LeishMANIAdb
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Proteophosphoglycan ppg4

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Proteophosphoglycan ppg4
Gene product:
hypothetical protein
Species:
Leishmania infantum
UniProt:
A4I6S3_LEIIN
TriTrypDb:
LINF_310021600
Length:
500

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 35
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 13, no: 0
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005929 cilium 4 14
GO:0042995 cell projection 2 14
GO:0043226 organelle 2 14
GO:0043227 membrane-bounded organelle 3 14
GO:0110165 cellular anatomical entity 1 14
GO:0120025 plasma membrane bounded cell projection 3 14
GO:0005886 plasma membrane 3 2
GO:0016020 membrane 2 4

Expansion

Sequence features

A4I6S3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6S3

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0004672 protein kinase activity 3 1
GO:0004674 protein serine/threonine kinase activity 4 1
GO:0016301 kinase activity 4 1
GO:0016740 transferase activity 2 1
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 1
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 1
GO:0140096 catalytic activity, acting on a protein 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 111 115 PF00656 0.308
CLV_NRD_NRD_1 246 248 PF00675 0.509
CLV_NRD_NRD_1 264 266 PF00675 0.538
CLV_NRD_NRD_1 3 5 PF00675 0.732
CLV_PCSK_KEX2_1 246 248 PF00082 0.508
CLV_PCSK_KEX2_1 264 266 PF00082 0.534
CLV_PCSK_KEX2_1 3 5 PF00082 0.732
CLV_PCSK_KEX2_1 469 471 PF00082 0.578
CLV_PCSK_PC1ET2_1 469 471 PF00082 0.578
CLV_PCSK_SKI1_1 171 175 PF00082 0.502
DEG_Nend_Nbox_1 1 3 PF02207 0.496
DEG_SPOP_SBC_1 289 293 PF00917 0.483
DEG_SPOP_SBC_1 296 300 PF00917 0.495
DEG_SPOP_SBC_1 304 308 PF00917 0.476
DEG_SPOP_SBC_1 312 316 PF00917 0.459
DEG_SPOP_SBC_1 320 324 PF00917 0.473
DEG_SPOP_SBC_1 328 332 PF00917 0.469
DEG_SPOP_SBC_1 336 340 PF00917 0.467
DEG_SPOP_SBC_1 344 348 PF00917 0.463
DEG_SPOP_SBC_1 352 356 PF00917 0.451
DEG_SPOP_SBC_1 360 364 PF00917 0.460
DEG_SPOP_SBC_1 368 372 PF00917 0.460
DEG_SPOP_SBC_1 376 380 PF00917 0.457
DEG_SPOP_SBC_1 384 388 PF00917 0.454
DEG_SPOP_SBC_1 392 396 PF00917 0.470
DEG_SPOP_SBC_1 400 404 PF00917 0.475
DEG_SPOP_SBC_1 408 412 PF00917 0.485
DEG_SPOP_SBC_1 416 420 PF00917 0.485
DEG_SPOP_SBC_1 424 428 PF00917 0.471
DOC_MAPK_gen_1 264 272 PF00069 0.381
DOC_MAPK_MEF2A_6 145 154 PF00069 0.290
DOC_PP1_RVXF_1 169 176 PF00149 0.277
DOC_USP7_MATH_1 179 183 PF00917 0.289
DOC_USP7_MATH_1 274 278 PF00917 0.360
DOC_USP7_MATH_1 486 490 PF00917 0.305
DOC_USP7_MATH_1 72 76 PF00917 0.297
DOC_USP7_MATH_2 212 218 PF00917 0.307
DOC_WW_Pin1_4 475 480 PF00397 0.460
LIG_14-3-3_CanoR_1 171 176 PF00244 0.286
LIG_14-3-3_CanoR_1 192 198 PF00244 0.290
LIG_14-3-3_CanoR_1 246 251 PF00244 0.339
LIG_14-3-3_CanoR_1 264 269 PF00244 0.325
LIG_14-3-3_CanoR_1 44 52 PF00244 0.406
LIG_Actin_WH2_2 156 173 PF00022 0.284
LIG_BIR_III_2 47 51 PF00653 0.385
LIG_deltaCOP1_diTrp_1 261 268 PF00928 0.332
LIG_eIF4E_1 92 98 PF01652 0.282
LIG_FHA_1 123 129 PF00498 0.287
LIG_FHA_1 197 203 PF00498 0.308
LIG_FHA_1 230 236 PF00498 0.360
LIG_FHA_1 60 66 PF00498 0.374
LIG_FHA_1 9 15 PF00498 0.540
LIG_FHA_2 106 112 PF00498 0.399
LIG_FHA_2 290 296 PF00498 0.480
LIG_FHA_2 298 304 PF00498 0.477
LIG_FHA_2 306 312 PF00498 0.458
LIG_FHA_2 314 320 PF00498 0.455
LIG_FHA_2 322 328 PF00498 0.464
LIG_FHA_2 330 336 PF00498 0.463
LIG_FHA_2 338 344 PF00498 0.460
LIG_FHA_2 346 352 PF00498 0.461
LIG_FHA_2 354 360 PF00498 0.456
LIG_FHA_2 362 368 PF00498 0.462
LIG_FHA_2 370 376 PF00498 0.460
LIG_FHA_2 378 384 PF00498 0.450
LIG_FHA_2 386 392 PF00498 0.457
LIG_FHA_2 394 400 PF00498 0.464
LIG_FHA_2 402 408 PF00498 0.456
LIG_FHA_2 410 416 PF00498 0.462
LIG_FHA_2 418 424 PF00498 0.479
LIG_FHA_2 426 432 PF00498 0.497
LIG_FHA_2 448 454 PF00498 0.337
LIG_FHA_2 77 83 PF00498 0.354
LIG_LIR_Gen_1 117 126 PF02991 0.334
LIG_LIR_Gen_1 174 183 PF02991 0.317
LIG_LIR_Gen_1 214 223 PF02991 0.329
LIG_LIR_Gen_1 238 245 PF02991 0.410
LIG_LIR_Gen_1 53 60 PF02991 0.332
LIG_LIR_Nem_3 117 121 PF02991 0.392
LIG_LIR_Nem_3 141 146 PF02991 0.335
LIG_LIR_Nem_3 166 170 PF02991 0.367
LIG_LIR_Nem_3 174 178 PF02991 0.306
LIG_LIR_Nem_3 53 57 PF02991 0.352
LIG_SH2_STAP1 118 122 PF00017 0.330
LIG_SH2_STAP1 203 207 PF00017 0.291
LIG_SH2_STAT3 203 206 PF00017 0.310
LIG_SH3_3 107 113 PF00018 0.448
LIG_SUMO_SIM_par_1 198 205 PF11976 0.295
LIG_TYR_ITIM 116 121 PF00017 0.395
MOD_CK1_1 101 107 PF00069 0.359
MOD_CK1_1 133 139 PF00069 0.308
MOD_CK1_1 166 172 PF00069 0.424
MOD_CK1_1 190 196 PF00069 0.371
MOD_CK1_1 217 223 PF00069 0.420
MOD_CK1_1 477 483 PF00069 0.471
MOD_CK1_1 53 59 PF00069 0.386
MOD_CK2_1 289 295 PF00069 0.474
MOD_CK2_1 297 303 PF00069 0.476
MOD_CK2_1 305 311 PF00069 0.459
MOD_CK2_1 313 319 PF00069 0.453
MOD_CK2_1 321 327 PF00069 0.463
MOD_CK2_1 329 335 PF00069 0.464
MOD_CK2_1 337 343 PF00069 0.460
MOD_CK2_1 345 351 PF00069 0.461
MOD_CK2_1 353 359 PF00069 0.455
MOD_CK2_1 361 367 PF00069 0.461
MOD_CK2_1 369 375 PF00069 0.461
MOD_CK2_1 377 383 PF00069 0.456
MOD_CK2_1 385 391 PF00069 0.459
MOD_CK2_1 393 399 PF00069 0.464
MOD_CK2_1 401 407 PF00069 0.455
MOD_CK2_1 409 415 PF00069 0.460
MOD_CK2_1 417 423 PF00069 0.489
MOD_CK2_1 425 431 PF00069 0.516
MOD_CK2_1 43 49 PF00069 0.401
MOD_GlcNHglycan 100 103 PF01048 0.579
MOD_GlcNHglycan 135 138 PF01048 0.588
MOD_GlcNHglycan 159 162 PF01048 0.538
MOD_GlcNHglycan 183 186 PF01048 0.553
MOD_GlcNHglycan 207 210 PF01048 0.610
MOD_GlcNHglycan 276 279 PF01048 0.543
MOD_GlcNHglycan 456 459 PF01048 0.570
MOD_GlcNHglycan 471 474 PF01048 0.642
MOD_GSK3_1 101 108 PF00069 0.370
MOD_GSK3_1 131 138 PF00069 0.424
MOD_GSK3_1 153 160 PF00069 0.382
MOD_GSK3_1 174 181 PF00069 0.304
MOD_GSK3_1 183 190 PF00069 0.367
MOD_GSK3_1 192 199 PF00069 0.327
MOD_GSK3_1 213 220 PF00069 0.428
MOD_GSK3_1 231 238 PF00069 0.325
MOD_GSK3_1 264 271 PF00069 0.374
MOD_GSK3_1 283 290 PF00069 0.444
MOD_GSK3_1 291 298 PF00069 0.510
MOD_GSK3_1 299 306 PF00069 0.498
MOD_GSK3_1 307 314 PF00069 0.471
MOD_GSK3_1 315 322 PF00069 0.467
MOD_GSK3_1 323 330 PF00069 0.466
MOD_GSK3_1 331 338 PF00069 0.464
MOD_GSK3_1 339 346 PF00069 0.463
MOD_GSK3_1 347 354 PF00069 0.456
MOD_GSK3_1 355 362 PF00069 0.457
MOD_GSK3_1 363 370 PF00069 0.460
MOD_GSK3_1 371 378 PF00069 0.464
MOD_GSK3_1 379 386 PF00069 0.460
MOD_GSK3_1 387 394 PF00069 0.468
MOD_GSK3_1 395 402 PF00069 0.477
MOD_GSK3_1 403 410 PF00069 0.479
MOD_GSK3_1 411 418 PF00069 0.501
MOD_GSK3_1 419 426 PF00069 0.493
MOD_GSK3_1 427 434 PF00069 0.462
MOD_GSK3_1 474 481 PF00069 0.479
MOD_GSK3_1 72 79 PF00069 0.317
MOD_GSK3_1 87 94 PF00069 0.371
MOD_N-GLC_2 254 256 PF02516 0.560
MOD_N-GLC_2 285 287 PF02516 0.679
MOD_NEK2_1 122 127 PF00069 0.384
MOD_NEK2_1 154 159 PF00069 0.349
MOD_NEK2_1 202 207 PF00069 0.360
MOD_NEK2_1 231 236 PF00069 0.397
MOD_NEK2_1 76 81 PF00069 0.312
MOD_NEK2_1 98 103 PF00069 0.331
MOD_NEK2_2 87 92 PF00069 0.282
MOD_OFUCOSY 281 287 PF10250 0.547
MOD_OFUCOSY 84 91 PF10250 0.522
MOD_PIKK_1 202 208 PF00454 0.337
MOD_PK_1 85 91 PF00069 0.326
MOD_PKA_1 246 252 PF00069 0.305
MOD_PKA_1 264 270 PF00069 0.320
MOD_PKA_1 469 475 PF00069 0.413
MOD_PKA_2 246 252 PF00069 0.302
MOD_PKA_2 264 270 PF00069 0.320
MOD_PKA_2 43 49 PF00069 0.404
MOD_PKA_2 469 475 PF00069 0.413
MOD_PKA_2 50 56 PF00069 0.335
MOD_Plk_1 116 122 PF00069 0.335
MOD_Plk_1 213 219 PF00069 0.332
MOD_Plk_2-3 431 437 PF00069 0.418
MOD_Plk_4 171 177 PF00069 0.361
MOD_Plk_4 196 202 PF00069 0.334
MOD_Plk_4 246 252 PF00069 0.341
MOD_Plk_4 92 98 PF00069 0.332
MOD_ProDKin_1 475 481 PF00069 0.460
TRG_ENDOCYTIC_2 118 121 PF00928 0.443
TRG_ER_diArg_1 2 4 PF00400 0.656
TRG_ER_diArg_1 245 247 PF00400 0.325
TRG_ER_diArg_1 263 265 PF00400 0.312

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8I9A6 Leishmania donovani 40% 100%
A0A3S5H6M4 Leishmania donovani 30% 76%
A4HVB0 Leishmania infantum 36% 100%
D1GJ51 Leishmania infantum 32% 100%
E9AGG5 Leishmania infantum 39% 100%
E9AGH0 Leishmania infantum 37% 100%
E9AP02 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 100%
E9AP03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E9B1U5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4QGI2 Leishmania major 31% 89%
Q4QGI4 Leishmania major 31% 93%
Q4QGL4 Leishmania major 39% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS