Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cytochrome b5-like Heme/Steroid binding domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I6P4_LEIIN

TriTrypDb:

LINF_310018300

Length:

162

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4I6P4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6P4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0020037	heme binding	4	1
GO:0046906	tetrapyrrole binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.579
CLV_C14_Caspase3-7	41	45	PF00656	0.530
CLV_PCSK_KEX2_1	160	162	PF00082	0.667
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.667
CLV_PCSK_SKI1_1	107	111	PF00082	0.432
CLV_PCSK_SKI1_1	40	44	PF00082	0.430
CLV_PCSK_SKI1_1	8	12	PF00082	0.381
DEG_SCF_FBW7_1	108	114	PF00400	0.632
DOC_CKS1_1	108	113	PF01111	0.632
DOC_CYCLIN_yCln2_LP_2	133	139	PF00134	0.356
DOC_MAPK_gen_1	130	137	PF00069	0.451
DOC_MAPK_MEF2A_6	130	137	PF00069	0.465
DOC_PP2B_LxvP_1	133	136	PF13499	0.356
DOC_USP7_MATH_1	111	115	PF00917	0.699
DOC_USP7_MATH_1	128	132	PF00917	0.598
DOC_USP7_MATH_1	28	32	PF00917	0.698
DOC_USP7_MATH_1	49	53	PF00917	0.603
DOC_WW_Pin1_4	100	105	PF00397	0.695
DOC_WW_Pin1_4	107	112	PF00397	0.632
DOC_WW_Pin1_4	77	82	PF00397	0.724
DOC_WW_Pin1_4	93	98	PF00397	0.631
LIG_APCC_ABBA_1	34	39	PF00400	0.606
LIG_BRCT_BRCA1_1	130	134	PF00533	0.631
LIG_FHA_1	101	107	PF00498	0.702
LIG_FHA_1	108	114	PF00498	0.653
LIG_FHA_2	122	128	PF00498	0.742
LIG_LIR_Apic_2	15	19	PF02991	0.578
LIG_LIR_Gen_1	152	159	PF02991	0.489
LIG_LIR_Nem_3	131	137	PF02991	0.452
LIG_LIR_Nem_3	152	158	PF02991	0.488
LIG_NRP_CendR_1	160	162	PF00754	0.701
LIG_REV1ctd_RIR_1	7	16	PF16727	0.585
LIG_SH2_PTP2	155	158	PF00017	0.434
LIG_SH2_SRC	16	19	PF00017	0.581
LIG_SH2_STAT5	155	158	PF00017	0.451
LIG_SH2_STAT5	16	19	PF00017	0.593
LIG_SH2_STAT5	22	25	PF00017	0.583
LIG_SH2_STAT5	37	40	PF00017	0.534
LIG_SH3_3	153	159	PF00018	0.529
LIG_SH3_3	75	81	PF00018	0.734
LIG_TRAF2_1	81	84	PF00917	0.751
LIG_TYR_ITIM	153	158	PF00017	0.576
MOD_CDK_SPxxK_3	100	107	PF00069	0.643
MOD_CK1_1	126	132	PF00069	0.722
MOD_CK2_1	121	127	PF00069	0.772
MOD_GlcNHglycan	149	152	PF01048	0.272
MOD_GSK3_1	107	114	PF00069	0.690
MOD_GSK3_1	117	124	PF00069	0.715
MOD_GSK3_1	73	80	PF00069	0.730
MOD_NEK2_1	147	152	PF00069	0.405
MOD_Plk_1	49	55	PF00069	0.718
MOD_Plk_4	12	18	PF00069	0.601
MOD_Plk_4	149	155	PF00069	0.274
MOD_ProDKin_1	100	106	PF00069	0.692
MOD_ProDKin_1	107	113	PF00069	0.632
MOD_ProDKin_1	77	83	PF00069	0.726
MOD_ProDKin_1	93	99	PF00069	0.632
TRG_ENDOCYTIC_2	155	158	PF00928	0.486
TRG_ENDOCYTIC_2	7	10	PF00928	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4E5	Leishmania donovani	100%	100%
A4HJ99	Leishmania braziliensis	68%	100%
E9B1R6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	97%
Q4Q6E5	Leishmania major	89%	100%