Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I6S5_LEIIN

TriTrypDb:

LINF_310021900

Length:

1039

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I6S5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6S5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	411	415	PF00656	0.621
CLV_NRD_NRD_1	282	284	PF00675	0.637
CLV_NRD_NRD_1	291	293	PF00675	0.467
CLV_NRD_NRD_1	36	38	PF00675	0.721
CLV_NRD_NRD_1	51	53	PF00675	0.557
CLV_NRD_NRD_1	551	553	PF00675	0.806
CLV_NRD_NRD_1	7	9	PF00675	0.619
CLV_NRD_NRD_1	731	733	PF00675	0.774
CLV_NRD_NRD_1	803	805	PF00675	0.709
CLV_NRD_NRD_1	840	842	PF00675	0.759
CLV_PCSK_FUR_1	280	284	PF00082	0.619
CLV_PCSK_FUR_1	288	292	PF00082	0.478
CLV_PCSK_FUR_1	728	732	PF00082	0.616
CLV_PCSK_KEX2_1	282	284	PF00082	0.637
CLV_PCSK_KEX2_1	290	292	PF00082	0.501
CLV_PCSK_KEX2_1	36	38	PF00082	0.721
CLV_PCSK_KEX2_1	51	53	PF00082	0.557
CLV_PCSK_KEX2_1	550	552	PF00082	0.795
CLV_PCSK_KEX2_1	7	9	PF00082	0.619
CLV_PCSK_KEX2_1	730	732	PF00082	0.833
CLV_PCSK_KEX2_1	803	805	PF00082	0.709
CLV_PCSK_PC7_1	278	284	PF00082	0.651
CLV_PCSK_SKI1_1	101	105	PF00082	0.730
CLV_PCSK_SKI1_1	1033	1037	PF00082	0.572
CLV_PCSK_SKI1_1	168	172	PF00082	0.527
CLV_PCSK_SKI1_1	175	179	PF00082	0.504
CLV_PCSK_SKI1_1	306	310	PF00082	0.552
CLV_PCSK_SKI1_1	595	599	PF00082	0.803
CLV_PCSK_SKI1_1	821	825	PF00082	0.672
CLV_PCSK_SKI1_1	955	959	PF00082	0.682
CLV_Separin_Metazoa	818	822	PF03568	0.670
DEG_APCC_DBOX_1	282	290	PF00400	0.609
DEG_APCC_DBOX_1	335	343	PF00400	0.599
DEG_COP1_1	81	91	PF00400	0.786
DEG_Nend_Nbox_1	1	3	PF02207	0.796
DEG_SIAH_1	745	753	PF03145	0.615
DEG_SPOP_SBC_1	658	662	PF00917	0.664
DOC_ANK_TNKS_1	830	837	PF00023	0.710
DOC_CYCLIN_RxL_1	97	107	PF00134	0.725
DOC_CYCLIN_yCln2_LP_2	386	392	PF00134	0.633
DOC_CYCLIN_yCln2_LP_2	718	724	PF00134	0.803
DOC_MAPK_JIP1_4	223	229	PF00069	0.514
DOC_MAPK_MEF2A_6	124	131	PF00069	0.594
DOC_PP1_RVXF_1	875	882	PF00149	0.672
DOC_PP2B_LxvP_1	683	686	PF13499	0.734
DOC_PP4_FxxP_1	313	316	PF00568	0.595
DOC_PP4_FxxP_1	440	443	PF00568	0.634
DOC_PP4_FxxP_1	490	493	PF00568	0.621
DOC_PP4_FxxP_1	788	791	PF00568	0.772
DOC_PP4_FxxP_1	859	862	PF00568	0.595
DOC_PP4_FxxP_1	888	891	PF00568	0.648
DOC_USP7_MATH_1	139	143	PF00917	0.709
DOC_USP7_MATH_1	156	160	PF00917	0.552
DOC_USP7_MATH_1	222	226	PF00917	0.718
DOC_USP7_MATH_1	240	244	PF00917	0.569
DOC_USP7_MATH_1	429	433	PF00917	0.667
DOC_USP7_MATH_1	50	54	PF00917	0.776
DOC_USP7_MATH_1	510	514	PF00917	0.818
DOC_USP7_MATH_1	539	543	PF00917	0.744
DOC_USP7_MATH_1	586	590	PF00917	0.740
DOC_USP7_MATH_1	614	618	PF00917	0.840
DOC_USP7_MATH_1	644	648	PF00917	0.737
DOC_USP7_MATH_1	658	662	PF00917	0.616
DOC_USP7_MATH_1	736	740	PF00917	0.629
DOC_USP7_MATH_1	791	795	PF00917	0.751
DOC_WW_Pin1_4	22	27	PF00397	0.788
DOC_WW_Pin1_4	267	272	PF00397	0.766
DOC_WW_Pin1_4	420	425	PF00397	0.702
DOC_WW_Pin1_4	45	50	PF00397	0.721
DOC_WW_Pin1_4	468	473	PF00397	0.691
DOC_WW_Pin1_4	640	645	PF00397	0.769
DOC_WW_Pin1_4	665	670	PF00397	0.674
DOC_WW_Pin1_4	68	73	PF00397	0.801
DOC_WW_Pin1_4	681	686	PF00397	0.657
DOC_WW_Pin1_4	739	744	PF00397	0.835
DOC_WW_Pin1_4	806	811	PF00397	0.785
DOC_WW_Pin1_4	830	835	PF00397	0.734
DOC_WW_Pin1_4	846	851	PF00397	0.660
DOC_WW_Pin1_4	89	94	PF00397	0.665
DOC_WW_Pin1_4	897	902	PF00397	0.658
DOC_WW_Pin1_4	962	967	PF00397	0.786
LIG_14-3-3_CanoR_1	291	300	PF00244	0.579
LIG_14-3-3_CanoR_1	51	57	PF00244	0.693
LIG_14-3-3_CanoR_1	550	559	PF00244	0.584
LIG_14-3-3_CanoR_1	576	580	PF00244	0.641
LIG_14-3-3_CanoR_1	793	799	PF00244	0.794
LIG_14-3-3_CanoR_1	852	862	PF00244	0.734
LIG_14-3-3_CanoR_1	896	901	PF00244	0.667
LIG_14-3-3_CanoR_1	979	985	PF00244	0.652
LIG_Actin_WH2_2	154	170	PF00022	0.649
LIG_Actin_WH2_2	710	725	PF00022	0.767
LIG_BRCT_BRCA1_1	153	157	PF00533	0.653
LIG_BRCT_BRCA1_1	766	770	PF00533	0.703
LIG_BRCT_BRCA1_1	855	859	PF00533	0.597
LIG_BRCT_BRCA1_1	899	903	PF00533	0.678
LIG_BRCT_BRCA1_1	916	920	PF00533	0.513
LIG_BRCT_BRCA1_2	916	922	PF00533	0.697
LIG_CtBP_PxDLS_1	669	673	PF00389	0.724
LIG_deltaCOP1_diTrp_1	878	888	PF00928	0.724
LIG_eIF4E_1	902	908	PF01652	0.590
LIG_FHA_1	1003	1009	PF00498	0.666
LIG_FHA_1	150	156	PF00498	0.679
LIG_FHA_1	203	209	PF00498	0.590
LIG_FHA_1	391	397	PF00498	0.536
LIG_FHA_1	4	10	PF00498	0.782
LIG_FHA_1	551	557	PF00498	0.736
LIG_FHA_1	631	637	PF00498	0.796
LIG_FHA_1	641	647	PF00498	0.632
LIG_FHA_1	98	104	PF00498	0.623
LIG_FHA_2	480	486	PF00498	0.604
LIG_FHA_2	69	75	PF00498	0.799
LIG_FHA_2	702	708	PF00498	0.745
LIG_FHA_2	780	786	PF00498	0.647
LIG_FHA_2	813	819	PF00498	0.463
LIG_LIR_Apic_2	141	146	PF02991	0.739
LIG_LIR_Apic_2	19	23	PF02991	0.702
LIG_LIR_Apic_2	311	316	PF02991	0.592
LIG_LIR_Apic_2	439	443	PF02991	0.631
LIG_LIR_Apic_2	488	493	PF02991	0.635
LIG_LIR_Apic_2	785	791	PF02991	0.741
LIG_LIR_Apic_2	856	862	PF02991	0.594
LIG_LIR_Apic_2	899	905	PF02991	0.630
LIG_LIR_Gen_1	398	404	PF02991	0.519
LIG_LIR_Gen_1	474	481	PF02991	0.598
LIG_LIR_Gen_1	797	806	PF02991	0.720
LIG_LIR_Gen_1	81	89	PF02991	0.792
LIG_LIR_Nem_3	154	160	PF02991	0.618
LIG_LIR_Nem_3	398	403	PF02991	0.530
LIG_LIR_Nem_3	474	480	PF02991	0.598
LIG_LIR_Nem_3	797	801	PF02991	0.709
LIG_LIR_Nem_3	81	85	PF02991	0.794
LIG_LIR_Nem_3	878	884	PF02991	0.731
LIG_MLH1_MIPbox_1	899	903	PF16413	0.667
LIG_MYND_1	681	685	PF01753	0.712
LIG_NRP_CendR_1	1038	1039	PF00754	0.695
LIG_Pex14_2	309	313	PF04695	0.575
LIG_SH2_CRK	1010	1014	PF00017	0.608
LIG_SH2_CRK	562	566	PF00017	0.621
LIG_SH2_NCK_1	143	147	PF00017	0.749
LIG_SH2_PTP2	20	23	PF00017	0.778
LIG_SH2_SRC	20	23	PF00017	0.778
LIG_SH2_SRC	775	778	PF00017	0.628
LIG_SH2_STAP1	381	385	PF00017	0.643
LIG_SH2_STAT3	579	582	PF00017	0.685
LIG_SH2_STAT5	1018	1021	PF00017	0.661
LIG_SH2_STAT5	102	105	PF00017	0.623
LIG_SH2_STAT5	20	23	PF00017	0.778
LIG_SH2_STAT5	203	206	PF00017	0.514
LIG_SH2_STAT5	579	582	PF00017	0.685
LIG_SH2_STAT5	902	905	PF00017	0.609
LIG_SH3_1	20	26	PF00018	0.785
LIG_SH3_1	740	746	PF00018	0.616
LIG_SH3_3	20	26	PF00018	0.785
LIG_SH3_3	332	338	PF00018	0.710
LIG_SH3_3	740	746	PF00018	0.778
LIG_SH3_3	935	941	PF00018	0.790
LIG_SH3_CIN85_PxpxPR_1	331	336	PF14604	0.649
LIG_SUMO_SIM_anti_2	647	653	PF11976	0.585
LIG_SUMO_SIM_par_1	338	345	PF11976	0.568
LIG_SUMO_SIM_par_1	633	643	PF11976	0.790
LIG_SUMO_SIM_par_1	667	673	PF11976	0.721
LIG_TRAF2_1	257	260	PF00917	0.619
LIG_TRAF2_1	815	818	PF00917	0.465
LIG_TRAF2_2	271	276	PF00917	0.730
LIG_TYR_ITIM	1008	1013	PF00017	0.585
LIG_WRC_WIRS_1	82	87	PF05994	0.719
MOD_CDC14_SPxK_1	48	51	PF00782	0.601
MOD_CDC14_SPxK_1	849	852	PF00782	0.615
MOD_CDK_SPK_2	739	744	PF00069	0.617
MOD_CDK_SPxK_1	45	51	PF00069	0.599
MOD_CDK_SPxK_1	846	852	PF00069	0.619
MOD_CDK_SPxxK_3	45	52	PF00069	0.815
MOD_CK1_1	107	113	PF00069	0.730
MOD_CK1_1	159	165	PF00069	0.638
MOD_CK1_1	207	213	PF00069	0.551
MOD_CK1_1	267	273	PF00069	0.825
MOD_CK1_1	345	351	PF00069	0.653
MOD_CK1_1	371	377	PF00069	0.683
MOD_CK1_1	409	415	PF00069	0.716
MOD_CK1_1	422	428	PF00069	0.726
MOD_CK1_1	445	451	PF00069	0.812
MOD_CK1_1	468	474	PF00069	0.714
MOD_CK1_1	544	550	PF00069	0.726
MOD_CK1_1	617	623	PF00069	0.714
MOD_CK1_1	647	653	PF00069	0.763
MOD_CK1_1	657	663	PF00069	0.726
MOD_CK1_1	668	674	PF00069	0.629
MOD_CK1_1	679	685	PF00069	0.707
MOD_CK1_1	694	700	PF00069	0.733
MOD_CK1_1	739	745	PF00069	0.841
MOD_CK1_1	794	800	PF00069	0.608
MOD_CK1_1	848	854	PF00069	0.789
MOD_CK1_1	975	981	PF00069	0.641
MOD_CK2_1	138	144	PF00069	0.815
MOD_CK2_1	50	56	PF00069	0.776
MOD_CK2_1	605	611	PF00069	0.830
MOD_CK2_1	68	74	PF00069	0.733
MOD_CK2_1	701	707	PF00069	0.696
MOD_CK2_1	713	719	PF00069	0.614
MOD_CK2_1	739	745	PF00069	0.830
MOD_CK2_1	779	785	PF00069	0.637
MOD_CK2_1	812	818	PF00069	0.464
MOD_CK2_1	970	976	PF00069	0.711
MOD_CK2_1	992	998	PF00069	0.630
MOD_GlcNHglycan	109	112	PF01048	0.679
MOD_GlcNHglycan	146	149	PF01048	0.704
MOD_GlcNHglycan	212	215	PF01048	0.674
MOD_GlcNHglycan	234	238	PF01048	0.820
MOD_GlcNHglycan	259	264	PF01048	0.799
MOD_GlcNHglycan	26	29	PF01048	0.776
MOD_GlcNHglycan	319	322	PF01048	0.668
MOD_GlcNHglycan	344	347	PF01048	0.621
MOD_GlcNHglycan	371	374	PF01048	0.611
MOD_GlcNHglycan	40	43	PF01048	0.597
MOD_GlcNHglycan	414	418	PF01048	0.719
MOD_GlcNHglycan	460	465	PF01048	0.702
MOD_GlcNHglycan	524	528	PF01048	0.784
MOD_GlcNHglycan	543	546	PF01048	0.658
MOD_GlcNHglycan	587	591	PF01048	0.805
MOD_GlcNHglycan	616	619	PF01048	0.829
MOD_GlcNHglycan	656	659	PF01048	0.801
MOD_GlcNHglycan	678	681	PF01048	0.801
MOD_GlcNHglycan	686	689	PF01048	0.724
MOD_GlcNHglycan	793	796	PF01048	0.728
MOD_GlcNHglycan	972	975	PF01048	0.639
MOD_GSK3_1	103	110	PF00069	0.644
MOD_GSK3_1	135	142	PF00069	0.698
MOD_GSK3_1	338	345	PF00069	0.576
MOD_GSK3_1	368	375	PF00069	0.673
MOD_GSK3_1	38	45	PF00069	0.676
MOD_GSK3_1	406	413	PF00069	0.664
MOD_GSK3_1	438	445	PF00069	0.805
MOD_GSK3_1	479	486	PF00069	0.508
MOD_GSK3_1	498	505	PF00069	0.675
MOD_GSK3_1	540	547	PF00069	0.737
MOD_GSK3_1	605	612	PF00069	0.777
MOD_GSK3_1	613	620	PF00069	0.820
MOD_GSK3_1	640	647	PF00069	0.753
MOD_GSK3_1	654	661	PF00069	0.673
MOD_GSK3_1	664	671	PF00069	0.679
MOD_GSK3_1	779	786	PF00069	0.728
MOD_GSK3_1	808	815	PF00069	0.584
MOD_GSK3_1	853	860	PF00069	0.812
MOD_GSK3_1	914	921	PF00069	0.724
MOD_GSK3_1	932	939	PF00069	0.738
MOD_GSK3_1	962	969	PF00069	0.707
MOD_N-GLC_1	107	112	PF02516	0.606
MOD_N-GLC_1	139	144	PF02516	0.689
MOD_N-GLC_1	452	457	PF02516	0.791
MOD_N-GLC_1	604	609	PF02516	0.613
MOD_N-GLC_1	694	699	PF02516	0.647
MOD_NEK2_1	103	108	PF00069	0.725
MOD_NEK2_1	135	140	PF00069	0.777
MOD_NEK2_1	202	207	PF00069	0.518
MOD_NEK2_1	395	400	PF00069	0.471
MOD_NEK2_1	670	675	PF00069	0.805
MOD_NEK2_1	676	681	PF00069	0.717
MOD_NEK2_1	693	698	PF00069	0.558
MOD_NEK2_1	713	718	PF00069	0.585
MOD_NEK2_1	779	784	PF00069	0.724
MOD_NEK2_1	970	975	PF00069	0.775
MOD_PIKK_1	978	984	PF00454	0.648
MOD_PKA_1	550	556	PF00069	0.566
MOD_PKA_2	135	141	PF00069	0.809
MOD_PKA_2	50	56	PF00069	0.819
MOD_PKA_2	550	556	PF00069	0.601
MOD_PKA_2	575	581	PF00069	0.638
MOD_PKA_2	676	682	PF00069	0.700
MOD_PKA_2	978	984	PF00069	0.636
MOD_PKB_1	290	298	PF00069	0.581
MOD_PKB_1	550	558	PF00069	0.647
MOD_Plk_1	139	145	PF00069	0.644
MOD_Plk_1	452	458	PF00069	0.762
MOD_Plk_1	460	466	PF00069	0.612
MOD_Plk_1	498	504	PF00069	0.768
MOD_Plk_1	713	719	PF00069	0.716
MOD_Plk_1	80	86	PF00069	0.791
MOD_Plk_1	992	998	PF00069	0.641
MOD_Plk_4	127	133	PF00069	0.706
MOD_Plk_4	156	162	PF00069	0.667
MOD_Plk_4	16	22	PF00069	0.708
MOD_Plk_4	395	401	PF00069	0.506
MOD_Plk_4	498	504	PF00069	0.694
MOD_Plk_4	575	581	PF00069	0.648
MOD_Plk_4	644	650	PF00069	0.793
MOD_Plk_4	713	719	PF00069	0.754
MOD_Plk_4	915	921	PF00069	0.725
MOD_Plk_4	992	998	PF00069	0.641
MOD_ProDKin_1	22	28	PF00069	0.790
MOD_ProDKin_1	267	273	PF00069	0.763
MOD_ProDKin_1	420	426	PF00069	0.705
MOD_ProDKin_1	45	51	PF00069	0.724
MOD_ProDKin_1	468	474	PF00069	0.684
MOD_ProDKin_1	640	646	PF00069	0.768
MOD_ProDKin_1	665	671	PF00069	0.672
MOD_ProDKin_1	68	74	PF00069	0.801
MOD_ProDKin_1	681	687	PF00069	0.659
MOD_ProDKin_1	739	745	PF00069	0.834
MOD_ProDKin_1	806	812	PF00069	0.780
MOD_ProDKin_1	830	836	PF00069	0.735
MOD_ProDKin_1	846	852	PF00069	0.660
MOD_ProDKin_1	89	95	PF00069	0.661
MOD_ProDKin_1	897	903	PF00069	0.652
MOD_ProDKin_1	962	968	PF00069	0.783
TRG_DiLeu_BaEn_1	173	178	PF01217	0.649
TRG_DiLeu_BaLyEn_6	335	340	PF01217	0.710
TRG_ENDOCYTIC_2	1010	1013	PF00928	0.606
TRG_ENDOCYTIC_2	1018	1021	PF00928	0.559
TRG_ER_diArg_1	1037	1039	PF00400	0.695
TRG_ER_diArg_1	280	283	PF00400	0.618
TRG_ER_diArg_1	288	291	PF00400	0.627
TRG_ER_diArg_1	35	37	PF00400	0.716
TRG_ER_diArg_1	550	552	PF00400	0.808
TRG_ER_diArg_1	7	9	PF00400	0.619
TRG_ER_diArg_1	727	730	PF00400	0.749
TRG_ER_diArg_1	895	898	PF00400	0.693

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILA0	Leptomonas seymouri	30%	100%
A0A3S7X4K1	Leishmania donovani	99%	100%
A4HJC9	Leishmania braziliensis	66%	100%
E9B1U7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q6B5	Leishmania major	87%	100%