LeishMANIAdb
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DHC_N2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DHC_N2 domain-containing protein
Gene product:
Leucine Rich repeat - putative
Species:
Leishmania infantum
UniProt:
A4I6P9_LEIIN
TriTrypDb:
LINF_310018800
Length:
898

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005929 cilium 4 7
GO:0042995 cell projection 2 7
GO:0043226 organelle 2 7
GO:0043227 membrane-bounded organelle 3 7
GO:0110165 cellular anatomical entity 1 7
GO:0120025 plasma membrane bounded cell projection 3 7

Expansion

Sequence features

A4I6P9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6P9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 179 183 PF00656 0.562
CLV_C14_Caspase3-7 221 225 PF00656 0.608
CLV_C14_Caspase3-7 617 621 PF00656 0.609
CLV_C14_Caspase3-7 713 717 PF00656 0.600
CLV_C14_Caspase3-7 773 777 PF00656 0.696
CLV_NRD_NRD_1 185 187 PF00675 0.719
CLV_NRD_NRD_1 653 655 PF00675 0.705
CLV_NRD_NRD_1 720 722 PF00675 0.683
CLV_NRD_NRD_1 731 733 PF00675 0.695
CLV_NRD_NRD_1 890 892 PF00675 0.566
CLV_PCSK_KEX2_1 185 187 PF00082 0.719
CLV_PCSK_KEX2_1 633 635 PF00082 0.513
CLV_PCSK_KEX2_1 653 655 PF00082 0.476
CLV_PCSK_KEX2_1 720 722 PF00082 0.663
CLV_PCSK_PC1ET2_1 633 635 PF00082 0.513
CLV_PCSK_SKI1_1 112 116 PF00082 0.643
CLV_PCSK_SKI1_1 159 163 PF00082 0.608
CLV_PCSK_SKI1_1 210 214 PF00082 0.619
CLV_PCSK_SKI1_1 270 274 PF00082 0.566
CLV_PCSK_SKI1_1 414 418 PF00082 0.564
CLV_PCSK_SKI1_1 531 535 PF00082 0.627
CLV_PCSK_SKI1_1 580 584 PF00082 0.527
CLV_PCSK_SKI1_1 673 677 PF00082 0.737
CLV_PCSK_SKI1_1 796 800 PF00082 0.510
DEG_APCC_DBOX_1 413 421 PF00400 0.535
DEG_APCC_DBOX_1 568 576 PF00400 0.607
DEG_APCC_DBOX_1 603 611 PF00400 0.636
DEG_APCC_DBOX_1 795 803 PF00400 0.568
DEG_MDM2_SWIB_1 48 56 PF02201 0.527
DEG_Nend_UBRbox_2 1 3 PF02207 0.665
DEG_SCF_FBW7_2 662 669 PF00400 0.617
DEG_SCF_FBW7_2 745 751 PF00400 0.448
DEG_SPOP_SBC_1 310 314 PF00917 0.564
DOC_CKS1_1 235 240 PF01111 0.700
DOC_CKS1_1 33 38 PF01111 0.810
DOC_CKS1_1 361 366 PF01111 0.645
DOC_CKS1_1 435 440 PF01111 0.591
DOC_CKS1_1 745 750 PF01111 0.586
DOC_CYCLIN_RxL_1 153 165 PF00134 0.495
DOC_MAPK_DCC_7 569 577 PF00069 0.546
DOC_MAPK_gen_1 479 486 PF00069 0.617
DOC_MAPK_gen_1 720 727 PF00069 0.641
DOC_MAPK_MEF2A_6 339 348 PF00069 0.679
DOC_MAPK_MEF2A_6 569 577 PF00069 0.546
DOC_PP2B_LxvP_1 88 91 PF13499 0.695
DOC_PP4_FxxP_1 184 187 PF00568 0.496
DOC_PP4_FxxP_1 235 238 PF00568 0.682
DOC_PP4_FxxP_1 72 75 PF00568 0.545
DOC_SPAK_OSR1_1 524 528 PF12202 0.412
DOC_USP7_MATH_1 140 144 PF00917 0.579
DOC_USP7_MATH_1 218 222 PF00917 0.407
DOC_USP7_MATH_1 278 282 PF00917 0.571
DOC_USP7_MATH_1 326 330 PF00917 0.737
DOC_USP7_MATH_1 553 557 PF00917 0.592
DOC_USP7_MATH_1 675 679 PF00917 0.701
DOC_USP7_MATH_1 700 704 PF00917 0.798
DOC_USP7_MATH_1 764 768 PF00917 0.503
DOC_USP7_MATH_2 659 665 PF00917 0.735
DOC_WW_Pin1_4 234 239 PF00397 0.687
DOC_WW_Pin1_4 32 37 PF00397 0.736
DOC_WW_Pin1_4 357 362 PF00397 0.645
DOC_WW_Pin1_4 434 439 PF00397 0.812
DOC_WW_Pin1_4 445 450 PF00397 0.648
DOC_WW_Pin1_4 452 457 PF00397 0.569
DOC_WW_Pin1_4 501 506 PF00397 0.550
DOC_WW_Pin1_4 536 541 PF00397 0.636
DOC_WW_Pin1_4 662 667 PF00397 0.624
DOC_WW_Pin1_4 680 685 PF00397 0.611
DOC_WW_Pin1_4 741 746 PF00397 0.660
DOC_WW_Pin1_4 760 765 PF00397 0.340
LIG_14-3-3_CanoR_1 109 115 PF00244 0.615
LIG_14-3-3_CanoR_1 297 307 PF00244 0.499
LIG_14-3-3_CanoR_1 365 370 PF00244 0.797
LIG_14-3-3_CanoR_1 45 49 PF00244 0.578
LIG_14-3-3_CanoR_1 531 537 PF00244 0.574
LIG_14-3-3_CanoR_1 653 659 PF00244 0.637
LIG_14-3-3_CanoR_1 671 679 PF00244 0.590
LIG_14-3-3_CanoR_1 720 725 PF00244 0.664
LIG_14-3-3_CanoR_1 732 736 PF00244 0.671
LIG_14-3-3_CanoR_1 8 12 PF00244 0.657
LIG_14-3-3_CterR_2 896 898 PF00244 0.610
LIG_Actin_WH2_2 53 69 PF00022 0.652
LIG_APCC_ABBA_1 547 552 PF00400 0.545
LIG_BRCT_BRCA1_1 166 170 PF00533 0.587
LIG_BRCT_BRCA1_1 291 295 PF00533 0.478
LIG_CaM_IQ_9 605 621 PF13499 0.557
LIG_Clathr_ClatBox_1 533 537 PF01394 0.523
LIG_Clathr_ClatBox_1 839 843 PF01394 0.508
LIG_EH_1 119 123 PF12763 0.653
LIG_EH_1 846 850 PF12763 0.533
LIG_eIF4E_1 249 255 PF01652 0.501
LIG_eIF4E_1 804 810 PF01652 0.617
LIG_FAT_LD_1 151 159 PF03623 0.492
LIG_FHA_1 229 235 PF00498 0.681
LIG_FHA_1 33 39 PF00498 0.724
LIG_FHA_1 339 345 PF00498 0.712
LIG_FHA_1 446 452 PF00498 0.693
LIG_FHA_1 563 569 PF00498 0.535
LIG_FHA_1 780 786 PF00498 0.588
LIG_FHA_1 83 89 PF00498 0.661
LIG_FHA_1 835 841 PF00498 0.501
LIG_FHA_1 851 857 PF00498 0.343
LIG_FHA_1 867 873 PF00498 0.396
LIG_FHA_2 177 183 PF00498 0.554
LIG_FHA_2 240 246 PF00498 0.656
LIG_FHA_2 435 441 PF00498 0.621
LIG_FHA_2 615 621 PF00498 0.617
LIG_GBD_Chelix_1 150 158 PF00786 0.532
LIG_GBD_Chelix_1 250 258 PF00786 0.544
LIG_LIR_Apic_2 182 187 PF02991 0.484
LIG_LIR_Apic_2 69 75 PF02991 0.637
LIG_LIR_Gen_1 146 155 PF02991 0.571
LIG_LIR_Gen_1 164 173 PF02991 0.351
LIG_LIR_Gen_1 383 393 PF02991 0.737
LIG_LIR_Gen_1 47 56 PF02991 0.534
LIG_LIR_Gen_1 586 593 PF02991 0.516
LIG_LIR_Gen_1 594 605 PF02991 0.524
LIG_LIR_Gen_1 646 652 PF02991 0.594
LIG_LIR_Gen_1 778 785 PF02991 0.632
LIG_LIR_Nem_3 146 150 PF02991 0.587
LIG_LIR_Nem_3 164 169 PF02991 0.360
LIG_LIR_Nem_3 172 176 PF02991 0.416
LIG_LIR_Nem_3 383 388 PF02991 0.646
LIG_LIR_Nem_3 47 51 PF02991 0.534
LIG_LIR_Nem_3 503 509 PF02991 0.524
LIG_LIR_Nem_3 594 600 PF02991 0.562
LIG_LIR_Nem_3 646 650 PF02991 0.585
LIG_LIR_Nem_3 778 783 PF02991 0.571
LIG_LIR_Nem_3 786 792 PF02991 0.501
LIG_LIR_Nem_3 843 849 PF02991 0.500
LIG_LIR_Nem_3 853 857 PF02991 0.501
LIG_LYPXL_yS_3 506 509 PF13949 0.532
LIG_MLH1_MIPbox_1 166 170 PF16413 0.587
LIG_NRBOX 128 134 PF00104 0.478
LIG_PCNA_yPIPBox_3 413 426 PF02747 0.581
LIG_PCNA_yPIPBox_3 512 526 PF02747 0.406
LIG_Pex14_2 169 173 PF04695 0.480
LIG_Pex14_2 271 275 PF04695 0.549
LIG_Pex14_2 48 52 PF04695 0.525
LIG_Pex14_2 686 690 PF04695 0.543
LIG_PTB_Apo_2 684 691 PF02174 0.658
LIG_PTB_Apo_2 848 855 PF02174 0.540
LIG_Rb_LxCxE_1 859 880 PF01857 0.620
LIG_SH2_NCK_1 647 651 PF00017 0.606
LIG_SH2_PTP2 789 792 PF00017 0.548
LIG_SH2_STAP1 166 170 PF00017 0.587
LIG_SH2_STAP1 196 200 PF00017 0.498
LIG_SH2_STAP1 697 701 PF00017 0.582
LIG_SH2_STAT3 108 111 PF00017 0.662
LIG_SH2_STAT3 557 560 PF00017 0.520
LIG_SH2_STAT5 249 252 PF00017 0.604
LIG_SH2_STAT5 303 306 PF00017 0.520
LIG_SH2_STAT5 362 365 PF00017 0.646
LIG_SH2_STAT5 779 782 PF00017 0.529
LIG_SH2_STAT5 789 792 PF00017 0.449
LIG_SH3_2 573 578 PF14604 0.513
LIG_SH3_3 28 34 PF00018 0.832
LIG_SH3_3 358 364 PF00018 0.807
LIG_SH3_3 432 438 PF00018 0.619
LIG_SH3_3 570 576 PF00018 0.522
LIG_SH3_3 742 748 PF00018 0.606
LIG_SUMO_SIM_anti_2 127 134 PF11976 0.456
LIG_SUMO_SIM_par_1 208 216 PF11976 0.532
LIG_SUMO_SIM_par_1 341 349 PF11976 0.755
LIG_SUMO_SIM_par_1 532 539 PF11976 0.676
LIG_SUMO_SIM_par_1 563 571 PF11976 0.542
LIG_SUMO_SIM_par_1 781 787 PF11976 0.502
LIG_SUMO_SIM_par_1 807 813 PF11976 0.518
LIG_TRAF2_1 143 146 PF00917 0.657
LIG_TRAF2_1 649 652 PF00917 0.705
LIG_TYR_ITIM 645 650 PF00017 0.543
LIG_WRC_WIRS_1 11 16 PF05994 0.704
LIG_WRC_WIRS_1 170 175 PF05994 0.484
LIG_WRC_WIRS_1 181 186 PF05994 0.586
MOD_CDK_SPK_2 360 365 PF00069 0.645
MOD_CDK_SPK_2 662 667 PF00069 0.624
MOD_CDK_SPxxK_3 452 459 PF00069 0.608
MOD_CDK_SPxxK_3 536 543 PF00069 0.619
MOD_CK1_1 206 212 PF00069 0.412
MOD_CK1_1 298 304 PF00069 0.453
MOD_CK1_1 335 341 PF00069 0.714
MOD_CK1_1 360 366 PF00069 0.644
MOD_CK1_1 535 541 PF00069 0.523
MOD_CK1_1 680 686 PF00069 0.704
MOD_CK1_1 711 717 PF00069 0.725
MOD_CK1_1 731 737 PF00069 0.512
MOD_CK1_1 744 750 PF00069 0.458
MOD_CK1_1 879 885 PF00069 0.516
MOD_CK2_1 140 146 PF00069 0.562
MOD_CK2_1 239 245 PF00069 0.677
MOD_CK2_1 299 305 PF00069 0.594
MOD_CK2_1 317 323 PF00069 0.811
MOD_CK2_1 731 737 PF00069 0.723
MOD_GlcNHglycan 166 169 PF01048 0.433
MOD_GlcNHglycan 251 254 PF01048 0.561
MOD_GlcNHglycan 307 310 PF01048 0.496
MOD_GlcNHglycan 323 327 PF01048 0.799
MOD_GlcNHglycan 588 591 PF01048 0.542
MOD_GlcNHglycan 673 676 PF01048 0.653
MOD_GlcNHglycan 771 775 PF01048 0.570
MOD_GlcNHglycan 879 882 PF01048 0.549
MOD_GSK3_1 153 160 PF00069 0.509
MOD_GSK3_1 176 183 PF00069 0.542
MOD_GSK3_1 206 213 PF00069 0.513
MOD_GSK3_1 224 231 PF00069 0.581
MOD_GSK3_1 249 256 PF00069 0.526
MOD_GSK3_1 278 285 PF00069 0.562
MOD_GSK3_1 295 302 PF00069 0.534
MOD_GSK3_1 305 312 PF00069 0.445
MOD_GSK3_1 322 329 PF00069 0.738
MOD_GSK3_1 331 338 PF00069 0.679
MOD_GSK3_1 340 347 PF00069 0.710
MOD_GSK3_1 532 539 PF00069 0.562
MOD_GSK3_1 620 627 PF00069 0.510
MOD_GSK3_1 657 664 PF00069 0.799
MOD_GSK3_1 671 678 PF00069 0.753
MOD_GSK3_1 706 713 PF00069 0.714
MOD_GSK3_1 760 767 PF00069 0.674
MOD_GSK3_1 779 786 PF00069 0.417
MOD_GSK3_1 818 825 PF00069 0.487
MOD_GSK3_1 872 879 PF00069 0.586
MOD_N-GLC_1 228 233 PF02516 0.700
MOD_N-GLC_1 239 244 PF02516 0.499
MOD_N-GLC_1 680 685 PF02516 0.580
MOD_N-GLC_1 850 855 PF02516 0.510
MOD_NEK2_1 161 166 PF00069 0.563
MOD_NEK2_1 169 174 PF00069 0.437
MOD_NEK2_1 180 185 PF00069 0.547
MOD_NEK2_1 295 300 PF00069 0.553
MOD_NEK2_1 332 337 PF00069 0.666
MOD_NEK2_1 373 378 PF00069 0.782
MOD_NEK2_1 583 588 PF00069 0.479
MOD_NEK2_1 66 71 PF00069 0.545
MOD_NEK2_1 690 695 PF00069 0.790
MOD_NEK2_1 7 12 PF00069 0.666
MOD_NEK2_1 707 712 PF00069 0.531
MOD_NEK2_1 728 733 PF00069 0.752
MOD_NEK2_1 783 788 PF00069 0.523
MOD_NEK2_1 842 847 PF00069 0.442
MOD_NEK2_1 860 865 PF00069 0.372
MOD_NEK2_1 876 881 PF00069 0.441
MOD_NEK2_2 157 162 PF00069 0.520
MOD_PIKK_1 107 113 PF00454 0.674
MOD_PIKK_1 38 44 PF00454 0.630
MOD_PIKK_1 493 499 PF00454 0.567
MOD_PIKK_1 652 658 PF00454 0.740
MOD_PK_1 365 371 PF00069 0.755
MOD_PK_1 720 726 PF00069 0.651
MOD_PKA_1 720 726 PF00069 0.615
MOD_PKA_2 296 302 PF00069 0.573
MOD_PKA_2 427 433 PF00069 0.782
MOD_PKA_2 44 50 PF00069 0.587
MOD_PKA_2 520 526 PF00069 0.522
MOD_PKA_2 568 574 PF00069 0.616
MOD_PKA_2 652 658 PF00069 0.601
MOD_PKA_2 66 72 PF00069 0.566
MOD_PKA_2 7 13 PF00069 0.650
MOD_PKA_2 719 725 PF00069 0.760
MOD_PKA_2 731 737 PF00069 0.638
MOD_Plk_1 228 234 PF00069 0.692
MOD_Plk_1 289 295 PF00069 0.551
MOD_Plk_1 562 568 PF00069 0.610
MOD_Plk_1 842 848 PF00069 0.501
MOD_Plk_1 850 856 PF00069 0.522
MOD_Plk_2-3 620 626 PF00069 0.457
MOD_Plk_2-3 818 824 PF00069 0.544
MOD_Plk_4 125 131 PF00069 0.530
MOD_Plk_4 176 182 PF00069 0.528
MOD_Plk_4 2 8 PF00069 0.663
MOD_Plk_4 299 305 PF00069 0.487
MOD_Plk_4 373 379 PF00069 0.637
MOD_Plk_4 44 50 PF00069 0.581
MOD_Plk_4 470 476 PF00069 0.496
MOD_Plk_4 583 589 PF00069 0.577
MOD_Plk_4 66 72 PF00069 0.487
MOD_Plk_4 720 726 PF00069 0.610
MOD_Plk_4 764 770 PF00069 0.659
MOD_Plk_4 866 872 PF00069 0.497
MOD_ProDKin_1 234 240 PF00069 0.692
MOD_ProDKin_1 32 38 PF00069 0.736
MOD_ProDKin_1 357 363 PF00069 0.646
MOD_ProDKin_1 434 440 PF00069 0.811
MOD_ProDKin_1 445 451 PF00069 0.650
MOD_ProDKin_1 452 458 PF00069 0.569
MOD_ProDKin_1 501 507 PF00069 0.552
MOD_ProDKin_1 536 542 PF00069 0.622
MOD_ProDKin_1 662 668 PF00069 0.622
MOD_ProDKin_1 680 686 PF00069 0.610
MOD_ProDKin_1 741 747 PF00069 0.647
MOD_ProDKin_1 760 766 PF00069 0.346
MOD_SUMO_for_1 666 669 PF00179 0.602
MOD_SUMO_rev_2 202 212 PF00179 0.603
MOD_SUMO_rev_2 347 353 PF00179 0.739
TRG_AP2beta_CARGO_1 594 604 PF09066 0.625
TRG_DiLeu_BaEn_1 2 7 PF01217 0.581
TRG_DiLeu_BaEn_3 290 296 PF01217 0.486
TRG_DiLeu_BaEn_3 399 405 PF01217 0.531
TRG_DiLeu_LyEn_5 529 534 PF01217 0.542
TRG_ENDOCYTIC_2 166 169 PF00928 0.591
TRG_ENDOCYTIC_2 506 509 PF00928 0.532
TRG_ENDOCYTIC_2 588 591 PF00928 0.611
TRG_ENDOCYTIC_2 647 650 PF00928 0.604
TRG_ENDOCYTIC_2 789 792 PF00928 0.548
TRG_ENDOCYTIC_2 846 849 PF00928 0.605
TRG_ER_diArg_1 184 186 PF00400 0.714
TRG_ER_diArg_1 401 404 PF00400 0.531
TRG_ER_diArg_1 577 580 PF00400 0.535
TRG_ER_diArg_1 719 721 PF00400 0.651
TRG_Pf-PMV_PEXEL_1 403 408 PF00026 0.621
TRG_Pf-PMV_PEXEL_1 559 563 PF00026 0.615

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5A0 Leptomonas seymouri 32% 95%
A0A3S7X4D3 Leishmania donovani 99% 100%
A4HJA6 Leishmania braziliensis 63% 100%
E9B1S1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
Q4Q6E0 Leishmania major 85% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS