Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I6U5_LEIIN

TriTrypDb:

LINF_310024200

Length:

275

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4I6U5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6U5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.540
CLV_NRD_NRD_1	149	151	PF00675	0.411
CLV_PCSK_KEX2_1	142	144	PF00082	0.525
CLV_PCSK_KEX2_1	171	173	PF00082	0.560
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.614
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.479
CLV_PCSK_PC7_1	138	144	PF00082	0.516
CLV_PCSK_SKI1_1	104	108	PF00082	0.547
CLV_PCSK_SKI1_1	151	155	PF00082	0.481
CLV_PCSK_SKI1_1	172	176	PF00082	0.592
DOC_ANK_TNKS_1	164	171	PF00023	0.567
DOC_PP1_RVXF_1	72	78	PF00149	0.696
DOC_USP7_MATH_1	196	200	PF00917	0.502
DOC_USP7_MATH_1	235	239	PF00917	0.410
DOC_USP7_MATH_1	270	274	PF00917	0.594
DOC_USP7_MATH_1	67	71	PF00917	0.575
DOC_USP7_MATH_1	99	103	PF00917	0.704
LIG_14-3-3_CanoR_1	120	126	PF00244	0.678
LIG_14-3-3_CanoR_1	263	271	PF00244	0.522
LIG_BIR_III_4	167	171	PF00653	0.564
LIG_FHA_2	205	211	PF00498	0.565
LIG_FHA_2	214	220	PF00498	0.374
LIG_FHA_2	86	92	PF00498	0.721
LIG_Integrin_isoDGR_2	95	97	PF01839	0.536
LIG_LIR_Gen_1	238	248	PF02991	0.496
LIG_LIR_Nem_3	219	224	PF02991	0.398
LIG_LIR_Nem_3	238	243	PF02991	0.396
LIG_SH2_CRK	240	244	PF00017	0.494
LIG_SH2_STAT5	230	233	PF00017	0.472
LIG_SH2_STAT5	247	250	PF00017	0.288
LIG_SH2_STAT5	61	64	PF00017	0.519
LIG_SUMO_SIM_par_1	212	219	PF11976	0.453
LIG_UBA3_1	162	171	PF00899	0.499
MOD_CK1_1	102	108	PF00069	0.546
MOD_CK1_1	3	9	PF00069	0.552
MOD_CK2_1	213	219	PF00069	0.456
MOD_Cter_Amidation	169	172	PF01082	0.558
MOD_GlcNHglycan	62	65	PF01048	0.654
MOD_GlcNHglycan	68	72	PF01048	0.677
MOD_GSK3_1	29	36	PF00069	0.633
MOD_GSK3_1	98	105	PF00069	0.708
MOD_NEK2_1	131	136	PF00069	0.633
MOD_NEK2_1	181	186	PF00069	0.455
MOD_NEK2_1	204	209	PF00069	0.578
MOD_NEK2_1	60	65	PF00069	0.598
MOD_NEK2_2	196	201	PF00069	0.512
MOD_NEK2_2	73	78	PF00069	0.608
MOD_NEK2_2	99	104	PF00069	0.548
MOD_OFUCOSY	47	53	PF10250	0.486
MOD_PIKK_1	19	25	PF00454	0.514
MOD_PIKK_1	190	196	PF00454	0.510
MOD_PKA_2	253	259	PF00069	0.377
MOD_Plk_1	67	73	PF00069	0.650
MOD_Plk_4	210	216	PF00069	0.470
MOD_SUMO_for_1	141	144	PF00179	0.610
MOD_SUMO_rev_2	144	153	PF00179	0.470
MOD_SUMO_rev_2	167	173	PF00179	0.577
TRG_DiLeu_BaEn_4	250	256	PF01217	0.399
TRG_ENDOCYTIC_2	221	224	PF00928	0.405
TRG_ENDOCYTIC_2	240	243	PF00928	0.379
TRG_ER_diArg_1	257	260	PF00400	0.545
TRG_NLS_MonoExtC_3	134	140	PF00514	0.518
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2I0	Leptomonas seymouri	61%	100%
A0A1X0NRC6	Trypanosomatidae	45%	99%
A0A3Q8IFD5	Leishmania donovani	99%	100%
A0A422MYM9	Trypanosoma rangeli	45%	99%
A4HJF0	Leishmania braziliensis	84%	100%
C9ZMB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B1W8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q694	Leishmania major	95%	100%
V5AZM2	Trypanosoma cruzi	44%	100%