LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I6M4_LEIIN
TriTrypDb:
LINF_310016100
Length:
1121

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I6M4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6M4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 628 632 PF00656 0.513
CLV_C14_Caspase3-7 653 657 PF00656 0.703
CLV_C14_Caspase3-7 742 746 PF00656 0.676
CLV_C14_Caspase3-7 781 785 PF00656 0.640
CLV_NRD_NRD_1 1119 1121 PF00675 0.538
CLV_NRD_NRD_1 205 207 PF00675 0.472
CLV_NRD_NRD_1 240 242 PF00675 0.585
CLV_NRD_NRD_1 284 286 PF00675 0.444
CLV_NRD_NRD_1 397 399 PF00675 0.432
CLV_NRD_NRD_1 437 439 PF00675 0.458
CLV_NRD_NRD_1 5 7 PF00675 0.673
CLV_NRD_NRD_1 65 67 PF00675 0.498
CLV_NRD_NRD_1 803 805 PF00675 0.562
CLV_NRD_NRD_1 906 908 PF00675 0.554
CLV_PCSK_FUR_1 3 7 PF00082 0.669
CLV_PCSK_KEX2_1 1036 1038 PF00082 0.525
CLV_PCSK_KEX2_1 199 201 PF00082 0.504
CLV_PCSK_KEX2_1 205 207 PF00082 0.493
CLV_PCSK_KEX2_1 240 242 PF00082 0.585
CLV_PCSK_KEX2_1 284 286 PF00082 0.444
CLV_PCSK_KEX2_1 396 398 PF00082 0.466
CLV_PCSK_KEX2_1 437 439 PF00082 0.489
CLV_PCSK_KEX2_1 5 7 PF00082 0.722
CLV_PCSK_KEX2_1 65 67 PF00082 0.498
CLV_PCSK_KEX2_1 906 908 PF00082 0.583
CLV_PCSK_PC1ET2_1 1036 1038 PF00082 0.525
CLV_PCSK_PC1ET2_1 199 201 PF00082 0.504
CLV_PCSK_PC7_1 1032 1038 PF00082 0.509
CLV_PCSK_SKI1_1 1042 1046 PF00082 0.473
CLV_PCSK_SKI1_1 105 109 PF00082 0.412
CLV_PCSK_SKI1_1 132 136 PF00082 0.568
CLV_PCSK_SKI1_1 205 209 PF00082 0.455
CLV_PCSK_SKI1_1 284 288 PF00082 0.446
CLV_PCSK_SKI1_1 355 359 PF00082 0.421
CLV_PCSK_SKI1_1 447 451 PF00082 0.488
CLV_PCSK_SKI1_1 465 469 PF00082 0.208
CLV_PCSK_SKI1_1 507 511 PF00082 0.452
CLV_PCSK_SKI1_1 518 522 PF00082 0.442
CLV_PCSK_SKI1_1 810 814 PF00082 0.769
CLV_PCSK_SKI1_1 877 881 PF00082 0.588
DEG_APCC_DBOX_1 283 291 PF00400 0.347
DEG_APCC_DBOX_1 446 454 PF00400 0.534
DEG_APCC_DBOX_1 513 521 PF00400 0.551
DEG_APCC_DBOX_1 999 1007 PF00400 0.518
DEG_Nend_Nbox_1 1 3 PF02207 0.668
DEG_SCF_FBW7_1 34 41 PF00400 0.495
DEG_SCF_FBW7_2 304 311 PF00400 0.691
DEG_SCF_TRCP1_1 941 946 PF00400 0.559
DEG_SPOP_SBC_1 290 294 PF00917 0.551
DOC_CKS1_1 250 255 PF01111 0.630
DOC_CKS1_1 35 40 PF01111 0.600
DOC_CKS1_1 583 588 PF01111 0.585
DOC_CKS1_1 92 97 PF01111 0.446
DOC_CYCLIN_RxL_1 426 436 PF00134 0.464
DOC_CYCLIN_RxL_1 501 512 PF00134 0.553
DOC_CYCLIN_RxL_1 99 112 PF00134 0.441
DOC_CYCLIN_yCln2_LP_2 92 98 PF00134 0.446
DOC_MAPK_gen_1 1036 1043 PF00069 0.495
DOC_MAPK_gen_1 272 280 PF00069 0.391
DOC_MAPK_gen_1 437 445 PF00069 0.580
DOC_MAPK_gen_1 514 522 PF00069 0.551
DOC_MAPK_gen_1 866 875 PF00069 0.534
DOC_MAPK_MEF2A_6 1036 1045 PF00069 0.577
DOC_PP1_RVXF_1 1040 1046 PF00149 0.469
DOC_PP1_RVXF_1 1109 1115 PF00149 0.445
DOC_PP1_RVXF_1 270 277 PF00149 0.386
DOC_PP1_RVXF_1 445 452 PF00149 0.530
DOC_PP1_RVXF_1 505 512 PF00149 0.555
DOC_PP2B_LxvP_1 443 446 PF13499 0.545
DOC_USP7_MATH_1 1057 1061 PF00917 0.362
DOC_USP7_MATH_1 228 232 PF00917 0.528
DOC_USP7_MATH_1 27 31 PF00917 0.700
DOC_USP7_MATH_1 38 42 PF00917 0.598
DOC_USP7_MATH_1 473 477 PF00917 0.504
DOC_USP7_MATH_1 573 577 PF00917 0.613
DOC_USP7_MATH_1 590 594 PF00917 0.679
DOC_USP7_MATH_1 649 653 PF00917 0.695
DOC_USP7_MATH_1 752 756 PF00917 0.546
DOC_USP7_MATH_1 871 875 PF00917 0.757
DOC_USP7_MATH_1 886 890 PF00917 0.527
DOC_USP7_MATH_1 918 922 PF00917 0.756
DOC_USP7_MATH_1 939 943 PF00917 0.641
DOC_USP7_UBL2_3 1107 1111 PF12436 0.512
DOC_USP7_UBL2_3 322 326 PF12436 0.369
DOC_USP7_UBL2_3 806 810 PF12436 0.723
DOC_USP7_UBL2_3 813 817 PF12436 0.666
DOC_USP7_UBL2_3 830 834 PF12436 0.747
DOC_USP7_UBL2_3 9 13 PF12436 0.628
DOC_USP7_UBL2_3 977 981 PF12436 0.684
DOC_WW_Pin1_4 100 105 PF00397 0.462
DOC_WW_Pin1_4 249 254 PF00397 0.674
DOC_WW_Pin1_4 299 304 PF00397 0.749
DOC_WW_Pin1_4 312 317 PF00397 0.632
DOC_WW_Pin1_4 34 39 PF00397 0.611
DOC_WW_Pin1_4 582 587 PF00397 0.581
DOC_WW_Pin1_4 91 96 PF00397 0.434
LIG_14-3-3_CanoR_1 1000 1004 PF00244 0.523
LIG_14-3-3_CanoR_1 1032 1039 PF00244 0.483
LIG_14-3-3_CanoR_1 241 247 PF00244 0.616
LIG_14-3-3_CanoR_1 366 375 PF00244 0.464
LIG_14-3-3_CanoR_1 421 431 PF00244 0.570
LIG_14-3-3_CanoR_1 472 481 PF00244 0.393
LIG_14-3-3_CanoR_1 572 579 PF00244 0.676
LIG_14-3-3_CanoR_1 678 686 PF00244 0.651
LIG_Actin_WH2_2 273 290 PF00022 0.404
LIG_Actin_WH2_2 474 489 PF00022 0.487
LIG_APCC_ABBAyCdc20_2 39 45 PF00400 0.437
LIG_BIR_III_2 589 593 PF00653 0.583
LIG_Clathr_ClatBox_1 358 362 PF01394 0.419
LIG_Clathr_ClatBox_1 467 471 PF01394 0.413
LIG_EH1_1 81 89 PF00400 0.522
LIG_eIF4E_1 102 108 PF01652 0.429
LIG_FHA_1 1025 1031 PF00498 0.439
LIG_FHA_1 1098 1104 PF00498 0.470
LIG_FHA_1 176 182 PF00498 0.529
LIG_FHA_1 316 322 PF00498 0.664
LIG_FHA_1 332 338 PF00498 0.342
LIG_FHA_1 426 432 PF00498 0.471
LIG_FHA_1 544 550 PF00498 0.382
LIG_FHA_1 583 589 PF00498 0.691
LIG_FHA_1 678 684 PF00498 0.769
LIG_FHA_1 932 938 PF00498 0.708
LIG_FHA_2 101 107 PF00498 0.444
LIG_FHA_2 170 176 PF00498 0.536
LIG_FHA_2 246 252 PF00498 0.604
LIG_FHA_2 296 302 PF00498 0.638
LIG_FHA_2 648 654 PF00498 0.670
LIG_FHA_2 858 864 PF00498 0.745
LIG_FHA_2 918 924 PF00498 0.701
LIG_FHA_2 959 965 PF00498 0.601
LIG_LIR_Apic_2 30 35 PF02991 0.530
LIG_LIR_Apic_2 51 56 PF02991 0.531
LIG_LIR_Apic_2 673 679 PF02991 0.595
LIG_LIR_Gen_1 178 188 PF02991 0.441
LIG_LIR_Gen_1 666 674 PF02991 0.658
LIG_LIR_Nem_3 227 232 PF02991 0.428
LIG_LIR_Nem_3 267 273 PF02991 0.393
LIG_LIR_Nem_3 329 333 PF02991 0.476
LIG_LIR_Nem_3 373 379 PF02991 0.470
LIG_LIR_Nem_3 54 60 PF02991 0.452
LIG_LIR_Nem_3 666 671 PF02991 0.679
LIG_LIR_Nem_3 738 743 PF02991 0.679
LIG_MYND_3 144 148 PF01753 0.453
LIG_NRBOX 1002 1008 PF00104 0.603
LIG_PCNA_PIPBox_1 144 153 PF02747 0.446
LIG_PCNA_PIPBox_1 706 715 PF02747 0.530
LIG_PTB_Apo_2 67 74 PF02174 0.476
LIG_PTB_Phospho_1 67 73 PF10480 0.477
LIG_SH2_CRK 271 275 PF00017 0.389
LIG_SH2_CRK 376 380 PF00017 0.460
LIG_SH2_CRK 53 57 PF00017 0.456
LIG_SH2_NCK_1 376 380 PF00017 0.460
LIG_SH2_NCK_1 53 57 PF00017 0.456
LIG_SH2_STAP1 109 113 PF00017 0.363
LIG_SH2_STAP1 60 64 PF00017 0.591
LIG_SH2_STAP1 73 77 PF00017 0.352
LIG_SH2_STAT3 60 63 PF00017 0.495
LIG_SH2_STAT5 102 105 PF00017 0.446
LIG_SH2_STAT5 333 336 PF00017 0.467
LIG_SH2_STAT5 485 488 PF00017 0.507
LIG_SH2_STAT5 53 56 PF00017 0.444
LIG_SH3_1 32 38 PF00018 0.629
LIG_SH3_3 139 145 PF00018 0.471
LIG_SH3_3 247 253 PF00018 0.620
LIG_SH3_3 32 38 PF00018 0.674
LIG_SH3_3 567 573 PF00018 0.609
LIG_SH3_3 948 954 PF00018 0.658
LIG_SUMO_SIM_anti_2 1090 1095 PF11976 0.484
LIG_SUMO_SIM_par_1 1026 1031 PF11976 0.436
LIG_SUMO_SIM_par_1 276 281 PF11976 0.494
LIG_SUMO_SIM_par_1 427 434 PF11976 0.516
LIG_SUMO_SIM_par_1 466 471 PF11976 0.375
LIG_TRAF2_1 405 408 PF00917 0.510
LIG_TRAF2_1 575 578 PF00917 0.771
LIG_TRAF2_1 659 662 PF00917 0.742
LIG_TRAF2_1 670 673 PF00917 0.569
LIG_TRAF2_1 727 730 PF00917 0.676
LIG_TRAF2_1 778 781 PF00917 0.672
LIG_TRAF2_1 850 853 PF00917 0.645
LIG_TRAF2_1 854 857 PF00917 0.651
LIG_TRAF2_1 920 923 PF00917 0.631
LIG_TYR_ITSM 225 232 PF00017 0.423
LIG_WRC_WIRS_1 147 152 PF05994 0.441
LIG_WRC_WIRS_1 177 182 PF05994 0.435
MOD_CDK_SPK_2 100 105 PF00069 0.462
MOD_CDK_SPK_2 249 254 PF00069 0.446
MOD_CDK_SPK_2 34 39 PF00069 0.523
MOD_CK1_1 1092 1098 PF00069 0.497
MOD_CK1_1 169 175 PF00069 0.479
MOD_CK1_1 231 237 PF00069 0.544
MOD_CK1_1 245 251 PF00069 0.512
MOD_CK1_1 537 543 PF00069 0.471
MOD_CK1_1 911 917 PF00069 0.675
MOD_CK2_1 100 106 PF00069 0.460
MOD_CK2_1 1023 1029 PF00069 0.462
MOD_CK2_1 198 204 PF00069 0.512
MOD_CK2_1 295 301 PF00069 0.600
MOD_CK2_1 402 408 PF00069 0.522
MOD_CK2_1 528 534 PF00069 0.489
MOD_CK2_1 565 571 PF00069 0.655
MOD_CK2_1 572 578 PF00069 0.685
MOD_CK2_1 847 853 PF00069 0.560
MOD_CK2_1 857 863 PF00069 0.532
MOD_CK2_1 917 923 PF00069 0.726
MOD_CK2_1 958 964 PF00069 0.587
MOD_Cter_Amidation 3 6 PF01082 0.670
MOD_Cter_Amidation 828 831 PF01082 0.642
MOD_GlcNHglycan 17 20 PF01048 0.691
MOD_GlcNHglycan 200 203 PF01048 0.581
MOD_GlcNHglycan 382 385 PF01048 0.495
MOD_GlcNHglycan 539 542 PF01048 0.471
MOD_GlcNHglycan 690 695 PF01048 0.641
MOD_GlcNHglycan 847 852 PF01048 0.590
MOD_GlcNHglycan 913 916 PF01048 0.667
MOD_GlcNHglycan 940 944 PF01048 0.678
MOD_GlcNHglycan 945 948 PF01048 0.734
MOD_GlcNHglycan 978 981 PF01048 0.774
MOD_GSK3_1 1106 1113 PF00069 0.546
MOD_GSK3_1 166 173 PF00069 0.422
MOD_GSK3_1 224 231 PF00069 0.424
MOD_GSK3_1 245 252 PF00069 0.485
MOD_GSK3_1 291 298 PF00069 0.536
MOD_GSK3_1 299 306 PF00069 0.688
MOD_GSK3_1 331 338 PF00069 0.527
MOD_GSK3_1 34 41 PF00069 0.610
MOD_GSK3_1 420 427 PF00069 0.487
MOD_GSK3_1 471 478 PF00069 0.440
MOD_GSK3_1 539 546 PF00069 0.512
MOD_GSK3_1 83 90 PF00069 0.498
MOD_GSK3_1 939 946 PF00069 0.642
MOD_LATS_1 969 975 PF00433 0.550
MOD_N-GLC_1 1097 1102 PF02516 0.535
MOD_N-GLC_1 126 131 PF02516 0.455
MOD_N-GLC_1 366 371 PF02516 0.459
MOD_NEK2_1 1023 1028 PF00069 0.463
MOD_NEK2_1 1030 1035 PF00069 0.471
MOD_NEK2_1 1067 1072 PF00069 0.471
MOD_NEK2_1 1094 1099 PF00069 0.472
MOD_NEK2_1 208 213 PF00069 0.450
MOD_NEK2_1 420 425 PF00069 0.488
MOD_NEK2_1 451 456 PF00069 0.453
MOD_NEK2_1 500 505 PF00069 0.494
MOD_NEK2_1 543 548 PF00069 0.405
MOD_NEK2_1 59 64 PF00069 0.480
MOD_NEK2_1 618 623 PF00069 0.620
MOD_NEK2_1 629 634 PF00069 0.585
MOD_NEK2_1 647 652 PF00069 0.440
MOD_NEK2_2 38 43 PF00069 0.429
MOD_PIKK_1 233 239 PF00454 0.500
MOD_PIKK_1 422 428 PF00454 0.446
MOD_PIKK_1 565 571 PF00454 0.717
MOD_PIKK_1 59 65 PF00454 0.504
MOD_PIKK_1 857 863 PF00454 0.548
MOD_PIKK_1 87 93 PF00454 0.302
MOD_PK_1 83 89 PF00069 0.419
MOD_PKA_1 5 11 PF00069 0.720
MOD_PKA_1 976 982 PF00069 0.691
MOD_PKA_2 1031 1037 PF00069 0.488
MOD_PKA_2 365 371 PF00069 0.454
MOD_PKA_2 420 426 PF00069 0.456
MOD_PKA_2 471 477 PF00069 0.402
MOD_PKA_2 5 11 PF00069 0.663
MOD_PKA_2 677 683 PF00069 0.680
MOD_PKA_2 999 1005 PF00069 0.531
MOD_PKB_1 3 11 PF00069 0.669
MOD_Plk_1 1089 1095 PF00069 0.484
MOD_Plk_1 126 132 PF00069 0.519
MOD_Plk_1 441 447 PF00069 0.501
MOD_Plk_1 451 457 PF00069 0.415
MOD_Plk_1 562 568 PF00069 0.624
MOD_Plk_1 700 706 PF00069 0.534
MOD_Plk_1 857 863 PF00069 0.685
MOD_Plk_1 871 877 PF00069 0.689
MOD_Plk_2-3 1024 1030 PF00069 0.438
MOD_Plk_4 1089 1095 PF00069 0.484
MOD_Plk_4 1110 1116 PF00069 0.420
MOD_Plk_4 146 152 PF00069 0.442
MOD_Plk_4 157 163 PF00069 0.404
MOD_Plk_4 176 182 PF00069 0.328
MOD_Plk_4 27 33 PF00069 0.529
MOD_Plk_4 534 540 PF00069 0.477
MOD_Plk_4 83 89 PF00069 0.519
MOD_ProDKin_1 100 106 PF00069 0.460
MOD_ProDKin_1 249 255 PF00069 0.670
MOD_ProDKin_1 299 305 PF00069 0.753
MOD_ProDKin_1 312 318 PF00069 0.627
MOD_ProDKin_1 34 40 PF00069 0.599
MOD_ProDKin_1 582 588 PF00069 0.582
MOD_ProDKin_1 91 97 PF00069 0.443
MOD_SUMO_for_1 645 648 PF00179 0.480
MOD_SUMO_for_1 750 753 PF00179 0.730
MOD_SUMO_rev_2 191 201 PF00179 0.523
MOD_SUMO_rev_2 531 538 PF00179 0.448
MOD_SUMO_rev_2 610 618 PF00179 0.525
TRG_DiLeu_BaEn_1 204 209 PF01217 0.586
TRG_DiLeu_BaEn_1 534 539 PF01217 0.445
TRG_DiLeu_BaEn_4 882 888 PF01217 0.669
TRG_DiLeu_BaLyEn_6 1002 1007 PF01217 0.518
TRG_ENDOCYTIC_2 229 232 PF00928 0.431
TRG_ENDOCYTIC_2 271 274 PF00928 0.389
TRG_ENDOCYTIC_2 376 379 PF00928 0.461
TRG_ER_diArg_1 2 5 PF00400 0.671
TRG_ER_diArg_1 239 241 PF00400 0.586
TRG_ER_diArg_1 396 398 PF00400 0.438
TRG_ER_diArg_1 513 516 PF00400 0.463
TRG_ER_diArg_1 65 67 PF00400 0.502
TRG_NES_CRM1_1 512 526 PF08389 0.553
TRG_Pf-PMV_PEXEL_1 1005 1010 PF00026 0.507
TRG_Pf-PMV_PEXEL_1 572 577 PF00026 0.676
TRG_Pf-PMV_PEXEL_1 75 80 PF00026 0.548

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HU54 Leptomonas seymouri 47% 96%
A0A3S7X4E0 Leishmania donovani 100% 100%
A4HJ80 Leishmania braziliensis 66% 98%
E9B1P7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4Q6G3 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS