Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I6K1_LEIIN

TriTrypDb:

LINF_310008900

Length:

992

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0012505	endomembrane system	2	1
GO:0044232	organelle membrane contact site	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0140284	endoplasmic reticulum-endosome membrane contact site	3	1

Expansion

Sequence features

A4I6K1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6K1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.413
CLV_C14_Caspase3-7	408	412	PF00656	0.641
CLV_C14_Caspase3-7	453	457	PF00656	0.491
CLV_C14_Caspase3-7	573	577	PF00656	0.374
CLV_C14_Caspase3-7	63	67	PF00656	0.418
CLV_C14_Caspase3-7	94	98	PF00656	0.284
CLV_NRD_NRD_1	122	124	PF00675	0.369
CLV_NRD_NRD_1	204	206	PF00675	0.272
CLV_NRD_NRD_1	343	345	PF00675	0.586
CLV_NRD_NRD_1	436	438	PF00675	0.549
CLV_NRD_NRD_1	50	52	PF00675	0.398
CLV_NRD_NRD_1	501	503	PF00675	0.529
CLV_NRD_NRD_1	564	566	PF00675	0.480
CLV_NRD_NRD_1	601	603	PF00675	0.360
CLV_NRD_NRD_1	608	610	PF00675	0.395
CLV_NRD_NRD_1	68	70	PF00675	0.390
CLV_NRD_NRD_1	692	694	PF00675	0.443
CLV_NRD_NRD_1	856	858	PF00675	0.488
CLV_NRD_NRD_1	914	916	PF00675	0.409
CLV_PCSK_FUR_1	602	606	PF00082	0.356
CLV_PCSK_FUR_1	912	916	PF00082	0.350
CLV_PCSK_KEX2_1	16	18	PF00082	0.460
CLV_PCSK_KEX2_1	211	213	PF00082	0.303
CLV_PCSK_KEX2_1	342	344	PF00082	0.581
CLV_PCSK_KEX2_1	49	51	PF00082	0.415
CLV_PCSK_KEX2_1	501	503	PF00082	0.529
CLV_PCSK_KEX2_1	564	566	PF00082	0.480
CLV_PCSK_KEX2_1	604	606	PF00082	0.379
CLV_PCSK_KEX2_1	608	610	PF00082	0.376
CLV_PCSK_KEX2_1	692	694	PF00082	0.443
CLV_PCSK_KEX2_1	855	857	PF00082	0.493
CLV_PCSK_KEX2_1	914	916	PF00082	0.441
CLV_PCSK_KEX2_1	987	989	PF00082	0.480
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.460
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.303
CLV_PCSK_PC1ET2_1	604	606	PF00082	0.362
CLV_PCSK_PC1ET2_1	855	857	PF00082	0.399
CLV_PCSK_PC1ET2_1	987	989	PF00082	0.480
CLV_PCSK_PC7_1	688	694	PF00082	0.424
CLV_PCSK_SKI1_1	13	17	PF00082	0.439
CLV_PCSK_SKI1_1	182	186	PF00082	0.301
CLV_PCSK_SKI1_1	236	240	PF00082	0.450
CLV_PCSK_SKI1_1	343	347	PF00082	0.580
CLV_PCSK_SKI1_1	437	441	PF00082	0.527
CLV_PCSK_SKI1_1	56	60	PF00082	0.403
CLV_PCSK_SKI1_1	565	569	PF00082	0.587
CLV_PCSK_SKI1_1	608	612	PF00082	0.442
DEG_APCC_DBOX_1	415	423	PF00400	0.556
DEG_APCC_DBOX_1	692	700	PF00400	0.432
DEG_APCC_DBOX_1	969	977	PF00400	0.396
DEG_MDM2_SWIB_1	589	597	PF02201	0.383
DEG_Nend_Nbox_1	1	3	PF02207	0.426
DEG_SPOP_SBC_1	926	930	PF00917	0.642
DOC_CKS1_1	309	314	PF01111	0.589
DOC_CKS1_1	637	642	PF01111	0.410
DOC_CYCLIN_RxL_1	602	613	PF00134	0.378
DOC_CYCLIN_yClb1_LxF_4	563	568	PF00134	0.475
DOC_MAPK_DCC_7	212	222	PF00069	0.325
DOC_MAPK_DCC_7	956	966	PF00069	0.528
DOC_MAPK_gen_1	13	21	PF00069	0.387
DOC_MAPK_gen_1	352	360	PF00069	0.619
DOC_MAPK_gen_1	602	612	PF00069	0.376
DOC_MAPK_gen_1	855	864	PF00069	0.460
DOC_MAPK_MEF2A_6	84	92	PF00069	0.278
DOC_MAPK_MEF2A_6	857	866	PF00069	0.431
DOC_MAPK_RevD_3	900	915	PF00069	0.321
DOC_PP1_RVXF_1	562	569	PF00149	0.472
DOC_PP2B_LxvP_1	663	666	PF13499	0.464
DOC_PP4_FxxP_1	2	5	PF00568	0.402
DOC_PP4_FxxP_1	700	703	PF00568	0.425
DOC_USP7_MATH_1	382	386	PF00917	0.528
DOC_USP7_MATH_1	402	406	PF00917	0.577
DOC_USP7_MATH_1	527	531	PF00917	0.530
DOC_USP7_MATH_1	540	544	PF00917	0.544
DOC_USP7_MATH_1	790	794	PF00917	0.385
DOC_USP7_MATH_1	831	835	PF00917	0.433
DOC_USP7_MATH_1	926	930	PF00917	0.611
DOC_WW_Pin1_4	286	291	PF00397	0.647
DOC_WW_Pin1_4	308	313	PF00397	0.587
DOC_WW_Pin1_4	359	364	PF00397	0.746
DOC_WW_Pin1_4	376	381	PF00397	0.480
DOC_WW_Pin1_4	571	576	PF00397	0.371
DOC_WW_Pin1_4	636	641	PF00397	0.442
DOC_WW_Pin1_4	927	932	PF00397	0.662
DOC_WW_Pin1_4	95	100	PF00397	0.284
LIG_14-3-3_CanoR_1	143	149	PF00244	0.304
LIG_14-3-3_CanoR_1	236	245	PF00244	0.430
LIG_14-3-3_CanoR_1	307	312	PF00244	0.640
LIG_14-3-3_CanoR_1	342	348	PF00244	0.582
LIG_14-3-3_CanoR_1	501	510	PF00244	0.366
LIG_14-3-3_CanoR_1	515	519	PF00244	0.416
LIG_14-3-3_CanoR_1	609	615	PF00244	0.385
LIG_14-3-3_CanoR_1	620	624	PF00244	0.392
LIG_14-3-3_CanoR_1	69	73	PF00244	0.388
LIG_14-3-3_CanoR_1	745	751	PF00244	0.496
LIG_14-3-3_CanoR_1	861	867	PF00244	0.379
LIG_14-3-3_CanoR_1	868	877	PF00244	0.398
LIG_14-3-3_CanoR_1	914	923	PF00244	0.468
LIG_14-3-3_CanoR_1	982	987	PF00244	0.483
LIG_Actin_WH2_2	127	145	PF00022	0.304
LIG_Actin_WH2_2	730	747	PF00022	0.443
LIG_APCC_ABBA_1	642	647	PF00400	0.374
LIG_BRCT_BRCA1_1	157	161	PF00533	0.304
LIG_BRCT_BRCA1_1	165	169	PF00533	0.304
LIG_BRCT_BRCA1_1	392	396	PF00533	0.579
LIG_CaM_NSCaTE_8	676	683	PF13499	0.425
LIG_Clathr_ClatBox_1	596	600	PF01394	0.371
LIG_CSL_BTD_1	613	616	PF09270	0.397
LIG_CtBP_PxDLS_1	219	223	PF00389	0.304
LIG_CtBP_PxDLS_1	830	834	PF00389	0.500
LIG_deltaCOP1_diTrp_1	27	33	PF00928	0.332
LIG_deltaCOP1_diTrp_1	461	465	PF00928	0.373
LIG_FAT_LD_1	476	484	PF03623	0.339
LIG_FHA_1	129	135	PF00498	0.293
LIG_FHA_1	143	149	PF00498	0.264
LIG_FHA_1	16	22	PF00498	0.416
LIG_FHA_1	495	501	PF00498	0.378
LIG_FHA_1	63	69	PF00498	0.404
LIG_FHA_1	760	766	PF00498	0.376
LIG_FHA_1	946	952	PF00498	0.688
LIG_FHA_2	237	243	PF00498	0.430
LIG_FHA_2	317	323	PF00498	0.679
LIG_FHA_2	372	378	PF00498	0.735
LIG_FHA_2	543	549	PF00498	0.566
LIG_FHA_2	571	577	PF00498	0.346
LIG_FHA_2	61	67	PF00498	0.418
LIG_FHA_2	707	713	PF00498	0.517
LIG_FHA_2	736	742	PF00498	0.360
LIG_FHA_2	762	768	PF00498	0.373
LIG_FHA_2	845	851	PF00498	0.496
LIG_FHA_2	92	98	PF00498	0.304
LIG_FHA_2	928	934	PF00498	0.572
LIG_Integrin_RGD_1	723	725	PF01839	0.479
LIG_LIR_Gen_1	27	35	PF02991	0.336
LIG_LIR_Gen_1	324	335	PF02991	0.645
LIG_LIR_Gen_1	393	402	PF02991	0.586
LIG_LIR_Gen_1	429	440	PF02991	0.467
LIG_LIR_Gen_1	461	470	PF02991	0.387
LIG_LIR_Gen_1	591	599	PF02991	0.389
LIG_LIR_Gen_1	767	777	PF02991	0.358
LIG_LIR_Gen_1	814	825	PF02991	0.353
LIG_LIR_Gen_1	865	873	PF02991	0.342
LIG_LIR_Nem_3	158	164	PF02991	0.304
LIG_LIR_Nem_3	27	32	PF02991	0.334
LIG_LIR_Nem_3	303	309	PF02991	0.580
LIG_LIR_Nem_3	393	399	PF02991	0.580
LIG_LIR_Nem_3	429	435	PF02991	0.457
LIG_LIR_Nem_3	461	465	PF02991	0.380
LIG_LIR_Nem_3	517	523	PF02991	0.383
LIG_LIR_Nem_3	57	62	PF02991	0.406
LIG_LIR_Nem_3	591	596	PF02991	0.398
LIG_LIR_Nem_3	639	645	PF02991	0.409
LIG_LIR_Nem_3	673	679	PF02991	0.567
LIG_LIR_Nem_3	767	772	PF02991	0.346
LIG_LIR_Nem_3	814	820	PF02991	0.439
LIG_LIR_Nem_3	865	869	PF02991	0.374
LIG_MLH1_MIPbox_1	157	161	PF16413	0.304
LIG_MYND_3	473	477	PF01753	0.449
LIG_NRBOX	475	481	PF00104	0.378
LIG_NRBOX	901	907	PF00104	0.331
LIG_PDZ_Class_2	987	992	PF00595	0.536
LIG_Pex14_1	29	33	PF04695	0.332
LIG_Pex14_1	372	376	PF04695	0.560
LIG_Pex14_2	589	593	PF04695	0.369
LIG_PTB_Apo_2	33	40	PF02174	0.366
LIG_RPA_C_Fungi	339	351	PF08784	0.585
LIG_SH2_CRK	306	310	PF00017	0.591
LIG_SH2_CRK	432	436	PF00017	0.512
LIG_SH2_CRK	661	665	PF00017	0.392
LIG_SH2_CRK	677	681	PF00017	0.361
LIG_SH2_GRB2like	91	94	PF00017	0.304
LIG_SH2_NCK_1	888	892	PF00017	0.495
LIG_SH2_PTP2	698	701	PF00017	0.416
LIG_SH2_PTP2	769	772	PF00017	0.365
LIG_SH2_SRC	25	28	PF00017	0.339
LIG_SH2_SRC	645	648	PF00017	0.344
LIG_SH2_SRC	769	772	PF00017	0.398
LIG_SH2_STAP1	234	238	PF00017	0.388
LIG_SH2_STAP1	432	436	PF00017	0.512
LIG_SH2_STAP1	681	685	PF00017	0.297
LIG_SH2_STAT3	781	784	PF00017	0.412
LIG_SH2_STAT5	244	247	PF00017	0.352
LIG_SH2_STAT5	25	28	PF00017	0.339
LIG_SH2_STAT5	31	34	PF00017	0.332
LIG_SH2_STAT5	62	65	PF00017	0.407
LIG_SH2_STAT5	645	648	PF00017	0.344
LIG_SH2_STAT5	698	701	PF00017	0.423
LIG_SH2_STAT5	746	749	PF00017	0.432
LIG_SH2_STAT5	769	772	PF00017	0.430
LIG_SH2_STAT5	79	82	PF00017	0.304
LIG_SH2_STAT5	91	94	PF00017	0.304
LIG_SH3_3	177	183	PF00018	0.304
LIG_SH3_3	287	293	PF00018	0.671
LIG_SH3_3	396	402	PF00018	0.597
LIG_SH3_3	696	702	PF00018	0.436
LIG_SH3_3	805	811	PF00018	0.397
LIG_SUMO_SIM_anti_2	821	826	PF11976	0.373
LIG_SUMO_SIM_par_1	594	601	PF11976	0.387
LIG_TRAF2_1	320	323	PF00917	0.612
LIG_TRAF2_1	426	429	PF00917	0.579
LIG_TRAF2_1	490	493	PF00917	0.436
LIG_TRAF2_1	811	814	PF00917	0.352
LIG_TYR_ITIM	679	684	PF00017	0.360
LIG_TYR_ITIM	685	690	PF00017	0.368
LIG_UBA3_1	184	190	PF00899	0.325
LIG_UBA3_1	838	846	PF00899	0.479
LIG_WW_1	231	234	PF00397	0.444
LIG_WW_3	701	705	PF00397	0.444
MOD_CDK_SPK_2	308	313	PF00069	0.587
MOD_CDK_SPK_2	95	100	PF00069	0.272
MOD_CDK_SPxxK_3	636	643	PF00069	0.441
MOD_CK1_1	175	181	PF00069	0.452
MOD_CK1_1	294	300	PF00069	0.660
MOD_CK1_1	321	327	PF00069	0.602
MOD_CK1_1	375	381	PF00069	0.633
MOD_CK1_1	735	741	PF00069	0.422
MOD_CK1_1	917	923	PF00069	0.620
MOD_CK1_1	927	933	PF00069	0.567
MOD_CK2_1	236	242	PF00069	0.438
MOD_CK2_1	254	260	PF00069	0.277
MOD_CK2_1	316	322	PF00069	0.681
MOD_CK2_1	388	394	PF00069	0.581
MOD_CK2_1	423	429	PF00069	0.582
MOD_CK2_1	542	548	PF00069	0.507
MOD_CK2_1	650	656	PF00069	0.382
MOD_CK2_1	706	712	PF00069	0.525
MOD_CK2_1	735	741	PF00069	0.388
MOD_CK2_1	761	767	PF00069	0.389
MOD_CK2_1	831	837	PF00069	0.445
MOD_CK2_1	844	850	PF00069	0.450
MOD_CK2_1	965	971	PF00069	0.427
MOD_GlcNHglycan	174	177	PF01048	0.332
MOD_GlcNHglycan	199	202	PF01048	0.305
MOD_GlcNHglycan	296	299	PF01048	0.594
MOD_GlcNHglycan	313	316	PF01048	0.565
MOD_GlcNHglycan	348	351	PF01048	0.582
MOD_GlcNHglycan	432	435	PF01048	0.468
MOD_GlcNHglycan	535	538	PF01048	0.529
MOD_GlcNHglycan	580	583	PF01048	0.350
MOD_GlcNHglycan	785	788	PF01048	0.565
MOD_GlcNHglycan	888	891	PF01048	0.560
MOD_GlcNHglycan	918	922	PF01048	0.594
MOD_GlcNHglycan	957	960	PF01048	0.535
MOD_GlcNHglycan	978	981	PF01048	0.365
MOD_GSK3_1	171	178	PF00069	0.320
MOD_GSK3_1	236	243	PF00069	0.409
MOD_GSK3_1	250	257	PF00069	0.346
MOD_GSK3_1	307	314	PF00069	0.646
MOD_GSK3_1	361	368	PF00069	0.596
MOD_GSK3_1	371	378	PF00069	0.624
MOD_GSK3_1	60	67	PF00069	0.460
MOD_GSK3_1	615	622	PF00069	0.410
MOD_GSK3_1	740	747	PF00069	0.565
MOD_GSK3_1	91	98	PF00069	0.284
MOD_GSK3_1	939	946	PF00069	0.769
MOD_GSK3_1	965	972	PF00069	0.550
MOD_GSK3_1	974	981	PF00069	0.476
MOD_N-GLC_1	137	142	PF02516	0.369
MOD_N-GLC_1	171	176	PF02516	0.335
MOD_N-GLC_1	21	26	PF02516	0.387
MOD_N-GLC_1	294	299	PF02516	0.635
MOD_N-GLC_1	372	377	PF02516	0.616
MOD_N-GLC_2	226	228	PF02516	0.399
MOD_NEK2_1	113	118	PF00069	0.304
MOD_NEK2_1	155	160	PF00069	0.307
MOD_NEK2_1	197	202	PF00069	0.314
MOD_NEK2_1	410	415	PF00069	0.559
MOD_NEK2_1	430	435	PF00069	0.418
MOD_NEK2_1	54	59	PF00069	0.385
MOD_NEK2_1	570	575	PF00069	0.371
MOD_NEK2_1	610	615	PF00069	0.401
MOD_NEK2_1	64	69	PF00069	0.397
MOD_NEK2_1	815	820	PF00069	0.397
MOD_NEK2_1	844	849	PF00069	0.394
MOD_NEK2_1	873	878	PF00069	0.434
MOD_NEK2_1	884	889	PF00069	0.485
MOD_NEK2_1	969	974	PF00069	0.579
MOD_NEK2_1	976	981	PF00069	0.450
MOD_PIKK_1	495	501	PF00454	0.415
MOD_PIKK_1	780	786	PF00454	0.412
MOD_PIKK_1	844	850	PF00454	0.367
MOD_PK_1	254	260	PF00069	0.359
MOD_PKA_1	343	349	PF00069	0.588
MOD_PKA_1	501	507	PF00069	0.365
MOD_PKA_1	914	920	PF00069	0.453
MOD_PKA_2	142	148	PF00069	0.304
MOD_PKA_2	155	161	PF00069	0.304
MOD_PKA_2	300	306	PF00069	0.619
MOD_PKA_2	343	349	PF00069	0.603
MOD_PKA_2	501	507	PF00069	0.365
MOD_PKA_2	514	520	PF00069	0.404
MOD_PKA_2	619	625	PF00069	0.399
MOD_PKA_2	68	74	PF00069	0.385
MOD_PKA_2	744	750	PF00069	0.491
MOD_PKA_2	914	920	PF00069	0.549
MOD_PKA_2	955	961	PF00069	0.550
MOD_PKA_2	969	975	PF00069	0.340
MOD_PKB_1	912	920	PF00069	0.441
MOD_Plk_1	137	143	PF00069	0.304
MOD_Plk_1	21	27	PF00069	0.383
MOD_Plk_1	213	219	PF00069	0.238
MOD_Plk_1	321	327	PF00069	0.598
MOD_Plk_1	372	378	PF00069	0.599
MOD_Plk_1	410	416	PF00069	0.647
MOD_Plk_1	428	434	PF00069	0.373
MOD_Plk_1	54	60	PF00069	0.390
MOD_Plk_1	740	746	PF00069	0.534
MOD_Plk_2-3	619	625	PF00069	0.379
MOD_Plk_2-3	712	718	PF00069	0.449
MOD_Plk_2-3	965	971	PF00069	0.406
MOD_Plk_4	128	134	PF00069	0.304
MOD_Plk_4	137	143	PF00069	0.304
MOD_Plk_4	175	181	PF00069	0.304
MOD_Plk_4	21	27	PF00069	0.383
MOD_Plk_4	213	219	PF00069	0.313
MOD_Plk_4	240	246	PF00069	0.378
MOD_Plk_4	382	388	PF00069	0.576
MOD_Plk_4	735	741	PF00069	0.564
MOD_ProDKin_1	286	292	PF00069	0.649
MOD_ProDKin_1	308	314	PF00069	0.587
MOD_ProDKin_1	359	365	PF00069	0.747
MOD_ProDKin_1	376	382	PF00069	0.477
MOD_ProDKin_1	571	577	PF00069	0.370
MOD_ProDKin_1	636	642	PF00069	0.437
MOD_ProDKin_1	927	933	PF00069	0.661
MOD_ProDKin_1	95	101	PF00069	0.284
MOD_SUMO_for_1	474	477	PF00179	0.382
MOD_SUMO_for_1	825	828	PF00179	0.410
MOD_SUMO_for_1	99	102	PF00179	0.303
MOD_SUMO_rev_2	116	126	PF00179	0.314
TRG_DiLeu_BaEn_1	675	680	PF01217	0.433
TRG_DiLeu_BaLyEn_6	180	185	PF01217	0.304
TRG_DiLeu_BaLyEn_6	518	523	PF01217	0.407
TRG_DiLeu_BaLyEn_6	606	611	PF01217	0.369
TRG_DiLeu_BaLyEn_6	715	720	PF01217	0.437
TRG_DiLeu_LyEn_5	675	680	PF01217	0.433
TRG_ENDOCYTIC_2	234	237	PF00928	0.448
TRG_ENDOCYTIC_2	306	309	PF00928	0.687
TRG_ENDOCYTIC_2	31	34	PF00928	0.332
TRG_ENDOCYTIC_2	432	435	PF00928	0.512
TRG_ENDOCYTIC_2	661	664	PF00928	0.423
TRG_ENDOCYTIC_2	677	680	PF00928	0.466
TRG_ENDOCYTIC_2	681	684	PF00928	0.288
TRG_ENDOCYTIC_2	687	690	PF00928	0.401
TRG_ENDOCYTIC_2	769	772	PF00928	0.399
TRG_ER_diArg_1	342	344	PF00400	0.587
TRG_ER_diArg_1	48	51	PF00400	0.389
TRG_ER_diArg_1	500	502	PF00400	0.528
TRG_ER_diArg_1	563	565	PF00400	0.490
TRG_ER_diArg_1	607	609	PF00400	0.386
TRG_ER_diArg_1	911	914	PF00400	0.321
TRG_NES_CRM1_1	260	272	PF08389	0.402
TRG_NES_CRM1_1	637	647	PF08389	0.353
TRG_NES_CRM1_1	814	828	PF08389	0.351
TRG_NLS_MonoExtN_4	602	607	PF00514	0.352
TRG_Pf-PMV_PEXEL_1	632	637	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	763	767	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P961	Leptomonas seymouri	61%	100%
A0A3S5H7P3	Leishmania donovani	100%	100%
A4HJ11	Leishmania braziliensis	74%	100%
E9B1I7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q6M7	Leishmania major	92%	100%