IMD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I6H9_LEIIN

TriTrypDb:

LINF_310014200

Length:

421

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I6H9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6H9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.410
CLV_NRD_NRD_1	123	125	PF00675	0.376
CLV_PCSK_KEX2_1	191	193	PF00082	0.393
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.342
CLV_PCSK_SKI1_1	104	108	PF00082	0.436
CLV_PCSK_SKI1_1	111	115	PF00082	0.452
CLV_PCSK_SKI1_1	117	121	PF00082	0.371
CLV_PCSK_SKI1_1	124	128	PF00082	0.352
CLV_PCSK_SKI1_1	322	326	PF00082	0.558
DOC_MAPK_gen_1	157	164	PF00069	0.362
DOC_PP4_FxxP_1	7	10	PF00568	0.432
DOC_USP7_MATH_1	115	119	PF00917	0.418
DOC_USP7_MATH_1	138	142	PF00917	0.453
DOC_USP7_MATH_1	160	164	PF00917	0.468
DOC_USP7_MATH_1	22	26	PF00917	0.383
DOC_USP7_MATH_1	53	57	PF00917	0.407
DOC_USP7_UBL2_3	103	107	PF12436	0.471
DOC_WW_Pin1_4	295	300	PF00397	0.634
DOC_WW_Pin1_4	307	312	PF00397	0.498
LIG_14-3-3_CanoR_1	230	234	PF00244	0.547
LIG_14-3-3_CanoR_1	281	287	PF00244	0.592
LIG_14-3-3_CanoR_1	313	321	PF00244	0.566
LIG_14-3-3_CanoR_1	376	382	PF00244	0.538
LIG_Actin_WH2_2	88	105	PF00022	0.417
LIG_AP2alpha_1	171	175	PF02296	0.392
LIG_BIR_II_1	1	5	PF00653	0.558
LIG_BRCT_BRCA1_1	272	276	PF00533	0.527
LIG_BRCT_BRCA1_1	47	51	PF00533	0.396
LIG_BRCT_BRCA1_1	55	59	PF00533	0.416
LIG_FHA_1	200	206	PF00498	0.406
LIG_FHA_1	333	339	PF00498	0.632
LIG_FHA_2	207	213	PF00498	0.434
LIG_FHA_2	300	306	PF00498	0.587
LIG_FHA_2	40	46	PF00498	0.391
LIG_FHA_2	403	409	PF00498	0.448
LIG_FHA_2	58	64	PF00498	0.386
LIG_LIR_Apic_2	6	10	PF02991	0.446
LIG_LIR_Gen_1	172	182	PF02991	0.476
LIG_LIR_Gen_1	48	59	PF02991	0.434
LIG_LIR_Nem_3	118	123	PF02991	0.425
LIG_LIR_Nem_3	172	178	PF02991	0.402
LIG_LIR_Nem_3	25	29	PF02991	0.423
LIG_LIR_Nem_3	352	358	PF02991	0.556
LIG_LIR_Nem_3	48	54	PF02991	0.429
LIG_Pex14_2	171	175	PF04695	0.414
LIG_Rb_LxCxE_1	216	235	PF01857	0.402
LIG_SH2_CRK	87	91	PF00017	0.345
LIG_SH2_SRC	67	70	PF00017	0.372
LIG_SH2_STAT5	193	196	PF00017	0.444
LIG_SH2_STAT5	372	375	PF00017	0.752
LIG_SH2_STAT5	391	394	PF00017	0.476
LIG_SH2_STAT5	67	70	PF00017	0.383
LIG_SH3_3	303	309	PF00018	0.589
LIG_SH3_3	336	342	PF00018	0.523
LIG_SH3_3	383	389	PF00018	0.728
LIG_SH3_3	414	420	PF00018	0.517
LIG_SH3_3	92	98	PF00018	0.385
LIG_SUMO_SIM_anti_2	243	249	PF11976	0.398
LIG_TRAF2_1	214	217	PF00917	0.445
LIG_TRAF2_2	10	15	PF00917	0.392
LIG_TRFH_1	254	258	PF08558	0.549
LIG_UBA3_1	33	38	PF00899	0.404
LIG_WRC_WIRS_1	23	28	PF05994	0.375
LIG_WRC_WIRS_1	371	376	PF05994	0.543
LIG_WW_1	369	372	PF00397	0.524
LIG_WW_3	290	294	PF00397	0.583
MOD_CDC14_SPxK_1	310	313	PF00782	0.514
MOD_CDK_SPxK_1	307	313	PF00069	0.520
MOD_CK1_1	149	155	PF00069	0.489
MOD_CK1_1	243	249	PF00069	0.462
MOD_CK1_1	272	278	PF00069	0.574
MOD_CK1_1	380	386	PF00069	0.545
MOD_CK2_1	102	108	PF00069	0.540
MOD_CK2_1	115	121	PF00069	0.351
MOD_CK2_1	211	217	PF00069	0.444
MOD_CK2_1	229	235	PF00069	0.442
MOD_CK2_1	299	305	PF00069	0.530
MOD_CK2_1	341	347	PF00069	0.573
MOD_CK2_1	39	45	PF00069	0.402
MOD_CK2_1	402	408	PF00069	0.448
MOD_CK2_1	57	63	PF00069	0.542
MOD_CK2_1	74	80	PF00069	0.415
MOD_GlcNHglycan	116	120	PF01048	0.443
MOD_GlcNHglycan	26	29	PF01048	0.402
MOD_GlcNHglycan	315	318	PF01048	0.556
MOD_GlcNHglycan	343	346	PF01048	0.587
MOD_GlcNHglycan	383	386	PF01048	0.558
MOD_GSK3_1	24	31	PF00069	0.368
MOD_GSK3_1	265	272	PF00069	0.595
MOD_GSK3_1	295	302	PF00069	0.600
MOD_GSK3_1	320	327	PF00069	0.522
MOD_GSK3_1	377	384	PF00069	0.553
MOD_GSK3_1	398	405	PF00069	0.466
MOD_GSK3_1	408	415	PF00069	0.474
MOD_GSK3_1	53	60	PF00069	0.413
MOD_N-GLC_1	183	188	PF02516	0.420
MOD_NEK2_1	102	107	PF00069	0.420
MOD_NEK2_1	144	149	PF00069	0.469
MOD_NEK2_1	265	270	PF00069	0.559
MOD_PIKK_1	248	254	PF00454	0.531
MOD_PIKK_1	356	362	PF00454	0.544
MOD_PKA_1	270	276	PF00069	0.504
MOD_PKA_2	229	235	PF00069	0.451
MOD_Plk_1	115	121	PF00069	0.602
MOD_Plk_1	243	249	PF00069	0.451
MOD_Plk_2-3	74	80	PF00069	0.372
MOD_Plk_4	200	206	PF00069	0.410
MOD_Plk_4	229	235	PF00069	0.478
MOD_Plk_4	243	249	PF00069	0.370
MOD_Plk_4	377	383	PF00069	0.551
MOD_ProDKin_1	295	301	PF00069	0.636
MOD_ProDKin_1	307	313	PF00069	0.499
MOD_SUMO_for_1	113	116	PF00179	0.398
TRG_DiLeu_BaEn_4	216	222	PF01217	0.422
TRG_ENDOCYTIC_2	193	196	PF00928	0.444
TRG_ENDOCYTIC_2	87	90	PF00928	0.372
TRG_ER_diArg_1	292	295	PF00400	0.577
TRG_NLS_MonoExtN_4	122	128	PF00514	0.386
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3S1	Leptomonas seymouri	50%	92%
A0A3Q8IG21	Leishmania donovani	97%	100%
A0A3Q8IIE7	Leishmania donovani	92%	100%
A4H6C6	Leishmania braziliensis	24%	100%
A4HJ56	Leishmania braziliensis	66%	100%
E9AHL0	Leishmania infantum	93%	100%
E9B1M8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
E9B1N5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
E9B1N6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q6H8	Leishmania major	86%	100%
Q4Q6I6	Leishmania major	83%	100%
Q4QI82	Leishmania major	24%	100%