Putative cytochrome c oxidase VIII (COX VIII)

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome c oxidase VIII (COX VIII) - putative

Species:

Leishmania infantum

UniProt:

A4I6T5_LEIIN

TriTrypDb:

LINF_310023000

Length:

157

Annotations

Annotations by Jardim et al.

Electron Transport Chain (see tricarboxylic acid section for Complex II), cytochrome c oxidase VIII (COX VIII)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I6T5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6T5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016491	oxidoreductase activity	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.423
CLV_PCSK_KEX2_1	116	118	PF00082	0.558
CLV_PCSK_KEX2_1	3	5	PF00082	0.423
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.558
CLV_PCSK_SKI1_1	24	28	PF00082	0.381
CLV_PCSK_SKI1_1	54	58	PF00082	0.391
CLV_PCSK_SKI1_1	79	83	PF00082	0.400
DEG_MDM2_SWIB_1	37	44	PF02201	0.609
DEG_Nend_Nbox_1	1	3	PF02207	0.640
DOC_CYCLIN_RxL_1	21	30	PF00134	0.593
DOC_CYCLIN_yCln2_LP_2	69	75	PF00134	0.643
DOC_MAPK_gen_1	3	11	PF00069	0.615
DOC_MAPK_MEF2A_6	3	11	PF00069	0.615
DOC_PP4_FxxP_1	138	141	PF00568	0.373
DOC_USP7_MATH_1	7	11	PF00917	0.611
LIG_14-3-3_CanoR_1	3	7	PF00244	0.619
LIG_BRCT_BRCA1_1	33	37	PF00533	0.622
LIG_deltaCOP1_diTrp_1	110	115	PF00928	0.348
LIG_deltaCOP1_diTrp_1	130	138	PF00928	0.364
LIG_deltaCOP1_diTrp_1	58	61	PF00928	0.532
LIG_FHA_2	149	155	PF00498	0.415
LIG_LIR_Apic_2	135	141	PF02991	0.372
LIG_LIR_Gen_1	89	98	PF02991	0.315
LIG_LIR_Nem_3	89	95	PF02991	0.303
LIG_LIR_Nem_3	97	103	PF02991	0.413
LIG_PDZ_Class_3	152	157	PF00595	0.412
LIG_Pex14_1	111	115	PF04695	0.346
LIG_Pex14_1	61	65	PF04695	0.539
LIG_Pex14_1	84	88	PF04695	0.304
LIG_Pex14_2	37	41	PF04695	0.530
LIG_Pex14_2	57	61	PF04695	0.549
LIG_Pex14_2	99	103	PF04695	0.450
LIG_SH2_PTP2	95	98	PF00017	0.323
LIG_SH2_STAP1	100	104	PF00017	0.363
LIG_SH2_STAT5	142	145	PF00017	0.401
LIG_SH2_STAT5	92	95	PF00017	0.319
LIG_SH3_3	19	25	PF00018	0.622
LIG_TYR_ITIM	93	98	PF00017	0.323
LIG_WRC_WIRS_1	100	105	PF05994	0.324
LIG_WRC_WIRS_1	87	92	PF05994	0.338
MOD_CK2_1	148	154	PF00069	0.480
MOD_GSK3_1	7	14	PF00069	0.582
MOD_GSK3_1	73	80	PF00069	0.548
MOD_GSK3_1	94	101	PF00069	0.318
MOD_NEK2_1	11	16	PF00069	0.562
MOD_NEK2_1	2	7	PF00069	0.625
MOD_NEK2_1	49	54	PF00069	0.545
MOD_NEK2_1	91	96	PF00069	0.327
MOD_NEK2_1	99	104	PF00069	0.405
MOD_PKA_2	2	8	PF00069	0.620
MOD_PKA_2	20	26	PF00069	0.575
MOD_PKA_2	73	79	PF00069	0.562
MOD_Plk_4	91	97	PF00069	0.323
MOD_Plk_4	99	105	PF00069	0.437
MOD_SUMO_for_1	115	118	PF00179	0.382
MOD_SUMO_rev_2	130	139	PF00179	0.365
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.583
TRG_ENDOCYTIC_2	100	103	PF00928	0.325
TRG_ENDOCYTIC_2	142	145	PF00928	0.401
TRG_ENDOCYTIC_2	95	98	PF00928	0.319
TRG_ER_diArg_1	2	4	PF00400	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I617	Leptomonas seymouri	92%	100%
A0A0S4IMC0	Bodo saltans	60%	81%
A0A1X0NPR4	Trypanosomatidae	79%	100%
A0A3Q8ICK1	Leishmania donovani	100%	100%
A0A422NZ85	Trypanosoma rangeli	80%	100%
A4HJD8	Leishmania braziliensis	94%	100%
C9ZMA7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9B1V7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4Q6A5	Leishmania major	99%	100%