Enkurin domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I6U4_LEIIN

TriTrypDb:

LINF_310024100

Length:

282

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I6U4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6U4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.682
CLV_NRD_NRD_1	20	22	PF00675	0.799
CLV_NRD_NRD_1	225	227	PF00675	0.437
CLV_NRD_NRD_1	260	262	PF00675	0.448
CLV_PCSK_KEX2_1	128	130	PF00082	0.596
CLV_PCSK_KEX2_1	224	226	PF00082	0.481
CLV_PCSK_KEX2_1	260	262	PF00082	0.475
CLV_PCSK_SKI1_1	225	229	PF00082	0.592
CLV_PCSK_SKI1_1	241	245	PF00082	0.359
CLV_PCSK_SKI1_1	260	264	PF00082	0.340
CLV_PCSK_SKI1_1	58	62	PF00082	0.662
DEG_APCC_DBOX_1	224	232	PF00400	0.487
DEG_Nend_UBRbox_3	1	3	PF02207	0.454
DOC_MAPK_gen_1	108	115	PF00069	0.506
DOC_PP2B_LxvP_1	60	63	PF13499	0.588
DOC_USP7_MATH_1	152	156	PF00917	0.598
DOC_USP7_MATH_1	25	29	PF00917	0.650
DOC_USP7_UBL2_3	18	22	PF12436	0.731
DOC_WW_Pin1_4	16	21	PF00397	0.644
DOC_WW_Pin1_4	172	177	PF00397	0.534
LIG_14-3-3_CanoR_1	129	135	PF00244	0.554
LIG_14-3-3_CanoR_1	96	101	PF00244	0.517
LIG_Actin_WH2_2	227	243	PF00022	0.464
LIG_FHA_1	102	108	PF00498	0.582
LIG_FHA_2	131	137	PF00498	0.645
LIG_FHA_2	252	258	PF00498	0.414
LIG_LIR_Gen_1	157	168	PF02991	0.511
LIG_LIR_Nem_3	146	151	PF02991	0.649
LIG_LIR_Nem_3	157	163	PF02991	0.642
LIG_LIR_Nem_3	213	218	PF02991	0.459
LIG_NRBOX	235	241	PF00104	0.404
LIG_PTB_Apo_2	147	154	PF02174	0.518
LIG_SH2_CRK	215	219	PF00017	0.452
LIG_SH2_CRK	57	61	PF00017	0.513
LIG_SH2_STAT3	276	279	PF00017	0.593
LIG_SH2_STAT5	160	163	PF00017	0.650
LIG_SH3_3	244	250	PF00018	0.435
LIG_SH3_3	73	79	PF00018	0.482
LIG_TRAF2_1	277	280	PF00917	0.433
MOD_CDC14_SPxK_1	175	178	PF00782	0.504
MOD_CDC14_SPxK_1	19	22	PF00782	0.593
MOD_CDK_SPK_2	16	21	PF00069	0.593
MOD_CDK_SPxK_1	16	22	PF00069	0.713
MOD_CDK_SPxK_1	172	178	PF00069	0.529
MOD_CK1_1	169	175	PF00069	0.496
MOD_CK2_1	229	235	PF00069	0.541
MOD_GlcNHglycan	109	112	PF01048	0.566
MOD_GlcNHglycan	120	123	PF01048	0.608
MOD_GlcNHglycan	172	175	PF01048	0.613
MOD_GSK3_1	107	114	PF00069	0.662
MOD_GSK3_1	12	19	PF00069	0.643
MOD_GSK3_1	166	173	PF00069	0.514
MOD_GSK3_1	58	65	PF00069	0.629
MOD_N-GLC_1	1	6	PF02516	0.446
MOD_N-GLC_1	251	256	PF02516	0.406
MOD_N-GLC_1	30	35	PF02516	0.627
MOD_NEK2_1	1	6	PF00069	0.610
MOD_NEK2_1	153	158	PF00069	0.581
MOD_NEK2_1	251	256	PF00069	0.406
MOD_NEK2_1	95	100	PF00069	0.570
MOD_PK_1	12	18	PF00069	0.611
MOD_PKA_2	95	101	PF00069	0.594
MOD_Plk_1	50	56	PF00069	0.607
MOD_Plk_4	130	136	PF00069	0.586
MOD_ProDKin_1	16	22	PF00069	0.645
MOD_ProDKin_1	172	178	PF00069	0.529
MOD_SUMO_rev_2	238	246	PF00179	0.522
TRG_DiLeu_BaEn_1	223	228	PF01217	0.595
TRG_DiLeu_BaEn_1	235	240	PF01217	0.479
TRG_DiLeu_LyEn_5	223	228	PF01217	0.421
TRG_ENDOCYTIC_2	160	163	PF00928	0.650
TRG_ENDOCYTIC_2	215	218	PF00928	0.596
TRG_ENDOCYTIC_2	57	60	PF00928	0.527
TRG_ER_diArg_1	127	129	PF00400	0.593
TRG_ER_diArg_1	193	196	PF00400	0.504
TRG_ER_diArg_1	224	226	PF00400	0.571
TRG_ER_diArg_1	259	261	PF00400	0.452
TRG_NES_CRM1_1	177	189	PF08389	0.424
TRG_NLS_MonoExtC_3	20	25	PF00514	0.594
TRG_NLS_MonoExtN_4	18	25	PF00514	0.594
TRG_Pf-PMV_PEXEL_1	225	230	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	261	266	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBJ9	Leptomonas seymouri	75%	99%
A0A1X0NQE4	Trypanosomatidae	58%	100%
A0A3Q8IK28	Leishmania donovani	99%	100%
A0A3R7JXC5	Trypanosoma rangeli	60%	100%
A4HJE9	Leishmania braziliensis	89%	100%
C9ZMB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9B1W7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q695	Leishmania major	99%	100%
V5AJB0	Trypanosoma cruzi	55%	100%