LeishMANIAdb
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Biotin/lipoate protein ligase-like protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Biotin/lipoate protein ligase-like protein
Gene product:
biotin/lipoate protein ligase-like protein
Species:
Leishmania infantum
UniProt:
A4I6N1_LEIIN
TriTrypDb:
LINF_310016800
Length:
263

Annotations

Annotations by Jardim et al.

Protein modification, Biotin/lipoate ligase-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 2
Pissara et al. no yes: 8
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I6N1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6N1

PDB structure(s): 6jhu_A , 7dbs_A

Function

Biological processes
Term Name Level Count
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0019538 protein metabolic process 3 12
GO:0036211 protein modification process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0044238 primary metabolic process 2 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004077 biotin-[acetyl-CoA-carboxylase] ligase activity 4 10
GO:0016874 ligase activity 2 12
GO:0016879 ligase activity, forming carbon-nitrogen bonds 3 10
GO:0018271 biotin-protein ligase activity 3 10
GO:0140096 catalytic activity, acting on a protein 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 223 225 PF00082 0.434
CLV_PCSK_PC1ET2_1 223 225 PF00082 0.491
CLV_PCSK_SKI1_1 163 167 PF00082 0.498
CLV_PCSK_SKI1_1 217 221 PF00082 0.447
DOC_MAPK_DCC_7 75 84 PF00069 0.484
DOC_MAPK_MEF2A_6 75 84 PF00069 0.457
DOC_PP1_RVXF_1 6 12 PF00149 0.246
DOC_PP4_FxxP_1 63 66 PF00568 0.416
DOC_USP7_MATH_1 105 109 PF00917 0.522
DOC_USP7_UBL2_3 213 217 PF12436 0.501
DOC_WW_Pin1_4 178 183 PF00397 0.423
DOC_WW_Pin1_4 196 201 PF00397 0.419
DOC_WW_Pin1_4 51 56 PF00397 0.436
LIG_14-3-3_CanoR_1 102 109 PF00244 0.388
LIG_14-3-3_CanoR_1 248 254 PF00244 0.473
LIG_14-3-3_CanoR_1 26 34 PF00244 0.514
LIG_14-3-3_CanoR_1 50 55 PF00244 0.456
LIG_CtBP_PxDLS_1 231 235 PF00389 0.478
LIG_FHA_1 16 22 PF00498 0.461
LIG_FHA_1 60 66 PF00498 0.436
LIG_FHA_2 133 139 PF00498 0.483
LIG_FHA_2 179 185 PF00498 0.478
LIG_FHA_2 196 202 PF00498 0.309
LIG_FHA_2 251 257 PF00498 0.487
LIG_LIR_Apic_2 51 55 PF02991 0.480
LIG_LIR_Apic_2 62 66 PF02991 0.486
LIG_LIR_Gen_1 209 219 PF02991 0.481
LIG_LIR_Nem_3 140 146 PF02991 0.465
LIG_LIR_Nem_3 209 214 PF02991 0.475
LIG_LIR_Nem_3 241 245 PF02991 0.370
LIG_PDZ_Class_2 258 263 PF00595 0.432
LIG_Pex14_1 190 194 PF04695 0.313
LIG_SH2_STAT5 143 146 PF00017 0.497
LIG_SH3_3 77 83 PF00018 0.410
LIG_WRC_WIRS_1 208 213 PF05994 0.514
LIG_WRC_WIRS_1 60 65 PF05994 0.416
MOD_CDK_SPK_2 178 183 PF00069 0.292
MOD_CDK_SPK_2 51 56 PF00069 0.447
MOD_CK1_1 238 244 PF00069 0.492
MOD_CK2_1 132 138 PF00069 0.436
MOD_CK2_1 195 201 PF00069 0.468
MOD_CK2_1 203 209 PF00069 0.370
MOD_GlcNHglycan 103 106 PF01048 0.256
MOD_GlcNHglycan 255 260 PF01048 0.522
MOD_GSK3_1 101 108 PF00069 0.500
MOD_GSK3_1 196 203 PF00069 0.470
MOD_GSK3_1 21 28 PF00069 0.490
MOD_GSK3_1 44 51 PF00069 0.475
MOD_NEK2_1 215 220 PF00069 0.394
MOD_NEK2_1 25 30 PF00069 0.495
MOD_NEK2_1 59 64 PF00069 0.436
MOD_PKA_2 101 107 PF00069 0.388
MOD_PKA_2 203 209 PF00069 0.438
MOD_PKA_2 247 253 PF00069 0.312
MOD_PKA_2 25 31 PF00069 0.458
MOD_PKA_2 44 50 PF00069 0.436
MOD_Plk_1 163 169 PF00069 0.491
MOD_Plk_1 215 221 PF00069 0.394
MOD_Plk_1 232 238 PF00069 0.450
MOD_Plk_4 132 138 PF00069 0.441
MOD_Plk_4 163 169 PF00069 0.508
MOD_Plk_4 203 209 PF00069 0.450
MOD_ProDKin_1 178 184 PF00069 0.423
MOD_ProDKin_1 196 202 PF00069 0.418
MOD_ProDKin_1 51 57 PF00069 0.436
MOD_SUMO_for_1 74 77 PF00179 0.522
TRG_DiLeu_BaLyEn_6 80 85 PF01217 0.495
TRG_ENDOCYTIC_2 143 146 PF00928 0.497
TRG_ENDOCYTIC_2 60 63 PF00928 0.447

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HUD5 Leptomonas seymouri 71% 100%
A0A0S4JE29 Bodo saltans 34% 85%
A0A1X0P3B0 Trypanosomatidae 51% 100%
A0A3R7NY08 Trypanosoma rangeli 48% 100%
A0A3S7X4E1 Leishmania donovani 98% 100%
A4HJ88 Leishmania braziliensis 85% 100%
D0A8L0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
E9B1Q4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
P46363 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 29% 87%
Q4Q6F6 Leishmania major 93% 100%
V5DNJ4 Trypanosoma cruzi 50% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS