Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I6N3_LEIIN

TriTrypDb:

LINF_310017000

Length:

682

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 3
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I6N3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6N3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	293	297	PF00656	0.612
CLV_C14_Caspase3-7	405	409	PF00656	0.717
CLV_C14_Caspase3-7	49	53	PF00656	0.662
CLV_C14_Caspase3-7	502	506	PF00656	0.591
CLV_C14_Caspase3-7	599	603	PF00656	0.726
CLV_NRD_NRD_1	218	220	PF00675	0.753
CLV_NRD_NRD_1	248	250	PF00675	0.607
CLV_NRD_NRD_1	555	557	PF00675	0.714
CLV_NRD_NRD_1	600	602	PF00675	0.738
CLV_NRD_NRD_1	612	614	PF00675	0.653
CLV_NRD_NRD_1	657	659	PF00675	0.661
CLV_PCSK_KEX2_1	217	219	PF00082	0.769
CLV_PCSK_KEX2_1	248	250	PF00082	0.601
CLV_PCSK_KEX2_1	600	602	PF00082	0.721
CLV_PCSK_SKI1_1	13	17	PF00082	0.330
CLV_PCSK_SKI1_1	146	150	PF00082	0.666
CLV_PCSK_SKI1_1	196	200	PF00082	0.576
CLV_PCSK_SKI1_1	369	373	PF00082	0.715
CLV_PCSK_SKI1_1	38	42	PF00082	0.455
CLV_PCSK_SKI1_1	450	454	PF00082	0.567
CLV_PCSK_SKI1_1	557	561	PF00082	0.708
CLV_PCSK_SKI1_1	673	677	PF00082	0.680
DEG_COP1_1	454	462	PF00400	0.711
DEG_SCF_TRCP1_1	79	84	PF00400	0.699
DEG_SPOP_SBC_1	576	580	PF00917	0.733
DOC_CDC14_PxL_1	323	331	PF14671	0.571
DOC_CKS1_1	351	356	PF01111	0.768
DOC_CYCLIN_RxL_1	193	201	PF00134	0.578
DOC_CYCLIN_RxL_1	554	563	PF00134	0.709
DOC_CYCLIN_yCln2_LP_2	281	287	PF00134	0.610
DOC_CYCLIN_yCln2_LP_2	371	377	PF00134	0.596
DOC_MAPK_gen_1	234	240	PF00069	0.507
DOC_MAPK_MEF2A_6	337	344	PF00069	0.763
DOC_MAPK_MEF2A_6	480	487	PF00069	0.687
DOC_PP1_RVXF_1	11	17	PF00149	0.332
DOC_PP2B_LxvP_1	281	284	PF13499	0.610
DOC_PP2B_LxvP_1	457	460	PF13499	0.727
DOC_PP4_FxxP_1	305	308	PF00568	0.726
DOC_USP7_MATH_1	275	279	PF00917	0.766
DOC_USP7_MATH_1	287	291	PF00917	0.778
DOC_USP7_MATH_1	452	456	PF00917	0.812
DOC_USP7_MATH_1	466	470	PF00917	0.604
DOC_USP7_MATH_1	498	502	PF00917	0.755
DOC_USP7_MATH_1	503	507	PF00917	0.681
DOC_USP7_MATH_1	576	580	PF00917	0.785
DOC_USP7_MATH_1	581	585	PF00917	0.716
DOC_USP7_MATH_1	590	594	PF00917	0.857
DOC_WW_Pin1_4	19	24	PF00397	0.365
DOC_WW_Pin1_4	204	209	PF00397	0.737
DOC_WW_Pin1_4	30	35	PF00397	0.429
DOC_WW_Pin1_4	330	335	PF00397	0.628
DOC_WW_Pin1_4	350	355	PF00397	0.634
DOC_WW_Pin1_4	386	391	PF00397	0.741
DOC_WW_Pin1_4	436	441	PF00397	0.723
DOC_WW_Pin1_4	516	521	PF00397	0.818
DOC_WW_Pin1_4	54	59	PF00397	0.645
DOC_WW_Pin1_4	547	552	PF00397	0.839
DOC_WW_Pin1_4	583	588	PF00397	0.816
DOC_WW_Pin1_4	604	609	PF00397	0.630
DOC_WW_Pin1_4	62	67	PF00397	0.713
LIG_14-3-3_CanoR_1	146	155	PF00244	0.686
LIG_14-3-3_CanoR_1	345	349	PF00244	0.769
LIG_14-3-3_CanoR_1	36	41	PF00244	0.449
LIG_14-3-3_CanoR_1	361	368	PF00244	0.563
LIG_14-3-3_CanoR_1	421	429	PF00244	0.695
LIG_14-3-3_CanoR_1	456	460	PF00244	0.723
LIG_14-3-3_CanoR_1	522	528	PF00244	0.654
LIG_14-3-3_CanoR_1	571	575	PF00244	0.724
LIG_14-3-3_CanoR_1	668	676	PF00244	0.549
LIG_BIR_II_1	1	5	PF00653	0.440
LIG_BRCT_BRCA1_1	11	15	PF00533	0.321
LIG_BRCT_BRCA1_1	6	10	PF00533	0.320
LIG_EH_1	92	96	PF12763	0.678
LIG_FHA_1	24	30	PF00498	0.401
LIG_FHA_1	345	351	PF00498	0.766
LIG_FHA_1	390	396	PF00498	0.703
LIG_FHA_1	470	476	PF00498	0.801
LIG_FHA_1	561	567	PF00498	0.706
LIG_FHA_2	291	297	PF00498	0.656
LIG_FHA_2	465	471	PF00498	0.735
LIG_FHA_2	586	592	PF00498	0.606
LIG_FHA_2	74	80	PF00498	0.599
LIG_Integrin_RGD_1	267	269	PF01839	0.707
LIG_Integrin_RGD_1	622	624	PF01839	0.767
LIG_LIR_Apic_2	304	308	PF02991	0.725
LIG_LIR_Apic_2	387	391	PF02991	0.740
LIG_LIR_Gen_1	137	148	PF02991	0.679
LIG_LIR_Gen_1	413	419	PF02991	0.638
LIG_LIR_Gen_1	439	448	PF02991	0.715
LIG_LIR_Gen_1	46	55	PF02991	0.708
LIG_LIR_Gen_1	505	516	PF02991	0.592
LIG_LIR_Gen_1	667	676	PF02991	0.657
LIG_LIR_Nem_3	137	143	PF02991	0.685
LIG_LIR_Nem_3	149	155	PF02991	0.552
LIG_LIR_Nem_3	223	229	PF02991	0.664
LIG_LIR_Nem_3	253	259	PF02991	0.673
LIG_LIR_Nem_3	413	418	PF02991	0.641
LIG_LIR_Nem_3	433	437	PF02991	0.797
LIG_LIR_Nem_3	439	445	PF02991	0.651
LIG_LIR_Nem_3	46	50	PF02991	0.703
LIG_LIR_Nem_3	573	577	PF02991	0.618
LIG_LIR_Nem_3	667	672	PF02991	0.646
LIG_MLH1_MIPbox_1	6	10	PF16413	0.320
LIG_MYND_1	516	520	PF01753	0.638
LIG_PCNA_yPIPBox_3	361	372	PF02747	0.713
LIG_Pex14_2	11	15	PF04695	0.321
LIG_Pex14_2	6	10	PF04695	0.320
LIG_Pex14_2	665	669	PF04695	0.718
LIG_PTAP_UEV_1	459	464	PF05743	0.618
LIG_REV1ctd_RIR_1	224	232	PF16727	0.641
LIG_REV1ctd_RIR_1	7	17	PF16727	0.327
LIG_SH2_CRK	256	260	PF00017	0.685
LIG_SH2_CRK	388	392	PF00017	0.737
LIG_SH2_NCK_1	140	144	PF00017	0.722
LIG_SH2_NCK_1	388	392	PF00017	0.737
LIG_SH2_STAP1	577	581	PF00017	0.626
LIG_SH2_STAT5	140	143	PF00017	0.726
LIG_SH2_STAT5	4	7	PF00017	0.330
LIG_SH2_STAT5	47	50	PF00017	0.663
LIG_SH3_2	191	196	PF14604	0.688
LIG_SH3_2	373	378	PF14604	0.744
LIG_SH3_2	587	592	PF14604	0.715
LIG_SH3_2	63	68	PF14604	0.599
LIG_SH3_3	188	194	PF00018	0.689
LIG_SH3_3	197	203	PF00018	0.604
LIG_SH3_3	205	211	PF00018	0.554
LIG_SH3_3	256	262	PF00018	0.712
LIG_SH3_3	31	37	PF00018	0.538
LIG_SH3_3	348	354	PF00018	0.719
LIG_SH3_3	370	376	PF00018	0.751
LIG_SH3_3	434	440	PF00018	0.725
LIG_SH3_3	457	463	PF00018	0.617
LIG_SH3_3	486	492	PF00018	0.726
LIG_SH3_3	517	523	PF00018	0.783
LIG_SH3_3	524	530	PF00018	0.719
LIG_SH3_3	57	63	PF00018	0.682
LIG_SH3_3	584	590	PF00018	0.783
LIG_SUMO_SIM_anti_2	278	283	PF11976	0.718
LIG_SUMO_SIM_par_1	523	528	PF11976	0.654
LIG_TRAF2_1	462	465	PF00917	0.722
LIG_TRAF2_2	354	359	PF00917	0.732
LIG_UBA3_1	675	679	PF00899	0.653
LIG_WRC_WIRS_1	302	307	PF05994	0.816
LIG_WRC_WIRS_1	47	52	PF05994	0.618
LIG_WW_3	193	197	PF00397	0.684
MOD_CDC14_SPxK_1	33	36	PF00782	0.442
MOD_CDC14_SPxK_1	519	522	PF00782	0.750
MOD_CDC14_SPxK_1	65	68	PF00782	0.708
MOD_CDK_SPK_2	54	59	PF00069	0.553
MOD_CDK_SPK_2	549	554	PF00069	0.617
MOD_CDK_SPxK_1	30	36	PF00069	0.443
MOD_CDK_SPxK_1	516	522	PF00069	0.750
MOD_CDK_SPxK_1	62	68	PF00069	0.706
MOD_CDK_SPxxK_3	330	337	PF00069	0.630
MOD_CDK_SPxxK_3	350	357	PF00069	0.639
MOD_CDK_SPxxK_3	547	554	PF00069	0.769
MOD_CDK_SPxxK_3	585	592	PF00069	0.604
MOD_CDK_SPxxK_3	604	611	PF00069	0.539
MOD_CK1_1	156	162	PF00069	0.559
MOD_CK1_1	270	276	PF00069	0.765
MOD_CK1_1	290	296	PF00069	0.671
MOD_CK1_1	317	323	PF00069	0.688
MOD_CK1_1	389	395	PF00069	0.807
MOD_CK1_1	401	407	PF00069	0.634
MOD_CK1_1	410	416	PF00069	0.818
MOD_CK1_1	417	423	PF00069	0.682
MOD_CK1_1	455	461	PF00069	0.773
MOD_CK1_1	469	475	PF00069	0.654
MOD_CK1_1	528	534	PF00069	0.789
MOD_CK1_1	54	60	PF00069	0.772
MOD_CK1_1	570	576	PF00069	0.765
MOD_CK1_1	580	586	PF00069	0.624
MOD_CK1_1	593	599	PF00069	0.806
MOD_CK1_1	604	610	PF00069	0.671
MOD_CK1_1	88	94	PF00069	0.679
MOD_CK2_1	209	215	PF00069	0.789
MOD_CK2_1	410	416	PF00069	0.750
MOD_CK2_1	443	449	PF00069	0.662
MOD_CK2_1	458	464	PF00069	0.669
MOD_Cter_Amidation	215	218	PF01082	0.773
MOD_GlcNHglycan	111	114	PF01048	0.743
MOD_GlcNHglycan	285	288	PF01048	0.817
MOD_GlcNHglycan	289	292	PF01048	0.629
MOD_GlcNHglycan	319	322	PF01048	0.771
MOD_GlcNHglycan	400	403	PF01048	0.652
MOD_GlcNHglycan	410	413	PF01048	0.781
MOD_GlcNHglycan	429	432	PF01048	0.624
MOD_GlcNHglycan	460	463	PF01048	0.749
MOD_GlcNHglycan	52	56	PF01048	0.690
MOD_GlcNHglycan	527	530	PF01048	0.720
MOD_GlcNHglycan	574	577	PF01048	0.750
MOD_GlcNHglycan	579	582	PF01048	0.679
MOD_GlcNHglycan	583	586	PF01048	0.762
MOD_GlcNHglycan	669	672	PF01048	0.532
MOD_GlcNHglycan	77	82	PF01048	0.711
MOD_GSK3_1	19	26	PF00069	0.365
MOD_GSK3_1	194	201	PF00069	0.622
MOD_GSK3_1	283	290	PF00069	0.840
MOD_GSK3_1	317	324	PF00069	0.752
MOD_GSK3_1	357	364	PF00069	0.615
MOD_GSK3_1	386	393	PF00069	0.741
MOD_GSK3_1	406	413	PF00069	0.818
MOD_GSK3_1	436	443	PF00069	0.586
MOD_GSK3_1	469	476	PF00069	0.753
MOD_GSK3_1	487	494	PF00069	0.535
MOD_GSK3_1	525	532	PF00069	0.805
MOD_GSK3_1	560	567	PF00069	0.738
MOD_GSK3_1	572	579	PF00069	0.763
MOD_GSK3_1	581	588	PF00069	0.671
MOD_GSK3_1	590	597	PF00069	0.775
MOD_GSK3_1	629	636	PF00069	0.767
MOD_GSK3_1	73	80	PF00069	0.686
MOD_GSK3_1	81	88	PF00069	0.661
MOD_GSK3_1	95	102	PF00069	0.661
MOD_N-GLC_1	220	225	PF02516	0.699
MOD_N-GLC_1	314	319	PF02516	0.693
MOD_N-GLC_1	602	607	PF02516	0.771
MOD_N-GLC_1	614	619	PF02516	0.622
MOD_N-GLC_2	161	163	PF02516	0.673
MOD_NEK2_1	344	349	PF00069	0.770
MOD_NEK2_1	51	56	PF00069	0.639
MOD_NEK2_1	564	569	PF00069	0.742
MOD_NEK2_1	572	577	PF00069	0.734
MOD_NEK2_1	594	599	PF00069	0.852
MOD_NEK2_1	9	14	PF00069	0.377
MOD_NEK2_1	95	100	PF00069	0.579
MOD_NEK2_2	301	306	PF00069	0.652
MOD_NEK2_2	4	9	PF00069	0.328
MOD_PIKK_1	141	147	PF00454	0.711
MOD_PIKK_1	307	313	PF00454	0.723
MOD_PIKK_1	344	350	PF00454	0.768
MOD_PIKK_1	361	367	PF00454	0.550
MOD_PIKK_1	390	396	PF00454	0.742
MOD_PIKK_1	638	644	PF00454	0.607
MOD_PKA_2	317	323	PF00069	0.719
MOD_PKA_2	344	350	PF00069	0.692
MOD_PKA_2	420	426	PF00069	0.707
MOD_PKA_2	455	461	PF00069	0.720
MOD_PKA_2	503	509	PF00069	0.589
MOD_PKA_2	532	538	PF00069	0.608
MOD_PKA_2	570	576	PF00069	0.721
MOD_PKA_2	667	673	PF00069	0.539
MOD_Plk_1	252	258	PF00069	0.558
MOD_Plk_1	440	446	PF00069	0.562
MOD_Plk_1	492	498	PF00069	0.744
MOD_Plk_1	590	596	PF00069	0.747
MOD_Plk_1	601	607	PF00069	0.663
MOD_Plk_2-3	220	226	PF00069	0.584
MOD_Plk_2-3	46	52	PF00069	0.622
MOD_Plk_2-3	73	79	PF00069	0.595
MOD_Plk_4	162	168	PF00069	0.669
MOD_Plk_4	25	31	PF00069	0.409
MOD_Plk_4	414	420	PF00069	0.700
MOD_Plk_4	46	52	PF00069	0.666
MOD_Plk_4	469	475	PF00069	0.610
MOD_ProDKin_1	19	25	PF00069	0.369
MOD_ProDKin_1	204	210	PF00069	0.737
MOD_ProDKin_1	30	36	PF00069	0.431
MOD_ProDKin_1	330	336	PF00069	0.629
MOD_ProDKin_1	350	356	PF00069	0.637
MOD_ProDKin_1	386	392	PF00069	0.740
MOD_ProDKin_1	436	442	PF00069	0.724
MOD_ProDKin_1	516	522	PF00069	0.820
MOD_ProDKin_1	54	60	PF00069	0.650
MOD_ProDKin_1	547	553	PF00069	0.838
MOD_ProDKin_1	583	589	PF00069	0.815
MOD_ProDKin_1	604	610	PF00069	0.630
MOD_ProDKin_1	62	68	PF00069	0.715
MOD_SUMO_rev_2	215	223	PF00179	0.743
TRG_DiLeu_BaEn_1	78	83	PF01217	0.641
TRG_DiLeu_BaEn_2	45	51	PF01217	0.624
TRG_DiLeu_BaEn_4	224	230	PF01217	0.631
TRG_ENDOCYTIC_2	140	143	PF00928	0.726
TRG_ENDOCYTIC_2	256	259	PF00928	0.685
TRG_ENDOCYTIC_2	47	50	PF00928	0.663
TRG_ENDOCYTIC_2	508	511	PF00928	0.743
TRG_ER_diArg_1	217	219	PF00400	0.769
TRG_ER_diArg_1	237	240	PF00400	0.386
TRG_ER_diArg_1	553	556	PF00400	0.609
TRG_ER_diArg_1	68	71	PF00400	0.732
TRG_NLS_Bipartite_1	217	238	PF00514	0.661
TRG_Pf-PMV_PEXEL_1	146	151	PF00026	0.668

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4B7	Leishmania donovani	99%	100%
E9B1Q6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4Q6F4	Leishmania major	80%	100%