Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I6T4_LEIIN

TriTrypDb:

LINF_310022900

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I6T4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6T4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.498
CLV_NRD_NRD_1	226	228	PF00675	0.533
CLV_NRD_NRD_1	319	321	PF00675	0.621
CLV_PCSK_KEX2_1	226	228	PF00082	0.498
CLV_PCSK_SKI1_1	260	264	PF00082	0.419
CLV_PCSK_SKI1_1	77	81	PF00082	0.559
DEG_Nend_Nbox_1	1	3	PF02207	0.396
DEG_SPOP_SBC_1	239	243	PF00917	0.515
DEG_SPOP_SBC_1	36	40	PF00917	0.557
DOC_CKS1_1	58	63	PF01111	0.527
DOC_MAPK_gen_1	41	48	PF00069	0.553
DOC_MAPK_MEF2A_6	41	48	PF00069	0.610
DOC_PP2B_LxvP_1	44	47	PF13499	0.554
DOC_USP7_MATH_1	106	110	PF00917	0.597
DOC_USP7_MATH_1	291	295	PF00917	0.531
DOC_USP7_MATH_1	71	75	PF00917	0.727
DOC_WW_Pin1_4	57	62	PF00397	0.558
LIG_14-3-3_CanoR_1	148	155	PF00244	0.428
LIG_14-3-3_CanoR_1	214	222	PF00244	0.505
LIG_14-3-3_CanoR_1	268	274	PF00244	0.606
LIG_14-3-3_CanoR_1	309	315	PF00244	0.502
LIG_14-3-3_CanoR_1	5	11	PF00244	0.494
LIG_Actin_WH2_2	307	322	PF00022	0.668
LIG_BRCT_BRCA1_1	108	112	PF00533	0.611
LIG_CSL_BTD_1	11	14	PF09270	0.382
LIG_eIF4E_1	82	88	PF01652	0.585
LIG_FHA_1	280	286	PF00498	0.566
LIG_FHA_1	29	35	PF00498	0.431
LIG_FHA_1	58	64	PF00498	0.606
LIG_FHA_2	241	247	PF00498	0.626
LIG_LIR_Gen_1	109	119	PF02991	0.482
LIG_LIR_Nem_3	109	115	PF02991	0.539
LIG_LIR_Nem_3	183	188	PF02991	0.382
LIG_PCNA_yPIPBox_3	226	237	PF02747	0.593
LIG_SH2_CRK	212	216	PF00017	0.426
LIG_SH2_SRC	118	121	PF00017	0.419
LIG_SH2_STAT5	118	121	PF00017	0.511
LIG_SH2_STAT5	212	215	PF00017	0.516
LIG_SH3_3	88	94	PF00018	0.496
LIG_SUMO_SIM_anti_2	19	24	PF11976	0.374
LIG_SUMO_SIM_par_1	135	141	PF11976	0.432
LIG_SUMO_SIM_par_1	153	159	PF11976	0.522
LIG_SUMO_SIM_par_1	234	246	PF11976	0.602
LIG_SUMO_SIM_par_1	30	35	PF11976	0.459
LIG_TRAF2_1	276	279	PF00917	0.618
MOD_CK1_1	122	128	PF00069	0.510
MOD_CK1_1	138	144	PF00069	0.539
MOD_CK1_1	242	248	PF00069	0.669
MOD_CK1_1	294	300	PF00069	0.615
MOD_CK2_1	111	117	PF00069	0.549
MOD_CK2_1	166	172	PF00069	0.614
MOD_CK2_1	273	279	PF00069	0.577
MOD_GlcNHglycan	108	111	PF01048	0.547
MOD_GlcNHglycan	129	132	PF01048	0.504
MOD_GlcNHglycan	182	185	PF01048	0.531
MOD_GlcNHglycan	202	205	PF01048	0.534
MOD_GlcNHglycan	285	288	PF01048	0.596
MOD_GlcNHglycan	296	299	PF01048	0.503
MOD_GlcNHglycan	68	71	PF01048	0.623
MOD_GSK3_1	119	126	PF00069	0.527
MOD_GSK3_1	12	19	PF00069	0.436
MOD_GSK3_1	143	150	PF00069	0.509
MOD_GSK3_1	238	245	PF00069	0.581
MOD_GSK3_1	269	276	PF00069	0.590
MOD_GSK3_1	279	286	PF00069	0.600
MOD_GSK3_1	71	78	PF00069	0.648
MOD_N-GLC_1	273	278	PF02516	0.572
MOD_NEK2_1	119	124	PF00069	0.497
MOD_NEK2_1	135	140	PF00069	0.337
MOD_NEK2_1	147	152	PF00069	0.376
MOD_NEK2_1	161	166	PF00069	0.365
MOD_NEK2_1	187	192	PF00069	0.386
MOD_NEK2_1	200	205	PF00069	0.388
MOD_NEK2_1	215	220	PF00069	0.338
MOD_PIKK_1	104	110	PF00454	0.635
MOD_PIKK_1	245	251	PF00454	0.742
MOD_PKA_2	147	153	PF00069	0.431
MOD_PKA_2	279	285	PF00069	0.620
MOD_PKA_2	294	300	PF00069	0.504
MOD_Plk_1	119	125	PF00069	0.512
MOD_Plk_1	161	167	PF00069	0.458
MOD_Plk_1	273	279	PF00069	0.613
MOD_Plk_1	75	81	PF00069	0.628
MOD_Plk_4	111	117	PF00069	0.500
MOD_Plk_4	16	22	PF00069	0.324
MOD_Plk_4	28	34	PF00069	0.426
MOD_Plk_4	6	12	PF00069	0.406
MOD_ProDKin_1	57	63	PF00069	0.570
MOD_SUMO_rev_2	171	181	PF00179	0.563
TRG_DiLeu_BaEn_1	76	81	PF01217	0.570
TRG_DiLeu_BaEn_4	196	202	PF01217	0.510
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.544
TRG_ENDOCYTIC_2	212	215	PF00928	0.418
TRG_ER_diArg_1	226	228	PF00400	0.550
TRG_ER_diArg_1	41	44	PF00400	0.587
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6A2	Leptomonas seymouri	62%	99%
A0A1X0NQ31	Trypanosomatidae	41%	97%
A0A3R7KN88	Trypanosoma rangeli	42%	100%
A0A3S7X4K4	Leishmania donovani	100%	100%
A4HJD7	Leishmania braziliensis	88%	100%
C9ZMA6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B1V6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q6A6	Leishmania major	95%	100%
V5BFH9	Trypanosoma cruzi	42%	100%