THO complex subunit 7

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I6R2_LEIIN

TriTrypDb:

LINF_310020300

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I6R2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6R2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	294	298	PF00656	0.416
CLV_NRD_NRD_1	118	120	PF00675	0.565
CLV_NRD_NRD_1	246	248	PF00675	0.550
CLV_NRD_NRD_1	253	255	PF00675	0.539
CLV_NRD_NRD_1	64	66	PF00675	0.618
CLV_PCSK_FUR_1	251	255	PF00082	0.412
CLV_PCSK_FUR_1	62	66	PF00082	0.433
CLV_PCSK_KEX2_1	118	120	PF00082	0.585
CLV_PCSK_KEX2_1	207	209	PF00082	0.663
CLV_PCSK_KEX2_1	246	248	PF00082	0.599
CLV_PCSK_KEX2_1	251	253	PF00082	0.570
CLV_PCSK_KEX2_1	283	285	PF00082	0.451
CLV_PCSK_KEX2_1	64	66	PF00082	0.618
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.601
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.417
CLV_PCSK_PC7_1	247	253	PF00082	0.404
CLV_PCSK_PC7_1	279	285	PF00082	0.419
CLV_PCSK_SKI1_1	284	288	PF00082	0.436
CLV_PCSK_SKI1_1	65	69	PF00082	0.563
DEG_APCC_DBOX_1	145	153	PF00400	0.531
DEG_Nend_Nbox_1	1	3	PF02207	0.469
DOC_MAPK_gen_1	283	289	PF00069	0.465
DOC_MAPK_MEF2A_6	274	282	PF00069	0.565
DOC_PP4_FxxP_1	135	138	PF00568	0.510
DOC_USP7_MATH_1	12	16	PF00917	0.551
DOC_USP7_MATH_1	138	142	PF00917	0.425
DOC_USP7_MATH_1	213	217	PF00917	0.755
DOC_USP7_MATH_1	23	27	PF00917	0.422
DOC_USP7_UBL2_3	111	115	PF12436	0.561
LIG_14-3-3_CanoR_1	100	110	PF00244	0.454
LIG_14-3-3_CanoR_1	156	163	PF00244	0.471
LIG_14-3-3_CanoR_1	164	170	PF00244	0.399
LIG_14-3-3_CanoR_1	33	41	PF00244	0.490
LIG_Actin_WH2_2	110	126	PF00022	0.482
LIG_Actin_WH2_2	166	183	PF00022	0.447
LIG_FHA_1	102	108	PF00498	0.590
LIG_FHA_1	165	171	PF00498	0.476
LIG_FHA_1	233	239	PF00498	0.498
LIG_FHA_1	35	41	PF00498	0.466
LIG_FHA_1	43	49	PF00498	0.439
LIG_FHA_2	186	192	PF00498	0.610
LIG_LIR_Nem_3	332	337	PF02991	0.566
LIG_Pex14_2	131	135	PF04695	0.500
LIG_SUMO_SIM_par_1	42	49	PF11976	0.474
LIG_WRC_WIRS_1	13	18	PF05994	0.554
MOD_CK1_1	42	48	PF00069	0.492
MOD_CK2_1	155	161	PF00069	0.611
MOD_GlcNHglycan	215	218	PF01048	0.708
MOD_GlcNHglycan	315	318	PF01048	0.552
MOD_GlcNHglycan	54	57	PF01048	0.623
MOD_GlcNHglycan	58	61	PF01048	0.572
MOD_GSK3_1	213	220	PF00069	0.728
MOD_GSK3_1	52	59	PF00069	0.671
MOD_NEK2_1	163	168	PF00069	0.535
MOD_NEK2_1	34	39	PF00069	0.457
MOD_NEK2_1	76	81	PF00069	0.597
MOD_NEK2_2	12	17	PF00069	0.500
MOD_PIKK_1	155	161	PF00454	0.510
MOD_PIKK_1	263	269	PF00454	0.468
MOD_PKA_1	252	258	PF00069	0.542
MOD_PKA_2	155	161	PF00069	0.461
MOD_PKA_2	163	169	PF00069	0.403
MOD_PKA_2	245	251	PF00069	0.643
MOD_PKA_2	252	258	PF00069	0.582
MOD_PKA_2	34	40	PF00069	0.606
MOD_Plk_1	42	48	PF00069	0.415
MOD_SUMO_for_1	173	176	PF00179	0.437
MOD_SUMO_rev_2	108	117	PF00179	0.505
MOD_SUMO_rev_2	166	175	PF00179	0.496
MOD_SUMO_rev_2	297	306	PF00179	0.598
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.506
TRG_ER_diArg_1	117	119	PF00400	0.603
TRG_ER_diArg_1	251	254	PF00400	0.577
TRG_ER_diArg_1	62	65	PF00400	0.528
TRG_NES_CRM1_1	276	292	PF08389	0.423
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXL4	Leptomonas seymouri	40%	100%
A0A3S7X4F2	Leishmania donovani	100%	100%
A0A422NZ65	Trypanosoma rangeli	29%	100%
A4HJB9	Leishmania braziliensis	74%	100%
C9ZWT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B1T4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q6C7	Leishmania major	91%	100%