LeishMANIAdb
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Ubiquitin-like domain-containing protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ubiquitin-like domain-containing protein
Gene product:
Tir chaperone protein (CesT) family - putative
Species:
Leishmania infantum
UniProt:
A4I6G8_LEIIN
TriTrypDb:
LINF_310013100
Length:
317

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 110
Promastigote: 175, 177, 178

Expansion

Sequence features

A4I6G8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6G8

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 9
GO:0008104 protein localization 4 9
GO:0009306 protein secretion 4 9
GO:0009987 cellular process 1 9
GO:0015031 protein transport 4 9
GO:0030254 protein secretion by the type III secretion system 4 9
GO:0032940 secretion by cell 3 9
GO:0033036 macromolecule localization 2 9
GO:0035592 establishment of protein localization to extracellular region 4 9
GO:0045184 establishment of protein localization 3 9
GO:0046903 secretion 4 9
GO:0051179 localization 1 9
GO:0051234 establishment of localization 2 9
GO:0051641 cellular localization 2 9
GO:0055085 transmembrane transport 2 9
GO:0070727 cellular macromolecule localization 3 9
GO:0071692 protein localization to extracellular region 5 9
GO:0071702 organic substance transport 4 9
GO:0071705 nitrogen compound transport 4 9
GO:0071806 protein transmembrane transport 3 9
GO:0140352 export from cell 2 9
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 10 14 PF00656 0.510
CLV_C14_Caspase3-7 178 182 PF00656 0.535
CLV_NRD_NRD_1 112 114 PF00675 0.562
CLV_NRD_NRD_1 14 16 PF00675 0.432
CLV_NRD_NRD_1 172 174 PF00675 0.621
CLV_NRD_NRD_1 34 36 PF00675 0.272
CLV_PCSK_KEX2_1 112 114 PF00082 0.562
CLV_PCSK_KEX2_1 172 174 PF00082 0.622
CLV_PCSK_KEX2_1 34 36 PF00082 0.421
CLV_PCSK_SKI1_1 15 19 PF00082 0.390
CLV_PCSK_SKI1_1 205 209 PF00082 0.334
CLV_PCSK_SKI1_1 35 39 PF00082 0.274
CLV_PCSK_SKI1_1 4 8 PF00082 0.411
DEG_APCC_DBOX_1 21 29 PF00400 0.395
DEG_APCC_DBOX_1 246 254 PF00400 0.468
DEG_Nend_UBRbox_2 1 3 PF02207 0.482
DEG_SPOP_SBC_1 279 283 PF00917 0.534
DOC_ANK_TNKS_1 164 171 PF00023 0.543
DOC_MAPK_gen_1 15 21 PF00069 0.411
DOC_MAPK_gen_1 247 255 PF00069 0.468
DOC_MAPK_MEF2A_6 196 203 PF00069 0.534
DOC_USP7_MATH_1 156 160 PF00917 0.723
DOC_USP7_MATH_1 186 190 PF00917 0.469
DOC_USP7_UBL2_3 187 191 PF12436 0.437
DOC_WW_Pin1_4 287 292 PF00397 0.482
LIG_14-3-3_CanoR_1 172 180 PF00244 0.686
LIG_14-3-3_CanoR_1 307 312 PF00244 0.540
LIG_14-3-3_CanoR_1 35 41 PF00244 0.428
LIG_APCC_ABBA_1 298 303 PF00400 0.493
LIG_BRCT_BRCA1_1 199 203 PF00533 0.468
LIG_BRCT_BRCA1_2 199 205 PF00533 0.547
LIG_eIF4E_1 231 237 PF01652 0.468
LIG_FHA_1 206 212 PF00498 0.468
LIG_FHA_1 225 231 PF00498 0.468
LIG_FHA_1 279 285 PF00498 0.482
LIG_FHA_2 113 119 PF00498 0.784
LIG_FHA_2 211 217 PF00498 0.534
LIG_GBD_Chelix_1 193 201 PF00786 0.319
LIG_Integrin_RGD_1 22 24 PF01839 0.431
LIG_Integrin_RGD_TGFB_3 22 28 PF01839 0.398
LIG_LIR_Apic_2 39 43 PF02991 0.416
LIG_LIR_Gen_1 214 225 PF02991 0.534
LIG_LIR_Nem_3 214 220 PF02991 0.534
LIG_SH2_CRK 233 237 PF00017 0.468
LIG_SH2_NCK_1 117 121 PF00017 0.610
LIG_SH2_NCK_1 223 227 PF00017 0.534
LIG_SH2_SRC 117 120 PF00017 0.617
LIG_SH2_SRC 223 226 PF00017 0.487
LIG_SH2_SRC 231 234 PF00017 0.447
LIG_SH2_STAP1 233 237 PF00017 0.468
LIG_SH2_STAP1 251 255 PF00017 0.468
LIG_SH2_STAT3 106 109 PF00017 0.714
LIG_SH2_STAT5 231 234 PF00017 0.468
LIG_SH2_STAT5 36 39 PF00017 0.451
LIG_SH3_3 152 158 PF00018 0.515
LIG_SH3_3 238 244 PF00018 0.519
LIG_SH3_3 79 85 PF00018 0.679
LIG_SUMO_SIM_par_1 276 283 PF11976 0.469
LIG_WW_3 162 166 PF00397 0.640
MOD_CK1_1 175 181 PF00069 0.644
MOD_CK1_1 235 241 PF00069 0.547
MOD_CK2_1 112 118 PF00069 0.781
MOD_Cter_Amidation 13 16 PF01082 0.431
MOD_GlcNHglycan 109 112 PF01048 0.771
MOD_GlcNHglycan 158 161 PF01048 0.735
MOD_GSK3_1 215 222 PF00069 0.468
MOD_GSK3_1 231 238 PF00069 0.468
MOD_N-GLC_1 205 210 PF02516 0.268
MOD_NEK2_1 197 202 PF00069 0.486
MOD_NEK2_1 255 260 PF00069 0.468
MOD_NEK2_1 280 285 PF00069 0.465
MOD_NEK2_1 301 306 PF00069 0.488
MOD_NEK2_1 55 60 PF00069 0.395
MOD_NEK2_2 186 191 PF00069 0.432
MOD_PIKK_1 112 118 PF00454 0.750
MOD_PIKK_1 270 276 PF00454 0.503
MOD_PIKK_1 89 95 PF00454 0.725
MOD_PKA_1 112 118 PF00069 0.559
MOD_PKA_1 172 178 PF00069 0.591
MOD_PKA_2 112 118 PF00069 0.765
MOD_PKA_2 172 178 PF00069 0.694
MOD_Plk_1 205 211 PF00069 0.468
MOD_Plk_1 215 221 PF00069 0.468
MOD_Plk_1 55 61 PF00069 0.464
MOD_Plk_4 232 238 PF00069 0.520
MOD_Plk_4 255 261 PF00069 0.468
MOD_Plk_4 301 307 PF00069 0.546
MOD_Plk_4 55 61 PF00069 0.426
MOD_ProDKin_1 287 293 PF00069 0.482
TRG_DiLeu_BaEn_1 44 49 PF01217 0.513
TRG_ENDOCYTIC_2 233 236 PF00928 0.468
TRG_ENDOCYTIC_2 251 254 PF00928 0.468
TRG_ER_diArg_1 172 174 PF00400 0.621
TRG_ER_diArg_1 33 35 PF00400 0.397
TRG_NES_CRM1_1 188 202 PF08389 0.360
TRG_Pf-PMV_PEXEL_1 309 313 PF00026 0.367
TRG_Pf-PMV_PEXEL_1 53 57 PF00026 0.531

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HT22 Leptomonas seymouri 55% 95%
A0A1X0P075 Trypanosomatidae 44% 88%
A0A3S7X487 Leishmania donovani 100% 100%
A4HJ54 Leishmania braziliensis 74% 98%
E9B1M5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q9BHG3 Leishmania major 92% 100%
V5BJ53 Trypanosoma cruzi 44% 90%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS