Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein phosphatase 2C - putative

Species:

Leishmania infantum

UniProt:

A4I6Q8_LEIIN

TriTrypDb:

LINF_310019900

Length:

2567

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I6Q8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6Q8

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004721	phosphoprotein phosphatase activity	3	7
GO:0004722	protein serine/threonine phosphatase activity	4	7
GO:0005488	binding	1	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1056	1060	PF00656	0.738
CLV_C14_Caspase3-7	1162	1166	PF00656	0.651
CLV_C14_Caspase3-7	1503	1507	PF00656	0.665
CLV_C14_Caspase3-7	195	199	PF00656	0.617
CLV_C14_Caspase3-7	2433	2437	PF00656	0.591
CLV_C14_Caspase3-7	2523	2527	PF00656	0.638
CLV_C14_Caspase3-7	65	69	PF00656	0.639
CLV_C14_Caspase3-7	706	710	PF00656	0.683
CLV_C14_Caspase3-7	760	764	PF00656	0.653
CLV_MEL_PAP_1	2328	2334	PF00089	0.313

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P341	Leptomonas seymouri	46%	97%
A0A3Q8ISL3	Leishmania donovani	99%	100%
A4HJ68	Leishmania braziliensis	64%	99%
E9B1T0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q6D1	Leishmania major	91%	100%

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