Putative monoglyceride lipase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

monoglyceride lipase - putative

Species:

Leishmania infantum

UniProt:

A4I6N9_LEIIN

TriTrypDb:

LINF_310017800

Length:

311

Annotations

Annotations by Jardim et al.

Lipid Metabolism, monoglyceride lipase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Show entries

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Previous1Next

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I6N9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6N9

Function

Could not find GO biological_process term for this entry.

Show entries

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016298	lipase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0047372	acylglycerol lipase activity	5	7
GO:0052689	carboxylic ester hydrolase activity	4	7

Previous1Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	194	196	PF00675	0.308
CLV_NRD_NRD_1	283	285	PF00675	0.319
CLV_PCSK_KEX2_1	283	285	PF00082	0.359
CLV_PCSK_SKI1_1	12	16	PF00082	0.422
CLV_PCSK_SKI1_1	266	270	PF00082	0.294
DOC_CKS1_1	13	18	PF01111	0.413
DOC_CKS1_1	204	209	PF01111	0.249
DOC_MAPK_gen_1	224	233	PF00069	0.426
DOC_MAPK_MEF2A_6	73	81	PF00069	0.292
DOC_PP1_RVXF_1	56	63	PF00149	0.254

Previous1 2 3 4 5…11Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4ITL6	Bodo saltans	48%	96%
A0A3R7L576	Trypanosoma rangeli	50%	100%
A0A3S7X4B8	Leishmania donovani	100%	100%
A0QNZ7	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	31%	100%
A4HJ94	Leishmania braziliensis	85%	100%
C9ZM73	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
C9ZWV1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	99%
E9B1R1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O07427	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	30%	100%
O34705	Bacillus subtilis (strain 168)	27%	100%

Previous1 2Next