LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4I6T3_LEIIN
TriTrypDb:
LINF_310022800
Length:
262

Annotations

Annotations by Jardim et al.

Ribosomal Protein, Mitochondrial ribosomal L51 / S25

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 10
GO:0005840 ribosome 5 10
GO:0032991 protein-containing complex 1 11
GO:0043226 organelle 2 10
GO:0043227 membrane-bounded organelle 3 10
GO:0043228 non-membrane-bounded organelle 3 10
GO:0043229 intracellular organelle 3 10
GO:0043231 intracellular membrane-bounded organelle 4 10
GO:0043232 intracellular non-membrane-bounded organelle 4 10
GO:0110165 cellular anatomical entity 1 10
GO:1990904 ribonucleoprotein complex 2 11
GO:0000315 organellar large ribosomal subunit 5 1
GO:0005762 mitochondrial large ribosomal subunit 3 1
GO:0015934 large ribosomal subunit 4 1
GO:0044391 ribosomal subunit 3 1
GO:0098798 mitochondrial protein-containing complex 2 1

Expansion

Sequence features

A4I6T3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6T3

PDB structure(s): 7aih_Ab , 7am2_Ab , 7ane_Ab

Function

Biological processes
Term Name Level Count
GO:0006412 translation 4 11
GO:0006518 peptide metabolic process 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009058 biosynthetic process 2 11
GO:0009059 macromolecule biosynthetic process 4 11
GO:0009987 cellular process 1 11
GO:0019538 protein metabolic process 3 11
GO:0032543 mitochondrial translation 5 11
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 11
GO:0043043 peptide biosynthetic process 5 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043603 amide metabolic process 3 11
GO:0043604 amide biosynthetic process 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044249 cellular biosynthetic process 3 11
GO:0044260 obsolete cellular macromolecule metabolic process 3 11
GO:0044271 cellular nitrogen compound biosynthetic process 4 11
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
GO:1901566 organonitrogen compound biosynthetic process 4 11
GO:1901576 organic substance biosynthetic process 3 11
Molecular functions
Term Name Level Count
GO:0003735 structural constituent of ribosome 2 11
GO:0005198 structural molecule activity 1 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 106 108 PF00675 0.406
CLV_NRD_NRD_1 134 136 PF00675 0.444
CLV_NRD_NRD_1 165 167 PF00675 0.565
CLV_NRD_NRD_1 241 243 PF00675 0.421
CLV_NRD_NRD_1 253 255 PF00675 0.446
CLV_PCSK_FUR_1 163 167 PF00082 0.595
CLV_PCSK_KEX2_1 106 108 PF00082 0.420
CLV_PCSK_KEX2_1 165 167 PF00082 0.565
CLV_PCSK_KEX2_1 240 242 PF00082 0.425
CLV_PCSK_SKI1_1 135 139 PF00082 0.527
DOC_MAPK_MEF2A_6 38 47 PF00069 0.296
DOC_MAPK_MEF2A_6 72 81 PF00069 0.344
DOC_PP2B_LxvP_1 258 261 PF13499 0.473
DOC_PP4_FxxP_1 223 226 PF00568 0.426
DOC_USP7_MATH_1 171 175 PF00917 0.514
DOC_USP7_MATH_1 226 230 PF00917 0.543
DOC_USP7_MATH_1 53 57 PF00917 0.372
DOC_USP7_UBL2_3 136 140 PF12436 0.481
DOC_USP7_UBL2_3 255 259 PF12436 0.445
DOC_WW_Pin1_4 14 19 PF00397 0.431
LIG_14-3-3_CanoR_1 106 110 PF00244 0.410
LIG_14-3-3_CanoR_1 135 144 PF00244 0.422
LIG_14-3-3_CanoR_1 189 198 PF00244 0.454
LIG_14-3-3_CanoR_1 72 78 PF00244 0.347
LIG_BIR_II_1 1 5 PF00653 0.424
LIG_BRCT_BRCA1_1 69 73 PF00533 0.419
LIG_FHA_1 173 179 PF00498 0.437
LIG_FHA_2 136 142 PF00498 0.528
LIG_FHA_2 157 163 PF00498 0.559
LIG_FHA_2 190 196 PF00498 0.415
LIG_FHA_2 214 220 PF00498 0.449
LIG_IBAR_NPY_1 114 116 PF08397 0.532
LIG_LIR_Apic_2 221 226 PF02991 0.562
LIG_LIR_Gen_1 219 226 PF02991 0.568
LIG_LIR_Nem_3 112 116 PF02991 0.516
LIG_LIR_Nem_3 139 145 PF02991 0.380
LIG_LIR_Nem_3 219 223 PF02991 0.427
LIG_LYPXL_yS_3 40 43 PF13949 0.292
LIG_PCNA_yPIPBox_3 20 29 PF02747 0.515
LIG_SH2_NCK_1 167 171 PF00017 0.606
LIG_SH2_STAP1 69 73 PF00017 0.357
LIG_SH2_STAT3 145 148 PF00017 0.395
LIG_SH2_STAT3 149 152 PF00017 0.372
LIG_SH2_STAT5 116 119 PF00017 0.560
LIG_SH2_STAT5 145 148 PF00017 0.390
LIG_SH2_STAT5 167 170 PF00017 0.605
LIG_SH2_STAT5 32 35 PF00017 0.397
LIG_SH3_3 209 215 PF00018 0.602
LIG_TRAF2_1 174 177 PF00917 0.565
MOD_CDC14_SPxK_1 17 20 PF00782 0.480
MOD_CDK_SPxK_1 14 20 PF00069 0.458
MOD_CK1_1 221 227 PF00069 0.524
MOD_CK1_1 55 61 PF00069 0.369
MOD_CK2_1 135 141 PF00069 0.386
MOD_CK2_1 171 177 PF00069 0.475
MOD_CK2_1 189 195 PF00069 0.418
MOD_CK2_1 213 219 PF00069 0.452
MOD_GlcNHglycan 97 100 PF01048 0.452
MOD_GSK3_1 105 112 PF00069 0.351
MOD_GSK3_1 131 138 PF00069 0.609
MOD_GSK3_1 93 100 PF00069 0.490
MOD_N-GLC_1 196 201 PF02516 0.427
MOD_N-GLC_1 93 98 PF02516 0.487
MOD_NEK2_1 28 33 PF00069 0.307
MOD_NEK2_1 73 78 PF00069 0.353
MOD_NEK2_1 97 102 PF00069 0.458
MOD_PK_1 67 73 PF00069 0.419
MOD_PKA_1 135 141 PF00069 0.413
MOD_PKA_1 165 171 PF00069 0.603
MOD_PKA_2 105 111 PF00069 0.405
MOD_PKA_2 165 171 PF00069 0.561
MOD_PKB_1 163 171 PF00069 0.598
MOD_Plk_1 156 162 PF00069 0.524
MOD_Plk_1 196 202 PF00069 0.451
MOD_Plk_1 218 224 PF00069 0.573
MOD_Plk_1 226 232 PF00069 0.562
MOD_Plk_1 53 59 PF00069 0.362
MOD_Plk_1 93 99 PF00069 0.488
MOD_Plk_2-3 156 162 PF00069 0.553
MOD_Plk_2-3 172 178 PF00069 0.569
MOD_Plk_4 218 224 PF00069 0.573
MOD_Plk_4 28 34 PF00069 0.397
MOD_ProDKin_1 14 20 PF00069 0.440
MOD_SUMO_for_1 153 156 PF00179 0.400
TRG_ENDOCYTIC_2 167 170 PF00928 0.605
TRG_ENDOCYTIC_2 220 223 PF00928 0.422
TRG_ENDOCYTIC_2 40 43 PF00928 0.292
TRG_ER_diArg_1 163 166 PF00400 0.542
TRG_ER_diArg_1 239 242 PF00400 0.427
TRG_ER_diArg_1 47 50 PF00400 0.292
TRG_Pf-PMV_PEXEL_1 135 139 PF00026 0.390

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZE9 Leptomonas seymouri 89% 100%
A0A0S4IRQ7 Bodo saltans 52% 94%
A0A1X0NRH7 Trypanosomatidae 63% 100%
A0A3Q8ISM3 Leishmania donovani 99% 100%
A0A3R7MT16 Trypanosoma rangeli 65% 100%
A4HJD6 Leishmania braziliensis 93% 100%
C9ZMA5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 62% 100%
E9B1V5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
Q4Q6A7 Leishmania major 97% 100%
V5BPL4 Trypanosoma cruzi 64% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS