Putative c2 domain protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

c2 domain protein - putative

Species:

Leishmania infantum

UniProt:

A4I6H2_LEIIN

TriTrypDb:

LINF_310013500

Length:

245

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, c2 domain

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I6H2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6H2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.310
CLV_NRD_NRD_1	33	35	PF00675	0.214
DEG_SPOP_SBC_1	45	49	PF00917	0.248
DOC_PIKK_1	76	84	PF02985	0.300
DOC_USP7_MATH_1	130	134	PF00917	0.397
DOC_USP7_MATH_1	173	177	PF00917	0.524
DOC_USP7_MATH_1	46	50	PF00917	0.242
DOC_USP7_UBL2_3	36	40	PF12436	0.308
DOC_WW_Pin1_4	240	245	PF00397	0.525
LIG_14-3-3_CanoR_1	34	41	PF00244	0.251
LIG_14-3-3_CanoR_1	97	107	PF00244	0.272
LIG_Actin_WH2_2	92	110	PF00022	0.253
LIG_BRCT_BRCA1_1	195	199	PF00533	0.484
LIG_FHA_1	153	159	PF00498	0.459
LIG_FHA_1	94	100	PF00498	0.436
LIG_GBD_Chelix_1	99	107	PF00786	0.248
LIG_LIR_Apic_2	227	232	PF02991	0.535
LIG_LIR_Gen_1	101	112	PF02991	0.402
LIG_LIR_Gen_1	24	31	PF02991	0.343
LIG_LIR_Nem_3	101	107	PF02991	0.334
LIG_LIR_Nem_3	24	29	PF02991	0.343
LIG_PDZ_Class_1	240	245	PF00595	0.491
LIG_SH2_CRK	229	233	PF00017	0.605
LIG_SH2_NCK_1	143	147	PF00017	0.345
LIG_SH2_PTP2	26	29	PF00017	0.307
LIG_SH2_STAP1	206	210	PF00017	0.509
LIG_SH2_STAP1	88	92	PF00017	0.327
LIG_SH2_STAT3	200	203	PF00017	0.577
LIG_SH2_STAT3	206	209	PF00017	0.586
LIG_SH2_STAT3	218	221	PF00017	0.596
LIG_SH2_STAT5	200	203	PF00017	0.585
LIG_SH2_STAT5	26	29	PF00017	0.312
LIG_SH3_1	229	235	PF00018	0.501
LIG_SH3_3	167	173	PF00018	0.596
LIG_SH3_3	185	191	PF00018	0.564
LIG_SH3_3	210	216	PF00018	0.623
LIG_SH3_3	229	235	PF00018	0.642
LIG_SH3_4	193	200	PF00018	0.487
LIG_TRAF2_1	139	142	PF00917	0.370
MOD_CK2_1	110	116	PF00069	0.453
MOD_CK2_1	136	142	PF00069	0.376
MOD_CK2_1	171	177	PF00069	0.495
MOD_GlcNHglycan	113	116	PF01048	0.336
MOD_GSK3_1	107	114	PF00069	0.413
MOD_GSK3_1	198	205	PF00069	0.522
MOD_GSK3_1	36	43	PF00069	0.315
MOD_N-GLC_1	153	158	PF02516	0.409
MOD_NEK2_1	107	112	PF00069	0.466
MOD_NEK2_1	224	229	PF00069	0.479
MOD_NEK2_2	46	51	PF00069	0.298
MOD_PIKK_1	193	199	PF00454	0.502
MOD_PIKK_1	34	40	PF00454	0.335
MOD_PKA_1	34	40	PF00069	0.259
MOD_Plk_4	131	137	PF00069	0.430
MOD_Plk_4	224	230	PF00069	0.582
TRG_ENDOCYTIC_2	26	29	PF00928	0.308
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.288
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D0	Leptomonas seymouri	62%	85%
A0A3Q8IFD2	Leishmania donovani	36%	100%
A0A3S7X485	Leishmania donovani	50%	100%
A0A3S7X4C0	Leishmania donovani	97%	100%
A4HJ46	Leishmania braziliensis	39%	100%
A4HJ57	Leishmania braziliensis	67%	97%
A4HJ58	Leishmania braziliensis	52%	100%
A4I6G2	Leishmania infantum	36%	100%
A4I6H3	Leishmania infantum	49%	100%
E9B1L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	98%
E9B1N0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
E9B1N1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
Q9BHE7	Leishmania major	74%	100%
Q9BHE8	Leishmania major	49%	100%
Q9BHF8	Leishmania major	38%	99%