8AW64 Oryza sativa subsp. indica 32% 100%
B8B2R4 Oryza sativa subsp. indica 34% 100%
C9ZXT4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 96%
D0A0I6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9ARZ6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B1X5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
O59797 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 35% 100%
P25293 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 31% 97%
P28656 Mus musculus 33% 100%
P55209 Homo sapiens 33% 100%
P78920 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 33% 100%
Q28EB4 Xenopus tropicalis 33% 100%
Q2TA40 Bos taurus 33% 100%
Q4Q687 Leishmania major 93% 100%
Q4QDH7 Leishmania major 30% 100%
Q4U0Y4 Xenopus laevis 31% 100%
Q53WK4 Oryza sativa subsp. japonica 32% 100%
Q55ED1 Dictyostelium discoideum 29% 100%
Q5AAI8 Candida albicans (strain SC5314 / ATCC MYA-2876) 31% 93%
Q5R4D4 Pongo abelii 33% 100%
Q5U2Z3 Rattus norvegicus 33% 100%
Q5VND6 Oryza sativa subsp. japonica 34% 100%
Q70Z16 Nicotiana tabacum 31% 100%
Q70Z17 Nicotiana tabacum 35% 100%
Q70Z18 Nicotiana tabacum 35% 100%
Q70Z19 Nicotiana tabacum 31% 100%
Q78ZA7 Mus musculus 34% 100%
Q7ZY81 Xenopus laevis 34% 100%
Q94K07 Arabidopsis thaliana 35% 100%
Q99733 Homo sapiens 32% 100%
Q9SZI2 Arabidopsis thaliana 35% 100%
Q9Z2G8 Rattus norvegicus 33% 100%
Q9ZUP3 Arabidopsis thaliana 34% 100%
V5BUC1 Trypanosoma cruzi 43% 89%
V5BX23 Trypanosoma cruzi 25% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS