Cilia- and flagella-associated protein 300

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4498) - putative

Species:

Leishmania infantum

UniProt:

A4I6N4_LEIIN

TriTrypDb:

LINF_310017300

Length:

381

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0005856	cytoskeleton	5	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4I6N4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6N4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.631
CLV_C14_Caspase3-7	21	25	PF00656	0.568
CLV_NRD_NRD_1	296	298	PF00675	0.321
CLV_PCSK_KEX2_1	182	184	PF00082	0.461
CLV_PCSK_KEX2_1	296	298	PF00082	0.321
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.516
CLV_PCSK_PC7_1	292	298	PF00082	0.224
CLV_PCSK_SKI1_1	102	106	PF00082	0.363
CLV_PCSK_SKI1_1	134	138	PF00082	0.549
CLV_PCSK_SKI1_1	157	161	PF00082	0.573
CLV_PCSK_SKI1_1	199	203	PF00082	0.356
CLV_PCSK_SKI1_1	251	255	PF00082	0.312
CLV_PCSK_SKI1_1	29	33	PF00082	0.471
CLV_PCSK_SKI1_1	297	301	PF00082	0.224
CLV_Separin_Metazoa	144	148	PF03568	0.493
DEG_APCC_DBOX_1	156	164	PF00400	0.538
DEG_Nend_Nbox_1	1	3	PF02207	0.522
DOC_MAPK_gen_1	296	304	PF00069	0.424
DOC_PP4_FxxP_1	105	108	PF00568	0.491
DOC_USP7_MATH_1	14	18	PF00917	0.590
DOC_USP7_MATH_1	27	31	PF00917	0.298
DOC_USP7_MATH_1	7	11	PF00917	0.629
DOC_USP7_MATH_1	70	74	PF00917	0.657
DOC_USP7_MATH_1	83	87	PF00917	0.613
DOC_USP7_MATH_2	53	59	PF00917	0.556
DOC_WW_Pin1_4	68	73	PF00397	0.749
LIG_14-3-3_CanoR_1	134	143	PF00244	0.535
LIG_14-3-3_CanoR_1	297	303	PF00244	0.511
LIG_Actin_WH2_2	148	163	PF00022	0.500
LIG_APCC_ABBA_1	187	192	PF00400	0.575
LIG_BIR_III_2	24	28	PF00653	0.489
LIG_FHA_1	371	377	PF00498	0.530
LIG_FHA_2	139	145	PF00498	0.414
LIG_FHA_2	165	171	PF00498	0.637
LIG_FHA_2	227	233	PF00498	0.642
LIG_FHA_2	306	312	PF00498	0.495
LIG_LIR_Apic_2	103	108	PF02991	0.482
LIG_LIR_Apic_2	47	53	PF02991	0.427
LIG_LIR_Gen_1	137	146	PF02991	0.423
LIG_LIR_Gen_1	261	272	PF02991	0.465
LIG_LIR_Gen_1	326	337	PF02991	0.489
LIG_LIR_Nem_3	130	136	PF02991	0.374
LIG_LIR_Nem_3	137	143	PF02991	0.413
LIG_LIR_Nem_3	26	31	PF02991	0.511
LIG_LIR_Nem_3	261	267	PF02991	0.483
LIG_LIR_Nem_3	293	298	PF02991	0.561
LIG_LIR_Nem_3	326	332	PF02991	0.539
LIG_LIR_Nem_3	335	341	PF02991	0.493
LIG_SH2_CRK	28	32	PF00017	0.493
LIG_SH2_CRK	295	299	PF00017	0.470
LIG_SH2_CRK	329	333	PF00017	0.555
LIG_SH2_CRK	338	342	PF00017	0.429
LIG_SH2_CRK	362	366	PF00017	0.459
LIG_SH2_CRK	50	54	PF00017	0.497
LIG_SH2_PTP2	364	367	PF00017	0.459
LIG_SH2_SRC	287	290	PF00017	0.484
LIG_SH2_STAT5	176	179	PF00017	0.578
LIG_SH2_STAT5	287	290	PF00017	0.473
LIG_SH2_STAT5	362	365	PF00017	0.459
LIG_SH3_3	66	72	PF00018	0.660
LIG_TRAF2_1	258	261	PF00917	0.555
LIG_TRAF2_1	308	311	PF00917	0.555
LIG_TRAF2_1	318	321	PF00917	0.516
LIG_TYR_ITIM	327	332	PF00017	0.450
LIG_TYR_ITIM	360	365	PF00017	0.470
LIG_WRC_WIRS_1	56	61	PF05994	0.628
MOD_CK1_1	370	376	PF00069	0.529
MOD_CK1_1	71	77	PF00069	0.689
MOD_CK2_1	138	144	PF00069	0.421
MOD_CK2_1	20	26	PF00069	0.535
MOD_CK2_1	221	227	PF00069	0.665
MOD_CK2_1	255	261	PF00069	0.532
MOD_CK2_1	305	311	PF00069	0.548
MOD_CK2_1	55	61	PF00069	0.666
MOD_GlcNHglycan	10	13	PF01048	0.613
MOD_GlcNHglycan	15	19	PF01048	0.512
MOD_GlcNHglycan	240	243	PF01048	0.563
MOD_GlcNHglycan	273	276	PF01048	0.392
MOD_GlcNHglycan	323	326	PF01048	0.365
MOD_GlcNHglycan	64	67	PF01048	0.651
MOD_GlcNHglycan	85	88	PF01048	0.613
MOD_GSK3_1	134	141	PF00069	0.522
MOD_GSK3_1	14	21	PF00069	0.565
MOD_GSK3_1	222	229	PF00069	0.690
MOD_GSK3_1	51	58	PF00069	0.591
MOD_GSK3_1	70	77	PF00069	0.649
MOD_N-GLC_2	361	363	PF02516	0.259
MOD_NEK2_1	100	105	PF00069	0.340
MOD_NEK2_1	236	241	PF00069	0.697
MOD_NEK2_1	298	303	PF00069	0.553
MOD_NEK2_2	27	32	PF00069	0.329
MOD_NEK2_2	344	349	PF00069	0.553
MOD_PKA_2	138	144	PF00069	0.527
MOD_PKB_1	49	57	PF00069	0.530
MOD_Plk_2-3	164	170	PF00069	0.679
MOD_Plk_2-3	192	198	PF00069	0.505
MOD_Plk_2-3	228	234	PF00069	0.707
MOD_Plk_2-3	55	61	PF00069	0.624
MOD_Plk_4	121	127	PF00069	0.681
MOD_Plk_4	27	33	PF00069	0.439
MOD_Plk_4	333	339	PF00069	0.500
MOD_Plk_4	344	350	PF00069	0.458
MOD_Plk_4	372	378	PF00069	0.555
MOD_ProDKin_1	68	74	PF00069	0.749
MOD_SUMO_for_1	213	216	PF00179	0.530
TRG_ENDOCYTIC_2	264	267	PF00928	0.459
TRG_ENDOCYTIC_2	28	31	PF00928	0.508
TRG_ENDOCYTIC_2	295	298	PF00928	0.473
TRG_ENDOCYTIC_2	329	332	PF00928	0.555
TRG_ENDOCYTIC_2	338	341	PF00928	0.553
TRG_ENDOCYTIC_2	362	365	PF00928	0.459
TRG_ER_diArg_1	295	297	PF00400	0.517
TRG_NES_CRM1_1	293	306	PF08389	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P369	Leptomonas seymouri	51%	100%
A0A0S4JGK6	Bodo saltans	29%	100%
A0A1X0NJZ3	Trypanosomatidae	31%	97%
A0A3S7X4F5	Leishmania donovani	99%	100%
A0A422NQV4	Trypanosoma rangeli	40%	100%
A4HJ90	Leishmania braziliensis	79%	100%
C9ZM71	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B1Q7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q6F3	Leishmania major	93%	100%
V5DGC7	Trypanosoma cruzi	39%	96%