LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I6L6_LEIIN
TriTrypDb:
LINF_310014800 *
Length:
76

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 2, no: 7
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A4I6L6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6L6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 46 48 PF00082 0.629
CLV_PCSK_PC1ET2_1 46 48 PF00082 0.717
DEG_Nend_UBRbox_3 1 3 PF02207 0.513
DOC_MAPK_gen_1 46 53 PF00069 0.446
DOC_MAPK_JIP1_4 47 53 PF00069 0.451
DOC_MAPK_MEF2A_6 20 28 PF00069 0.524
DOC_MAPK_RevD_3 32 47 PF00069 0.381
DOC_PP2B_LxvP_1 51 54 PF13499 0.465
DOC_USP7_MATH_1 16 20 PF00917 0.696
DOC_USP7_MATH_1 61 65 PF00917 0.537
LIG_FHA_2 58 64 PF00498 0.571
LIG_LIR_Nem_3 21 26 PF02991 0.629
LIG_PDZ_Class_3 71 76 PF00595 0.592
LIG_Pex14_2 23 27 PF04695 0.523
LIG_SH2_STAT5 42 45 PF00017 0.474
LIG_TRAF2_1 19 22 PF00917 0.731
MOD_CK2_1 16 22 PF00069 0.657
MOD_CK2_1 57 63 PF00069 0.526
MOD_CK2_1 68 74 PF00069 0.541
MOD_GSK3_1 53 60 PF00069 0.469
MOD_NEK2_1 30 35 PF00069 0.381
MOD_Plk_4 53 59 PF00069 0.514

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IF91 Leishmania donovani 100% 96%
A0A3S7X498 Leishmania donovani 96% 96%
A4HJ65 Leishmania braziliensis 88% 100%
A4I6M0 Leishmania infantum 96% 96%
D0A7A1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 71%
E9B1P1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q9BHG9 Leishmania major 97% 100%
V5AXX0 Trypanosoma cruzi 62% 78%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS