Lipase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Lipase

Gene product:

lipase - putative

Species:

Leishmania infantum

UniProt:

A4I6H7_LEIIN

TriTrypDb:

LINF_310014000

Length:

308

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 11, no: 9
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4I6H7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6H7

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	21
GO:0008152	metabolic process	1	21
GO:0044238	primary metabolic process	2	21
GO:0071704	organic substance metabolic process	2	21

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004806	triglyceride lipase activity	5	12
GO:0016298	lipase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0052689	carboxylic ester hydrolase activity	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	267	271	PF00656	0.310
CLV_C14_Caspase3-7	32	36	PF00656	0.341
CLV_NRD_NRD_1	111	113	PF00675	0.199
CLV_NRD_NRD_1	143	145	PF00675	0.492
CLV_NRD_NRD_1	37	39	PF00675	0.289
CLV_PCSK_KEX2_1	111	113	PF00082	0.204
CLV_PCSK_KEX2_1	143	145	PF00082	0.490
CLV_PCSK_KEX2_1	37	39	PF00082	0.270
CLV_PCSK_SKI1_1	152	156	PF00082	0.295
CLV_PCSK_SKI1_1	187	191	PF00082	0.430
DOC_PP4_FxxP_1	201	204	PF00568	0.319
DOC_USP7_MATH_1	194	198	PF00917	0.472
DOC_USP7_MATH_1	2	6	PF00917	0.561
DOC_USP7_MATH_1	36	40	PF00917	0.428
DOC_USP7_MATH_1	52	56	PF00917	0.371
DOC_USP7_MATH_1	64	68	PF00917	0.307
LIG_14-3-3_CanoR_1	100	110	PF00244	0.348
LIG_14-3-3_CanoR_1	143	147	PF00244	0.265
LIG_14-3-3_CanoR_1	193	199	PF00244	0.232
LIG_14-3-3_CanoR_1	226	234	PF00244	0.319
LIG_14-3-3_CanoR_1	37	41	PF00244	0.459
LIG_BRCT_BRCA1_1	241	245	PF00533	0.587
LIG_EH1_1	67	75	PF00400	0.303
LIG_FHA_1	273	279	PF00498	0.483
LIG_FHA_1	69	75	PF00498	0.377
LIG_FHA_2	102	108	PF00498	0.490
LIG_FHA_2	44	50	PF00498	0.478
LIG_HP1_1	194	198	PF01393	0.232
LIG_LIR_Apic_2	200	204	PF02991	0.333
LIG_LIR_Gen_1	138	146	PF02991	0.312
LIG_LIR_Gen_1	242	253	PF02991	0.497
LIG_LIR_Gen_1	39	50	PF02991	0.291
LIG_LIR_Nem_3	138	142	PF02991	0.336
LIG_LIR_Nem_3	242	248	PF02991	0.446
LIG_LIR_Nem_3	287	292	PF02991	0.361
LIG_LIR_Nem_3	39	45	PF02991	0.389
LIG_LIR_Nem_3	46	50	PF02991	0.354
LIG_PDZ_Class_2	303	308	PF00595	0.601
LIG_PTB_Apo_2	205	212	PF02174	0.328
LIG_PTB_Apo_2	41	48	PF02174	0.267
LIG_PTB_Apo_2	62	69	PF02174	0.489
LIG_PTB_Phospho_1	41	47	PF10480	0.266
LIG_REV1ctd_RIR_1	187	193	PF16727	0.232
LIG_SH2_CRK	160	164	PF00017	0.260
LIG_SH2_CRK	42	46	PF00017	0.393
LIG_SH2_GRB2like	42	45	PF00017	0.265
LIG_SH2_NCK_1	42	46	PF00017	0.424
LIG_SH2_NCK_1	47	51	PF00017	0.460
LIG_SH2_PTP2	85	88	PF00017	0.252
LIG_SH2_SRC	42	45	PF00017	0.476
LIG_SH2_SRC	47	50	PF00017	0.528
LIG_SH2_STAT5	139	142	PF00017	0.357
LIG_SH2_STAT5	199	202	PF00017	0.329
LIG_SH2_STAT5	253	256	PF00017	0.474
LIG_SH2_STAT5	291	294	PF00017	0.393
LIG_SH2_STAT5	85	88	PF00017	0.375
LIG_SH3_3	110	116	PF00018	0.378
LIG_SH3_3	188	194	PF00018	0.448
LIG_SH3_3	232	238	PF00018	0.306
LIG_SUMO_SIM_anti_2	7	13	PF11976	0.479
LIG_SUMO_SIM_par_1	194	200	PF11976	0.404
LIG_TRAF2_1	104	107	PF00917	0.232
LIG_TYR_ITIM	40	45	PF00017	0.361
LIG_TYR_ITIM	83	88	PF00017	0.347
LIG_WRC_WIRS_1	198	203	PF05994	0.349
MOD_CK1_1	197	203	PF00069	0.488
MOD_CK1_1	220	226	PF00069	0.388
MOD_CK1_1	239	245	PF00069	0.644
MOD_CK1_1	4	10	PF00069	0.630
MOD_CK2_1	101	107	PF00069	0.406
MOD_GlcNHglycan	101	104	PF01048	0.366
MOD_GlcNHglycan	122	125	PF01048	0.244
MOD_GlcNHglycan	20	23	PF01048	0.623
MOD_GlcNHglycan	239	242	PF01048	0.607
MOD_GlcNHglycan	266	270	PF01048	0.467
MOD_GlcNHglycan	296	299	PF01048	0.528
MOD_GlcNHglycan	89	94	PF01048	0.479
MOD_GSK3_1	25	32	PF00069	0.445
MOD_GSK3_1	64	71	PF00069	0.417
MOD_LATS_1	224	230	PF00433	0.232
MOD_N-GLC_1	43	48	PF02516	0.380
MOD_NEK2_1	135	140	PF00069	0.357
MOD_NEK2_1	18	23	PF00069	0.565
MOD_NEK2_1	189	194	PF00069	0.434
MOD_NEK2_1	225	230	PF00069	0.431
MOD_NEK2_1	68	73	PF00069	0.407
MOD_NEK2_1	99	104	PF00069	0.351
MOD_NEK2_2	194	199	PF00069	0.232
MOD_PIKK_1	101	107	PF00454	0.476
MOD_PIKK_1	29	35	PF00454	0.354
MOD_PK_1	69	75	PF00069	0.307
MOD_PKA_2	142	148	PF00069	0.259
MOD_PKA_2	220	226	PF00069	0.349
MOD_PKA_2	294	300	PF00069	0.526
MOD_PKA_2	36	42	PF00069	0.532
MOD_PKA_2	99	105	PF00069	0.316
MOD_Plk_1	152	158	PF00069	0.378
MOD_Plk_1	43	49	PF00069	0.383
MOD_Plk_4	194	200	PF00069	0.415
MOD_Plk_4	69	75	PF00069	0.332
MOD_Plk_4	78	84	PF00069	0.530
TRG_ENDOCYTIC_2	139	142	PF00928	0.349
TRG_ENDOCYTIC_2	160	163	PF00928	0.419
TRG_ENDOCYTIC_2	42	45	PF00928	0.348
TRG_ENDOCYTIC_2	47	50	PF00928	0.377
TRG_ENDOCYTIC_2	85	88	PF00928	0.375
TRG_ER_diArg_1	110	112	PF00400	0.199
TRG_ER_diArg_1	142	144	PF00400	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0D0	Leptomonas seymouri	30%	86%
A0A0S4IJE8	Bodo saltans	32%	94%
A0A0S4J5D7	Bodo saltans	35%	99%
A0A0S4JTA1	Bodo saltans	34%	100%
A0A1X0NH29	Trypanosomatidae	35%	100%
A0A1X0NZH3	Trypanosomatidae	32%	73%
A0A1X0P001	Trypanosomatidae	35%	90%
A0A3Q8IFI3	Leishmania donovani	32%	84%
A0A3Q8IG97	Leishmania donovani	100%	100%
A0A3S7X4C1	Leishmania donovani	37%	100%
A2QSY5	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	27%	100%
A4HJN0	Leishmania braziliensis	32%	100%
A4HLK7	Leishmania braziliensis	40%	100%
A4I6H8	Leishmania infantum	38%	100%
A4I752	Leishmania infantum	32%	84%
B8NIB8	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	25%	100%
C9ZME7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	84%
E9B246	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
O42807	Aspergillus niger	27%	100%
O42815	Aspergillus tubingensis	26%	100%
O59952	Thermomyces lanuginosus	30%	100%
P0CT91	Sodiomyces alcalophilus	28%	74%
P19515	Rhizomucor miehei	31%	85%
P61869	Penicillium cyclopium	29%	100%
P61870	Penicillium camembertii	29%	100%
Q0CBM7	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	28%	100%
Q2UNW5	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	25%	100%
Q4Q615	Leishmania major	31%	100%
Q4Q6I0	Leishmania major	89%	100%
Q9BHD5	Leishmania major	36%	100%
Q9P979	Aspergillus awamori	27%	100%
Q9XTR8	Caenorhabditis elegans	29%	87%
V5B761	Trypanosoma cruzi	31%	100%