Uncharacterized protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I6M5_LEIIN

TriTrypDb:

LINF_310016200

Length:

751

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote: 556, 558

Expansion

Sequence features

A4I6M5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6M5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	353	359	PF00089	0.576
CLV_NRD_NRD_1	142	144	PF00675	0.419
CLV_NRD_NRD_1	151	153	PF00675	0.389
CLV_NRD_NRD_1	223	225	PF00675	0.534
CLV_NRD_NRD_1	237	239	PF00675	0.556
CLV_NRD_NRD_1	268	270	PF00675	0.608
CLV_NRD_NRD_1	284	286	PF00675	0.653
CLV_NRD_NRD_1	355	357	PF00675	0.590
CLV_NRD_NRD_1	493	495	PF00675	0.585
CLV_NRD_NRD_1	545	547	PF00675	0.497
CLV_NRD_NRD_1	552	554	PF00675	0.490
CLV_NRD_NRD_1	567	569	PF00675	0.508
CLV_NRD_NRD_1	614	616	PF00675	0.425
CLV_NRD_NRD_1	719	721	PF00675	0.402
CLV_NRD_NRD_1	726	728	PF00675	0.363
CLV_PCSK_FUR_1	22	26	PF00082	0.443
CLV_PCSK_KEX2_1	10	12	PF00082	0.362
CLV_PCSK_KEX2_1	142	144	PF00082	0.419
CLV_PCSK_KEX2_1	151	153	PF00082	0.389
CLV_PCSK_KEX2_1	223	225	PF00082	0.581
CLV_PCSK_KEX2_1	24	26	PF00082	0.481
CLV_PCSK_KEX2_1	268	270	PF00082	0.608
CLV_PCSK_KEX2_1	284	286	PF00082	0.637
CLV_PCSK_KEX2_1	355	357	PF00082	0.590
CLV_PCSK_KEX2_1	493	495	PF00082	0.566
CLV_PCSK_KEX2_1	545	547	PF00082	0.491
CLV_PCSK_KEX2_1	554	556	PF00082	0.477
CLV_PCSK_KEX2_1	567	569	PF00082	0.403
CLV_PCSK_KEX2_1	614	616	PF00082	0.444
CLV_PCSK_KEX2_1	719	721	PF00082	0.383
CLV_PCSK_KEX2_1	726	728	PF00082	0.372
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.403
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.379
CLV_PCSK_PC1ET2_1	554	556	PF00082	0.503
CLV_PCSK_SKI1_1	338	342	PF00082	0.603
CLV_PCSK_SKI1_1	635	639	PF00082	0.364
CLV_PCSK_SKI1_1	648	652	PF00082	0.385
CLV_PCSK_SKI1_1	7	11	PF00082	0.374
DEG_APCC_DBOX_1	179	187	PF00400	0.595
DEG_Nend_UBRbox_2	1	3	PF02207	0.692
DEG_SCF_FBW7_1	211	218	PF00400	0.631
DEG_SCF_FBW7_2	215	222	PF00400	0.625
DEG_SPOP_SBC_1	155	159	PF00917	0.665
DEG_SPOP_SBC_1	164	168	PF00917	0.510
DEG_SPOP_SBC_1	303	307	PF00917	0.446
DOC_ANK_TNKS_1	101	108	PF00023	0.724
DOC_CDC14_PxL_1	501	509	PF14671	0.359
DOC_CDC14_PxL_1	693	701	PF14671	0.587
DOC_CKS1_1	257	262	PF01111	0.335
DOC_CYCLIN_yCln2_LP_2	379	385	PF00134	0.419
DOC_MAPK_gen_1	22	32	PF00069	0.643
DOC_MAPK_gen_1	223	233	PF00069	0.625
DOC_MAPK_gen_1	355	363	PF00069	0.397
DOC_MAPK_gen_1	461	468	PF00069	0.381
DOC_MAPK_gen_1	493	499	PF00069	0.374
DOC_MAPK_gen_1	81	89	PF00069	0.541
DOC_MAPK_MEF2A_6	180	187	PF00069	0.565
DOC_MAPK_MEF2A_6	338	347	PF00069	0.357
DOC_MAPK_MEF2A_6	461	468	PF00069	0.387
DOC_MAPK_RevD_3	127	143	PF00069	0.563
DOC_MAPK_RevD_3	481	494	PF00069	0.374
DOC_PP1_RVXF_1	620	626	PF00149	0.624
DOC_PP2B_LxvP_1	379	382	PF13499	0.362
DOC_PP2B_LxvP_1	93	96	PF13499	0.601
DOC_PP2B_PxIxI_1	327	333	PF00149	0.318
DOC_PP4_FxxP_1	199	202	PF00568	0.627
DOC_USP7_MATH_1	105	109	PF00917	0.719
DOC_USP7_MATH_1	155	159	PF00917	0.668
DOC_USP7_MATH_1	242	246	PF00917	0.620
DOC_USP7_MATH_1	302	306	PF00917	0.490
DOC_USP7_MATH_1	370	374	PF00917	0.423
DOC_USP7_MATH_1	467	471	PF00917	0.339
DOC_USP7_MATH_1	573	577	PF00917	0.706
DOC_USP7_UBL2_3	644	648	PF12436	0.594
DOC_WW_Pin1_4	198	203	PF00397	0.634
DOC_WW_Pin1_4	211	216	PF00397	0.601
DOC_WW_Pin1_4	256	261	PF00397	0.359
DOC_WW_Pin1_4	304	309	PF00397	0.491
DOC_WW_Pin1_4	516	521	PF00397	0.312
DOC_WW_Pin1_4	555	560	PF00397	0.701
DOC_WW_Pin1_4	60	65	PF00397	0.624
DOC_WW_Pin1_4	738	743	PF00397	0.687
LIG_14-3-3_CanoR_1	151	160	PF00244	0.617
LIG_14-3-3_CanoR_1	180	186	PF00244	0.589
LIG_14-3-3_CanoR_1	224	233	PF00244	0.646
LIG_14-3-3_CanoR_1	25	33	PF00244	0.568
LIG_14-3-3_CanoR_1	268	276	PF00244	0.394
LIG_14-3-3_CanoR_1	380	386	PF00244	0.355
LIG_14-3-3_CanoR_1	45	51	PF00244	0.530
LIG_14-3-3_CanoR_1	553	559	PF00244	0.778
LIG_14-3-3_CanoR_1	666	673	PF00244	0.586
LIG_BIR_III_4	530	534	PF00653	0.727
LIG_BRCT_BRCA1_1	157	161	PF00533	0.592
LIG_eIF4E_1	181	187	PF01652	0.564
LIG_eIF4E_1	594	600	PF01652	0.512
LIG_eIF4E_1	693	699	PF01652	0.605
LIG_FHA_1	1	7	PF00498	0.660
LIG_FHA_1	129	135	PF00498	0.546
LIG_FHA_1	182	188	PF00498	0.588
LIG_FHA_1	244	250	PF00498	0.494
LIG_FHA_1	288	294	PF00498	0.402
LIG_FHA_1	348	354	PF00498	0.334
LIG_FHA_1	478	484	PF00498	0.372
LIG_FHA_1	593	599	PF00498	0.602
LIG_FHA_1	77	83	PF00498	0.602
LIG_FHA_2	151	157	PF00498	0.701
LIG_FHA_2	164	170	PF00498	0.519
LIG_FHA_2	339	345	PF00498	0.336
LIG_FHA_2	45	51	PF00498	0.700
LIG_FHA_2	455	461	PF00498	0.407
LIG_LIR_Apic_2	198	202	PF02991	0.626
LIG_LIR_Gen_1	158	165	PF02991	0.591
LIG_LIR_Gen_1	393	403	PF02991	0.300
LIG_LIR_Gen_1	423	433	PF02991	0.329
LIG_LIR_Gen_1	438	446	PF02991	0.343
LIG_LIR_Gen_1	450	459	PF02991	0.378
LIG_LIR_Gen_1	667	676	PF02991	0.600
LIG_LIR_Gen_1	690	701	PF02991	0.545
LIG_LIR_Nem_3	158	164	PF02991	0.591
LIG_LIR_Nem_3	270	276	PF02991	0.318
LIG_LIR_Nem_3	393	399	PF02991	0.299
LIG_LIR_Nem_3	423	429	PF02991	0.318
LIG_LIR_Nem_3	438	442	PF02991	0.337
LIG_LIR_Nem_3	496	501	PF02991	0.317
LIG_LIR_Nem_3	624	628	PF02991	0.576
LIG_LIR_Nem_3	633	639	PF02991	0.614
LIG_LIR_Nem_3	667	671	PF02991	0.590
LIG_LIR_Nem_3	690	696	PF02991	0.526
LIG_NRBOX	182	188	PF00104	0.565
LIG_NRBOX	398	404	PF00104	0.329
LIG_NRBOX	428	434	PF00104	0.314
LIG_PCNA_yPIPBox_3	81	93	PF02747	0.628
LIG_PDZ_Class_1	746	751	PF00595	0.632
LIG_Pex14_2	396	400	PF04695	0.356
LIG_PTB_Apo_2	652	659	PF02174	0.511
LIG_PTB_Phospho_1	652	658	PF10480	0.508
LIG_Rb_pABgroove_1	420	428	PF01858	0.326
LIG_SH2_CRK	426	430	PF00017	0.304
LIG_SH2_CRK	501	505	PF00017	0.345
LIG_SH2_CRK	668	672	PF00017	0.529
LIG_SH2_GRB2like	452	455	PF00017	0.443
LIG_SH2_NCK_1	387	391	PF00017	0.288
LIG_SH2_NCK_1	501	505	PF00017	0.361
LIG_SH2_NCK_1	668	672	PF00017	0.547
LIG_SH2_PTP2	439	442	PF00017	0.362
LIG_SH2_SRC	501	504	PF00017	0.268
LIG_SH2_SRC	69	72	PF00017	0.593
LIG_SH2_STAP1	426	430	PF00017	0.336
LIG_SH2_STAP1	594	598	PF00017	0.586
LIG_SH2_STAP1	659	663	PF00017	0.538
LIG_SH2_STAT5	12	15	PF00017	0.618
LIG_SH2_STAT5	439	442	PF00017	0.370
LIG_SH2_STAT5	452	455	PF00017	0.488
LIG_SH2_STAT5	594	597	PF00017	0.645
LIG_SH2_STAT5	636	639	PF00017	0.603
LIG_SH2_STAT5	69	72	PF00017	0.580
LIG_SH2_STAT5	693	696	PF00017	0.533
LIG_SH3_3	194	200	PF00018	0.577
LIG_SH3_3	254	260	PF00018	0.390
LIG_SH3_3	361	367	PF00018	0.402
LIG_SH3_3	514	520	PF00018	0.312
LIG_SH3_3	55	61	PF00018	0.717
LIG_SH3_3	704	710	PF00018	0.680
LIG_SH3_3	93	99	PF00018	0.605
LIG_SH3_5	710	714	PF00018	0.691
LIG_SUMO_SIM_anti_2	184	191	PF11976	0.613
LIG_SUMO_SIM_anti_2	344	350	PF11976	0.437
LIG_SUMO_SIM_anti_2	595	601	PF11976	0.549
LIG_SUMO_SIM_par_1	130	135	PF11976	0.629
LIG_SUMO_SIM_par_1	184	191	PF11976	0.548
LIG_SUMO_SIM_par_1	253	259	PF11976	0.351
LIG_TRAF2_1	741	744	PF00917	0.640
LIG_TYR_ITIM	499	504	PF00017	0.377
LIG_TYR_ITIM	592	597	PF00017	0.465
LIG_UBA3_1	293	301	PF00899	0.559
LIG_UBA3_1	399	404	PF00899	0.452
LIG_UBA3_1	698	704	PF00899	0.579
MOD_CDC14_SPxK_1	307	310	PF00782	0.559
MOD_CDK_SPxK_1	211	217	PF00069	0.541
MOD_CDK_SPxK_1	304	310	PF00069	0.572
MOD_CK1_1	100	106	PF00069	0.578
MOD_CK1_1	201	207	PF00069	0.720
MOD_CK1_1	306	312	PF00069	0.592
MOD_CK1_1	365	371	PF00069	0.608
MOD_CK1_1	450	456	PF00069	0.585
MOD_CK1_1	76	82	PF00069	0.594
MOD_CK2_1	100	106	PF00069	0.587
MOD_CK2_1	132	138	PF00069	0.477
MOD_CK2_1	150	156	PF00069	0.638
MOD_CK2_1	163	169	PF00069	0.498
MOD_CK2_1	338	344	PF00069	0.418
MOD_CK2_1	441	447	PF00069	0.379
MOD_CK2_1	467	473	PF00069	0.551
MOD_CK2_1	738	744	PF00069	0.573
MOD_DYRK1A_RPxSP_1	555	559	PF00069	0.634
MOD_GlcNHglycan	134	137	PF01048	0.466
MOD_GlcNHglycan	203	206	PF01048	0.669
MOD_GlcNHglycan	269	272	PF01048	0.362
MOD_GlcNHglycan	358	361	PF01048	0.695
MOD_GlcNHglycan	373	376	PF01048	0.586
MOD_GlcNHglycan	449	452	PF01048	0.659
MOD_GlcNHglycan	473	476	PF01048	0.489
MOD_GlcNHglycan	536	539	PF01048	0.671
MOD_GlcNHglycan	575	578	PF01048	0.663
MOD_GlcNHglycan	581	584	PF01048	0.705
MOD_GlcNHglycan	632	635	PF01048	0.552
MOD_GlcNHglycan	75	78	PF01048	0.485
MOD_GSK3_1	128	135	PF00069	0.488
MOD_GSK3_1	150	157	PF00069	0.641
MOD_GSK3_1	207	214	PF00069	0.716
MOD_GSK3_1	223	230	PF00069	0.730
MOD_GSK3_1	285	292	PF00069	0.494
MOD_GSK3_1	293	300	PF00069	0.510
MOD_GSK3_1	302	309	PF00069	0.670
MOD_GSK3_1	450	457	PF00069	0.494
MOD_GSK3_1	467	474	PF00069	0.308
MOD_GSK3_1	50	57	PF00069	0.581
MOD_GSK3_1	553	560	PF00069	0.639
MOD_GSK3_1	72	79	PF00069	0.645
MOD_N-GLC_1	592	597	PF02516	0.440
MOD_N-GLC_2	192	194	PF02516	0.520
MOD_NEK2_1	115	120	PF00069	0.554
MOD_NEK2_1	132	137	PF00069	0.313
MOD_NEK2_1	163	168	PF00069	0.486
MOD_NEK2_1	275	280	PF00069	0.431
MOD_NEK2_1	293	298	PF00069	0.303
MOD_NEK2_1	347	352	PF00069	0.387
MOD_NEK2_1	425	430	PF00069	0.398
MOD_NEK2_1	703	708	PF00069	0.586
MOD_NEK2_1	82	87	PF00069	0.555
MOD_NEK2_2	207	212	PF00069	0.618
MOD_NEK2_2	661	666	PF00069	0.473
MOD_PIKK_1	82	88	PF00454	0.506
MOD_PK_1	493	499	PF00069	0.452
MOD_PKA_1	151	157	PF00069	0.553
MOD_PKA_1	223	229	PF00069	0.647
MOD_PKA_1	24	30	PF00069	0.617
MOD_PKA_1	493	499	PF00069	0.452
MOD_PKA_1	553	559	PF00069	0.628
MOD_PKA_2	150	156	PF00069	0.593
MOD_PKA_2	223	229	PF00069	0.595
MOD_PKA_2	24	30	PF00069	0.593
MOD_PKA_2	267	273	PF00069	0.485
MOD_PKA_2	44	50	PF00069	0.394
MOD_PKA_2	493	499	PF00069	0.407
MOD_PKA_2	554	560	PF00069	0.649
MOD_PKA_2	630	636	PF00069	0.436
MOD_PKA_2	72	78	PF00069	0.483
MOD_PKB_1	551	559	PF00069	0.722
MOD_Plk_1	155	161	PF00069	0.549
MOD_Plk_1	243	249	PF00069	0.286
MOD_Plk_1	368	374	PF00069	0.515
MOD_Plk_1	468	474	PF00069	0.531
MOD_Plk_1	49	55	PF00069	0.642
MOD_Plk_1	592	598	PF00069	0.402
MOD_Plk_4	156	162	PF00069	0.377
MOD_Plk_4	181	187	PF00069	0.485
MOD_Plk_4	227	233	PF00069	0.508
MOD_Plk_4	289	295	PF00069	0.530
MOD_Plk_4	420	426	PF00069	0.383
MOD_Plk_4	428	434	PF00069	0.376
MOD_Plk_4	435	441	PF00069	0.345
MOD_Plk_4	493	499	PF00069	0.349
MOD_Plk_4	62	68	PF00069	0.467
MOD_Plk_4	703	709	PF00069	0.537
MOD_ProDKin_1	198	204	PF00069	0.557
MOD_ProDKin_1	211	217	PF00069	0.498
MOD_ProDKin_1	256	262	PF00069	0.359
MOD_ProDKin_1	304	310	PF00069	0.618
MOD_ProDKin_1	516	522	PF00069	0.312
MOD_ProDKin_1	555	561	PF00069	0.639
MOD_ProDKin_1	60	66	PF00069	0.520
MOD_ProDKin_1	738	744	PF00069	0.622
MOD_SUMO_rev_2	675	683	PF00179	0.469
TRG_DiLeu_BaEn_2	419	425	PF01217	0.327
TRG_DiLeu_BaEn_4	15	21	PF01217	0.395
TRG_DiLeu_BaEn_4	178	184	PF01217	0.400
TRG_DiLeu_BaLyEn_6	694	699	PF01217	0.536
TRG_ENDOCYTIC_2	426	429	PF00928	0.352
TRG_ENDOCYTIC_2	430	433	PF00928	0.391
TRG_ENDOCYTIC_2	439	442	PF00928	0.412
TRG_ENDOCYTIC_2	452	455	PF00928	0.470
TRG_ENDOCYTIC_2	501	504	PF00928	0.333
TRG_ENDOCYTIC_2	510	513	PF00928	0.354
TRG_ENDOCYTIC_2	594	597	PF00928	0.370
TRG_ENDOCYTIC_2	636	639	PF00928	0.496
TRG_ENDOCYTIC_2	668	671	PF00928	0.391
TRG_ENDOCYTIC_2	693	696	PF00928	0.404
TRG_ENDOCYTIC_2	729	732	PF00928	0.556
TRG_ER_diArg_1	101	104	PF00400	0.605
TRG_ER_diArg_1	283	285	PF00400	0.559
TRG_ER_diArg_1	355	357	PF00400	0.521
TRG_ER_diArg_1	461	464	PF00400	0.470
TRG_ER_diArg_1	492	494	PF00400	0.473
TRG_ER_diArg_1	544	546	PF00400	0.631
TRG_ER_diArg_1	567	569	PF00400	0.683
TRG_ER_diArg_1	613	615	PF00400	0.539
TRG_NES_CRM1_1	124	138	PF08389	0.417
TRG_NES_CRM1_1	344	354	PF08389	0.437
TRG_NLS_MonoExtN_4	223	228	PF00514	0.666
TRG_NLS_MonoExtN_4	551	557	PF00514	0.672
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	611	616	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P427	Leptomonas seymouri	59%	100%
A0A3R7LDE0	Trypanosoma rangeli	35%	100%
A0A3S7X4C5	Leishmania donovani	100%	100%
A4HJ81	Leishmania braziliensis	77%	100%
D0A0I5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B1P8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q9BHG4	Leishmania major	93%	100%
V5BX02	Trypanosoma cruzi	36%	100%