Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM - RBD - or RNP domain) - putative

Species:

Leishmania infantum

UniProt:

A4I6M8_LEIIN

TriTrypDb:

LINF_310016500

Length:

772

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I6M8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6M8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	384	388	PF00656	0.706
CLV_MEL_PAP_1	472	478	PF00089	0.397
CLV_NRD_NRD_1	229	231	PF00675	0.547
CLV_NRD_NRD_1	246	248	PF00675	0.386
CLV_NRD_NRD_1	393	395	PF00675	0.469
CLV_NRD_NRD_1	474	476	PF00675	0.476
CLV_NRD_NRD_1	556	558	PF00675	0.652
CLV_NRD_NRD_1	649	651	PF00675	0.597
CLV_PCSK_KEX2_1	229	231	PF00082	0.545
CLV_PCSK_KEX2_1	393	395	PF00082	0.469
CLV_PCSK_KEX2_1	473	475	PF00082	0.613
CLV_PCSK_KEX2_1	555	557	PF00082	0.648
CLV_PCSK_KEX2_1	649	651	PF00082	0.597
CLV_PCSK_PC1ET2_1	555	557	PF00082	0.648
CLV_PCSK_SKI1_1	229	233	PF00082	0.533
CLV_PCSK_SKI1_1	433	437	PF00082	0.397
CLV_PCSK_SKI1_1	656	660	PF00082	0.551
CLV_PCSK_SKI1_1	728	732	PF00082	0.612
DEG_APCC_DBOX_1	655	663	PF00400	0.551
DEG_COP1_1	9	19	PF00400	0.701
DOC_CYCLIN_yCln2_LP_2	349	355	PF00134	0.735
DOC_MAPK_FxFP_2	353	356	PF00069	0.607
DOC_MAPK_gen_1	393	400	PF00069	0.441
DOC_MAPK_gen_1	503	511	PF00069	0.567
DOC_MAPK_gen_1	555	564	PF00069	0.643
DOC_MAPK_MEF2A_6	555	564	PF00069	0.643
DOC_MAPK_MEF2A_6	656	665	PF00069	0.549
DOC_MAPK_RevD_3	543	557	PF00069	0.563
DOC_PP1_RVXF_1	726	733	PF00149	0.630
DOC_PP2B_LxvP_1	349	352	PF13499	0.727
DOC_PP4_FxxP_1	353	356	PF00568	0.755
DOC_USP7_MATH_1	206	210	PF00917	0.707
DOC_USP7_MATH_1	214	218	PF00917	0.588
DOC_USP7_MATH_1	242	246	PF00917	0.405
DOC_USP7_MATH_1	341	345	PF00917	0.561
DOC_USP7_MATH_1	41	45	PF00917	0.577
DOC_USP7_MATH_1	549	553	PF00917	0.638
DOC_USP7_MATH_1	563	567	PF00917	0.521
DOC_WW_Pin1_4	15	20	PF00397	0.698
DOC_WW_Pin1_4	155	160	PF00397	0.477
DOC_WW_Pin1_4	175	180	PF00397	0.342
DOC_WW_Pin1_4	202	207	PF00397	0.679
DOC_WW_Pin1_4	357	362	PF00397	0.576
DOC_WW_Pin1_4	490	495	PF00397	0.375
DOC_WW_Pin1_4	9	14	PF00397	0.799
LIG_14-3-3_CanoR_1	408	415	PF00244	0.478
LIG_14-3-3_CanoR_1	454	461	PF00244	0.532
LIG_14-3-3_CanoR_1	598	606	PF00244	0.589
LIG_14-3-3_CanoR_1	687	695	PF00244	0.408
LIG_Actin_WH2_2	361	378	PF00022	0.547
LIG_BIR_II_1	1	5	PF00653	0.691
LIG_BIR_III_2	38	42	PF00653	0.539
LIG_BIR_III_2	478	482	PF00653	0.598
LIG_BRCT_BRCA1_1	405	409	PF00533	0.483
LIG_BRCT_BRCA1_1	634	638	PF00533	0.605
LIG_EH1_1	462	470	PF00400	0.365
LIG_eIF4E_1	657	663	PF01652	0.547
LIG_FHA_1	21	27	PF00498	0.660
LIG_FHA_1	421	427	PF00498	0.437
LIG_FHA_1	446	452	PF00498	0.644
LIG_FHA_1	495	501	PF00498	0.492
LIG_FHA_1	51	57	PF00498	0.631
LIG_FHA_1	642	648	PF00498	0.492
LIG_FHA_1	687	693	PF00498	0.369
LIG_FHA_1	78	84	PF00498	0.513
LIG_FHA_2	189	195	PF00498	0.606
LIG_FHA_2	416	422	PF00498	0.409
LIG_GBD_Chelix_1	464	472	PF00786	0.396
LIG_Integrin_isoDGR_2	685	687	PF01839	0.457
LIG_LIR_Gen_1	104	110	PF02991	0.630
LIG_LIR_LC3C_4	194	199	PF02991	0.519
LIG_LIR_Nem_3	104	108	PF02991	0.630
LIG_LIR_Nem_3	268	273	PF02991	0.574
LIG_LIR_Nem_3	651	657	PF02991	0.567
LIG_LIR_Nem_3	755	761	PF02991	0.605
LIG_NRBOX	421	427	PF00104	0.563
LIG_PCNA_yPIPBox_3	91	99	PF02747	0.525
LIG_PDZ_Class_2	767	772	PF00595	0.483
LIG_Pex14_1	120	124	PF04695	0.630
LIG_Pex14_2	733	737	PF04695	0.575
LIG_SH2_STAP1	170	174	PF00017	0.458
LIG_SH2_STAP1	633	637	PF00017	0.585
LIG_SH2_STAT5	105	108	PF00017	0.630
LIG_SH2_STAT5	139	142	PF00017	0.495
LIG_SH2_STAT5	657	660	PF00017	0.547
LIG_SH3_1	557	563	PF00018	0.638
LIG_SH3_2	145	150	PF14604	0.538
LIG_SH3_3	13	19	PF00018	0.700
LIG_SH3_3	142	148	PF00018	0.635
LIG_SH3_3	297	303	PF00018	0.617
LIG_SH3_3	34	40	PF00018	0.569
LIG_SH3_3	506	512	PF00018	0.485
LIG_SH3_3	557	563	PF00018	0.638
LIG_SUMO_SIM_anti_2	194	201	PF11976	0.515
LIG_SUMO_SIM_par_1	194	201	PF11976	0.542
LIG_SUMO_SIM_par_1	27	34	PF11976	0.559
LIG_SUMO_SIM_par_1	747	755	PF11976	0.381
LIG_TRAF2_1	668	671	PF00917	0.587
LIG_WRC_WIRS_1	487	492	PF05994	0.462
LIG_WRC_WIRS_1	564	569	PF05994	0.649
MOD_CDC14_SPxK_1	158	161	PF00782	0.487
MOD_CDK_SPK_2	202	207	PF00069	0.613
MOD_CDK_SPxK_1	155	161	PF00069	0.484
MOD_CK1_1	289	295	PF00069	0.654
MOD_CK1_1	3	9	PF00069	0.827
MOD_CK1_1	378	384	PF00069	0.610
MOD_CK1_1	420	426	PF00069	0.434
MOD_CK1_1	44	50	PF00069	0.616
MOD_CK1_1	57	63	PF00069	0.525
MOD_CK1_1	624	630	PF00069	0.666
MOD_CK1_1	64	70	PF00069	0.570
MOD_CK1_1	641	647	PF00069	0.502
MOD_CK2_1	415	421	PF00069	0.519
MOD_CK2_1	572	578	PF00069	0.659
MOD_CK2_1	586	592	PF00069	0.628
MOD_CK2_1	69	75	PF00069	0.555
MOD_CK2_1	9	15	PF00069	0.705
MOD_GlcNHglycan	2	5	PF01048	0.733
MOD_GlcNHglycan	200	203	PF01048	0.636
MOD_GlcNHglycan	216	219	PF01048	0.773
MOD_GlcNHglycan	258	261	PF01048	0.681
MOD_GlcNHglycan	290	294	PF01048	0.724
MOD_GlcNHglycan	318	321	PF01048	0.642
MOD_GlcNHglycan	343	346	PF01048	0.589
MOD_GlcNHglycan	377	380	PF01048	0.699
MOD_GlcNHglycan	405	408	PF01048	0.485
MOD_GlcNHglycan	443	446	PF01048	0.672
MOD_GlcNHglycan	465	468	PF01048	0.364
MOD_GlcNHglycan	623	627	PF01048	0.791
MOD_GlcNHglycan	640	643	PF01048	0.435
MOD_GlcNHglycan	678	681	PF01048	0.601
MOD_GlcNHglycan	725	728	PF01048	0.665
MOD_GSK3_1	198	205	PF00069	0.625
MOD_GSK3_1	274	281	PF00069	0.621
MOD_GSK3_1	285	292	PF00069	0.623
MOD_GSK3_1	316	323	PF00069	0.601
MOD_GSK3_1	403	410	PF00069	0.481
MOD_GSK3_1	441	448	PF00069	0.673
MOD_GSK3_1	486	493	PF00069	0.371
MOD_GSK3_1	50	57	PF00069	0.574
MOD_GSK3_1	59	66	PF00069	0.558
MOD_GSK3_1	622	629	PF00069	0.771
MOD_N-GLC_1	175	180	PF02516	0.504
MOD_N-GLC_1	50	55	PF02516	0.603
MOD_N-GLC_1	57	62	PF02516	0.604
MOD_N-GLC_1	64	69	PF02516	0.528
MOD_N-GLC_1	723	728	PF02516	0.586
MOD_N-GLC_2	262	264	PF02516	0.580
MOD_NEK2_1	31	36	PF00069	0.719
MOD_NEK2_1	339	344	PF00069	0.521
MOD_NEK2_1	375	380	PF00069	0.718
MOD_NEK2_1	403	408	PF00069	0.576
MOD_NEK2_1	428	433	PF00069	0.462
MOD_NEK2_1	520	525	PF00069	0.684
MOD_NEK2_1	621	626	PF00069	0.640
MOD_NEK2_1	69	74	PF00069	0.655
MOD_NEK2_1	737	742	PF00069	0.413
MOD_NEK2_1	77	82	PF00069	0.515
MOD_NEK2_2	242	247	PF00069	0.410
MOD_OFUCOSY	263	269	PF10250	0.542
MOD_OFUCOSY	309	315	PF10250	0.533
MOD_PIKK_1	381	387	PF00454	0.595
MOD_PIKK_1	420	426	PF00454	0.493
MOD_PIKK_1	453	459	PF00454	0.566
MOD_PIKK_1	50	56	PF00454	0.631
MOD_PIKK_1	520	526	PF00454	0.656
MOD_PIKK_1	742	748	PF00454	0.458
MOD_PKA_2	375	381	PF00069	0.595
MOD_PKA_2	407	413	PF00069	0.495
MOD_PKA_2	453	459	PF00069	0.539
MOD_PKA_2	597	603	PF00069	0.589
MOD_PKA_2	686	692	PF00069	0.392
MOD_PKA_2	69	75	PF00069	0.555
MOD_PKA_2	751	757	PF00069	0.474
MOD_Plk_1	188	194	PF00069	0.456
MOD_Plk_1	420	426	PF00069	0.434
MOD_Plk_1	50	56	PF00069	0.604
MOD_Plk_1	57	63	PF00069	0.604
MOD_Plk_1	64	70	PF00069	0.527
MOD_Plk_1	650	656	PF00069	0.425
MOD_Plk_1	728	734	PF00069	0.597
MOD_Plk_4	41	47	PF00069	0.637
MOD_Plk_4	494	500	PF00069	0.489
MOD_Plk_4	549	555	PF00069	0.675
MOD_Plk_4	563	569	PF00069	0.652
MOD_Plk_4	572	578	PF00069	0.647
MOD_Plk_4	64	70	PF00069	0.640
MOD_Plk_4	728	734	PF00069	0.449
MOD_Plk_4	765	771	PF00069	0.455
MOD_ProDKin_1	155	161	PF00069	0.484
MOD_ProDKin_1	175	181	PF00069	0.332
MOD_ProDKin_1	202	208	PF00069	0.683
MOD_ProDKin_1	357	363	PF00069	0.566
MOD_ProDKin_1	490	496	PF00069	0.373
MOD_ProDKin_1	9	15	PF00069	0.801
TRG_DiLeu_BaEn_1	421	426	PF01217	0.431
TRG_DiLeu_BaEn_1	694	699	PF01217	0.495
TRG_DiLeu_BaLyEn_6	744	749	PF01217	0.452
TRG_ENDOCYTIC_2	105	108	PF00928	0.630
TRG_ENDOCYTIC_2	122	125	PF00928	0.434
TRG_ENDOCYTIC_2	139	142	PF00928	0.368
TRG_ER_diArg_1	106	109	PF00400	0.630
TRG_ER_diArg_1	229	231	PF00400	0.545
TRG_ER_diArg_1	472	475	PF00400	0.454
TRG_ER_diArg_1	500	503	PF00400	0.527
TRG_ER_diArg_1	556	558	PF00400	0.558
TRG_NES_CRM1_1	478	492	PF08389	0.507
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.305

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IET1	Leishmania donovani	99%	100%
A0A3S7X4F6	Leishmania donovani	31%	86%
A4I6M7	Leishmania infantum	32%	86%
E9B1Q1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
Q4Q6F9	Leishmania major	89%	100%