Surface_antigen-like_protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I6S2_LEIIN

TriTrypDb:

LINF_310021500

Length:

440

Annotations

LeishMANIAdb annotations

Publication identifier(s): 8702946
A surface coat protein involved in immune evasion in Leishmaniids. Extremely fast evolving, almost completely disordered mucin-like protein. . Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 50

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 24, no: 1
NetGPI	no	yes: 0, no: 25

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	26
GO:0042995	cell projection	2	26
GO:0043226	organelle	2	26
GO:0043227	membrane-bounded organelle	3	26
GO:0110165	cellular anatomical entity	1	26
GO:0120025	plasma membrane bounded cell projection	3	26
GO:0016020	membrane	2	6

Expansion

Sequence features

A4I6S2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6S2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	224	226	PF00675	0.351
CLV_NRD_NRD_1	363	365	PF00675	0.536
CLV_NRD_NRD_1	374	376	PF00675	0.536
CLV_NRD_NRD_1	6	8	PF00675	0.453
CLV_PCSK_KEX2_1	224	226	PF00082	0.335
CLV_PCSK_KEX2_1	363	365	PF00082	0.538
CLV_PCSK_KEX2_1	374	376	PF00082	0.536
CLV_PCSK_KEX2_1	6	8	PF00082	0.453
CLV_PCSK_SKI1_1	176	180	PF00082	0.386
CLV_PCSK_SKI1_1	7	11	PF00082	0.574
DEG_APCC_DBOX_1	405	413	PF00400	0.535
DEG_APCC_DBOX_1	6	14	PF00400	0.504
DEG_SCF_FBW7_1	323	328	PF00400	0.553
DEG_SPOP_SBC_1	291	295	PF00917	0.603
DEG_SPOP_SBC_1	299	303	PF00917	0.588
DOC_MAPK_gen_1	147	156	PF00069	0.317
DOC_MAPK_gen_1	371	379	PF00069	0.538
DOC_MAPK_gen_1	6	13	PF00069	0.460
DOC_PP1_RVXF_1	222	229	PF00149	0.308
DOC_PP2B_LxvP_1	22	25	PF13499	0.523
DOC_USP7_MATH_1	102	106	PF00917	0.396
DOC_USP7_MATH_1	192	196	PF00917	0.342
DOC_USP7_MATH_1	298	302	PF00917	0.609
DOC_USP7_MATH_1	323	327	PF00917	0.564
DOC_USP7_MATH_1	348	352	PF00917	0.552
DOC_USP7_MATH_1	59	63	PF00917	0.335
DOC_USP7_MATH_1	74	78	PF00917	0.301
DOC_WW_Pin1_4	265	270	PF00397	0.373
DOC_WW_Pin1_4	292	297	PF00397	0.580
DOC_WW_Pin1_4	30	35	PF00397	0.527
DOC_WW_Pin1_4	321	326	PF00397	0.557
DOC_WW_Pin1_4	346	351	PF00397	0.568
LIG_14-3-3_CanoR_1	176	181	PF00244	0.291
LIG_14-3-3_CanoR_1	61	66	PF00244	0.370
LIG_BRCT_BRCA1_1	173	177	PF00533	0.324
LIG_Clathr_ClatBox_1	122	126	PF01394	0.302
LIG_deltaCOP1_diTrp_1	263	272	PF00928	0.368
LIG_DLG_GKlike_1	243	250	PF00625	0.337
LIG_FHA_1	101	107	PF00498	0.408
LIG_FHA_1	136	142	PF00498	0.359
LIG_FHA_1	151	157	PF00498	0.314
LIG_FHA_1	208	214	PF00498	0.427
LIG_FHA_1	268	274	PF00498	0.372
LIG_FHA_1	412	418	PF00498	0.548
LIG_FHA_1	62	68	PF00498	0.430
LIG_FHA_2	108	114	PF00498	0.579
LIG_FHA_2	210	216	PF00498	0.467
LIG_FHA_2	292	298	PF00498	0.585
LIG_FHA_2	317	323	PF00498	0.570
LIG_FHA_2	342	348	PF00498	0.562
LIG_LIR_Gen_1	117	128	PF02991	0.361
LIG_LIR_Gen_1	143	151	PF02991	0.392
LIG_LIR_Gen_1	168	177	PF02991	0.358
LIG_LIR_Gen_1	215	223	PF02991	0.399
LIG_LIR_Gen_1	240	247	PF02991	0.460
LIG_LIR_Gen_1	33	43	PF02991	0.485
LIG_LIR_Nem_3	117	123	PF02991	0.417
LIG_LIR_Nem_3	143	148	PF02991	0.413
LIG_LIR_Nem_3	174	180	PF02991	0.539
LIG_LIR_Nem_3	183	189	PF02991	0.456
LIG_LIR_Nem_3	270	275	PF02991	0.351
LIG_LIR_Nem_3	33	38	PF02991	0.462
LIG_LIR_Nem_3	430	435	PF02991	0.494
LIG_LIR_Nem_3	87	91	PF02991	0.413
LIG_MYND_3	244	248	PF01753	0.349
LIG_Pex14_2	237	241	PF04695	0.317
LIG_PTB_Apo_2	251	258	PF02174	0.306
LIG_SH2_CRK	120	124	PF00017	0.363
LIG_SH2_CRK	158	162	PF00017	0.317
LIG_SH2_NCK_1	158	162	PF00017	0.317
LIG_SH2_STAP1	392	396	PF00017	0.546
LIG_SH2_STAT5	158	161	PF00017	0.532
LIG_SH3_3	109	115	PF00018	0.403
LIG_SH3_3	28	34	PF00018	0.487
LIG_SH3_CIN85_PxpxPR_1	401	406	PF14604	0.538
LIG_SUMO_SIM_par_1	378	383	PF11976	0.529
LIG_TYR_ITIM	118	123	PF00017	0.444
LIG_TYR_ITIM	156	161	PF00017	0.348
MOD_CK1_1	105	111	PF00069	0.390
MOD_CK1_1	143	149	PF00069	0.490
MOD_CK1_1	160	166	PF00069	0.418
MOD_CK1_1	168	174	PF00069	0.477
MOD_CK1_1	194	200	PF00069	0.500
MOD_CK1_1	264	270	PF00069	0.399
MOD_CK1_1	302	308	PF00069	0.599
MOD_CK1_1	310	316	PF00069	0.660
MOD_CK1_1	327	333	PF00069	0.579
MOD_CK1_1	335	341	PF00069	0.558
MOD_CK1_1	351	357	PF00069	0.565
MOD_CK2_1	107	113	PF00069	0.509
MOD_CK2_1	194	200	PF00069	0.460
MOD_CK2_1	209	215	PF00069	0.364
MOD_CK2_1	291	297	PF00069	0.560
MOD_CK2_1	302	308	PF00069	0.559
MOD_CK2_1	316	322	PF00069	0.558
MOD_CK2_1	327	333	PF00069	0.554
MOD_CK2_1	341	347	PF00069	0.551
MOD_CK2_1	54	60	PF00069	0.510
MOD_Cter_Amidation	372	375	PF01082	0.531
MOD_DYRK1A_RPxSP_1	30	34	PF00069	0.468
MOD_GlcNHglycan	196	199	PF01048	0.390
MOD_GlcNHglycan	302	305	PF01048	0.578
MOD_GlcNHglycan	308	312	PF01048	0.596
MOD_GlcNHglycan	327	330	PF01048	0.536
MOD_GlcNHglycan	333	337	PF01048	0.554
MOD_GlcNHglycan	351	354	PF01048	0.552
MOD_GlcNHglycan	80	83	PF01048	0.361
MOD_GSK3_1	137	144	PF00069	0.467
MOD_GSK3_1	156	163	PF00069	0.424
MOD_GSK3_1	167	174	PF00069	0.477
MOD_GSK3_1	176	183	PF00069	0.345
MOD_GSK3_1	233	240	PF00069	0.404
MOD_GSK3_1	261	268	PF00069	0.600
MOD_GSK3_1	298	305	PF00069	0.610
MOD_GSK3_1	307	314	PF00069	0.652
MOD_GSK3_1	317	324	PF00069	0.640
MOD_GSK3_1	332	339	PF00069	0.567
MOD_GSK3_1	342	349	PF00069	0.564
MOD_GSK3_1	74	81	PF00069	0.355
MOD_GSK3_1	96	103	PF00069	0.394
MOD_N-GLC_1	96	101	PF02516	0.319
MOD_N-GLC_2	256	258	PF02516	0.406
MOD_NEK2_1	100	105	PF00069	0.364
MOD_NEK2_1	156	161	PF00069	0.336
MOD_NEK2_1	178	183	PF00069	0.294
MOD_NEK2_1	233	238	PF00069	0.444
MOD_NEK2_1	78	83	PF00069	0.432
MOD_PIKK_1	204	210	PF00454	0.350
MOD_PKB_1	426	434	PF00069	0.499
MOD_Plk_1	118	124	PF00069	0.485
MOD_Plk_1	215	221	PF00069	0.402
MOD_Plk_1	96	102	PF00069	0.327
MOD_Plk_4	118	124	PF00069	0.359
MOD_Plk_4	261	267	PF00069	0.403
MOD_Plk_4	96	102	PF00069	0.364
MOD_ProDKin_1	265	271	PF00069	0.367
MOD_ProDKin_1	292	298	PF00069	0.581
MOD_ProDKin_1	30	36	PF00069	0.519
MOD_ProDKin_1	321	327	PF00069	0.558
MOD_ProDKin_1	346	352	PF00069	0.568
TRG_ENDOCYTIC_2	120	123	PF00928	0.506
TRG_ENDOCYTIC_2	158	161	PF00928	0.380
TRG_ENDOCYTIC_2	234	237	PF00928	0.374
TRG_ER_diArg_1	223	225	PF00400	0.351
TRG_ER_diArg_1	28	31	PF00400	0.468
TRG_ER_diArg_1	412	415	PF00400	0.531
TRG_ER_diArg_1	425	428	PF00400	0.501
TRG_ER_diArg_1	6	8	PF00400	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I121	Leptomonas seymouri	25%	88%
A0A3Q8I9A6	Leishmania donovani	35%	100%
A0A3Q8IIJ9	Leishmania donovani	29%	100%
A0A3Q8IK15	Leishmania donovani	97%	83%
A0A3S7X4J4	Leishmania donovani	29%	100%
A4H4D2	Leishmania braziliensis	28%	100%
A4HJC8	Leishmania braziliensis	30%	100%
A4HVB0	Leishmania infantum	35%	100%
A4I6S4	Leishmania infantum	30%	100%
E8NHP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E8NHQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	67%
E9AGG5	Leishmania infantum	35%	100%
E9AGH0	Leishmania infantum	37%	100%
E9AP02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9AP03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AP07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9B1U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9B1U6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
Q4Q6B6	Leishmania major	31%	100%
Q4Q6B7	Leishmania major	32%	100%
Q4Q6B8	Leishmania major	82%	83%
Q4QGJ6	Leishmania major	31%	77%
Q4QGL4	Leishmania major	32%	100%
Q4QGL5	Leishmania major	33%	80%