Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I6M6_LEIIN

TriTrypDb:

LINF_310016300

Length:

951

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I6M6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6M6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.632
CLV_C14_Caspase3-7	236	240	PF00656	0.624
CLV_C14_Caspase3-7	822	826	PF00656	0.775
CLV_C14_Caspase3-7	864	868	PF00656	0.618
CLV_C14_Caspase3-7	915	919	PF00656	0.649
CLV_NRD_NRD_1	144	146	PF00675	0.683
CLV_NRD_NRD_1	222	224	PF00675	0.562
CLV_NRD_NRD_1	275	277	PF00675	0.776
CLV_NRD_NRD_1	290	292	PF00675	0.480
CLV_NRD_NRD_1	329	331	PF00675	0.697
CLV_NRD_NRD_1	505	507	PF00675	0.445
CLV_NRD_NRD_1	52	54	PF00675	0.630
CLV_NRD_NRD_1	528	530	PF00675	0.424
CLV_NRD_NRD_1	787	789	PF00675	0.452
CLV_PCSK_KEX2_1	144	146	PF00082	0.683
CLV_PCSK_KEX2_1	222	224	PF00082	0.562
CLV_PCSK_KEX2_1	275	277	PF00082	0.739
CLV_PCSK_KEX2_1	286	288	PF00082	0.394
CLV_PCSK_KEX2_1	290	292	PF00082	0.532
CLV_PCSK_KEX2_1	299	301	PF00082	0.450
CLV_PCSK_KEX2_1	329	331	PF00082	0.697
CLV_PCSK_KEX2_1	505	507	PF00082	0.445
CLV_PCSK_KEX2_1	52	54	PF00082	0.725
CLV_PCSK_KEX2_1	528	530	PF00082	0.424
CLV_PCSK_KEX2_1	66	68	PF00082	0.582
CLV_PCSK_KEX2_1	78	80	PF00082	0.543
CLV_PCSK_KEX2_1	787	789	PF00082	0.452
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.450
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.523
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.648
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.543
CLV_PCSK_PC7_1	524	530	PF00082	0.432
CLV_PCSK_SKI1_1	213	217	PF00082	0.530
CLV_PCSK_SKI1_1	395	399	PF00082	0.679
CLV_PCSK_SKI1_1	44	48	PF00082	0.798
CLV_PCSK_SKI1_1	472	476	PF00082	0.581
CLV_PCSK_SKI1_1	488	492	PF00082	0.393
CLV_PCSK_SKI1_1	499	503	PF00082	0.459
CLV_PCSK_SKI1_1	556	560	PF00082	0.468
CLV_PCSK_SKI1_1	619	623	PF00082	0.405
CLV_PCSK_SKI1_1	721	725	PF00082	0.474
CLV_PCSK_SKI1_1	788	792	PF00082	0.455
DEG_APCC_DBOX_1	66	74	PF00400	0.583
DEG_MDM2_SWIB_1	614	621	PF02201	0.429
DEG_SPOP_SBC_1	355	359	PF00917	0.536
DEG_SPOP_SBC_1	730	734	PF00917	0.683
DOC_CDC14_PxL_1	536	544	PF14671	0.382
DOC_CDC14_PxL_1	639	647	PF14671	0.735
DOC_CKS1_1	226	231	PF01111	0.555
DOC_CKS1_1	47	52	PF01111	0.604
DOC_CKS1_1	702	707	PF01111	0.391
DOC_CYCLIN_RxL_1	483	493	PF00134	0.465
DOC_CYCLIN_RxL_1	552	563	PF00134	0.452
DOC_CYCLIN_RxL_1	613	624	PF00134	0.403
DOC_CYCLIN_yCln2_LP_2	723	726	PF00134	0.459
DOC_MAPK_gen_1	66	75	PF00069	0.628
DOC_MAPK_gen_1	78	84	PF00069	0.495
DOC_MAPK_MEF2A_6	69	77	PF00069	0.544
DOC_PP1_RVXF_1	497	503	PF00149	0.507
DOC_PP1_SILK_1	446	451	PF00149	0.503
DOC_PP2B_LxvP_1	723	726	PF13499	0.459
DOC_USP7_MATH_1	183	187	PF00917	0.633
DOC_USP7_MATH_1	263	267	PF00917	0.699
DOC_USP7_MATH_1	317	321	PF00917	0.622
DOC_USP7_MATH_1	364	368	PF00917	0.529
DOC_USP7_MATH_1	408	412	PF00917	0.627
DOC_USP7_MATH_1	465	469	PF00917	0.654
DOC_USP7_MATH_1	568	572	PF00917	0.350
DOC_USP7_MATH_1	653	657	PF00917	0.638
DOC_USP7_MATH_1	728	732	PF00917	0.617
DOC_USP7_MATH_1	794	798	PF00917	0.453
DOC_USP7_MATH_1	847	851	PF00917	0.636
DOC_USP7_UBL2_3	295	299	PF12436	0.528
DOC_USP7_UBL2_3	62	66	PF12436	0.663
DOC_WW_Pin1_4	157	162	PF00397	0.681
DOC_WW_Pin1_4	225	230	PF00397	0.720
DOC_WW_Pin1_4	318	323	PF00397	0.576
DOC_WW_Pin1_4	349	354	PF00397	0.564
DOC_WW_Pin1_4	46	51	PF00397	0.580
DOC_WW_Pin1_4	467	472	PF00397	0.592
DOC_WW_Pin1_4	701	706	PF00397	0.393
DOC_WW_Pin1_4	726	731	PF00397	0.605
LIG_14-3-3_CanoR_1	144	149	PF00244	0.644
LIG_14-3-3_CanoR_1	182	192	PF00244	0.574
LIG_14-3-3_CanoR_1	452	461	PF00244	0.531
LIG_14-3-3_CanoR_1	567	577	PF00244	0.415
LIG_14-3-3_CanoR_1	69	74	PF00244	0.637
LIG_14-3-3_CanoR_1	81	85	PF00244	0.555
LIG_Actin_WH2_2	353	371	PF00022	0.632
LIG_Actin_WH2_2	879	895	PF00022	0.550
LIG_deltaCOP1_diTrp_1	615	622	PF00928	0.393
LIG_deltaCOP1_diTrp_1	693	698	PF00928	0.372
LIG_eIF4E_1	496	502	PF01652	0.503
LIG_EVH1_1	724	728	PF00568	0.566
LIG_FHA_1	103	109	PF00498	0.722
LIG_FHA_1	226	232	PF00498	0.592
LIG_FHA_1	242	248	PF00498	0.561
LIG_FHA_1	350	356	PF00498	0.669
LIG_FHA_1	370	376	PF00498	0.651
LIG_FHA_1	41	47	PF00498	0.664
LIG_FHA_1	456	462	PF00498	0.613
LIG_FHA_1	70	76	PF00498	0.544
LIG_FHA_1	702	708	PF00498	0.362
LIG_FHA_1	934	940	PF00498	0.597
LIG_FHA_2	133	139	PF00498	0.652
LIG_FHA_2	234	240	PF00498	0.632
LIG_FHA_2	545	551	PF00498	0.495
LIG_FHA_2	818	824	PF00498	0.675
LIG_FHA_2	920	926	PF00498	0.711
LIG_GSK3_LRP6_1	726	732	PF00069	0.575
LIG_LIR_Apic_2	376	380	PF02991	0.560
LIG_LIR_Gen_1	306	315	PF02991	0.470
LIG_LIR_Gen_1	611	622	PF02991	0.519
LIG_LIR_Gen_1	636	645	PF02991	0.726
LIG_LIR_Gen_1	83	92	PF02991	0.501
LIG_LIR_Gen_1	945	951	PF02991	0.529
LIG_LIR_Nem_3	306	311	PF02991	0.457
LIG_LIR_Nem_3	611	617	PF02991	0.457
LIG_LIR_Nem_3	620	625	PF02991	0.420
LIG_LIR_Nem_3	636	642	PF02991	0.600
LIG_LIR_Nem_3	763	769	PF02991	0.578
LIG_LIR_Nem_3	83	88	PF02991	0.487
LIG_LIR_Nem_3	945	950	PF02991	0.525
LIG_Pex14_1	618	622	PF04695	0.394
LIG_Pex14_1	695	699	PF04695	0.356
LIG_Pex14_2	614	618	PF04695	0.385
LIG_Pex14_2	942	946	PF04695	0.529
LIG_SH2_CRK	390	394	PF00017	0.693
LIG_SH2_CRK	445	449	PF00017	0.722
LIG_SH2_NCK_1	377	381	PF00017	0.572
LIG_SH2_PTP2	537	540	PF00017	0.367
LIG_SH2_SRC	537	540	PF00017	0.440
LIG_SH2_SRC	95	98	PF00017	0.653
LIG_SH2_STAP1	146	150	PF00017	0.641
LIG_SH2_STAT5	106	109	PF00017	0.744
LIG_SH2_STAT5	390	393	PF00017	0.653
LIG_SH2_STAT5	489	492	PF00017	0.462
LIG_SH2_STAT5	496	499	PF00017	0.377
LIG_SH2_STAT5	537	540	PF00017	0.405
LIG_SH2_STAT5	628	631	PF00017	0.578
LIG_SH2_STAT5	702	705	PF00017	0.392
LIG_SH2_STAT5	766	769	PF00017	0.483
LIG_SH3_3	107	113	PF00018	0.614
LIG_SH3_3	223	229	PF00018	0.671
LIG_SH3_3	240	246	PF00018	0.651
LIG_SH3_3	70	76	PF00018	0.652
LIG_SH3_3	722	728	PF00018	0.503
LIG_SH3_3	753	759	PF00018	0.600
LIG_SH3_3	91	97	PF00018	0.595
LIG_SH3_4	893	900	PF00018	0.603
LIG_SUMO_SIM_par_1	105	112	PF11976	0.679
LIG_SUMO_SIM_par_1	910	916	PF11976	0.583
LIG_TRAF2_1	279	282	PF00917	0.465
LIG_TRAF2_1	321	324	PF00917	0.660
LIG_TRAF2_1	712	715	PF00917	0.632
LIG_TYR_ITIM	443	448	PF00017	0.723
LIG_TYR_ITIM	533	538	PF00017	0.564
MOD_CDK_SPK_2	467	472	PF00069	0.563
MOD_CDK_SPxK_1	46	52	PF00069	0.580
MOD_CDK_SPxxK_3	157	164	PF00069	0.646
MOD_CDK_SPxxK_3	46	53	PF00069	0.567
MOD_CK1_1	266	272	PF00069	0.608
MOD_CK1_1	30	36	PF00069	0.763
MOD_CK1_1	358	364	PF00069	0.613
MOD_CK1_1	416	422	PF00069	0.665
MOD_CK1_1	5	11	PF00069	0.610
MOD_CK1_1	584	590	PF00069	0.604
MOD_CK1_1	65	71	PF00069	0.563
MOD_CK1_1	655	661	PF00069	0.626
MOD_CK1_1	729	735	PF00069	0.637
MOD_CK1_1	828	834	PF00069	0.730
MOD_CK1_1	83	89	PF00069	0.553
MOD_CK1_1	919	925	PF00069	0.685
MOD_CK1_1	945	951	PF00069	0.601
MOD_CK2_1	132	138	PF00069	0.700
MOD_CK2_1	148	154	PF00069	0.601
MOD_CK2_1	184	190	PF00069	0.617
MOD_CK2_1	276	282	PF00069	0.546
MOD_CK2_1	317	323	PF00069	0.810
MOD_CK2_1	364	370	PF00069	0.611
MOD_CK2_1	544	550	PF00069	0.465
MOD_CK2_1	577	583	PF00069	0.457
MOD_CK2_1	641	647	PF00069	0.584
MOD_CK2_1	709	715	PF00069	0.492
MOD_CK2_1	817	823	PF00069	0.697
MOD_CK2_1	945	951	PF00069	0.514
MOD_CMANNOS	695	698	PF00535	0.359
MOD_Cter_Amidation	327	330	PF01082	0.606
MOD_DYRK1A_RPxSP_1	157	161	PF00069	0.622
MOD_DYRK1A_RPxSP_1	225	229	PF00069	0.530
MOD_GlcNHglycan	260	263	PF01048	0.678
MOD_GlcNHglycan	268	271	PF01048	0.612
MOD_GlcNHglycan	29	32	PF01048	0.682
MOD_GlcNHglycan	313	316	PF01048	0.613
MOD_GlcNHglycan	398	401	PF01048	0.626
MOD_GlcNHglycan	460	464	PF01048	0.626
MOD_GlcNHglycan	562	565	PF01048	0.420
MOD_GlcNHglycan	588	591	PF01048	0.661
MOD_GlcNHglycan	592	595	PF01048	0.687
MOD_GlcNHglycan	655	658	PF01048	0.660
MOD_GlcNHglycan	659	662	PF01048	0.606
MOD_GlcNHglycan	686	689	PF01048	0.357
MOD_GlcNHglycan	7	10	PF01048	0.612
MOD_GlcNHglycan	711	714	PF01048	0.497
MOD_GlcNHglycan	808	811	PF01048	0.588
MOD_GlcNHglycan	825	828	PF01048	0.563
MOD_GlcNHglycan	867	870	PF01048	0.635
MOD_GlcNHglycan	873	877	PF01048	0.553
MOD_GlcNHglycan	904	907	PF01048	0.574
MOD_GSK3_1	144	151	PF00069	0.716
MOD_GSK3_1	258	265	PF00069	0.679
MOD_GSK3_1	266	273	PF00069	0.534
MOD_GSK3_1	354	361	PF00069	0.531
MOD_GSK3_1	369	376	PF00069	0.639
MOD_GSK3_1	415	422	PF00069	0.645
MOD_GSK3_1	451	458	PF00069	0.570
MOD_GSK3_1	573	580	PF00069	0.573
MOD_GSK3_1	586	593	PF00069	0.521
MOD_GSK3_1	637	644	PF00069	0.577
MOD_GSK3_1	649	656	PF00069	0.625
MOD_GSK3_1	65	72	PF00069	0.657
MOD_GSK3_1	668	675	PF00069	0.375
MOD_GSK3_1	726	733	PF00069	0.630
MOD_GSK3_1	815	822	PF00069	0.662
MOD_GSK3_1	823	830	PF00069	0.743
MOD_GSK3_1	831	838	PF00069	0.659
MOD_GSK3_1	865	872	PF00069	0.618
MOD_N-GLC_1	183	188	PF02516	0.644
MOD_N-GLC_1	239	244	PF02516	0.595
MOD_N-GLC_1	27	32	PF02516	0.692
MOD_N-GLC_1	422	427	PF02516	0.639
MOD_N-GLC_1	452	457	PF02516	0.506
MOD_NEK2_1	241	246	PF00069	0.712
MOD_NEK2_1	29	34	PF00069	0.640
MOD_NEK2_1	311	316	PF00069	0.568
MOD_NEK2_1	341	346	PF00069	0.620
MOD_NEK2_1	444	449	PF00069	0.507
MOD_NEK2_1	490	495	PF00069	0.434
MOD_NEK2_1	554	559	PF00069	0.389
MOD_NEK2_1	573	578	PF00069	0.454
MOD_NEK2_1	769	774	PF00069	0.422
MOD_NEK2_1	865	870	PF00069	0.674
MOD_NEK2_1	942	947	PF00069	0.529
MOD_NEK2_2	364	369	PF00069	0.606
MOD_PIKK_1	369	375	PF00454	0.647
MOD_PIKK_1	388	394	PF00454	0.560
MOD_PIKK_1	423	429	PF00454	0.677
MOD_PIKK_1	478	484	PF00454	0.646
MOD_PIKK_1	56	62	PF00454	0.635
MOD_PIKK_1	581	587	PF00454	0.569
MOD_PIKK_1	744	750	PF00454	0.661
MOD_PK_1	144	150	PF00069	0.656
MOD_PK_1	613	619	PF00069	0.347
MOD_PK_1	800	806	PF00069	0.514
MOD_PKA_1	144	150	PF00069	0.618
MOD_PKA_2	144	150	PF00069	0.671
MOD_PKA_2	266	272	PF00069	0.741
MOD_PKA_2	328	334	PF00069	0.684
MOD_PKA_2	419	425	PF00069	0.609
MOD_PKA_2	451	457	PF00069	0.578
MOD_PKA_2	80	86	PF00069	0.491
MOD_PKA_2	812	818	PF00069	0.622
MOD_PKB_1	225	233	PF00069	0.572
MOD_PKB_1	450	458	PF00069	0.508
MOD_PKB_1	67	75	PF00069	0.563
MOD_Plk_1	173	179	PF00069	0.634
MOD_Plk_1	239	245	PF00069	0.599
MOD_Plk_1	554	560	PF00069	0.468
MOD_Plk_1	795	801	PF00069	0.427
MOD_Plk_1	887	893	PF00069	0.600
MOD_Plk_2-3	916	922	PF00069	0.674
MOD_Plk_4	102	108	PF00069	0.676
MOD_Plk_4	173	179	PF00069	0.777
MOD_Plk_4	227	233	PF00069	0.686
MOD_Plk_4	379	385	PF00069	0.607
MOD_Plk_4	444	450	PF00069	0.631
MOD_Plk_4	613	619	PF00069	0.433
MOD_Plk_4	668	674	PF00069	0.508
MOD_Plk_4	80	86	PF00069	0.534
MOD_Plk_4	887	893	PF00069	0.570
MOD_Plk_4	942	948	PF00069	0.600
MOD_ProDKin_1	157	163	PF00069	0.682
MOD_ProDKin_1	225	231	PF00069	0.720
MOD_ProDKin_1	318	324	PF00069	0.579
MOD_ProDKin_1	349	355	PF00069	0.563
MOD_ProDKin_1	46	52	PF00069	0.581
MOD_ProDKin_1	467	473	PF00069	0.590
MOD_ProDKin_1	701	707	PF00069	0.391
MOD_ProDKin_1	726	732	PF00069	0.615
MOD_SUMO_for_1	298	301	PF00179	0.394
MOD_SUMO_rev_2	301	307	PF00179	0.456
MOD_SUMO_rev_2	620	627	PF00179	0.453
MOD_SUMO_rev_2	63	68	PF00179	0.596
MOD_SUMO_rev_2	785	792	PF00179	0.403
TRG_DiLeu_BaEn_1	861	866	PF01217	0.679
TRG_DiLeu_BaEn_1	873	878	PF01217	0.472
TRG_DiLeu_BaEn_1	887	892	PF01217	0.510
TRG_DiLeu_BaEn_4	887	893	PF01217	0.513
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.544
TRG_DiLeu_BaLyEn_6	273	278	PF01217	0.647
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.594
TRG_ENDOCYTIC_2	390	393	PF00928	0.681
TRG_ENDOCYTIC_2	445	448	PF00928	0.720
TRG_ENDOCYTIC_2	535	538	PF00928	0.417
TRG_ENDOCYTIC_2	628	631	PF00928	0.553
TRG_ENDOCYTIC_2	700	703	PF00928	0.587
TRG_ENDOCYTIC_2	766	769	PF00928	0.483
TRG_ER_diArg_1	144	146	PF00400	0.632
TRG_ER_diArg_1	222	225	PF00400	0.559
TRG_ER_diArg_1	275	277	PF00400	0.683
TRG_ER_diArg_1	449	452	PF00400	0.660
TRG_ER_diArg_1	51	53	PF00400	0.634
TRG_ER_diArg_1	528	530	PF00400	0.424
TRG_ER_diArg_1	67	70	PF00400	0.534
TRG_ER_diArg_1	786	788	PF00400	0.455
TRG_NES_CRM1_1	620	635	PF08389	0.446
TRG_NLS_Bipartite_1	275	289	PF00514	0.529
TRG_NLS_Bipartite_1	52	70	PF00514	0.570
TRG_NLS_MonoExtN_4	394	399	PF00514	0.640
TRG_Pf-PMV_PEXEL_1	499	504	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	528	532	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	556	560	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	619	624	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC02	Leptomonas seymouri	43%	97%
A0A3S7X4E6	Leishmania donovani	99%	100%
A4HJ82	Leishmania braziliensis	62%	98%
E9B1P9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q6G1	Leishmania major	86%	100%