Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I6T2_LEIIN

TriTrypDb:

LINF_310022700

Length:

445

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I6T2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6T2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	41	45	PF00656	0.717
CLV_PCSK_SKI1_1	237	241	PF00082	0.725
DEG_SCF_FBW7_1	162	169	PF00400	0.705
DEG_SPOP_SBC_1	172	176	PF00917	0.666
DOC_CKS1_1	238	243	PF01111	0.673
DOC_CKS1_1	365	370	PF01111	0.750
DOC_CYCLIN_yCln2_LP_2	239	245	PF00134	0.647
DOC_MAPK_gen_1	436	445	PF00069	0.575
DOC_MAPK_MEF2A_6	436	445	PF00069	0.627
DOC_MAPK_MEF2A_6	68	76	PF00069	0.687
DOC_PP2B_LxvP_1	239	242	PF13499	0.642
DOC_PP4_FxxP_1	264	267	PF00568	0.622
DOC_USP7_MATH_1	172	176	PF00917	0.711
DOC_USP7_MATH_1	219	223	PF00917	0.699
DOC_USP7_MATH_1	267	271	PF00917	0.690
DOC_USP7_MATH_1	313	317	PF00917	0.614
DOC_USP7_MATH_1	355	359	PF00917	0.675
DOC_USP7_MATH_1	391	395	PF00917	0.720
DOC_USP7_MATH_1	399	403	PF00917	0.592
DOC_USP7_MATH_1	412	416	PF00917	0.606
DOC_WW_Pin1_4	101	106	PF00397	0.607
DOC_WW_Pin1_4	113	118	PF00397	0.533
DOC_WW_Pin1_4	158	163	PF00397	0.701
DOC_WW_Pin1_4	183	188	PF00397	0.699
DOC_WW_Pin1_4	194	199	PF00397	0.614
DOC_WW_Pin1_4	226	231	PF00397	0.650
DOC_WW_Pin1_4	237	242	PF00397	0.614
DOC_WW_Pin1_4	247	252	PF00397	0.590
DOC_WW_Pin1_4	294	299	PF00397	0.729
DOC_WW_Pin1_4	364	369	PF00397	0.752
DOC_WW_Pin1_4	378	383	PF00397	0.594
DOC_WW_Pin1_4	4	9	PF00397	0.611
DOC_WW_Pin1_4	46	51	PF00397	0.678
DOC_WW_Pin1_4	84	89	PF00397	0.676
LIG_14-3-3_CanoR_1	113	117	PF00244	0.685
LIG_14-3-3_CanoR_1	180	185	PF00244	0.668
LIG_14-3-3_CanoR_1	439	444	PF00244	0.534
LIG_14-3-3_CanoR_1	80	85	PF00244	0.662
LIG_Actin_WH2_2	314	332	PF00022	0.560
LIG_Actin_WH2_2	67	82	PF00022	0.571
LIG_APCC_ABBAyCdc20_2	431	437	PF00400	0.617
LIG_BIR_II_1	1	5	PF00653	0.683
LIG_deltaCOP1_diTrp_1	425	433	PF00928	0.543
LIG_FHA_1	261	267	PF00498	0.719
LIG_FHA_1	275	281	PF00498	0.620
LIG_FHA_1	286	292	PF00498	0.590
LIG_FHA_2	309	315	PF00498	0.740
LIG_FHA_2	39	45	PF00498	0.764
LIG_LIR_Apic_2	116	122	PF02991	0.729
LIG_LIR_Apic_2	262	267	PF02991	0.611
LIG_LIR_Gen_1	165	173	PF02991	0.712
LIG_LIR_Gen_1	437	445	PF02991	0.613
LIG_LIR_Nem_3	165	171	PF02991	0.713
LIG_LIR_Nem_3	437	443	PF02991	0.603
LIG_PDZ_Class_2	440	445	PF00595	0.607
LIG_SH2_CRK	119	123	PF00017	0.729
LIG_SH2_CRK	235	239	PF00017	0.707
LIG_SH2_CRK	245	249	PF00017	0.612
LIG_SH2_NCK_1	119	123	PF00017	0.729
LIG_SH2_NCK_1	245	249	PF00017	0.668
LIG_SH2_SRC	245	248	PF00017	0.606
LIG_SH2_STAT5	273	276	PF00017	0.651
LIG_SH2_STAT5	366	369	PF00017	0.709
LIG_SH3_1	235	241	PF00018	0.651
LIG_SH3_1	245	251	PF00018	0.586
LIG_SH3_2	372	377	PF14604	0.679
LIG_SH3_3	181	187	PF00018	0.643
LIG_SH3_3	227	233	PF00018	0.630
LIG_SH3_3	235	241	PF00018	0.621
LIG_SH3_3	245	251	PF00018	0.558
LIG_SH3_3	277	283	PF00018	0.742
LIG_SH3_3	369	375	PF00018	0.784
LIG_SH3_3	413	419	PF00018	0.555
LIG_SUMO_SIM_anti_2	277	282	PF11976	0.648
LIG_UBA3_1	57	61	PF00899	0.672
MOD_CDC14_SPxK_1	161	164	PF00782	0.691
MOD_CDK_SPxK_1	158	164	PF00069	0.668
MOD_CK1_1	111	117	PF00069	0.741
MOD_CK1_1	120	126	PF00069	0.565
MOD_CK1_1	143	149	PF00069	0.631
MOD_CK1_1	158	164	PF00069	0.496
MOD_CK1_1	175	181	PF00069	0.631
MOD_CK1_1	183	189	PF00069	0.727
MOD_CK1_1	226	232	PF00069	0.625
MOD_CK1_1	250	256	PF00069	0.697
MOD_CK1_1	262	268	PF00069	0.562
MOD_CK1_1	296	302	PF00069	0.741
MOD_CK1_1	341	347	PF00069	0.733
MOD_CK1_1	38	44	PF00069	0.741
MOD_CK1_1	423	429	PF00069	0.634
MOD_DYRK1A_RPxSP_1	113	117	PF00069	0.685
MOD_GlcNHglycan	110	113	PF01048	0.849
MOD_GlcNHglycan	129	132	PF01048	0.690
MOD_GlcNHglycan	175	178	PF01048	0.760
MOD_GlcNHglycan	190	193	PF01048	0.634
MOD_GlcNHglycan	209	212	PF01048	0.515
MOD_GlcNHglycan	253	256	PF01048	0.663
MOD_GlcNHglycan	270	273	PF01048	0.495
MOD_GlcNHglycan	306	309	PF01048	0.732
MOD_GlcNHglycan	340	343	PF01048	0.695
MOD_GlcNHglycan	358	361	PF01048	0.562
MOD_GlcNHglycan	393	396	PF01048	0.679
MOD_GlcNHglycan	397	400	PF01048	0.651
MOD_GlcNHglycan	401	404	PF01048	0.637
MOD_GlcNHglycan	65	68	PF01048	0.752
MOD_GSK3_1	108	115	PF00069	0.717
MOD_GSK3_1	117	124	PF00069	0.641
MOD_GSK3_1	125	132	PF00069	0.726
MOD_GSK3_1	135	142	PF00069	0.592
MOD_GSK3_1	158	165	PF00069	0.707
MOD_GSK3_1	171	178	PF00069	0.695
MOD_GSK3_1	219	226	PF00069	0.676
MOD_GSK3_1	247	254	PF00069	0.738
MOD_GSK3_1	304	311	PF00069	0.702
MOD_GSK3_1	391	398	PF00069	0.632
MOD_GSK3_1	414	421	PF00069	0.672
MOD_GSK3_1	423	430	PF00069	0.663
MOD_GSK3_1	63	70	PF00069	0.666
MOD_GSK3_1	80	87	PF00069	0.575
MOD_N-GLC_1	140	145	PF02516	0.648
MOD_N-GLC_1	207	212	PF02516	0.648
MOD_N-GLC_1	304	309	PF02516	0.785
MOD_N-GLC_1	46	51	PF02516	0.678
MOD_NEK2_1	188	193	PF00069	0.672
MOD_NEK2_1	268	273	PF00069	0.744
MOD_NEK2_1	274	279	PF00069	0.699
MOD_NEK2_1	79	84	PF00069	0.616
MOD_PIKK_1	136	142	PF00454	0.587
MOD_PIKK_1	221	227	PF00454	0.709
MOD_PK_1	180	186	PF00069	0.667
MOD_PKA_2	112	118	PF00069	0.685
MOD_PKA_2	155	161	PF00069	0.638
MOD_PKA_2	376	382	PF00069	0.675
MOD_PKA_2	79	85	PF00069	0.684
MOD_Plk_1	166	172	PF00069	0.714
MOD_Plk_1	313	319	PF00069	0.580
MOD_Plk_4	200	206	PF00069	0.646
MOD_Plk_4	276	282	PF00069	0.689
MOD_Plk_4	296	302	PF00069	0.502
MOD_Plk_4	313	319	PF00069	0.597
MOD_Plk_4	67	73	PF00069	0.573
MOD_ProDKin_1	101	107	PF00069	0.609
MOD_ProDKin_1	113	119	PF00069	0.534
MOD_ProDKin_1	158	164	PF00069	0.709
MOD_ProDKin_1	183	189	PF00069	0.702
MOD_ProDKin_1	194	200	PF00069	0.606
MOD_ProDKin_1	226	232	PF00069	0.652
MOD_ProDKin_1	237	243	PF00069	0.616
MOD_ProDKin_1	247	253	PF00069	0.588
MOD_ProDKin_1	294	300	PF00069	0.729
MOD_ProDKin_1	364	370	PF00069	0.754
MOD_ProDKin_1	378	384	PF00069	0.594
MOD_ProDKin_1	4	10	PF00069	0.613
MOD_ProDKin_1	46	52	PF00069	0.676
MOD_ProDKin_1	84	90	PF00069	0.678
TRG_ENDOCYTIC_2	20	23	PF00928	0.705

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4K9	Leishmania donovani	98%	100%
A4HJD5	Leishmania braziliensis	62%	91%
E9B1V4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	94%
Q4Q6A8	Leishmania major	87%	96%