Putative c2 domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

c2 domain protein - putative

Species:

Leishmania infantum

UniProt:

A4I6H3_LEIIN

TriTrypDb:

LINF_310013600

Length:

288

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I6H3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6H3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	275	277	PF00675	0.540
CLV_PCSK_KEX2_1	275	277	PF00082	0.540
DOC_ANK_TNKS_1	127	134	PF00023	0.403
DOC_MAPK_gen_1	19	29	PF00069	0.285
DOC_MAPK_MEF2A_6	22	31	PF00069	0.285
DOC_PIKK_1	76	84	PF02985	0.322
DOC_PP2B_LxvP_1	176	179	PF13499	0.595
DOC_PP4_MxPP_1	199	202	PF00568	0.492
DOC_USP7_UBL2_3	36	40	PF12436	0.391
DOC_WW_Pin1_4	110	115	PF00397	0.359
LIG_14-3-3_CanoR_1	135	141	PF00244	0.499
LIG_EVH1_1	171	175	PF00568	0.538
LIG_FHA_1	101	107	PF00498	0.350
LIG_FHA_1	135	141	PF00498	0.550
LIG_FHA_1	94	100	PF00498	0.354
LIG_LIR_Apic_2	152	156	PF02991	0.566
LIG_LIR_Apic_2	236	240	PF02991	0.624
LIG_LIR_Gen_1	102	108	PF02991	0.333
LIG_LIR_Gen_1	24	31	PF02991	0.357
LIG_LIR_Gen_1	64	72	PF02991	0.274
LIG_LIR_Nem_3	102	107	PF02991	0.356
LIG_LIR_Nem_3	24	29	PF02991	0.357
LIG_PCNA_PIPBox_1	68	77	PF02747	0.274
LIG_Pex14_1	54	58	PF04695	0.336
LIG_PTB_Apo_2	52	59	PF02174	0.285
LIG_SH2_CRK	153	157	PF00017	0.562
LIG_SH2_CRK	198	202	PF00017	0.632
LIG_SH2_CRK	209	213	PF00017	0.680
LIG_SH2_CRK	237	241	PF00017	0.662
LIG_SH2_CRK	247	251	PF00017	0.640
LIG_SH2_CRK	268	272	PF00017	0.551
LIG_SH2_CRK	282	286	PF00017	0.538
LIG_SH2_PTP2	159	162	PF00017	0.531
LIG_SH2_PTP2	26	29	PF00017	0.316
LIG_SH2_SRC	159	162	PF00017	0.531
LIG_SH2_SRC	207	210	PF00017	0.569
LIG_SH2_STAP1	184	188	PF00017	0.532
LIG_SH2_STAP1	88	92	PF00017	0.449
LIG_SH2_STAT5	159	162	PF00017	0.525
LIG_SH2_STAT5	26	29	PF00017	0.322
LIG_SH3_1	198	204	PF00018	0.577
LIG_SH3_1	209	215	PF00018	0.579
LIG_SH3_1	237	243	PF00018	0.553
LIG_SH3_1	247	253	PF00018	0.575
LIG_SH3_2	270	275	PF14604	0.548
LIG_SH3_3	169	175	PF00018	0.583
LIG_SH3_3	17	23	PF00018	0.345
LIG_SH3_3	198	204	PF00018	0.606
LIG_SH3_3	209	215	PF00018	0.789
LIG_SH3_3	237	243	PF00018	0.653
LIG_SH3_3	247	253	PF00018	0.588
LIG_SH3_3	259	265	PF00018	0.567
LIG_SH3_3	267	273	PF00018	0.466
LIG_SUMO_SIM_par_1	120	125	PF11976	0.422
LIG_SUMO_SIM_par_1	136	141	PF11976	0.488
MOD_CK2_1	110	116	PF00069	0.461
MOD_GlcNHglycan	184	187	PF01048	0.561
MOD_GSK3_1	141	148	PF00069	0.540
MOD_GSK3_1	30	37	PF00069	0.263
MOD_GSK3_1	84	91	PF00069	0.268
MOD_N-GLC_1	233	238	PF02516	0.540
MOD_NEK2_1	107	112	PF00069	0.632
MOD_NEK2_1	84	89	PF00069	0.268
MOD_PIKK_1	218	224	PF00454	0.562
MOD_PIKK_1	34	40	PF00454	0.331
MOD_PKA_2	134	140	PF00069	0.437
MOD_Plk_1	233	239	PF00069	0.538
MOD_Plk_4	100	106	PF00069	0.318
MOD_Plk_4	141	147	PF00069	0.533
MOD_ProDKin_1	110	116	PF00069	0.354
TRG_ENDOCYTIC_2	196	199	PF00928	0.648
TRG_ENDOCYTIC_2	26	29	PF00928	0.316
TRG_ENDOCYTIC_2	65	68	PF00928	0.274
TRG_ER_diArg_1	275	277	PF00400	0.540
TRG_Pf-PMV_PEXEL_1	120	125	PF00026	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2M8	Leptomonas seymouri	60%	100%
A0A3Q8IFD2	Leishmania donovani	35%	100%
A0A3S7X485	Leishmania donovani	100%	100%
A0A3S7X4C0	Leishmania donovani	48%	100%
A4HJ57	Leishmania braziliensis	49%	93%
A4HJ58	Leishmania braziliensis	72%	94%
A4I6G2	Leishmania infantum	34%	100%
A4I6H2	Leishmania infantum	49%	100%
E9B1N0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9B1N1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	96%
Q9BHE8	Leishmania major	94%	100%
Q9BHF8	Leishmania major	36%	100%