LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Leucine Rich repeat - putative
Species:
Leishmania infantum
UniProt:
A4I6T8_LEIIN
TriTrypDb:
LINF_310023300
Length:
811

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005929 cilium 4 14
GO:0042995 cell projection 2 14
GO:0043226 organelle 2 14
GO:0043227 membrane-bounded organelle 3 14
GO:0110165 cellular anatomical entity 1 14
GO:0120025 plasma membrane bounded cell projection 3 14
GO:0005737 cytoplasm 2 1
GO:0016020 membrane 2 2

Expansion

Sequence features

A4I6T8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6T8

Function

Biological processes
Term Name Level Count
GO:0000226 microtubule cytoskeleton organization 3 1
GO:0006457 protein folding 2 1
GO:0006996 organelle organization 4 1
GO:0007010 cytoskeleton organization 5 1
GO:0007017 microtubule-based process 2 1
GO:0007021 tubulin complex assembly 6 1
GO:0007023 post-chaperonin tubulin folding pathway 3 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0043933 protein-containing complex organization 4 1
GO:0065003 protein-containing complex assembly 5 1
GO:0071840 cellular component organization or biogenesis 2 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0008092 cytoskeletal protein binding 3 1
GO:0015631 tubulin binding 4 1
GO:0043014 alpha-tubulin binding 5 1
GO:0003824 catalytic activity 1 1
GO:0016787 hydrolase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 367 371 PF00656 0.301
CLV_C14_Caspase3-7 454 458 PF00656 0.445
CLV_NRD_NRD_1 286 288 PF00675 0.319
CLV_NRD_NRD_1 31 33 PF00675 0.580
CLV_NRD_NRD_1 60 62 PF00675 0.612
CLV_NRD_NRD_1 654 656 PF00675 0.409
CLV_NRD_NRD_1 765 767 PF00675 0.326
CLV_PCSK_FUR_1 58 62 PF00082 0.511
CLV_PCSK_KEX2_1 286 288 PF00082 0.301
CLV_PCSK_KEX2_1 31 33 PF00082 0.580
CLV_PCSK_KEX2_1 60 62 PF00082 0.612
CLV_PCSK_KEX2_1 654 656 PF00082 0.327
CLV_PCSK_KEX2_1 787 789 PF00082 0.383
CLV_PCSK_PC1ET2_1 787 789 PF00082 0.338
CLV_PCSK_SKI1_1 196 200 PF00082 0.466
CLV_PCSK_SKI1_1 420 424 PF00082 0.375
CLV_PCSK_SKI1_1 517 521 PF00082 0.255
CLV_PCSK_SKI1_1 551 555 PF00082 0.345
CLV_PCSK_SKI1_1 766 770 PF00082 0.429
CLV_PCSK_SKI1_1 802 806 PF00082 0.401
DEG_APCC_DBOX_1 272 280 PF00400 0.323
DEG_SCF_FBW7_1 658 665 PF00400 0.275
DOC_CDC14_PxL_1 372 380 PF14671 0.296
DOC_CDC14_PxL_1 510 518 PF14671 0.306
DOC_CYCLIN_RxL_1 417 425 PF00134 0.555
DOC_CYCLIN_RxL_1 512 525 PF00134 0.335
DOC_MAPK_gen_1 34 43 PF00069 0.653
DOC_MAPK_gen_1 512 521 PF00069 0.375
DOC_MAPK_gen_1 766 775 PF00069 0.301
DOC_MAPK_MEF2A_6 36 45 PF00069 0.360
DOC_MAPK_MEF2A_6 512 520 PF00069 0.303
DOC_MAPK_MEF2A_6 741 750 PF00069 0.282
DOC_MAPK_MEF2A_6 766 775 PF00069 0.318
DOC_MAPK_NFAT4_5 766 774 PF00069 0.298
DOC_PP1_RVXF_1 433 440 PF00149 0.304
DOC_PP2B_LxvP_1 109 112 PF13499 0.532
DOC_PP2B_LxvP_1 267 270 PF13499 0.476
DOC_USP7_MATH_1 22 26 PF00917 0.573
DOC_USP7_MATH_1 233 237 PF00917 0.312
DOC_USP7_MATH_1 30 34 PF00917 0.507
DOC_USP7_MATH_1 51 55 PF00917 0.501
DOC_USP7_MATH_1 662 666 PF00917 0.381
DOC_USP7_MATH_1 671 675 PF00917 0.286
DOC_USP7_MATH_1 730 734 PF00917 0.343
DOC_USP7_MATH_1 90 94 PF00917 0.593
DOC_USP7_MATH_2 177 183 PF00917 0.365
DOC_USP7_UBL2_3 192 196 PF12436 0.286
DOC_USP7_UBL2_3 770 774 PF12436 0.467
DOC_WW_Pin1_4 171 176 PF00397 0.383
DOC_WW_Pin1_4 24 29 PF00397 0.561
DOC_WW_Pin1_4 620 625 PF00397 0.295
DOC_WW_Pin1_4 658 663 PF00397 0.267
DOC_WW_Pin1_4 98 103 PF00397 0.506
LIG_14-3-3_CanoR_1 149 155 PF00244 0.482
LIG_14-3-3_CanoR_1 273 282 PF00244 0.347
LIG_14-3-3_CanoR_1 36 43 PF00244 0.432
LIG_14-3-3_CanoR_1 420 425 PF00244 0.463
LIG_14-3-3_CanoR_1 466 471 PF00244 0.342
LIG_14-3-3_CanoR_1 479 484 PF00244 0.357
LIG_14-3-3_CanoR_1 638 642 PF00244 0.365
LIG_14-3-3_CanoR_1 667 675 PF00244 0.476
LIG_14-3-3_CanoR_1 700 705 PF00244 0.281
LIG_Actin_WH2_2 202 219 PF00022 0.299
LIG_Actin_WH2_2 67 85 PF00022 0.349
LIG_Actin_WH2_2 686 702 PF00022 0.292
LIG_BIR_II_1 1 5 PF00653 0.529
LIG_BIR_III_2 50 54 PF00653 0.473
LIG_BRCT_BRCA1_1 551 555 PF00533 0.327
LIG_BRCT_BRCA1_1 702 706 PF00533 0.322
LIG_Clathr_ClatBox_1 421 425 PF01394 0.290
LIG_Clathr_ClatBox_1 736 740 PF01394 0.290
LIG_FHA_1 104 110 PF00498 0.474
LIG_FHA_1 142 148 PF00498 0.456
LIG_FHA_1 197 203 PF00498 0.322
LIG_FHA_1 213 219 PF00498 0.290
LIG_FHA_1 446 452 PF00498 0.421
LIG_FHA_1 92 98 PF00498 0.573
LIG_FHA_2 174 180 PF00498 0.354
LIG_FHA_2 377 383 PF00498 0.452
LIG_FHA_2 452 458 PF00498 0.435
LIG_FHA_2 467 473 PF00498 0.277
LIG_FHA_2 567 573 PF00498 0.304
LIG_FHA_2 681 687 PF00498 0.312
LIG_Integrin_isoDGR_2 264 266 PF01839 0.494
LIG_LIR_Gen_1 399 410 PF02991 0.380
LIG_LIR_Gen_1 44 53 PF02991 0.454
LIG_LIR_Gen_1 542 553 PF02991 0.338
LIG_LIR_Gen_1 703 712 PF02991 0.344
LIG_LIR_Gen_1 751 759 PF02991 0.300
LIG_LIR_Gen_1 777 786 PF02991 0.318
LIG_LIR_Nem_3 399 405 PF02991 0.376
LIG_LIR_Nem_3 44 48 PF02991 0.421
LIG_LIR_Nem_3 462 467 PF02991 0.381
LIG_LIR_Nem_3 542 548 PF02991 0.320
LIG_LIR_Nem_3 552 557 PF02991 0.278
LIG_LIR_Nem_3 687 693 PF02991 0.345
LIG_LIR_Nem_3 703 709 PF02991 0.276
LIG_LIR_Nem_3 751 755 PF02991 0.550
LIG_LIR_Nem_3 777 783 PF02991 0.372
LIG_LRP6_Inhibitor_1 429 435 PF00058 0.288
LIG_MLH1_MIPbox_1 551 555 PF16413 0.327
LIG_NRBOX 153 159 PF00104 0.299
LIG_NRBOX 417 423 PF00104 0.301
LIG_NRBOX 515 521 PF00104 0.259
LIG_PCNA_yPIPBox_3 149 158 PF02747 0.321
LIG_Rb_LxCxE_1 159 179 PF01857 0.298
LIG_SH2_CRK 752 756 PF00017 0.319
LIG_SH2_GRB2like 402 405 PF00017 0.282
LIG_SH2_NCK_1 210 214 PF00017 0.268
LIG_SH2_NCK_1 780 784 PF00017 0.321
LIG_SH2_SRC 780 783 PF00017 0.319
LIG_SH2_STAP1 210 214 PF00017 0.310
LIG_SH2_STAP1 780 784 PF00017 0.321
LIG_SH2_STAT5 377 380 PF00017 0.317
LIG_SH2_STAT5 402 405 PF00017 0.282
LIG_SH2_STAT5 752 755 PF00017 0.312
LIG_SH2_STAT5 785 788 PF00017 0.388
LIG_SH3_3 172 178 PF00018 0.345
LIG_SUMO_SIM_anti_2 528 533 PF11976 0.463
LIG_SUMO_SIM_anti_2 674 679 PF11976 0.273
LIG_SUMO_SIM_anti_2 7 14 PF11976 0.440
LIG_SUMO_SIM_anti_2 806 811 PF11976 0.434
LIG_SUMO_SIM_par_1 419 425 PF11976 0.540
LIG_SUMO_SIM_par_1 447 454 PF11976 0.480
LIG_SUMO_SIM_par_1 517 522 PF11976 0.271
LIG_TRAF2_1 608 611 PF00917 0.307
LIG_TYR_ITIM 400 405 PF00017 0.285
LIG_TYR_ITIM 750 755 PF00017 0.298
LIG_TYR_ITIM 778 783 PF00017 0.296
LIG_UBA3_1 400 407 PF00899 0.293
LIG_UBA3_1 518 523 PF00899 0.333
LIG_UBA3_1 768 774 PF00899 0.303
LIG_WRC_WIRS_1 205 210 PF05994 0.299
MOD_CDK_SPxxK_3 24 31 PF00069 0.546
MOD_CK1_1 171 177 PF00069 0.365
MOD_CK1_1 2 8 PF00069 0.590
MOD_CK1_1 212 218 PF00069 0.443
MOD_CK1_1 445 451 PF00069 0.468
MOD_CK1_1 561 567 PF00069 0.306
MOD_CK1_1 593 599 PF00069 0.360
MOD_CK1_1 640 646 PF00069 0.319
MOD_CK1_1 665 671 PF00069 0.483
MOD_CK1_1 85 91 PF00069 0.696
MOD_CK2_1 150 156 PF00069 0.329
MOD_CK2_1 173 179 PF00069 0.396
MOD_CK2_1 233 239 PF00069 0.298
MOD_CK2_1 479 485 PF00069 0.391
MOD_CK2_1 605 611 PF00069 0.435
MOD_CK2_1 716 722 PF00069 0.317
MOD_Cter_Amidation 58 61 PF01082 0.484
MOD_GlcNHglycan 103 106 PF01048 0.567
MOD_GlcNHglycan 133 136 PF01048 0.385
MOD_GlcNHglycan 170 173 PF01048 0.330
MOD_GlcNHglycan 211 214 PF01048 0.362
MOD_GlcNHglycan 313 316 PF01048 0.254
MOD_GlcNHglycan 457 460 PF01048 0.456
MOD_GlcNHglycan 550 554 PF01048 0.336
MOD_GlcNHglycan 560 563 PF01048 0.282
MOD_GlcNHglycan 669 672 PF01048 0.453
MOD_GlcNHglycan 756 759 PF01048 0.302
MOD_GlcNHglycan 84 87 PF01048 0.602
MOD_GSK3_1 204 211 PF00069 0.436
MOD_GSK3_1 274 281 PF00069 0.310
MOD_GSK3_1 30 37 PF00069 0.715
MOD_GSK3_1 307 314 PF00069 0.326
MOD_GSK3_1 382 389 PF00069 0.384
MOD_GSK3_1 405 412 PF00069 0.375
MOD_GSK3_1 416 423 PF00069 0.349
MOD_GSK3_1 447 454 PF00069 0.375
MOD_GSK3_1 471 478 PF00069 0.323
MOD_GSK3_1 521 528 PF00069 0.294
MOD_GSK3_1 589 596 PF00069 0.337
MOD_GSK3_1 620 627 PF00069 0.541
MOD_GSK3_1 636 643 PF00069 0.316
MOD_GSK3_1 658 665 PF00069 0.393
MOD_GSK3_1 667 674 PF00069 0.352
MOD_GSK3_1 700 707 PF00069 0.275
MOD_GSK3_1 725 732 PF00069 0.422
MOD_GSK3_1 750 757 PF00069 0.332
MOD_LATS_1 477 483 PF00433 0.253
MOD_N-GLC_1 138 143 PF02516 0.441
MOD_N-GLC_1 150 155 PF02516 0.314
MOD_N-GLC_1 168 173 PF02516 0.258
MOD_N-GLC_1 244 249 PF02516 0.285
MOD_N-GLC_1 678 683 PF02516 0.363
MOD_N-GLC_1 748 753 PF02516 0.416
MOD_NEK2_1 103 108 PF00069 0.500
MOD_NEK2_1 150 155 PF00069 0.416
MOD_NEK2_1 208 213 PF00069 0.475
MOD_NEK2_1 288 293 PF00069 0.374
MOD_NEK2_1 307 312 PF00069 0.345
MOD_NEK2_1 335 340 PF00069 0.322
MOD_NEK2_1 381 386 PF00069 0.368
MOD_NEK2_1 394 399 PF00069 0.383
MOD_NEK2_1 405 410 PF00069 0.314
MOD_NEK2_1 41 46 PF00069 0.494
MOD_NEK2_1 440 445 PF00069 0.384
MOD_NEK2_1 451 456 PF00069 0.338
MOD_NEK2_1 475 480 PF00069 0.456
MOD_NEK2_1 497 502 PF00069 0.434
MOD_NEK2_1 519 524 PF00069 0.413
MOD_NEK2_1 555 560 PF00069 0.352
MOD_NEK2_1 614 619 PF00069 0.431
MOD_NEK2_1 626 631 PF00069 0.424
MOD_NEK2_1 636 641 PF00069 0.356
MOD_NEK2_1 678 683 PF00069 0.293
MOD_NEK2_1 704 709 PF00069 0.384
MOD_NEK2_1 748 753 PF00069 0.303
MOD_NEK2_1 82 87 PF00069 0.611
MOD_NEK2_2 244 249 PF00069 0.273
MOD_NEK2_2 637 642 PF00069 0.473
MOD_NEK2_2 662 667 PF00069 0.360
MOD_PIKK_1 113 119 PF00454 0.477
MOD_PIKK_1 394 400 PF00454 0.296
MOD_PIKK_1 707 713 PF00454 0.277
MOD_PK_1 479 485 PF00069 0.260
MOD_PKA_2 30 36 PF00069 0.481
MOD_PKA_2 340 346 PF00069 0.315
MOD_PKA_2 478 484 PF00069 0.347
MOD_PKA_2 637 643 PF00069 0.491
MOD_PKA_2 760 766 PF00069 0.436
MOD_PKA_2 82 88 PF00069 0.445
MOD_PKB_1 32 40 PF00069 0.443
MOD_Plk_1 150 156 PF00069 0.314
MOD_Plk_1 244 250 PF00069 0.291
MOD_Plk_1 435 441 PF00069 0.298
MOD_Plk_1 471 477 PF00069 0.448
MOD_Plk_1 549 555 PF00069 0.347
MOD_Plk_1 564 570 PF00069 0.250
MOD_Plk_1 748 754 PF00069 0.405
MOD_Plk_1 805 811 PF00069 0.435
MOD_Plk_2-3 525 531 PF00069 0.287
MOD_Plk_2-3 605 611 PF00069 0.320
MOD_Plk_4 204 210 PF00069 0.329
MOD_Plk_4 249 255 PF00069 0.428
MOD_Plk_4 383 389 PF00069 0.482
MOD_Plk_4 396 402 PF00069 0.331
MOD_Plk_4 435 441 PF00069 0.310
MOD_Plk_4 451 457 PF00069 0.301
MOD_Plk_4 497 503 PF00069 0.355
MOD_Plk_4 805 811 PF00069 0.447
MOD_ProDKin_1 171 177 PF00069 0.384
MOD_ProDKin_1 24 30 PF00069 0.558
MOD_ProDKin_1 620 626 PF00069 0.293
MOD_ProDKin_1 658 664 PF00069 0.273
MOD_ProDKin_1 98 104 PF00069 0.506
MOD_SUMO_for_1 533 536 PF00179 0.286
MOD_SUMO_rev_2 536 546 PF00179 0.308
TRG_DiLeu_BaEn_2 203 209 PF01217 0.298
TRG_DiLeu_BaLyEn_6 417 422 PF01217 0.301
TRG_DiLeu_BaLyEn_6 583 588 PF01217 0.351
TRG_DiLeu_BaLyEn_6 621 626 PF01217 0.300
TRG_ENDOCYTIC_2 402 405 PF00928 0.282
TRG_ENDOCYTIC_2 752 755 PF00928 0.312
TRG_ENDOCYTIC_2 780 783 PF00928 0.481
TRG_ER_diArg_1 107 110 PF00400 0.478
TRG_ER_diArg_1 285 287 PF00400 0.319
TRG_ER_diArg_1 31 34 PF00400 0.714
TRG_ER_diArg_1 339 342 PF00400 0.320
TRG_ER_diArg_1 58 61 PF00400 0.594
TRG_ER_diArg_1 653 655 PF00400 0.408
TRG_LysEnd_GGAAcLL_1 806 811 PF00790 0.434
TRG_NES_CRM1_1 413 425 PF08389 0.291
TRG_NES_CRM1_1 511 525 PF08389 0.289
TRG_Pf-PMV_PEXEL_1 420 425 PF00026 0.393
TRG_Pf-PMV_PEXEL_1 607 611 PF00026 0.319

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0P1M5 Trypanosomatidae 26% 92%
A0A3Q8IGD6 Leishmania donovani 100% 100%
A0A3S5ISR4 Trypanosoma rangeli 26% 97%
A0A451EJK8 Leishmania donovani 25% 76%
A4H3R1 Leishmania braziliensis 23% 100%
D0A4F4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 96%
E9AG21 Leishmania infantum 25% 80%
E9AIU4 Leishmania braziliensis 77% 100%
E9B1W0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4Q6A2 Leishmania major 95% 100%
Q4QJ80 Leishmania major 24% 100%
V5BKI3 Trypanosoma cruzi 26% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS