Lipase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Lipase-like protein

Gene product:

lipase precursor-like protein

Species:

Leishmania infantum

UniProt:

A4I6H8_LEIIN

TriTrypDb:

LINF_310014100

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 7, no: 4
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I6H8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6H8

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004806	triglyceride lipase activity	5	7
GO:0016298	lipase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0052689	carboxylic ester hydrolase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.192
CLV_NRD_NRD_1	104	106	PF00675	0.289
CLV_NRD_NRD_1	2	4	PF00675	0.373
CLV_PCSK_KEX2_1	2	4	PF00082	0.373
CLV_PCSK_SKI1_1	172	176	PF00082	0.238
CLV_PCSK_SKI1_1	228	232	PF00082	0.350
DEG_Nend_UBRbox_1	1	4	PF02207	0.373
DEG_SPOP_SBC_1	196	200	PF00917	0.261
DOC_MAPK_gen_1	216	225	PF00069	0.401
DOC_MIT_MIM_1	130	138	PF04212	0.238
DOC_PP4_FxxP_1	152	155	PF00568	0.294
DOC_USP7_MATH_1	12	16	PF00917	0.381
DOC_USP7_UBL2_3	102	106	PF12436	0.291
LIG_14-3-3_CanoR_1	177	185	PF00244	0.331
LIG_14-3-3_CanoR_1	2	8	PF00244	0.416
LIG_14-3-3_CanoR_1	207	217	PF00244	0.533
LIG_14-3-3_CanoR_1	228	234	PF00244	0.392
LIG_Actin_WH2_2	131	147	PF00022	0.238
LIG_BRCT_BRCA1_1	199	203	PF00533	0.512
LIG_BRCT_BRCA1_2	199	205	PF00533	0.302
LIG_FHA_1	107	113	PF00498	0.283
LIG_FHA_1	197	203	PF00498	0.277
LIG_FHA_1	40	46	PF00498	0.351
LIG_FHA_1	50	56	PF00498	0.217
LIG_LIR_Apic_2	151	155	PF02991	0.294
LIG_LIR_Gen_1	109	114	PF02991	0.478
LIG_LIR_Nem_3	109	113	PF02991	0.383
LIG_LIR_Nem_3	192	196	PF02991	0.459
LIG_LIR_Nem_3	88	92	PF02991	0.338
LIG_PDZ_Class_1	229	234	PF00595	0.359
LIG_PDZ_Wminus1_1	232	234	PF00595	0.392
LIG_PTB_Apo_2	156	163	PF02174	0.304
LIG_PTB_Apo_2	80	87	PF02174	0.192
LIG_PTB_Phospho_1	80	86	PF10480	0.192
LIG_SH2_CRK	89	93	PF00017	0.321
LIG_SH2_SRC	195	198	PF00017	0.340
LIG_SH2_STAP1	110	114	PF00017	0.321
LIG_SH2_STAP1	86	90	PF00017	0.275
LIG_SH2_STAT5	150	153	PF00017	0.304
LIG_SH2_STAT5	195	198	PF00017	0.423
LIG_SH3_3	183	189	PF00018	0.316
LIG_Sin3_3	122	129	PF02671	0.227
LIG_SUMO_SIM_anti_2	183	189	PF11976	0.242
LIG_WRC_WIRS_1	149	154	PF05994	0.294
MOD_CK1_1	208	214	PF00069	0.560
MOD_CK1_1	74	80	PF00069	0.354
MOD_CK1_1	88	94	PF00069	0.241
MOD_CK2_1	195	201	PF00069	0.360
MOD_CK2_1	74	80	PF00069	0.447
MOD_GlcNHglycan	10	13	PF01048	0.339
MOD_GlcNHglycan	219	222	PF01048	0.589
MOD_GSK3_1	3	10	PF00069	0.518
MOD_GSK3_1	70	77	PF00069	0.252
MOD_N-GLC_1	208	213	PF02516	0.504
MOD_NEK2_1	19	24	PF00069	0.382
MOD_NEK2_1	203	208	PF00069	0.454
MOD_NEK2_1	217	222	PF00069	0.370
MOD_NEK2_1	49	54	PF00069	0.330
MOD_NEK2_1	85	90	PF00069	0.304
MOD_PIKK_1	39	45	PF00454	0.401
MOD_PKA_2	176	182	PF00069	0.310
MOD_PKA_2	49	55	PF00069	0.304
MOD_Plk_1	19	25	PF00069	0.442
MOD_Plk_4	165	171	PF00069	0.369
MOD_Plk_4	54	60	PF00069	0.218
MOD_Plk_4	85	91	PF00069	0.261
MOD_SUMO_rev_2	139	147	PF00179	0.238
TRG_ENDOCYTIC_2	110	113	PF00928	0.459
TRG_ENDOCYTIC_2	89	92	PF00928	0.343
TRG_ER_diArg_1	1	3	PF00400	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IJE8	Bodo saltans	34%	71%
A0A0S4J5D7	Bodo saltans	35%	75%
A0A0S4JTA1	Bodo saltans	36%	76%
A0A1X0NH29	Trypanosomatidae	38%	96%
A0A1X0NHD7	Trypanosomatidae	37%	100%
A0A1X0P001	Trypanosomatidae	39%	68%
A0A3Q8IG97	Leishmania donovani	38%	76%
A0A3S7X4C1	Leishmania donovani	99%	100%
A2QSY5	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	31%	83%
A4HLK7	Leishmania braziliensis	47%	70%
A4I6H7	Leishmania infantum	38%	100%
B8NIB8	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	35%	83%
O42807	Aspergillus niger	31%	83%
O42815	Aspergillus tubingensis	31%	84%
O59952	Thermomyces lanuginosus	36%	80%
P47145	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	71%
P61869	Penicillium cyclopium	30%	77%
P61870	Penicillium camembertii	30%	77%
Q0CBM7	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	34%	83%
Q2UNW5	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	35%	83%
Q4Q6I0	Leishmania major	38%	100%
Q9BHD5	Leishmania major	82%	100%
Q9P979	Aspergillus awamori	31%	83%
Q9XTR8	Caenorhabditis elegans	35%	66%
V5B761	Trypanosoma cruzi	39%	89%