LeishMANIAdb
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Surface membrane protein gp46-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Surface membrane protein gp46-like protein
Gene product:
surface membrane protein gp46-like protein
Species:
Leishmania infantum
UniProt:
A4I6S4_LEIIN
TriTrypDb:
LINF_310021800
Length:
302

Annotations

LeishMANIAdb annotations

Publication identifier(s): 8702946
A surface coat protein involved in immune evasion in Leishmaniids. Extremely fast evolving, almost completely disordered mucin-like protein. . Localization: Cell surface (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 60
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 33, no: 6
NetGPI no yes: 0, no: 39
Cellular components
Term Name Level Count
GO:0005929 cilium 4 40
GO:0042995 cell projection 2 40
GO:0043226 organelle 2 40
GO:0043227 membrane-bounded organelle 3 40
GO:0110165 cellular anatomical entity 1 40
GO:0120025 plasma membrane bounded cell projection 3 40
GO:0016020 membrane 2 7

Expansion

Sequence features

A4I6S4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6S4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 237 241 PF00656 0.452
CLV_NRD_NRD_1 215 217 PF00675 0.551
CLV_NRD_NRD_1 230 232 PF00675 0.446
CLV_NRD_NRD_1 50 52 PF00675 0.478
CLV_NRD_NRD_1 7 9 PF00675 0.712
CLV_PCSK_KEX2_1 215 217 PF00082 0.547
CLV_PCSK_KEX2_1 7 9 PF00082 0.712
CLV_PCSK_SKI1_1 107 111 PF00082 0.261
CLV_PCSK_SKI1_1 15 19 PF00082 0.632
CLV_PCSK_SKI1_1 159 163 PF00082 0.444
CLV_PCSK_SKI1_1 183 187 PF00082 0.475
CLV_PCSK_SKI1_1 51 55 PF00082 0.409
DEG_APCC_DBOX_1 14 22 PF00400 0.572
DOC_CYCLIN_yClb5_NLxxxL_5 190 199 PF00134 0.275
DOC_CYCLIN_yClb5_NLxxxL_5 238 247 PF00134 0.297
DOC_MAPK_gen_1 13 21 PF00069 0.583
DOC_MAPK_gen_1 231 238 PF00069 0.469
DOC_MAPK_MEF2A_6 15 23 PF00069 0.570
DOC_USP7_MATH_1 293 297 PF00917 0.448
DOC_USP7_MATH_1 98 102 PF00917 0.336
DOC_USP7_MATH_2 248 254 PF00917 0.460
DOC_USP7_UBL2_3 120 124 PF12436 0.346
DOC_WW_Pin1_4 27 32 PF00397 0.608
DOC_WW_Pin1_4 34 39 PF00397 0.499
LIG_14-3-3_CanoR_1 183 188 PF00244 0.375
LIG_14-3-3_CanoR_1 231 238 PF00244 0.470
LIG_APCC_ABBA_1 85 90 PF00400 0.298
LIG_BIR_III_2 59 63 PF00653 0.494
LIG_BRCT_BRCA1_1 276 280 PF00533 0.478
LIG_BRCT_BRCA1_1 68 72 PF00533 0.298
LIG_FHA_1 146 152 PF00498 0.349
LIG_FHA_1 170 176 PF00498 0.376
LIG_FHA_1 194 200 PF00498 0.369
LIG_FHA_1 218 224 PF00498 0.416
LIG_FHA_1 22 28 PF00498 0.634
LIG_FHA_1 242 248 PF00498 0.411
LIG_FHA_2 133 139 PF00498 0.454
LIG_FHA_2 172 178 PF00498 0.493
LIG_FHA_2 208 214 PF00498 0.503
LIG_FHA_2 235 241 PF00498 0.477
LIG_GBD_Chelix_1 19 27 PF00786 0.396
LIG_KLC1_Yacidic_2 86 90 PF13176 0.277
LIG_LIR_Gen_1 138 147 PF02991 0.471
LIG_LIR_Gen_1 154 161 PF02991 0.307
LIG_LIR_Gen_1 177 185 PF02991 0.417
LIG_LIR_Gen_1 186 195 PF02991 0.386
LIG_LIR_Gen_1 40 48 PF02991 0.463
LIG_LIR_Nem_3 130 134 PF02991 0.429
LIG_LIR_Nem_3 160 166 PF02991 0.357
LIG_LIR_Nem_3 177 182 PF02991 0.308
LIG_LIR_Nem_3 186 190 PF02991 0.324
LIG_LIR_Nem_3 226 230 PF02991 0.418
LIG_LIR_Nem_3 36 42 PF02991 0.536
LIG_NRBOX 24 30 PF00104 0.520
LIG_Pex14_1 163 167 PF04695 0.277
LIG_Pex14_2 53 57 PF04695 0.320
LIG_SH2_CRK 42 46 PF00017 0.574
LIG_SH2_GRB2like 143 146 PF00017 0.461
LIG_SH2_NCK_1 42 46 PF00017 0.333
LIG_SH2_PTP2 108 111 PF00017 0.243
LIG_SH2_STAP1 143 147 PF00017 0.306
LIG_SH2_STAT5 108 111 PF00017 0.445
LIG_SH2_STAT5 139 142 PF00017 0.382
LIG_SH2_STAT5 88 91 PF00017 0.591
LIG_SH3_3 92 98 PF00018 0.549
LIG_SUMO_SIM_par_1 19 24 PF11976 0.506
LIG_TYR_ITSM 38 45 PF00017 0.317
MOD_CDC14_SPxK_1 30 33 PF00782 0.378
MOD_CDK_SPxK_1 27 33 PF00069 0.377
MOD_CK1_1 130 136 PF00069 0.370
MOD_CK1_1 141 147 PF00069 0.298
MOD_CK1_1 202 208 PF00069 0.378
MOD_CK1_1 234 240 PF00069 0.417
MOD_CK1_1 253 259 PF00069 0.379
MOD_CK1_1 274 280 PF00069 0.462
MOD_CK1_1 37 43 PF00069 0.531
MOD_CK1_1 78 84 PF00069 0.423
MOD_CK2_1 132 138 PF00069 0.452
MOD_CK2_1 171 177 PF00069 0.481
MOD_CK2_1 207 213 PF00069 0.521
MOD_GlcNHglycan 101 104 PF01048 0.310
MOD_GlcNHglycan 159 162 PF01048 0.378
MOD_GlcNHglycan 204 207 PF01048 0.396
MOD_GlcNHglycan 252 255 PF01048 0.454
MOD_GlcNHglycan 42 45 PF01048 0.454
MOD_GSK3_1 110 117 PF00069 0.398
MOD_GSK3_1 119 126 PF00069 0.438
MOD_GSK3_1 141 148 PF00069 0.381
MOD_GSK3_1 195 202 PF00069 0.438
MOD_GSK3_1 219 226 PF00069 0.435
MOD_GSK3_1 232 239 PF00069 0.421
MOD_GSK3_1 75 82 PF00069 0.419
MOD_N-GLC_1 114 119 PF02516 0.488
MOD_N-GLC_1 193 198 PF02516 0.389
MOD_N-GLC_1 241 246 PF02516 0.528
MOD_N-GLC_2 266 268 PF02516 0.301
MOD_N-GLC_2 299 301 PF02516 0.522
MOD_NEK2_1 110 115 PF00069 0.346
MOD_NEK2_1 123 128 PF00069 0.293
MOD_NEK2_1 147 152 PF00069 0.351
MOD_NEK2_1 171 176 PF00069 0.415
MOD_NEK2_1 195 200 PF00069 0.381
MOD_NEK2_1 219 224 PF00069 0.342
MOD_NEK2_2 119 124 PF00069 0.362
MOD_PK_1 232 238 PF00069 0.309
MOD_PK_1 66 72 PF00069 0.287
MOD_PKA_1 231 237 PF00069 0.446
MOD_PKB_1 181 189 PF00069 0.232
MOD_Plk_1 114 120 PF00069 0.485
MOD_Plk_1 286 292 PF00069 0.496
MOD_Plk_4 207 213 PF00069 0.414
MOD_Plk_4 253 259 PF00069 0.458
MOD_Plk_4 271 277 PF00069 0.481
MOD_Plk_4 286 292 PF00069 0.462
MOD_ProDKin_1 27 33 PF00069 0.613
MOD_ProDKin_1 34 40 PF00069 0.500
TRG_DiLeu_BaLyEn_6 59 64 PF01217 0.324
TRG_ENDOCYTIC_2 108 111 PF00928 0.466
TRG_ENDOCYTIC_2 139 142 PF00928 0.479
TRG_ENDOCYTIC_2 42 45 PF00928 0.580
TRG_ER_diArg_1 181 184 PF00400 0.418
TRG_ER_diArg_1 6 8 PF00400 0.716

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P227 Leptomonas seymouri 34% 96%
A0A0N0P276 Leptomonas seymouri 27% 98%
A0A0N0P2L4 Leptomonas seymouri 31% 100%
A0A0N0P4M2 Leptomonas seymouri 26% 100%
A0A0N1HY53 Leptomonas seymouri 34% 100%
A0A0S4IIK7 Bodo saltans 27% 73%
A0A0S4IR61 Bodo saltans 29% 75%
A0A0S4IY39 Bodo saltans 27% 93%
A0A0S4IZC7 Bodo saltans 33% 73%
A0A0S4J1A6 Bodo saltans 28% 70%
A0A0S4J353 Bodo saltans 25% 100%
A0A0S4J805 Bodo saltans 29% 100%
A0A0S4JEK1 Bodo saltans 25% 74%
A0A0S4JMF9 Bodo saltans 32% 76%
A0A0S4JMG0 Bodo saltans 30% 87%
A0A0S4JS11 Bodo saltans 31% 94%
A0A0S4JS89 Bodo saltans 31% 68%
A0A0S4JU20 Bodo saltans 27% 100%
A0A0S4KHE4 Bodo saltans 34% 82%
A0A0S4KL26 Bodo saltans 25% 83%
A0A0S4KMV2 Bodo saltans 30% 77%
A0A1X0NKN8 Trypanosomatidae 26% 100%
A0A3Q8I9A6 Leishmania donovani 33% 78%
A0A3Q8I9D0 Leishmania donovani 36% 100%
A0A3Q8IFC2 Leishmania donovani 33% 69%
A0A3Q8IIJ9 Leishmania donovani 99% 100%
A0A3S5H6D6 Leishmania donovani 26% 100%
A0A3S7WPB2 Leishmania donovani 25% 100%
A0A3S7X4J4 Leishmania donovani 99% 100%
A4H4D2 Leishmania braziliensis 25% 100%
A4H4G6 Leishmania braziliensis 25% 99%
A4H5P0 Leishmania braziliensis 29% 100%
A4HBX3 Leishmania braziliensis 35% 67%
A4HJC8 Leishmania braziliensis 69% 100%
A4HJX1 Leishmania braziliensis 35% 69%
A4HTX9 Leishmania infantum 26% 100%
A4HVB0 Leishmania infantum 34% 100%
A4I6S2 Leishmania infantum 30% 69%
E8NHG5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 68%
E8NHP8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
E9ACQ0 Leishmania major 25% 100%
E9AG65 Leishmania infantum 25% 100%
E9AGG5 Leishmania infantum 32% 72%
E9AGH0 Leishmania infantum 35% 80%
E9AKM8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9AMQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9AP02 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9AP03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9AP07 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9AP08 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9B1U3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 66%
E9B1U4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B1U5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 72%
E9B1U6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
F4HTV6 Arabidopsis thaliana 26% 100%
P35334 Phaseolus vulgaris 25% 88%
P58822 Phaseolus vulgaris 25% 88%
P58823 Phaseolus vulgaris 25% 88%
Q25331 Leishmania major 31% 100%
Q4PSE6 Arabidopsis thaliana 28% 70%
Q4Q6B6 Leishmania major 91% 100%
Q4Q6B7 Leishmania major 91% 100%
Q4QC79 Leishmania major 37% 66%
Q4QGJ4 Leishmania major 31% 100%
Q4QGJ7 Leishmania major 31% 100%
Q4QGK6 Leishmania major 31% 100%
Q4QGL4 Leishmania major 35% 100%
Q4QHW6 Leishmania major 26% 100%
Q8GT95 Oryza sativa subsp. japonica 26% 91%
Q8W3M4 Arabidopsis thaliana 27% 75%
Q9M5J8 Arabidopsis thaliana 30% 92%
Q9M5J9 Arabidopsis thaliana 27% 92%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS