Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I6K2_LEIIN

TriTrypDb:

LINF_310009000

Length:

678

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I6K2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6K2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004497	monooxygenase activity	3	2
GO:0005488	binding	1	2
GO:0005506	iron ion binding	6	2
GO:0016491	oxidoreductase activity	2	2
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	2
GO:0020037	heme binding	4	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046906	tetrapyrrole binding	3	2
GO:0046914	transition metal ion binding	5	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.594
CLV_C14_Caspase3-7	329	333	PF00656	0.380
CLV_NRD_NRD_1	21	23	PF00675	0.607
CLV_NRD_NRD_1	33	35	PF00675	0.467
CLV_PCSK_KEX2_1	21	23	PF00082	0.613
CLV_PCSK_KEX2_1	33	35	PF00082	0.480
CLV_PCSK_KEX2_1	528	530	PF00082	0.411
CLV_PCSK_PC1ET2_1	528	530	PF00082	0.527
CLV_PCSK_PC7_1	29	35	PF00082	0.589
CLV_PCSK_PC7_1	524	530	PF00082	0.442
CLV_PCSK_SKI1_1	137	141	PF00082	0.468
CLV_PCSK_SKI1_1	306	310	PF00082	0.378
CLV_PCSK_SKI1_1	39	43	PF00082	0.624
CLV_PCSK_SKI1_1	538	542	PF00082	0.459
DEG_Nend_UBRbox_1	1	4	PF02207	0.667
DEG_SCF_FBW7_1	497	504	PF00400	0.442
DEG_SCF_FBW7_1	77	84	PF00400	0.514
DEG_SPOP_SBC_1	67	71	PF00917	0.533
DOC_CDC14_PxL_1	308	316	PF14671	0.319
DOC_CKS1_1	133	138	PF01111	0.536
DOC_CYCLIN_yCln2_LP_2	573	579	PF00134	0.413
DOC_CYCLIN_yCln2_LP_2	618	621	PF00134	0.455
DOC_MAPK_gen_1	528	535	PF00069	0.483
DOC_MAPK_MEF2A_6	289	297	PF00069	0.388
DOC_PP1_RVXF_1	135	141	PF00149	0.524
DOC_PP2B_LxvP_1	13	16	PF13499	0.627
DOC_PP2B_LxvP_1	190	193	PF13499	0.446
DOC_PP2B_LxvP_1	618	621	PF13499	0.459
DOC_PP4_FxxP_1	309	312	PF00568	0.448
DOC_PP4_FxxP_1	617	620	PF00568	0.411
DOC_PP4_MxPP_1	185	188	PF00568	0.599
DOC_USP7_MATH_1	112	116	PF00917	0.637
DOC_USP7_MATH_1	120	124	PF00917	0.557
DOC_USP7_MATH_1	142	146	PF00917	0.564
DOC_USP7_MATH_1	274	278	PF00917	0.520
DOC_USP7_MATH_1	366	370	PF00917	0.475
DOC_USP7_MATH_1	410	414	PF00917	0.691
DOC_USP7_MATH_1	416	420	PF00917	0.565
DOC_USP7_MATH_1	644	648	PF00917	0.545
DOC_USP7_MATH_1	81	85	PF00917	0.627
DOC_WW_Pin1_4	104	109	PF00397	0.694
DOC_WW_Pin1_4	116	121	PF00397	0.638
DOC_WW_Pin1_4	132	137	PF00397	0.646
DOC_WW_Pin1_4	170	175	PF00397	0.366
DOC_WW_Pin1_4	206	211	PF00397	0.636
DOC_WW_Pin1_4	358	363	PF00397	0.579
DOC_WW_Pin1_4	381	386	PF00397	0.496
DOC_WW_Pin1_4	406	411	PF00397	0.586
DOC_WW_Pin1_4	476	481	PF00397	0.452
DOC_WW_Pin1_4	497	502	PF00397	0.495
DOC_WW_Pin1_4	657	662	PF00397	0.672
DOC_WW_Pin1_4	77	82	PF00397	0.732
LIG_14-3-3_CanoR_1	110	120	PF00244	0.748
LIG_14-3-3_CanoR_1	156	163	PF00244	0.452
LIG_14-3-3_CanoR_1	2	8	PF00244	0.606
LIG_14-3-3_CanoR_1	266	274	PF00244	0.393
LIG_14-3-3_CanoR_1	301	309	PF00244	0.560
LIG_14-3-3_CanoR_1	438	444	PF00244	0.397
LIG_14-3-3_CanoR_1	633	640	PF00244	0.418
LIG_Actin_WH2_2	5	23	PF00022	0.607
LIG_APCC_ABBA_1	293	298	PF00400	0.364
LIG_BRCT_BRCA1_1	202	206	PF00533	0.472
LIG_BRCT_BRCA1_1	304	308	PF00533	0.581
LIG_Clathr_ClatBox_1	553	557	PF01394	0.490
LIG_CtBP_PxDLS_1	174	178	PF00389	0.488
LIG_FHA_1	133	139	PF00498	0.554
LIG_FHA_1	2	8	PF00498	0.748
LIG_FHA_1	30	36	PF00498	0.567
LIG_FHA_1	448	454	PF00498	0.461
LIG_FHA_1	502	508	PF00498	0.471
LIG_FHA_1	58	64	PF00498	0.466
LIG_FHA_2	247	253	PF00498	0.431
LIG_FHA_2	566	572	PF00498	0.468
LIG_IBAR_NPY_1	43	45	PF08397	0.513
LIG_LIR_Apic_2	131	136	PF02991	0.487
LIG_LIR_Nem_3	361	367	PF02991	0.500
LIG_LIR_Nem_3	469	475	PF02991	0.374
LIG_LIR_Nem_3	525	530	PF02991	0.396
LIG_LIR_Nem_3	568	573	PF02991	0.417
LIG_MYND_1	175	179	PF01753	0.492
LIG_MYND_1	616	620	PF01753	0.455
LIG_NRBOX	217	223	PF00104	0.384
LIG_NRBOX	562	568	PF00104	0.420
LIG_Pex14_2	360	364	PF04695	0.429
LIG_PTAP_UEV_1	411	416	PF05743	0.550
LIG_SH2_CRK	242	246	PF00017	0.378
LIG_SH2_CRK	625	629	PF00017	0.379
LIG_SH2_CRK	640	644	PF00017	0.375
LIG_SH2_NCK_1	625	629	PF00017	0.415
LIG_SH2_NCK_1	640	644	PF00017	0.375
LIG_SH2_PTP2	550	553	PF00017	0.448
LIG_SH2_STAP1	231	235	PF00017	0.496
LIG_SH2_STAP1	488	492	PF00017	0.429
LIG_SH2_STAP1	640	644	PF00017	0.408
LIG_SH2_STAT5	200	203	PF00017	0.466
LIG_SH2_STAT5	432	435	PF00017	0.379
LIG_SH2_STAT5	475	478	PF00017	0.330
LIG_SH2_STAT5	50	53	PF00017	0.502
LIG_SH2_STAT5	550	553	PF00017	0.450
LIG_SH3_2	412	417	PF14604	0.500
LIG_SH3_3	185	191	PF00018	0.487
LIG_SH3_3	268	274	PF00018	0.320
LIG_SH3_3	365	371	PF00018	0.373
LIG_SH3_3	38	44	PF00018	0.557
LIG_SH3_3	409	415	PF00018	0.545
LIG_SUMO_SIM_par_1	552	557	PF11976	0.328
LIG_TRAF2_1	313	316	PF00917	0.338
LIG_TRAF2_1	327	330	PF00917	0.392
LIG_TRAF2_1	87	90	PF00917	0.629
LIG_TYR_ITIM	623	628	PF00017	0.420
LIG_UBA3_1	197	202	PF00899	0.418
LIG_WRC_WIRS_1	247	252	PF05994	0.334
LIG_WRC_WIRS_1	567	572	PF05994	0.428
LIG_WW_3	186	190	PF00397	0.492
MOD_CDC14_SPxK_1	107	110	PF00782	0.585
MOD_CDK_SPK_2	132	137	PF00069	0.480
MOD_CDK_SPK_2	358	363	PF00069	0.531
MOD_CDK_SPxK_1	104	110	PF00069	0.571
MOD_CK1_1	128	134	PF00069	0.654
MOD_CK1_1	220	226	PF00069	0.433
MOD_CK1_1	278	284	PF00069	0.467
MOD_CK1_1	353	359	PF00069	0.519
MOD_CK1_1	384	390	PF00069	0.564
MOD_CK1_1	406	412	PF00069	0.544
MOD_CK1_1	464	470	PF00069	0.433
MOD_CK1_1	479	485	PF00069	0.272
MOD_CK2_1	111	117	PF00069	0.745
MOD_CK2_1	274	280	PF00069	0.462
MOD_CK2_1	310	316	PF00069	0.427
MOD_CK2_1	384	390	PF00069	0.606
MOD_CK2_1	393	399	PF00069	0.406
MOD_CK2_1	439	445	PF00069	0.441
MOD_CK2_1	516	522	PF00069	0.459
MOD_CK2_1	565	571	PF00069	0.477
MOD_GlcNHglycan	114	117	PF01048	0.761
MOD_GlcNHglycan	122	125	PF01048	0.719
MOD_GlcNHglycan	146	149	PF01048	0.590
MOD_GlcNHglycan	158	161	PF01048	0.573
MOD_GlcNHglycan	222	225	PF01048	0.415
MOD_GlcNHglycan	256	259	PF01048	0.428
MOD_GlcNHglycan	267	270	PF01048	0.513
MOD_GlcNHglycan	368	371	PF01048	0.477
MOD_GlcNHglycan	386	389	PF01048	0.578
MOD_GlcNHglycan	412	415	PF01048	0.603
MOD_GlcNHglycan	418	421	PF01048	0.480
MOD_GlcNHglycan	51	54	PF01048	0.488
MOD_GlcNHglycan	535	538	PF01048	0.555
MOD_GlcNHglycan	598	601	PF01048	0.574
MOD_GlcNHglycan	668	672	PF01048	0.634
MOD_GlcNHglycan	70	73	PF01048	0.613
MOD_GSK3_1	112	119	PF00069	0.736
MOD_GSK3_1	128	135	PF00069	0.682
MOD_GSK3_1	144	151	PF00069	0.497
MOD_GSK3_1	274	281	PF00069	0.488
MOD_GSK3_1	296	303	PF00069	0.502
MOD_GSK3_1	384	391	PF00069	0.530
MOD_GSK3_1	406	413	PF00069	0.669
MOD_GSK3_1	447	454	PF00069	0.462
MOD_GSK3_1	461	468	PF00069	0.297
MOD_GSK3_1	497	504	PF00069	0.367
MOD_GSK3_1	66	73	PF00069	0.562
MOD_GSK3_1	77	84	PF00069	0.559
MOD_N-GLC_1	348	353	PF02516	0.596
MOD_N-GLC_1	381	386	PF02516	0.500
MOD_NEK2_1	1	6	PF00069	0.648
MOD_NEK2_1	111	116	PF00069	0.691
MOD_NEK2_1	245	250	PF00069	0.343
MOD_NEK2_1	296	301	PF00069	0.332
MOD_NEK2_1	403	408	PF00069	0.593
MOD_NEK2_1	465	470	PF00069	0.363
MOD_NEK2_1	541	546	PF00069	0.425
MOD_NEK2_1	8	13	PF00069	0.604
MOD_NEK2_2	246	251	PF00069	0.347
MOD_PKA_2	1	7	PF00069	0.668
MOD_PKA_2	112	118	PF00069	0.760
MOD_PKA_2	125	131	PF00069	0.701
MOD_PKA_2	143	149	PF00069	0.646
MOD_PKA_2	265	271	PF00069	0.496
MOD_PKA_2	300	306	PF00069	0.473
MOD_PKA_2	416	422	PF00069	0.506
MOD_PKA_2	451	457	PF00069	0.493
MOD_PKA_2	595	601	PF00069	0.482
MOD_PKA_2	632	638	PF00069	0.542
MOD_PKB_1	154	162	PF00069	0.442
MOD_PKB_1	594	602	PF00069	0.433
MOD_Plk_1	287	293	PF00069	0.443
MOD_Plk_1	652	658	PF00069	0.558
MOD_Plk_1	89	95	PF00069	0.579
MOD_Plk_2-3	14	20	PF00069	0.511
MOD_Plk_4	128	134	PF00069	0.500
MOD_Plk_4	217	223	PF00069	0.384
MOD_Plk_4	259	265	PF00069	0.423
MOD_Plk_4	371	377	PF00069	0.421
MOD_Plk_4	461	467	PF00069	0.447
MOD_Plk_4	543	549	PF00069	0.256
MOD_Plk_4	8	14	PF00069	0.628
MOD_ProDKin_1	104	110	PF00069	0.700
MOD_ProDKin_1	116	122	PF00069	0.637
MOD_ProDKin_1	132	138	PF00069	0.644
MOD_ProDKin_1	170	176	PF00069	0.372
MOD_ProDKin_1	206	212	PF00069	0.648
MOD_ProDKin_1	358	364	PF00069	0.562
MOD_ProDKin_1	381	387	PF00069	0.493
MOD_ProDKin_1	406	412	PF00069	0.593
MOD_ProDKin_1	476	482	PF00069	0.460
MOD_ProDKin_1	497	503	PF00069	0.488
MOD_ProDKin_1	657	663	PF00069	0.671
MOD_ProDKin_1	77	83	PF00069	0.729
MOD_SUMO_for_1	201	204	PF00179	0.414
MOD_SUMO_rev_2	31	41	PF00179	0.582
TRG_DiLeu_BaEn_1	562	567	PF01217	0.281
TRG_DiLeu_BaLyEn_6	368	373	PF01217	0.370
TRG_DiLeu_BaLyEn_6	549	554	PF01217	0.432
TRG_ENDOCYTIC_2	242	245	PF00928	0.495
TRG_ENDOCYTIC_2	550	553	PF00928	0.448
TRG_ENDOCYTIC_2	574	577	PF00928	0.413
TRG_ENDOCYTIC_2	625	628	PF00928	0.426
TRG_ENDOCYTIC_2	640	643	PF00928	0.383
TRG_ER_diArg_1	153	156	PF00400	0.526
TRG_ER_diArg_1	20	22	PF00400	0.538
TRG_ER_diArg_1	33	36	PF00400	0.459
TRG_ER_diArg_1	405	408	PF00400	0.643
TRG_ER_FFAT_2	48	56	PF00635	0.519
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	344	348	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	485	489	PF00026	0.320
TRG_Pf-PMV_PEXEL_1	552	557	PF00026	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T2	Leptomonas seymouri	45%	100%
A0A3R7MH20	Trypanosoma rangeli	30%	100%
A0A3S7X435	Leishmania donovani	99%	100%
A4HJ12	Leishmania braziliensis	73%	100%
C9ZJE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9B1I8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q6M6	Leishmania major	90%	100%
V5AYQ1	Trypanosoma cruzi	29%	100%