tRNA:m(4)X modification enzyme TRM13

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CCCH zinc finger in TRM13 protein/U11-48K-like CHHC zinc finger/Methyltransferase TRM13 - putative

Species:

Leishmania infantum

UniProt:

A4I6K9_LEIIN

TriTrypDb:

LINF_310010600

Length:

626

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I6K9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6K9

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008033	tRNA processing	8	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0030488	tRNA methylation	5	1
GO:0032259	methylation	2	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008171	O-methyltransferase activity	5	12
GO:0008173	RNA methyltransferase activity	4	12
GO:0008175	tRNA methyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0062105	RNA 2'-O-methyltransferase activity	5	12
GO:0106050	tRNA 2'-O-methyltransferase activity	6	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140101	catalytic activity, acting on a tRNA	4	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	231	233	PF00675	0.500
CLV_NRD_NRD_1	40	42	PF00675	0.498
CLV_NRD_NRD_1	419	421	PF00675	0.219
CLV_NRD_NRD_1	49	51	PF00675	0.430
CLV_NRD_NRD_1	577	579	PF00675	0.278
CLV_NRD_NRD_1	581	583	PF00675	0.278
CLV_NRD_NRD_1	76	78	PF00675	0.578
CLV_NRD_NRD_1	99	101	PF00675	0.250
CLV_PCSK_KEX2_1	40	42	PF00082	0.497
CLV_PCSK_KEX2_1	419	421	PF00082	0.212
CLV_PCSK_KEX2_1	49	51	PF00082	0.416
CLV_PCSK_KEX2_1	577	579	PF00082	0.225
CLV_PCSK_KEX2_1	585	587	PF00082	0.196
CLV_PCSK_PC1ET2_1	585	587	PF00082	0.216
CLV_PCSK_SKI1_1	136	140	PF00082	0.593
CLV_PCSK_SKI1_1	171	175	PF00082	0.253
CLV_PCSK_SKI1_1	180	184	PF00082	0.386
CLV_PCSK_SKI1_1	378	382	PF00082	0.228
CLV_PCSK_SKI1_1	41	45	PF00082	0.496
CLV_PCSK_SKI1_1	447	451	PF00082	0.260
CLV_PCSK_SKI1_1	50	54	PF00082	0.423
CLV_PCSK_SKI1_1	611	615	PF00082	0.257
DEG_APCC_DBOX_1	406	414	PF00400	0.481
DEG_APCC_DBOX_1	446	454	PF00400	0.546
DEG_APCC_DBOX_1	49	57	PF00400	0.428
DEG_APCC_DBOX_1	523	531	PF00400	0.436
DEG_SCF_FBW7_1	389	395	PF00400	0.371
DEG_SCF_FBW7_2	128	135	PF00400	0.512
DEG_SPOP_SBC_1	30	34	PF00917	0.449
DOC_CKS1_1	386	391	PF01111	0.428
DOC_CKS1_1	58	63	PF01111	0.437
DOC_MAPK_DCC_7	49	58	PF00069	0.427
DOC_MAPK_DCC_7	535	545	PF00069	0.371
DOC_MAPK_gen_1	40	48	PF00069	0.460
DOC_MAPK_gen_1	425	433	PF00069	0.454
DOC_MAPK_gen_1	49	55	PF00069	0.444
DOC_MAPK_gen_1	582	593	PF00069	0.432
DOC_MAPK_HePTP_8	46	58	PF00069	0.452
DOC_MAPK_MEF2A_6	40	48	PF00069	0.457
DOC_MAPK_MEF2A_6	407	415	PF00069	0.460
DOC_MAPK_MEF2A_6	49	58	PF00069	0.444
DOC_MAPK_MEF2A_6	586	595	PF00069	0.515
DOC_PP1_RVXF_1	590	596	PF00149	0.515
DOC_PP2B_LxvP_1	543	546	PF13499	0.454
DOC_PP4_FxxP_1	58	61	PF00568	0.468
DOC_USP7_MATH_1	126	130	PF00917	0.628
DOC_USP7_MATH_1	157	161	PF00917	0.522
DOC_USP7_MATH_1	271	275	PF00917	0.628
DOC_USP7_MATH_1	30	34	PF00917	0.478
DOC_USP7_MATH_1	392	396	PF00917	0.444
DOC_USP7_MATH_1	455	459	PF00917	0.473
DOC_USP7_MATH_1	467	471	PF00917	0.539
DOC_USP7_MATH_1	546	550	PF00917	0.476
DOC_USP7_MATH_1	559	563	PF00917	0.363
DOC_WW_Pin1_4	124	129	PF00397	0.627
DOC_WW_Pin1_4	138	143	PF00397	0.673
DOC_WW_Pin1_4	16	21	PF00397	0.459
DOC_WW_Pin1_4	382	387	PF00397	0.460
DOC_WW_Pin1_4	388	393	PF00397	0.553
DOC_WW_Pin1_4	498	503	PF00397	0.429
DOC_WW_Pin1_4	536	541	PF00397	0.424
DOC_WW_Pin1_4	57	62	PF00397	0.487
LIG_14-3-3_CanoR_1	103	111	PF00244	0.496
LIG_14-3-3_CanoR_1	180	189	PF00244	0.501
LIG_14-3-3_CanoR_1	216	222	PF00244	0.377
LIG_14-3-3_CanoR_1	319	327	PF00244	0.579
LIG_14-3-3_CanoR_1	41	47	PF00244	0.477
LIG_14-3-3_CanoR_1	419	426	PF00244	0.494
LIG_14-3-3_CanoR_1	427	433	PF00244	0.461
LIG_14-3-3_CanoR_1	447	457	PF00244	0.355
LIG_Actin_WH2_2	166	182	PF00022	0.478
LIG_BRCT_BRCA1_1	18	22	PF00533	0.410
LIG_BRCT_BRCA1_1	9	13	PF00533	0.452
LIG_Clathr_ClatBox_1	410	414	PF01394	0.454
LIG_CSL_BTD_1	58	61	PF09270	0.422
LIG_CtBP_PxDLS_1	62	66	PF00389	0.404
LIG_FHA_1	116	122	PF00498	0.485
LIG_FHA_1	181	187	PF00498	0.457
LIG_FHA_1	310	316	PF00498	0.535
LIG_FHA_1	32	38	PF00498	0.482
LIG_FHA_1	359	365	PF00498	0.516
LIG_FHA_1	382	388	PF00498	0.542
LIG_FHA_1	43	49	PF00498	0.438
LIG_FHA_1	608	614	PF00498	0.509
LIG_FHA_2	216	222	PF00498	0.430
LIG_FHA_2	549	555	PF00498	0.529
LIG_FHA_2	607	613	PF00498	0.478
LIG_HP1_1	409	413	PF01393	0.515
LIG_Integrin_RGD_1	149	151	PF01839	0.507
LIG_LIR_Gen_1	330	337	PF02991	0.390
LIG_LIR_Gen_1	477	486	PF02991	0.424
LIG_LIR_Gen_1	554	563	PF02991	0.412
LIG_LIR_LC3C_4	245	248	PF02991	0.346
LIG_LIR_Nem_3	10	16	PF02991	0.455
LIG_LIR_Nem_3	330	335	PF02991	0.390
LIG_LIR_Nem_3	477	482	PF02991	0.440
LIG_LIR_Nem_3	554	560	PF02991	0.425
LIG_LIR_Nem_3	90	96	PF02991	0.362
LIG_Pex14_1	396	400	PF04695	0.428
LIG_SH2_CRK	295	299	PF00017	0.286
LIG_SH2_STAP1	165	169	PF00017	0.412
LIG_SH2_STAP1	238	242	PF00017	0.444
LIG_SH2_STAT5	115	118	PF00017	0.456
LIG_SH2_STAT5	181	184	PF00017	0.476
LIG_SH2_STAT5	188	191	PF00017	0.402
LIG_SH2_STAT5	598	601	PF00017	0.445
LIG_SH2_STAT5	608	611	PF00017	0.445
LIG_SH2_STAT5	97	100	PF00017	0.427
LIG_SH3_3	151	157	PF00018	0.250
LIG_SH3_3	383	389	PF00018	0.546
LIG_SH3_3	48	54	PF00018	0.432
LIG_SH3_3	507	513	PF00018	0.508
LIG_SH3_3	527	533	PF00018	0.428
LIG_SH3_3	79	85	PF00018	0.685
LIG_SH3_CIN85_PxpxPR_1	469	474	PF14604	0.388
LIG_SUMO_SIM_anti_2	245	250	PF11976	0.477
LIG_SUMO_SIM_par_1	408	414	PF11976	0.424
LIG_SUMO_SIM_par_1	513	519	PF11976	0.503
LIG_SxIP_EBH_1	465	474	PF03271	0.371
LIG_TRAF2_1	282	285	PF00917	0.540
LIG_TRAF2_1	553	556	PF00917	0.502
MOD_CK1_1	127	133	PF00069	0.703
MOD_CK1_1	140	146	PF00069	0.606
MOD_CK1_1	160	166	PF00069	0.323
MOD_CK1_1	269	275	PF00069	0.539
MOD_CK1_1	385	391	PF00069	0.516
MOD_CK1_1	395	401	PF00069	0.536
MOD_CK1_1	496	502	PF00069	0.422
MOD_CK1_1	562	568	PF00069	0.412
MOD_CK2_1	164	170	PF00069	0.460
MOD_CK2_1	360	366	PF00069	0.534
MOD_CK2_1	373	379	PF00069	0.433
MOD_CK2_1	548	554	PF00069	0.456
MOD_CK2_1	77	83	PF00069	0.698
MOD_Cter_Amidation	580	583	PF01082	0.260
MOD_GlcNHglycan	203	206	PF01048	0.467
MOD_GlcNHglycan	221	225	PF01048	0.389
MOD_GlcNHglycan	259	262	PF01048	0.623
MOD_GlcNHglycan	277	280	PF01048	0.444
MOD_GlcNHglycan	342	345	PF01048	0.328
MOD_GlcNHglycan	397	400	PF01048	0.240
MOD_GlcNHglycan	428	431	PF01048	0.302
MOD_GlcNHglycan	457	460	PF01048	0.298
MOD_GlcNHglycan	469	472	PF01048	0.206
MOD_GSK3_1	124	131	PF00069	0.574
MOD_GSK3_1	136	143	PF00069	0.741
MOD_GSK3_1	14	21	PF00069	0.430
MOD_GSK3_1	160	167	PF00069	0.475
MOD_GSK3_1	211	218	PF00069	0.525
MOD_GSK3_1	265	272	PF00069	0.647
MOD_GSK3_1	369	376	PF00069	0.478
MOD_GSK3_1	378	385	PF00069	0.516
MOD_GSK3_1	387	394	PF00069	0.530
MOD_GSK3_1	498	505	PF00069	0.424
MOD_GSK3_1	546	553	PF00069	0.478
MOD_GSK3_1	57	64	PF00069	0.543
MOD_GSK3_1	607	614	PF00069	0.482
MOD_GSK3_1	92	99	PF00069	0.359
MOD_N-GLC_1	160	165	PF02516	0.212
MOD_N-GLC_2	617	619	PF02516	0.222
MOD_NEK2_1	201	206	PF00069	0.472
MOD_NEK2_1	31	36	PF00069	0.468
MOD_NEK2_1	44	49	PF00069	0.444
MOD_NEK2_1	493	498	PF00069	0.422
MOD_NEK2_1	503	508	PF00069	0.399
MOD_NEK2_1	9	14	PF00069	0.440
MOD_NEK2_2	271	276	PF00069	0.521
MOD_OFUCOSY	11	18	PF10250	0.411
MOD_OFUCOSY	490	497	PF10250	0.236
MOD_PIKK_1	211	217	PF00454	0.579
MOD_PIKK_1	266	272	PF00454	0.467
MOD_PIKK_1	31	37	PF00454	0.478
MOD_PIKK_1	373	379	PF00454	0.502
MOD_PIKK_1	503	509	PF00454	0.460
MOD_PKA_1	419	425	PF00069	0.428
MOD_PKA_1	77	83	PF00069	0.556
MOD_PKA_2	215	221	PF00069	0.396
MOD_PKA_2	275	281	PF00069	0.678
MOD_PKA_2	318	324	PF00069	0.489
MOD_PKA_2	419	425	PF00069	0.455
MOD_PKA_2	426	432	PF00069	0.418
MOD_Plk_1	160	166	PF00069	0.412
MOD_Plk_4	110	116	PF00069	0.497
MOD_Plk_4	160	166	PF00069	0.418
MOD_Plk_4	18	24	PF00069	0.419
MOD_Plk_4	311	317	PF00069	0.483
MOD_Plk_4	92	98	PF00069	0.398
MOD_ProDKin_1	124	130	PF00069	0.630
MOD_ProDKin_1	138	144	PF00069	0.673
MOD_ProDKin_1	16	22	PF00069	0.462
MOD_ProDKin_1	382	388	PF00069	0.460
MOD_ProDKin_1	498	504	PF00069	0.429
MOD_ProDKin_1	536	542	PF00069	0.424
MOD_ProDKin_1	57	63	PF00069	0.489
TRG_DiLeu_BaEn_3	615	621	PF01217	0.420
TRG_DiLeu_BaEn_4	284	290	PF01217	0.514
TRG_DiLeu_BaLyEn_6	499	504	PF01217	0.428
TRG_ENDOCYTIC_2	295	298	PF00928	0.289
TRG_ENDOCYTIC_2	601	604	PF00928	0.515
TRG_ER_diArg_1	418	420	PF00400	0.412
TRG_ER_diArg_1	435	438	PF00400	0.412
TRG_ER_diArg_1	48	50	PF00400	0.475
TRG_NLS_MonoExtC_3	581	586	PF00514	0.460
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	586	590	PF00026	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMP0	Leptomonas seymouri	57%	100%
A0A0S4IU97	Bodo saltans	33%	100%
A0A1X0NKZ4	Trypanosomatidae	37%	100%
A0A3Q8IFC1	Leishmania donovani	99%	100%
A0A3R7N0X9	Trypanosoma rangeli	41%	100%
A4HJ30	Leishmania braziliensis	77%	100%
A7TSF4	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	22%	100%
C9ZN61	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B1K2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q6L1	Leishmania major	91%	100%
V5BII3	Trypanosoma cruzi	40%	100%