LeishMANIAdb
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Mevalonate kinase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mevalonate kinase
Gene product:
mevalonate kinase - putative
Species:
Leishmania infantum
UniProt:
A4I6L2_LEIIN
TriTrypDb:
LINF_310011000
Length:
329

Annotations

Annotations by Jardim et al.

Sterol metabolism/biosynthesis, mevalonate kinase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 10
GO:0110165 cellular anatomical entity 1 11
GO:0005777 peroxisome 6 1
GO:0005829 cytosol 2 1
GO:0020015 glycosome 7 1
GO:0042579 microbody 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I6L2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6L2

PDB structure(s): 2hfs_A , 2hfs_B , 2hfu_A , 2hfu_B

Function

Biological processes
Term Name Level Count
GO:0006084 acetyl-CoA metabolic process 5 11
GO:0006139 nucleobase-containing compound metabolic process 3 11
GO:0006163 purine nucleotide metabolic process 5 11
GO:0006629 lipid metabolic process 3 11
GO:0006637 acyl-CoA metabolic process 4 11
GO:0006644 phospholipid metabolic process 4 11
GO:0006694 steroid biosynthetic process 5 11
GO:0006725 cellular aromatic compound metabolic process 3 11
GO:0006753 nucleoside phosphate metabolic process 4 11
GO:0006790 sulfur compound metabolic process 3 11
GO:0006793 phosphorus metabolic process 3 11
GO:0006796 phosphate-containing compound metabolic process 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0008202 steroid metabolic process 4 11
GO:0008610 lipid biosynthetic process 4 11
GO:0008654 phospholipid biosynthetic process 5 11
GO:0009058 biosynthetic process 2 11
GO:0009117 nucleotide metabolic process 5 11
GO:0009150 purine ribonucleotide metabolic process 6 11
GO:0009240 isopentenyl diphosphate biosynthetic process 6 11
GO:0009259 ribonucleotide metabolic process 5 11
GO:0009987 cellular process 1 11
GO:0016125 sterol metabolic process 4 11
GO:0016126 sterol biosynthetic process 5 11
GO:0016310 phosphorylation 5 11
GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway 6 11
GO:0019637 organophosphate metabolic process 3 11
GO:0019693 ribose phosphate metabolic process 4 11
GO:0033865 nucleoside bisphosphate metabolic process 5 11
GO:0033875 ribonucleoside bisphosphate metabolic process 6 11
GO:0034032 purine nucleoside bisphosphate metabolic process 5 11
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0035383 thioester metabolic process 3 11
GO:0043603 amide metabolic process 3 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044255 cellular lipid metabolic process 3 11
GO:0044281 small molecule metabolic process 2 11
GO:0046483 heterocycle metabolic process 3 11
GO:0046490 isopentenyl diphosphate metabolic process 5 11
GO:0055086 nucleobase-containing small molecule metabolic process 3 11
GO:0071704 organic substance metabolic process 2 11
GO:0072521 purine-containing compound metabolic process 4 11
GO:0090407 organophosphate biosynthetic process 4 11
GO:1901135 carbohydrate derivative metabolic process 3 11
GO:1901360 organic cyclic compound metabolic process 3 11
GO:1901362 organic cyclic compound biosynthetic process 4 11
GO:1901564 organonitrogen compound metabolic process 3 11
GO:1901576 organic substance biosynthetic process 3 11
GO:1901615 organic hydroxy compound metabolic process 3 11
GO:1901617 organic hydroxy compound biosynthetic process 4 11
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0004496 mevalonate kinase activity 5 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016301 kinase activity 4 11
GO:0016740 transferase activity 2 11
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 11
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 152 156 PF00656 0.385
CLV_C14_Caspase3-7 297 301 PF00656 0.470
CLV_NRD_NRD_1 168 170 PF00675 0.340
CLV_NRD_NRD_1 6 8 PF00675 0.407
CLV_PCSK_KEX2_1 168 170 PF00082 0.340
CLV_PCSK_KEX2_1 217 219 PF00082 0.343
CLV_PCSK_KEX2_1 6 8 PF00082 0.430
CLV_PCSK_KEX2_1 71 73 PF00082 0.351
CLV_PCSK_PC1ET2_1 217 219 PF00082 0.343
CLV_PCSK_PC1ET2_1 6 8 PF00082 0.303
CLV_PCSK_PC1ET2_1 71 73 PF00082 0.380
CLV_PCSK_SKI1_1 173 177 PF00082 0.330
CLV_PCSK_SKI1_1 18 22 PF00082 0.244
CLV_PCSK_SKI1_1 231 235 PF00082 0.251
CLV_PCSK_SKI1_1 3 7 PF00082 0.463
CLV_PCSK_SKI1_1 304 308 PF00082 0.286
DEG_APCC_DBOX_1 183 191 PF00400 0.278
DEG_APCC_DBOX_1 91 99 PF00400 0.231
DOC_MAPK_MEF2A_6 285 292 PF00069 0.385
DOC_PP1_RVXF_1 16 23 PF00149 0.251
DOC_PP1_RVXF_1 175 182 PF00149 0.437
DOC_USP7_MATH_1 111 115 PF00917 0.385
DOC_USP7_MATH_1 293 297 PF00917 0.461
DOC_USP7_UBL2_3 173 177 PF12436 0.404
DOC_USP7_UBL2_3 8 12 PF12436 0.461
DOC_WW_Pin1_4 147 152 PF00397 0.385
LIG_14-3-3_CanoR_1 121 129 PF00244 0.416
LIG_14-3-3_CanoR_1 318 322 PF00244 0.318
LIG_14-3-3_CanoR_1 7 14 PF00244 0.295
LIG_APCC_ABBA_1 19 24 PF00400 0.240
LIG_APCC_ABBAyCdc20_2 18 24 PF00400 0.241
LIG_eIF4E_1 16 22 PF01652 0.326
LIG_FHA_1 196 202 PF00498 0.373
LIG_FHA_1 222 228 PF00498 0.448
LIG_FHA_2 130 136 PF00498 0.405
LIG_LIR_Gen_1 221 230 PF02991 0.350
LIG_LIR_Nem_3 160 164 PF02991 0.403
LIG_LIR_Nem_3 174 179 PF02991 0.304
LIG_LIR_Nem_3 221 226 PF02991 0.369
LIG_LIR_Nem_3 272 276 PF02991 0.465
LIG_PDZ_Class_1 324 329 PF00595 0.416
LIG_Pex14_2 22 26 PF04695 0.256
LIG_SH2_CRK 16 20 PF00017 0.332
LIG_SH2_CRK 161 165 PF00017 0.425
LIG_SH2_CRK 273 277 PF00017 0.479
LIG_SH2_GRB2like 220 223 PF00017 0.404
LIG_SH2_STAP1 223 227 PF00017 0.412
LIG_SH2_STAT3 319 322 PF00017 0.401
LIG_SH2_STAT3 67 70 PF00017 0.465
LIG_SH2_STAT5 186 189 PF00017 0.286
LIG_SH2_STAT5 223 226 PF00017 0.424
LIG_SH2_STAT5 319 322 PF00017 0.357
LIG_SH2_STAT5 41 44 PF00017 0.260
LIG_SH2_STAT5 67 70 PF00017 0.352
LIG_SH3_3 47 53 PF00018 0.410
LIG_SH3_3 59 65 PF00018 0.264
LIG_SH3_3 99 105 PF00018 0.292
LIG_SUMO_SIM_par_1 186 192 PF11976 0.319
LIG_TRAF2_1 132 135 PF00917 0.465
LIG_TYR_ITIM 14 19 PF00017 0.333
MOD_CK1_1 39 45 PF00069 0.325
MOD_CK2_1 129 135 PF00069 0.465
MOD_CK2_1 256 262 PF00069 0.385
MOD_GlcNHglycan 106 109 PF01048 0.161
MOD_GlcNHglycan 111 114 PF01048 0.185
MOD_GlcNHglycan 138 141 PF01048 0.193
MOD_GlcNHglycan 151 154 PF01048 0.183
MOD_GlcNHglycan 173 176 PF01048 0.420
MOD_GlcNHglycan 280 283 PF01048 0.185
MOD_GSK3_1 117 124 PF00069 0.427
MOD_GSK3_1 221 228 PF00069 0.481
MOD_GSK3_1 262 269 PF00069 0.499
MOD_GSK3_1 317 324 PF00069 0.425
MOD_N-GLC_1 129 134 PF02516 0.217
MOD_N-GLC_1 136 141 PF02516 0.178
MOD_N-GLC_1 194 199 PF02516 0.485
MOD_N-GLC_1 221 226 PF02516 0.347
MOD_NEK2_1 280 285 PF00069 0.385
MOD_OFUCOSY 253 260 PF10250 0.213
MOD_PIKK_1 225 231 PF00454 0.368
MOD_PKA_1 6 12 PF00069 0.348
MOD_PKA_2 317 323 PF00069 0.321
MOD_PKA_2 6 12 PF00069 0.318
MOD_Plk_1 136 142 PF00069 0.398
MOD_Plk_1 221 227 PF00069 0.342
MOD_Plk_4 262 268 PF00069 0.473
MOD_ProDKin_1 147 153 PF00069 0.385
TRG_ENDOCYTIC_2 16 19 PF00928 0.331
TRG_ENDOCYTIC_2 161 164 PF00928 0.425
TRG_ENDOCYTIC_2 186 189 PF00928 0.286
TRG_ENDOCYTIC_2 223 226 PF00928 0.365
TRG_ENDOCYTIC_2 273 276 PF00928 0.479
TRG_ER_diArg_1 167 169 PF00400 0.309
TRG_NLS_MonoExtN_4 3 10 PF00514 0.304
TRG_Pf-PMV_PEXEL_1 121 125 PF00026 0.213

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PE67 Leptomonas seymouri 78% 100%
A0A0S4KH54 Bodo saltans 60% 98%
A0A1D8PEL1 Candida albicans (strain SC5314 / ATCC MYA-2876) 24% 76%
A0A1X0NJ39 Trypanosomatidae 63% 100%
A0A3R7M8L1 Trypanosoma rangeli 60% 100%
A0A3S7X459 Leishmania donovani 100% 100%
A4HJ34 Leishmania braziliensis 87% 100%
B6YST1 Thermococcus onnurineus (strain NA1) 32% 99%
C5A7L8 Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3) 34% 99%
C6A3T5 Thermococcus sibiricus (strain DSM 12597 / MM 739) 32% 99%
C9ZN67 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 61% 100%
E9B1K6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
O27995 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 28% 100%
O58107 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) 27% 94%
O59291 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) 33% 98%
P07277 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 74%
P46086 Arabidopsis thaliana 25% 87%
Q03426 Homo sapiens 27% 83%
Q03PA8 Levilactobacillus brevis (strain ATCC 367 / BCRC 12310 / CIP 105137 / JCM 1170 / LMG 11437 / NCIMB 947 / NCTC 947) 25% 85%
Q09780 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 27% 81%
Q4Q6K7 Leishmania major 97% 100%
Q50559 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 30% 100%
Q58487 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 28% 100%
Q5E9T8 Bos taurus 25% 83%
Q5JEK8 Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) 30% 94%
Q5JJC6 Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) 33% 98%
Q86AG7 Dictyostelium discoideum 23% 84%
Q8U0F3 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 33% 99%
Q980D2 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 28% 100%
Q9HHB6 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 27% 93%
Q9R008 Mus musculus 27% 83%
Q9V187 Pyrococcus abyssi (strain GE5 / Orsay) 31% 98%
Q9Y946 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS