LeishMANIAdb
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Major Facilitator Superfamily (MFS)

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Major Facilitator Superfamily (MFS)
Gene product:
Major Facilitator Superfamily - putative
Species:
Leishmania infantum
UniProt:
A4I6G6_LEIIN
TriTrypDb:
LINF_310012900
Length:
979

Annotations

LeishMANIAdb annotations

Part of a gigantic, highly expanded family of Kinetoplastid transporters. Most similar to plant nodulins and animal monocarboxylate transporters.. Likely one of the main nutrient transporters in Kinetoplastida.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 9
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6
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Expansion

Sequence features

A4I6G6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6G6

Function

Could not find GO biological_process term for this entry.
Molecular functions
TermNameLevelCount
GO:0005215 transporter activity 1 5
GO:0022857 transmembrane transporter activity 2 5
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 131 135 PF00656 0.752
CLV_C14_Caspase3-7 145 149 PF00656 0.581
CLV_C14_Caspase3-7 427 431 PF00656 0.709
CLV_C14_Caspase3-7 509 513 PF00656 0.884
CLV_C14_Caspase3-7 534 538 PF00656 0.810
CLV_MEL_PAP_1 27 33 PF00089 0.540
CLV_NRD_NRD_1 127 129 PF00675 0.582
CLV_NRD_NRD_1 151 153 PF00675 0.446
CLV_NRD_NRD_1 370 372 PF00675 0.417
CLV_NRD_NRD_1 40 42 PF00675 0.612
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Homologs

ProteinTaxonomySequence identityCoverage
A0A3Q8IG09 Leishmania donovani 99% 100%
A4HJ52 Leishmania braziliensis 74% 100%
E9B1M3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 99%
Q4Q6J1 Leishmania major 93% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS