LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I6V0_LEIIN
TriTrypDb:
LINF_310024700
Length:
382

Annotations

LeishMANIAdb annotations

A membrane-associated protein in Kinetoplastids with quite unique helical folds.. Only expanded in the Strigomonas lineage

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Phosphorylation

Amastigote: 320

Expansion

Sequence features

A4I6V0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6V0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 105 107 PF00675 0.488
CLV_NRD_NRD_1 133 135 PF00675 0.405
CLV_NRD_NRD_1 276 278 PF00675 0.463
CLV_NRD_NRD_1 280 282 PF00675 0.525
CLV_NRD_NRD_1 283 285 PF00675 0.448
CLV_NRD_NRD_1 338 340 PF00675 0.484
CLV_NRD_NRD_1 65 67 PF00675 0.502
CLV_NRD_NRD_1 99 101 PF00675 0.462
CLV_PCSK_FUR_1 103 107 PF00082 0.437
CLV_PCSK_FUR_1 277 281 PF00082 0.415
CLV_PCSK_FUR_1 336 340 PF00082 0.499
CLV_PCSK_FUR_1 63 67 PF00082 0.511
CLV_PCSK_KEX2_1 105 107 PF00082 0.488
CLV_PCSK_KEX2_1 133 135 PF00082 0.431
CLV_PCSK_KEX2_1 276 278 PF00082 0.486
CLV_PCSK_KEX2_1 279 281 PF00082 0.530
CLV_PCSK_KEX2_1 338 340 PF00082 0.502
CLV_PCSK_KEX2_1 65 67 PF00082 0.501
CLV_PCSK_KEX2_1 99 101 PF00082 0.462
CLV_PCSK_PC1ET2_1 279 281 PF00082 0.451
CLV_PCSK_PC7_1 276 282 PF00082 0.398
CLV_PCSK_SKI1_1 324 328 PF00082 0.558
CLV_PCSK_SKI1_1 342 346 PF00082 0.427
CLV_Separin_Metazoa 49 53 PF03568 0.587
DEG_APCC_DBOX_1 136 144 PF00400 0.606
DEG_SCF_FBW7_1 192 197 PF00400 0.654
DEG_SCF_FBW7_1 215 221 PF00400 0.712
DEG_SCF_FBW7_1 326 331 PF00400 0.659
DOC_CKS1_1 215 220 PF01111 0.821
DOC_CKS1_1 325 330 PF01111 0.672
DOC_CYCLIN_yClb5_NLxxxL_5 112 119 PF00134 0.680
DOC_MAPK_gen_1 133 140 PF00069 0.632
DOC_MAPK_gen_1 262 271 PF00069 0.624
DOC_MAPK_gen_1 42 50 PF00069 0.625
DOC_MAPK_gen_1 63 73 PF00069 0.598
DOC_MAPK_HePTP_8 102 119 PF00069 0.633
DOC_MAPK_MEF2A_6 112 119 PF00069 0.626
DOC_MAPK_MEF2A_6 65 74 PF00069 0.573
DOC_PP4_FxxP_1 325 328 PF00568 0.650
DOC_PP4_FxxP_1 88 91 PF00568 0.592
DOC_USP7_MATH_1 218 222 PF00917 0.715
DOC_USP7_MATH_1 328 332 PF00917 0.758
DOC_USP7_MATH_1 350 354 PF00917 0.750
DOC_USP7_MATH_1 94 98 PF00917 0.647
DOC_WW_Pin1_4 185 190 PF00397 0.668
DOC_WW_Pin1_4 214 219 PF00397 0.713
DOC_WW_Pin1_4 314 319 PF00397 0.666
DOC_WW_Pin1_4 324 329 PF00397 0.655
DOC_WW_Pin1_4 346 351 PF00397 0.685
DOC_WW_Pin1_4 363 368 PF00397 0.745
LIG_14-3-3_CanoR_1 106 112 PF00244 0.662
LIG_14-3-3_CanoR_1 170 180 PF00244 0.641
LIG_14-3-3_CanoR_1 284 291 PF00244 0.593
LIG_14-3-3_CanoR_1 36 41 PF00244 0.620
LIG_14-3-3_CanoR_1 99 103 PF00244 0.665
LIG_BIR_II_1 1 5 PF00653 0.415
LIG_BIR_III_2 153 157 PF00653 0.662
LIG_BRCT_BRCA1_1 84 88 PF00533 0.638
LIG_CaM_IQ_9 269 284 PF13499 0.629
LIG_Clathr_ClatBox_1 72 76 PF01394 0.584
LIG_FHA_1 12 18 PF00498 0.320
LIG_FHA_1 191 197 PF00498 0.771
LIG_FHA_1 251 257 PF00498 0.661
LIG_FHA_2 170 176 PF00498 0.677
LIG_FHA_2 284 290 PF00498 0.603
LIG_Integrin_isoDGR_2 146 148 PF01839 0.456
LIG_LIR_Apic_2 85 91 PF02991 0.642
LIG_LIR_Nem_3 320 326 PF02991 0.629
LIG_LIR_Nem_3 343 348 PF02991 0.721
LIG_SH2_GRB2like 181 184 PF00017 0.708
LIG_SH2_GRB2like 31 34 PF00017 0.531
LIG_SH2_STAT5 181 184 PF00017 0.678
LIG_SH2_STAT5 31 34 PF00017 0.531
LIG_SH3_3 212 218 PF00018 0.719
LIG_SH3_3 223 229 PF00018 0.703
LIG_SH3_3 315 321 PF00018 0.636
LIG_SH3_3 361 367 PF00018 0.691
LIG_SH3_3 88 94 PF00018 0.602
LIG_SUMO_SIM_anti_2 268 274 PF11976 0.557
LIG_SUMO_SIM_anti_2 69 76 PF11976 0.578
LIG_SUMO_SIM_par_1 69 76 PF11976 0.578
LIG_TRAF2_1 200 203 PF00917 0.670
LIG_TRAF2_1 286 289 PF00917 0.646
LIG_TRAF2_1 349 352 PF00917 0.728
LIG_UBA3_1 271 279 PF00899 0.655
MOD_CDK_SPxxK_3 317 324 PF00069 0.646
MOD_CK1_1 3 9 PF00069 0.413
MOD_CK1_1 366 372 PF00069 0.656
MOD_CK2_1 169 175 PF00069 0.729
MOD_CK2_1 283 289 PF00069 0.629
MOD_CK2_1 346 352 PF00069 0.778
MOD_Cter_Amidation 369 372 PF01082 0.503
MOD_GlcNHglycan 220 223 PF01048 0.533
MOD_GlcNHglycan 342 345 PF01048 0.487
MOD_GlcNHglycan 368 371 PF01048 0.506
MOD_GlcNHglycan 95 99 PF01048 0.450
MOD_GSK3_1 171 178 PF00069 0.679
MOD_GSK3_1 184 191 PF00069 0.694
MOD_GSK3_1 210 217 PF00069 0.758
MOD_GSK3_1 32 39 PF00069 0.599
MOD_GSK3_1 324 331 PF00069 0.740
MOD_GSK3_1 346 353 PF00069 0.720
MOD_GSK3_1 94 101 PF00069 0.618
MOD_N-GLC_1 32 37 PF02516 0.403
MOD_N-GLC_1 334 339 PF02516 0.461
MOD_N-GLC_1 373 378 PF02516 0.524
MOD_NEK2_2 107 112 PF00069 0.629
MOD_NEK2_2 328 333 PF00069 0.700
MOD_NEK2_2 98 103 PF00069 0.614
MOD_PKA_2 169 175 PF00069 0.637
MOD_PKA_2 263 269 PF00069 0.646
MOD_PKA_2 283 289 PF00069 0.539
MOD_PKA_2 98 104 PF00069 0.644
MOD_Plk_1 123 129 PF00069 0.601
MOD_Plk_1 3 9 PF00069 0.445
MOD_Plk_1 351 357 PF00069 0.724
MOD_Plk_1 373 379 PF00069 0.723
MOD_Plk_4 351 357 PF00069 0.723
MOD_ProDKin_1 185 191 PF00069 0.670
MOD_ProDKin_1 214 220 PF00069 0.716
MOD_ProDKin_1 314 320 PF00069 0.662
MOD_ProDKin_1 324 330 PF00069 0.655
MOD_ProDKin_1 346 352 PF00069 0.686
MOD_ProDKin_1 363 369 PF00069 0.745
MOD_SUMO_rev_2 337 344 PF00179 0.678
TRG_ER_diArg_1 102 105 PF00400 0.677
TRG_ER_diArg_1 133 135 PF00400 0.631
TRG_ER_diArg_1 275 277 PF00400 0.588
TRG_ER_diArg_1 336 339 PF00400 0.699
TRG_ER_diArg_1 51 54 PF00400 0.601
TRG_ER_diArg_1 65 68 PF00400 0.687
TRG_NLS_MonoExtC_3 280 285 PF00514 0.625
TRG_NLS_MonoExtC_3 370 375 PF00514 0.696
TRG_NLS_MonoExtN_4 279 285 PF00514 0.618
TRG_NLS_MonoExtN_4 371 376 PF00514 0.693
TRG_Pf-PMV_PEXEL_1 65 69 PF00026 0.376

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HX69 Leptomonas seymouri 55% 98%
A0A3Q8IFM0 Leishmania donovani 100% 100%
A4HJF5 Leishmania braziliensis 65% 99%
E9B1X3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 99%
Q4Q689 Leishmania major 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS