Arrestin_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I6G3_LEIIN

TriTrypDb:

LINF_310012600

Length:

482

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I6G3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6G3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.616
CLV_C14_Caspase3-7	210	214	PF00656	0.596
CLV_C14_Caspase3-7	268	272	PF00656	0.660
CLV_NRD_NRD_1	55	57	PF00675	0.655
CLV_PCSK_KEX2_1	55	57	PF00082	0.655
CLV_PCSK_SKI1_1	276	280	PF00082	0.628
DEG_SCF_FBW7_1	109	116	PF00400	0.664
DEG_SCF_FBW7_1	446	453	PF00400	0.697
DOC_CKS1_1	110	115	PF01111	0.717
DOC_CKS1_1	138	143	PF01111	0.717
DOC_CKS1_1	196	201	PF01111	0.634
DOC_CKS1_1	447	452	PF01111	0.694
DOC_CYCLIN_yCln2_LP_2	378	384	PF00134	0.586
DOC_MAPK_DCC_7	101	110	PF00069	0.590
DOC_MAPK_gen_1	303	311	PF00069	0.475
DOC_MAPK_MEF2A_6	101	110	PF00069	0.590
DOC_MAPK_MEF2A_6	14	21	PF00069	0.480
DOC_MAPK_MEF2A_6	299	306	PF00069	0.479
DOC_MAPK_NFAT4_5	299	307	PF00069	0.476
DOC_PP2B_LxvP_1	378	381	PF13499	0.583
DOC_PP2B_LxvP_1	382	385	PF13499	0.599
DOC_PP4_FxxP_1	135	138	PF00568	0.773
DOC_PP4_MxPP_1	422	425	PF00568	0.749
DOC_USP7_MATH_1	177	181	PF00917	0.811
DOC_USP7_MATH_1	189	193	PF00917	0.529
DOC_USP7_MATH_1	450	454	PF00917	0.656
DOC_WW_Pin1_4	109	114	PF00397	0.655
DOC_WW_Pin1_4	119	124	PF00397	0.731
DOC_WW_Pin1_4	137	142	PF00397	0.518
DOC_WW_Pin1_4	195	200	PF00397	0.588
DOC_WW_Pin1_4	316	321	PF00397	0.697
DOC_WW_Pin1_4	446	451	PF00397	0.765
DOC_WW_Pin1_4	65	70	PF00397	0.558
LIG_14-3-3_CanoR_1	218	224	PF00244	0.563
LIG_14-3-3_CanoR_1	251	255	PF00244	0.438
LIG_14-3-3_CanoR_1	299	303	PF00244	0.504
LIG_14-3-3_CanoR_1	55	61	PF00244	0.503
LIG_BIR_II_1	1	5	PF00653	0.643
LIG_BIR_III_4	10	14	PF00653	0.665
LIG_BRCT_BRCA1_1	179	183	PF00533	0.745
LIG_CSL_BTD_1	317	320	PF09270	0.756
LIG_FHA_1	138	144	PF00498	0.620
LIG_FHA_1	196	202	PF00498	0.633
LIG_FHA_1	251	257	PF00498	0.461
LIG_FHA_1	343	349	PF00498	0.748
LIG_FHA_1	55	61	PF00498	0.497
LIG_IRF3_LxIS_1	191	197	PF10401	0.662
LIG_LIR_Apic_2	136	142	PF02991	0.671
LIG_LIR_Apic_2	253	257	PF02991	0.438
LIG_LIR_Apic_2	336	342	PF02991	0.594
LIG_LIR_Gen_1	2	11	PF02991	0.644
LIG_LIR_Nem_3	2	8	PF02991	0.655
LIG_LIR_Nem_3	42	48	PF02991	0.432
LIG_LIR_Nem_3	473	478	PF02991	0.759
LIG_LIR_Nem_3	98	103	PF02991	0.503
LIG_LYPXL_S_1	230	234	PF13949	0.504
LIG_LYPXL_yS_3	231	234	PF13949	0.558
LIG_MAD2	101	109	PF02301	0.466
LIG_NRBOX	374	380	PF00104	0.566
LIG_NRP_CendR_1	479	482	PF00754	0.714
LIG_Pex14_1	96	100	PF04695	0.500
LIG_Pex14_2	419	423	PF04695	0.655
LIG_PTB_Apo_2	94	101	PF02174	0.497
LIG_SH2_CRK	139	143	PF00017	0.760
LIG_SH2_CRK	254	258	PF00017	0.465
LIG_SH2_CRK	364	368	PF00017	0.637
LIG_SH2_CRK	478	482	PF00017	0.763
LIG_SH2_CRK	5	9	PF00017	0.636
LIG_SH2_NCK_1	5	9	PF00017	0.636
LIG_SH2_PTP2	16	19	PF00017	0.446
LIG_SH2_PTP2	45	48	PF00017	0.424
LIG_SH2_SRC	16	19	PF00017	0.446
LIG_SH2_STAP1	252	256	PF00017	0.454
LIG_SH2_STAP1	5	9	PF00017	0.636
LIG_SH2_STAT3	187	190	PF00017	0.660
LIG_SH2_STAT5	139	142	PF00017	0.758
LIG_SH2_STAT5	16	19	PF00017	0.446
LIG_SH2_STAT5	252	255	PF00017	0.460
LIG_SH2_STAT5	358	361	PF00017	0.619
LIG_SH2_STAT5	45	48	PF00017	0.424
LIG_SH3_3	114	120	PF00018	0.662
LIG_SH3_3	135	141	PF00018	0.734
LIG_SH3_3	338	344	PF00018	0.590
LIG_SH3_3	411	417	PF00018	0.665
LIG_SH3_3	437	443	PF00018	0.737
LIG_SH3_3	444	450	PF00018	0.692
LIG_SH3_3	471	477	PF00018	0.690
LIG_SH3_3	99	105	PF00018	0.483
LIG_SUMO_SIM_anti_2	275	282	PF11976	0.639
LIG_SUMO_SIM_par_1	275	282	PF11976	0.649
LIG_TYR_ITIM	229	234	PF00017	0.520
MOD_CDK_SPK_2	113	118	PF00069	0.715
MOD_CK1_1	122	128	PF00069	0.790
MOD_CK1_1	197	203	PF00069	0.566
MOD_CK1_1	324	330	PF00069	0.674
MOD_CK1_1	467	473	PF00069	0.755
MOD_CK1_1	62	68	PF00069	0.545
MOD_GlcNHglycan	124	127	PF01048	0.800
MOD_GlcNHglycan	135	138	PF01048	0.641
MOD_GlcNHglycan	145	148	PF01048	0.637
MOD_GlcNHglycan	149	152	PF01048	0.644
MOD_GlcNHglycan	158	162	PF01048	0.651
MOD_GlcNHglycan	171	174	PF01048	0.672
MOD_GlcNHglycan	180	183	PF01048	0.614
MOD_GlcNHglycan	202	205	PF01048	0.720
MOD_GlcNHglycan	210	213	PF01048	0.687
MOD_GlcNHglycan	240	243	PF01048	0.512
MOD_GlcNHglycan	295	298	PF01048	0.515
MOD_GlcNHglycan	335	338	PF01048	0.644
MOD_GlcNHglycan	388	391	PF01048	0.630
MOD_GlcNHglycan	452	455	PF01048	0.714
MOD_GlcNHglycan	466	469	PF01048	0.551
MOD_GlcNHglycan	5	8	PF01048	0.571
MOD_GlcNHglycan	62	65	PF01048	0.574
MOD_GlcNHglycan	74	77	PF01048	0.645
MOD_GSK3_1	108	115	PF00069	0.634
MOD_GSK3_1	133	140	PF00069	0.611
MOD_GSK3_1	143	150	PF00069	0.656
MOD_GSK3_1	165	172	PF00069	0.760
MOD_GSK3_1	190	197	PF00069	0.616
MOD_GSK3_1	238	245	PF00069	0.635
MOD_GSK3_1	326	333	PF00069	0.688
MOD_GSK3_1	394	401	PF00069	0.684
MOD_GSK3_1	446	453	PF00069	0.747
MOD_GSK3_1	466	473	PF00069	0.546
MOD_GSK3_1	55	62	PF00069	0.509
MOD_NEK2_1	143	148	PF00069	0.688
MOD_NEK2_1	194	199	PF00069	0.697
MOD_NEK2_1	238	243	PF00069	0.452
MOD_NEK2_1	348	353	PF00069	0.687
MOD_NEK2_1	398	403	PF00069	0.656
MOD_NEK2_1	60	65	PF00069	0.551
MOD_NEK2_1	72	77	PF00069	0.636
MOD_NEK2_2	418	423	PF00069	0.686
MOD_PIKK_1	467	473	PF00454	0.755
MOD_PIKK_1	74	80	PF00454	0.596
MOD_PKA_1	55	61	PF00069	0.613
MOD_PKA_2	217	223	PF00069	0.749
MOD_PKA_2	250	256	PF00069	0.428
MOD_PKA_2	298	304	PF00069	0.483
MOD_PKA_2	54	60	PF00069	0.497
MOD_PKA_2	72	78	PF00069	0.717
MOD_Plk_1	324	330	PF00069	0.628
MOD_Plk_1	461	467	PF00069	0.732
MOD_Plk_2-3	87	93	PF00069	0.605
MOD_Plk_4	190	196	PF00069	0.606
MOD_Plk_4	284	290	PF00069	0.551
MOD_Plk_4	394	400	PF00069	0.661
MOD_Plk_4	470	476	PF00069	0.665
MOD_ProDKin_1	109	115	PF00069	0.659
MOD_ProDKin_1	119	125	PF00069	0.732
MOD_ProDKin_1	137	143	PF00069	0.578
MOD_ProDKin_1	195	201	PF00069	0.592
MOD_ProDKin_1	316	322	PF00069	0.701
MOD_ProDKin_1	446	452	PF00069	0.762
MOD_ProDKin_1	65	71	PF00069	0.559
TRG_DiLeu_BaEn_1	275	280	PF01217	0.632
TRG_ENDOCYTIC_2	16	19	PF00928	0.403
TRG_ENDOCYTIC_2	231	234	PF00928	0.558
TRG_ENDOCYTIC_2	45	48	PF00928	0.565
TRG_ENDOCYTIC_2	5	8	PF00928	0.647
TRG_ER_diArg_1	302	305	PF00400	0.473
TRG_ER_diArg_1	54	56	PF00400	0.660

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8K0	Leptomonas seymouri	43%	100%
A0A3Q8ISG1	Leishmania donovani	100%	100%
A4HJ47	Leishmania braziliensis	69%	100%
E9B1M0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q6J4	Leishmania major	90%	100%