LeishMANIAdb
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Sodium stibogluconate resistance protein, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Sodium stibogluconate resistance protein, putative
Gene product:
sodium stibogluconate resistance protein - putative
Species:
Leishmania infantum
UniProt:
A4I6I2_LEIIN
TriTrypDb:
LINF_310015200 *
Length:
660

Annotations

LeishMANIAdb annotations

Although predicted to have a multi-helical architecture, the protein is not hydrophobic enough for a membrane protein.. Unique to kinetoplastids, fast-evolving and duplicated multiple times.

Annotations by Jardim et al.

Drug resistance proteins, Sodium stibogluconate resistance ,

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I6I2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6I2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 120 124 PF00656 0.702
CLV_C14_Caspase3-7 160 164 PF00656 0.814
CLV_C14_Caspase3-7 169 173 PF00656 0.711
CLV_NRD_NRD_1 1 3 PF00675 0.534
CLV_NRD_NRD_1 12 14 PF00675 0.510
CLV_NRD_NRD_1 344 346 PF00675 0.638
CLV_NRD_NRD_1 579 581 PF00675 0.688
CLV_NRD_NRD_1 616 618 PF00675 0.602
CLV_NRD_NRD_1 654 656 PF00675 0.559
CLV_PCSK_KEX2_1 12 14 PF00082 0.514
CLV_PCSK_KEX2_1 563 565 PF00082 0.713
CLV_PCSK_KEX2_1 578 580 PF00082 0.455
CLV_PCSK_PC1ET2_1 563 565 PF00082 0.735
CLV_PCSK_PC1ET2_1 578 580 PF00082 0.455
CLV_PCSK_PC7_1 574 580 PF00082 0.628
CLV_PCSK_SKI1_1 253 257 PF00082 0.492
CLV_PCSK_SKI1_1 270 274 PF00082 0.587
CLV_PCSK_SKI1_1 363 367 PF00082 0.554
CLV_PCSK_SKI1_1 564 568 PF00082 0.671
CLV_PCSK_SKI1_1 574 578 PF00082 0.516
CLV_PCSK_SKI1_1 60 64 PF00082 0.554
CLV_PCSK_SKI1_1 95 99 PF00082 0.589
DEG_APCC_DBOX_1 392 400 PF00400 0.708
DEG_Nend_UBRbox_1 1 4 PF02207 0.559
DOC_MAPK_MEF2A_6 185 193 PF00069 0.616
DOC_MAPK_MEF2A_6 592 599 PF00069 0.567
DOC_PP1_RVXF_1 407 414 PF00149 0.700
DOC_PP1_SILK_1 651 656 PF00149 0.482
DOC_PP2B_LxvP_1 517 520 PF13499 0.745
DOC_SPAK_OSR1_1 69 73 PF12202 0.550
DOC_USP7_MATH_1 16 20 PF00917 0.503
DOC_USP7_MATH_1 29 33 PF00917 0.476
DOC_USP7_MATH_1 386 390 PF00917 0.588
DOC_USP7_MATH_1 430 434 PF00917 0.586
DOC_USP7_MATH_1 484 488 PF00917 0.534
DOC_USP7_MATH_1 500 504 PF00917 0.507
DOC_USP7_MATH_1 606 610 PF00917 0.464
DOC_USP7_MATH_1 642 646 PF00917 0.507
DOC_USP7_MATH_2 373 379 PF00917 0.601
DOC_USP7_MATH_2 463 469 PF00917 0.569
DOC_USP7_UBL2_3 294 298 PF12436 0.526
DOC_WW_Pin1_4 18 23 PF00397 0.498
DOC_WW_Pin1_4 426 431 PF00397 0.632
DOC_WW_Pin1_4 459 464 PF00397 0.645
LIG_14-3-3_CanoR_1 304 309 PF00244 0.608
LIG_14-3-3_CanoR_1 340 347 PF00244 0.415
LIG_14-3-3_CanoR_1 43 48 PF00244 0.683
LIG_14-3-3_CanoR_1 454 460 PF00244 0.631
LIG_14-3-3_CanoR_1 466 470 PF00244 0.459
LIG_14-3-3_CanoR_1 69 78 PF00244 0.599
LIG_Actin_WH2_2 476 494 PF00022 0.608
LIG_AP2alpha_1 89 93 PF02296 0.603
LIG_BIR_III_2 123 127 PF00653 0.671
LIG_BRCT_BRCA1_1 102 106 PF00533 0.572
LIG_BRCT_BRCA1_1 306 310 PF00533 0.594
LIG_BRCT_BRCA1_1 624 628 PF00533 0.438
LIG_CSL_BTD_1 427 430 PF09270 0.620
LIG_EH1_1 647 655 PF00400 0.515
LIG_FHA_1 182 188 PF00498 0.559
LIG_FHA_1 240 246 PF00498 0.539
LIG_FHA_1 303 309 PF00498 0.617
LIG_FHA_1 631 637 PF00498 0.422
LIG_FHA_1 92 98 PF00498 0.497
LIG_FHA_2 508 514 PF00498 0.750
LIG_FHA_2 69 75 PF00498 0.598
LIG_GBD_Chelix_1 650 658 PF00786 0.490
LIG_Integrin_RGD_1 161 163 PF01839 0.742
LIG_LIR_Gen_1 213 222 PF02991 0.599
LIG_LIR_Gen_1 265 274 PF02991 0.681
LIG_LIR_Gen_1 337 343 PF02991 0.565
LIG_LIR_Gen_1 644 654 PF02991 0.552
LIG_LIR_Nem_3 188 193 PF02991 0.458
LIG_LIR_Nem_3 202 207 PF02991 0.483
LIG_LIR_Nem_3 213 217 PF02991 0.397
LIG_LIR_Nem_3 265 269 PF02991 0.676
LIG_LIR_Nem_3 329 333 PF02991 0.442
LIG_LIR_Nem_3 337 341 PF02991 0.551
LIG_LIR_Nem_3 503 508 PF02991 0.712
LIG_LIR_Nem_3 56 62 PF02991 0.623
LIG_LIR_Nem_3 644 650 PF02991 0.470
LIG_PCNA_yPIPBox_3 340 351 PF02747 0.374
LIG_Pex14_2 89 93 PF04695 0.603
LIG_SH2_CRK 204 208 PF00017 0.543
LIG_SH2_CRK 266 270 PF00017 0.653
LIG_SH2_CRK 322 326 PF00017 0.517
LIG_SH2_CRK 330 334 PF00017 0.439
LIG_SH2_CRK 338 342 PF00017 0.396
LIG_SH2_CRK 351 355 PF00017 0.376
LIG_SH2_CRK 59 63 PF00017 0.613
LIG_SH2_GRB2like 351 354 PF00017 0.373
LIG_SH2_GRB2like 581 584 PF00017 0.530
LIG_SH2_SRC 351 354 PF00017 0.373
LIG_SH2_SRC 581 584 PF00017 0.486
LIG_SH2_STAP1 24 28 PF00017 0.494
LIG_SH2_STAP1 351 355 PF00017 0.376
LIG_SH2_STAP1 508 512 PF00017 0.713
LIG_SH2_STAT3 76 79 PF00017 0.604
LIG_SH2_STAT5 214 217 PF00017 0.472
LIG_SH2_STAT5 234 237 PF00017 0.241
LIG_SH2_STAT5 322 325 PF00017 0.387
LIG_SH2_STAT5 330 333 PF00017 0.392
LIG_SH2_STAT5 376 379 PF00017 0.572
LIG_SH2_STAT5 471 474 PF00017 0.597
LIG_SH2_STAT5 581 584 PF00017 0.530
LIG_SH2_STAT5 76 79 PF00017 0.466
LIG_SH3_3 128 134 PF00018 0.749
LIG_SH3_3 186 192 PF00018 0.565
LIG_SH3_3 424 430 PF00018 0.669
LIG_SH3_3 478 484 PF00018 0.624
LIG_SH3_3 532 538 PF00018 0.758
LIG_SUMO_SIM_anti_2 478 484 PF11976 0.619
LIG_TRAF2_1 64 67 PF00917 0.546
LIG_TYR_ITIM 264 269 PF00017 0.642
LIG_TYR_ITIM 57 62 PF00017 0.601
LIG_UBA3_1 245 253 PF00899 0.564
LIG_UBA3_1 381 387 PF00899 0.548
LIG_UBA3_1 611 618 PF00899 0.453
LIG_UBA3_1 649 656 PF00899 0.546
LIG_WRC_WIRS_1 410 415 PF05994 0.683
MOD_CDK_SPK_2 18 23 PF00069 0.498
MOD_CDK_SPxxK_3 459 466 PF00069 0.644
MOD_CK1_1 289 295 PF00069 0.588
MOD_CK1_1 339 345 PF00069 0.608
MOD_CK1_1 403 409 PF00069 0.633
MOD_CK1_1 453 459 PF00069 0.657
MOD_CK1_1 555 561 PF00069 0.727
MOD_CK2_1 426 432 PF00069 0.434
MOD_CK2_1 459 465 PF00069 0.523
MOD_CK2_1 507 513 PF00069 0.722
MOD_CK2_1 68 74 PF00069 0.591
MOD_GlcNHglycan 101 105 PF01048 0.555
MOD_GlcNHglycan 157 160 PF01048 0.773
MOD_GlcNHglycan 166 169 PF01048 0.755
MOD_GlcNHglycan 25 28 PF01048 0.516
MOD_GlcNHglycan 275 278 PF01048 0.685
MOD_GlcNHglycan 280 284 PF01048 0.672
MOD_GlcNHglycan 31 34 PF01048 0.486
MOD_GlcNHglycan 423 426 PF01048 0.734
MOD_GlcNHglycan 432 435 PF01048 0.435
MOD_GlcNHglycan 531 534 PF01048 0.705
MOD_GlcNHglycan 556 560 PF01048 0.769
MOD_GlcNHglycan 619 622 PF01048 0.589
MOD_GlcNHglycan 624 627 PF01048 0.526
MOD_GSK3_1 177 184 PF00069 0.622
MOD_GSK3_1 235 242 PF00069 0.536
MOD_GSK3_1 298 305 PF00069 0.623
MOD_GSK3_1 395 402 PF00069 0.773
MOD_GSK3_1 426 433 PF00069 0.622
MOD_GSK3_1 465 472 PF00069 0.565
MOD_GSK3_1 586 593 PF00069 0.621
MOD_GSK3_1 602 609 PF00069 0.309
MOD_N-GLC_1 450 455 PF02516 0.649
MOD_N-GLC_1 630 635 PF02516 0.424
MOD_NEK2_1 144 149 PF00069 0.646
MOD_NEK2_1 237 242 PF00069 0.551
MOD_NEK2_1 308 313 PF00069 0.559
MOD_NEK2_1 334 339 PF00069 0.576
MOD_NEK2_1 399 404 PF00069 0.727
MOD_NEK2_1 421 426 PF00069 0.722
MOD_NEK2_1 491 496 PF00069 0.593
MOD_NEK2_1 611 616 PF00069 0.484
MOD_NEK2_1 89 94 PF00069 0.542
MOD_NEK2_2 177 182 PF00069 0.590
MOD_NEK2_2 484 489 PF00069 0.529
MOD_PIKK_1 239 245 PF00454 0.536
MOD_PIKK_1 404 410 PF00454 0.717
MOD_PIKK_1 453 459 PF00454 0.657
MOD_PK_1 43 49 PF00069 0.739
MOD_PKA_1 617 623 PF00069 0.589
MOD_PKA_2 339 345 PF00069 0.425
MOD_PKA_2 42 48 PF00069 0.691
MOD_PKA_2 453 459 PF00069 0.640
MOD_PKA_2 465 471 PF00069 0.461
MOD_PKA_2 529 535 PF00069 0.716
MOD_PKA_2 68 74 PF00069 0.591
MOD_Plk_1 590 596 PF00069 0.589
MOD_Plk_4 139 145 PF00069 0.658
MOD_Plk_4 210 216 PF00069 0.552
MOD_Plk_4 247 253 PF00069 0.373
MOD_Plk_4 304 310 PF00069 0.606
MOD_Plk_4 484 490 PF00069 0.525
MOD_Plk_4 606 612 PF00069 0.449
MOD_Plk_4 649 655 PF00069 0.604
MOD_ProDKin_1 18 24 PF00069 0.499
MOD_ProDKin_1 426 432 PF00069 0.629
MOD_ProDKin_1 459 465 PF00069 0.648
MOD_SUMO_rev_2 180 187 PF00179 0.525
TRG_DiLeu_BaEn_2 623 629 PF01217 0.473
TRG_DiLeu_BaLyEn_6 202 207 PF01217 0.551
TRG_DiLeu_BaLyEn_6 376 381 PF01217 0.522
TRG_DiLeu_BaLyEn_6 434 439 PF01217 0.614
TRG_DiLeu_BaLyEn_6 571 576 PF01217 0.609
TRG_ENDOCYTIC_2 203 206 PF00928 0.510
TRG_ENDOCYTIC_2 214 217 PF00928 0.400
TRG_ENDOCYTIC_2 234 237 PF00928 0.235
TRG_ENDOCYTIC_2 266 269 PF00928 0.659
TRG_ENDOCYTIC_2 321 324 PF00928 0.391
TRG_ENDOCYTIC_2 330 333 PF00928 0.385
TRG_ENDOCYTIC_2 338 341 PF00928 0.448
TRG_ENDOCYTIC_2 351 354 PF00928 0.373
TRG_ENDOCYTIC_2 508 511 PF00928 0.710
TRG_ENDOCYTIC_2 59 62 PF00928 0.607
TRG_ER_diArg_1 579 581 PF00400 0.535
TRG_NLS_Bipartite_1 563 582 PF00514 0.687
TRG_NLS_MonoCore_2 576 581 PF00514 0.643
TRG_NLS_MonoExtN_4 574 581 PF00514 0.646
TRG_Pf-PMV_PEXEL_1 205 209 PF00026 0.539
TRG_Pf-PMV_PEXEL_1 656 660 PF00026 0.480

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IFG5 Leishmania donovani 99% 100%
A0A3Q8ISI8 Leishmania donovani 95% 100%
A0A3S7X4A3 Leishmania donovani 99% 100%
A4HJ70 Leishmania braziliensis 61% 99%
A4HJ71 Leishmania braziliensis 65% 99%
A4HJ73 Leishmania braziliensis 64% 100%
A4HJW7 Leishmania braziliensis 59% 100%
A4I6L8 Leishmania infantum 99% 100%
E8NHD1 Leishmania infantum 98% 100%
E8NHD2 Leishmania infantum 94% 100%
E8NHE7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
E8NHE8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
E9B1P3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4Q6G7 Leishmania major 88% 100%
Q4Q6G8 Leishmania major 89% 100%
Q4Q6H0 Leishmania major 88% 100%
Q9BHE5 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS