LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I6M9_LEIIN
TriTrypDb:
LINF_310016600
Length:
384

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 75
Promastigote: 187
Promastigote/Amastigote: 143

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I6M9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6M9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 365 369 PF00656 0.580
CLV_NRD_NRD_1 202 204 PF00675 0.671
CLV_NRD_NRD_1 213 215 PF00675 0.636
CLV_NRD_NRD_1 262 264 PF00675 0.643
CLV_PCSK_FUR_1 199 203 PF00082 0.592
CLV_PCSK_KEX2_1 161 163 PF00082 0.548
CLV_PCSK_KEX2_1 199 201 PF00082 0.655
CLV_PCSK_KEX2_1 202 204 PF00082 0.635
CLV_PCSK_KEX2_1 213 215 PF00082 0.599
CLV_PCSK_KEX2_1 262 264 PF00082 0.584
CLV_PCSK_PC1ET2_1 161 163 PF00082 0.548
CLV_PCSK_PC1ET2_1 262 264 PF00082 0.584
CLV_PCSK_SKI1_1 137 141 PF00082 0.506
CLV_PCSK_SKI1_1 284 288 PF00082 0.597
DOC_CKS1_1 8 13 PF01111 0.580
DOC_PP2B_LxvP_1 346 349 PF13499 0.596
DOC_PP4_FxxP_1 8 11 PF00568 0.556
DOC_USP7_MATH_1 118 122 PF00917 0.535
DOC_USP7_MATH_1 176 180 PF00917 0.525
DOC_USP7_MATH_1 184 188 PF00917 0.540
DOC_USP7_MATH_1 253 257 PF00917 0.598
DOC_USP7_MATH_1 309 313 PF00917 0.691
DOC_USP7_MATH_1 51 55 PF00917 0.622
DOC_USP7_MATH_1 82 86 PF00917 0.582
DOC_USP7_UBL2_3 278 282 PF12436 0.620
DOC_USP7_UBL2_3 284 288 PF12436 0.520
DOC_USP7_UBL2_3 298 302 PF12436 0.493
DOC_WW_Pin1_4 140 145 PF00397 0.606
DOC_WW_Pin1_4 277 282 PF00397 0.584
DOC_WW_Pin1_4 7 12 PF00397 0.690
LIG_14-3-3_CanoR_1 50 59 PF00244 0.558
LIG_BIR_II_1 1 5 PF00653 0.693
LIG_FHA_1 232 238 PF00498 0.521
LIG_FHA_1 337 343 PF00498 0.584
LIG_FHA_1 53 59 PF00498 0.662
LIG_FHA_2 146 152 PF00498 0.498
LIG_FHA_2 239 245 PF00498 0.612
LIG_FHA_2 267 273 PF00498 0.519
LIG_FHA_2 8 14 PF00498 0.580
LIG_Integrin_isoDGR_2 245 247 PF01839 0.587
LIG_LIR_Apic_2 7 11 PF02991 0.556
LIG_LIR_Gen_1 178 186 PF02991 0.489
LIG_LIR_Nem_3 178 183 PF02991 0.493
LIG_PDZ_Class_1 379 384 PF00595 0.606
LIG_SH2_CRK 180 184 PF00017 0.493
LIG_SH2_NCK_1 180 184 PF00017 0.555
LIG_SH2_STAP1 180 184 PF00017 0.555
LIG_SH3_3 160 166 PF00018 0.566
LIG_SH3_3 53 59 PF00018 0.553
LIG_SH3_3 97 103 PF00018 0.583
LIG_SH3_4 284 291 PF00018 0.596
LIG_TRAF2_1 143 146 PF00917 0.493
LIG_TRAF2_1 256 259 PF00917 0.554
LIG_TRAF2_1 369 372 PF00917 0.614
MOD_CDK_SPK_2 277 282 PF00069 0.584
MOD_CDK_SPxxK_3 277 284 PF00069 0.584
MOD_CK1_1 179 185 PF00069 0.501
MOD_CK1_1 238 244 PF00069 0.611
MOD_CK1_1 257 263 PF00069 0.617
MOD_CK1_1 54 60 PF00069 0.622
MOD_CK1_1 65 71 PF00069 0.641
MOD_CK2_1 118 124 PF00069 0.563
MOD_CK2_1 140 146 PF00069 0.490
MOD_CK2_1 238 244 PF00069 0.609
MOD_CK2_1 253 259 PF00069 0.463
MOD_CK2_1 266 272 PF00069 0.516
MOD_CK2_1 309 315 PF00069 0.619
MOD_CK2_1 35 41 PF00069 0.576
MOD_CK2_1 7 13 PF00069 0.692
MOD_Cter_Amidation 158 161 PF01082 0.587
MOD_Cter_Amidation 211 214 PF01082 0.622
MOD_GlcNHglycan 1 4 PF01048 0.691
MOD_GlcNHglycan 111 114 PF01048 0.617
MOD_GlcNHglycan 120 123 PF01048 0.470
MOD_GlcNHglycan 188 191 PF01048 0.705
MOD_GlcNHglycan 259 262 PF01048 0.600
MOD_GlcNHglycan 302 305 PF01048 0.665
MOD_GlcNHglycan 315 319 PF01048 0.623
MOD_GlcNHglycan 346 349 PF01048 0.613
MOD_GlcNHglycan 37 40 PF01048 0.571
MOD_GlcNHglycan 67 70 PF01048 0.570
MOD_GlcNHglycan 84 87 PF01048 0.484
MOD_GSK3_1 140 147 PF00069 0.502
MOD_GSK3_1 222 229 PF00069 0.520
MOD_GSK3_1 231 238 PF00069 0.486
MOD_GSK3_1 253 260 PF00069 0.684
MOD_GSK3_1 262 269 PF00069 0.589
MOD_GSK3_1 296 303 PF00069 0.655
MOD_GSK3_1 33 40 PF00069 0.590
MOD_GSK3_1 54 61 PF00069 0.641
MOD_LATS_1 60 66 PF00433 0.567
MOD_N-GLC_1 22 27 PF02516 0.503
MOD_NEK2_1 35 40 PF00069 0.626
MOD_NEK2_2 222 227 PF00069 0.579
MOD_NEK2_2 231 236 PF00069 0.527
MOD_PIKK_1 215 221 PF00454 0.604
MOD_PIKK_1 238 244 PF00454 0.609
MOD_PIKK_1 254 260 PF00454 0.454
MOD_PIKK_1 309 315 PF00454 0.619
MOD_PKA_1 262 268 PF00069 0.577
MOD_PKA_2 107 113 PF00069 0.594
MOD_PKA_2 235 241 PF00069 0.521
MOD_PKA_2 262 268 PF00069 0.527
MOD_PKA_2 65 71 PF00069 0.655
MOD_Plk_1 150 156 PF00069 0.560
MOD_Plk_4 150 156 PF00069 0.528
MOD_Plk_4 96 102 PF00069 0.564
MOD_ProDKin_1 140 146 PF00069 0.608
MOD_ProDKin_1 277 283 PF00069 0.584
MOD_ProDKin_1 7 13 PF00069 0.692
MOD_SUMO_for_1 369 372 PF00179 0.585
MOD_SUMO_rev_2 121 128 PF00179 0.509
TRG_ENDOCYTIC_2 180 183 PF00928 0.494
TRG_ER_diArg_1 106 109 PF00400 0.565
TRG_ER_diArg_1 199 202 PF00400 0.646
TRG_ER_diArg_1 213 215 PF00400 0.595
TRG_ER_KDEL_1 381 384 PF00810 0.606
TRG_NLS_MonoExtC_3 159 164 PF00514 0.573
TRG_NLS_MonoExtN_4 158 164 PF00514 0.516

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IJY9 Leishmania donovani 97% 100%
A4HJ85 Leishmania braziliensis 36% 100%
E9B1Q2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 74% 99%
Q4Q6F8 Leishmania major 85% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS