Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I6V1_LEIIN

TriTrypDb:

LINF_310024800

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I6V1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6V1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.450
CLV_NRD_NRD_1	249	251	PF00675	0.526
CLV_NRD_NRD_1	402	404	PF00675	0.637
CLV_PCSK_KEX2_1	249	251	PF00082	0.526
CLV_PCSK_KEX2_1	402	404	PF00082	0.655
CLV_PCSK_SKI1_1	109	113	PF00082	0.395
CLV_PCSK_SKI1_1	130	134	PF00082	0.407
CLV_PCSK_SKI1_1	210	214	PF00082	0.454
CLV_PCSK_SKI1_1	374	378	PF00082	0.492
DEG_MDM2_SWIB_1	295	302	PF02201	0.459
DEG_Nend_UBRbox_1	1	4	PF02207	0.785
DEG_SCF_FBW7_2	71	78	PF00400	0.517
DOC_CKS1_1	101	106	PF01111	0.570
DOC_CKS1_1	285	290	PF01111	0.474
DOC_CKS1_1	72	77	PF01111	0.592
DOC_CYCLIN_yCln2_LP_2	69	72	PF00134	0.581
DOC_MAPK_gen_1	109	119	PF00069	0.470
DOC_MAPK_gen_1	205	215	PF00069	0.405
DOC_MAPK_MEF2A_6	110	119	PF00069	0.481
DOC_MAPK_NFAT4_5	112	120	PF00069	0.339
DOC_PP2B_LxvP_1	121	124	PF13499	0.461
DOC_PP2B_LxvP_1	69	72	PF13499	0.581
DOC_USP7_MATH_1	197	201	PF00917	0.599
DOC_USP7_MATH_1	291	295	PF00917	0.473
DOC_USP7_MATH_1	344	348	PF00917	0.692
DOC_USP7_MATH_1	358	362	PF00917	0.474
DOC_USP7_MATH_1	391	395	PF00917	0.729
DOC_USP7_MATH_1	8	12	PF00917	0.599
DOC_WW_Pin1_4	100	105	PF00397	0.494
DOC_WW_Pin1_4	238	243	PF00397	0.662
DOC_WW_Pin1_4	254	259	PF00397	0.298
DOC_WW_Pin1_4	284	289	PF00397	0.601
DOC_WW_Pin1_4	348	353	PF00397	0.617
DOC_WW_Pin1_4	71	76	PF00397	0.630
LIG_14-3-3_CanoR_1	109	119	PF00244	0.438
LIG_14-3-3_CanoR_1	2	7	PF00244	0.599
LIG_14-3-3_CanoR_1	274	279	PF00244	0.543
LIG_14-3-3_CanoR_1	43	47	PF00244	0.512
LIG_14-3-3_CanoR_1	60	70	PF00244	0.570
LIG_Actin_RPEL_3	102	121	PF02755	0.433
LIG_BRCT_BRCA1_1	250	254	PF00533	0.603
LIG_CaM_NSCaTE_8	129	136	PF13499	0.345
LIG_deltaCOP1_diTrp_1	297	304	PF00928	0.396
LIG_FHA_1	180	186	PF00498	0.505
LIG_FHA_1	22	28	PF00498	0.575
LIG_FHA_1	287	293	PF00498	0.573
LIG_FHA_1	393	399	PF00498	0.655
LIG_FHA_1	408	414	PF00498	0.511
LIG_FHA_2	101	107	PF00498	0.627
LIG_GSK3_LRP6_1	71	76	PF00069	0.541
LIG_LIR_Gen_1	113	124	PF02991	0.392
LIG_LIR_Gen_1	294	303	PF02991	0.407
LIG_LIR_Nem_3	113	119	PF02991	0.453
LIG_LIR_Nem_3	294	298	PF02991	0.473
LIG_LIR_Nem_3	33	39	PF02991	0.753
LIG_LYPXL_yS_3	36	39	PF13949	0.565
LIG_MYND_1	100	104	PF01753	0.500
LIG_MYND_1	18	22	PF01753	0.579
LIG_NRBOX	263	269	PF00104	0.342
LIG_Pex14_2	295	299	PF04695	0.467
LIG_PTAP_UEV_1	31	36	PF05743	0.560
LIG_SH2_CRK	223	227	PF00017	0.439
LIG_SH2_CRK	310	314	PF00017	0.471
LIG_SH2_CRK	357	361	PF00017	0.576
LIG_SH2_NCK_1	159	163	PF00017	0.486
LIG_SH2_NCK_1	223	227	PF00017	0.439
LIG_SH2_NCK_1	357	361	PF00017	0.576
LIG_SH2_SRC	223	226	PF00017	0.433
LIG_SH2_STAT3	98	101	PF00017	0.601
LIG_SH2_STAT5	369	372	PF00017	0.366
LIG_SH3_3	219	225	PF00018	0.448
LIG_SH3_3	236	242	PF00018	0.580
LIG_SH3_3	26	32	PF00018	0.671
LIG_SH3_3	282	288	PF00018	0.656
LIG_SH3_3	69	75	PF00018	0.643
LIG_SUMO_SIM_anti_2	319	327	PF11976	0.378
LIG_SUMO_SIM_par_1	231	237	PF11976	0.545
LIG_TRAF2_1	242	245	PF00917	0.748
LIG_TYR_ITIM	355	360	PF00017	0.544
LIG_UBA3_1	264	270	PF00899	0.472
LIG_WRC_WIRS_1	292	297	PF05994	0.435
MOD_CK1_1	176	182	PF00069	0.565
MOD_CK1_1	200	206	PF00069	0.448
MOD_CK1_1	248	254	PF00069	0.643
MOD_CK1_1	277	283	PF00069	0.668
MOD_CK1_1	347	353	PF00069	0.711
MOD_CK1_1	392	398	PF00069	0.740
MOD_CK1_1	45	51	PF00069	0.607
MOD_CK2_1	238	244	PF00069	0.594
MOD_GlcNHglycan	11	14	PF01048	0.691
MOD_GlcNHglycan	147	150	PF01048	0.479
MOD_GlcNHglycan	199	202	PF01048	0.444
MOD_GlcNHglycan	32	35	PF01048	0.711
MOD_GlcNHglycan	347	350	PF01048	0.690
MOD_GlcNHglycan	387	390	PF01048	0.646
MOD_GlcNHglycan	82	85	PF01048	0.567
MOD_GSK3_1	172	179	PF00069	0.527
MOD_GSK3_1	192	199	PF00069	0.566
MOD_GSK3_1	224	231	PF00069	0.599
MOD_GSK3_1	234	241	PF00069	0.708
MOD_GSK3_1	244	251	PF00069	0.659
MOD_GSK3_1	274	281	PF00069	0.477
MOD_GSK3_1	344	351	PF00069	0.652
MOD_GSK3_1	385	392	PF00069	0.678
MOD_GSK3_1	9	16	PF00069	0.627
MOD_NEK2_1	1	6	PF00069	0.574
MOD_NEK2_1	119	124	PF00069	0.376
MOD_NEK2_2	23	28	PF00069	0.616
MOD_NEK2_2	291	296	PF00069	0.451
MOD_PIKK_1	286	292	PF00454	0.540
MOD_PIKK_1	327	333	PF00454	0.586
MOD_PIKK_1	358	364	PF00454	0.543
MOD_PIKK_1	45	51	PF00454	0.500
MOD_PK_1	274	280	PF00069	0.370
MOD_PKA_2	1	7	PF00069	0.641
MOD_PKA_2	248	254	PF00069	0.684
MOD_PKA_2	30	36	PF00069	0.717
MOD_PKA_2	42	48	PF00069	0.479
MOD_PKA_2	8	14	PF00069	0.593
MOD_PKB_1	7	15	PF00069	0.601
MOD_Plk_1	228	234	PF00069	0.550
MOD_Plk_1	77	83	PF00069	0.600
MOD_Plk_4	228	234	PF00069	0.511
MOD_Plk_4	23	29	PF00069	0.598
MOD_Plk_4	42	48	PF00069	0.343
MOD_ProDKin_1	100	106	PF00069	0.486
MOD_ProDKin_1	238	244	PF00069	0.660
MOD_ProDKin_1	254	260	PF00069	0.287
MOD_ProDKin_1	284	290	PF00069	0.589
MOD_ProDKin_1	348	354	PF00069	0.613
MOD_ProDKin_1	71	77	PF00069	0.629
MOD_SUMO_rev_2	105	111	PF00179	0.349
MOD_SUMO_rev_2	126	132	PF00179	0.370
MOD_SUMO_rev_2	87	95	PF00179	0.733
TRG_DiLeu_BaLyEn_6	51	56	PF01217	0.429
TRG_ENDOCYTIC_2	310	313	PF00928	0.336
TRG_ENDOCYTIC_2	357	360	PF00928	0.581
TRG_ENDOCYTIC_2	36	39	PF00928	0.565
TRG_ER_diArg_1	402	405	PF00400	0.718
TRG_ER_diArg_1	6	9	PF00400	0.687
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	60	65	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3T2	Leptomonas seymouri	49%	100%
A0A1X0NVH2	Trypanosomatidae	28%	100%
A0A3R7MTX4	Trypanosoma rangeli	28%	100%
A0A3S7X4N0	Leishmania donovani	98%	100%
A4HJF6	Leishmania braziliensis	71%	99%
D0A7B7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B1X4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q688	Leishmania major	92%	100%
V5C1D3	Trypanosoma cruzi	30%	100%