LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
C2 domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4I6G2_LEIIN
TriTrypDb:
LINF_310012500
Length:
282

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I6G2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6G2

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005509 calcium ion binding 5 1
GO:0043167 ion binding 2 1
GO:0043169 cation binding 3 1
GO:0046872 metal ion binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 11 13 PF00675 0.327
CLV_PCSK_KEX2_1 142 144 PF00082 0.460
CLV_PCSK_PC1ET2_1 142 144 PF00082 0.460
CLV_PCSK_PC7_1 138 144 PF00082 0.443
DOC_CKS1_1 209 214 PF01111 0.569
DOC_MAPK_gen_1 104 113 PF00069 0.408
DOC_MAPK_MEF2A_6 106 115 PF00069 0.399
DOC_PP2B_LxvP_1 168 171 PF13499 0.524
DOC_PP4_FxxP_1 55 58 PF00568 0.304
DOC_SPAK_OSR1_1 54 58 PF12202 0.329
DOC_USP7_MATH_1 236 240 PF00917 0.600
DOC_USP7_MATH_1 248 252 PF00917 0.556
DOC_USP7_MATH_1 258 262 PF00917 0.530
DOC_USP7_UBL2_3 92 96 PF12436 0.329
DOC_WW_Pin1_4 185 190 PF00397 0.536
DOC_WW_Pin1_4 208 213 PF00397 0.583
DOC_WW_Pin1_4 244 249 PF00397 0.630
LIG_AP2alpha_2 24 26 PF02296 0.329
LIG_Clathr_ClatBox_1 115 119 PF01394 0.382
LIG_deltaCOP1_diTrp_1 48 55 PF00928 0.291
LIG_FHA_1 131 137 PF00498 0.501
LIG_FHA_1 36 42 PF00498 0.383
LIG_FHA_1 82 88 PF00498 0.429
LIG_FHA_1 89 95 PF00498 0.485
LIG_FHA_2 105 111 PF00498 0.394
LIG_FHA_2 72 78 PF00498 0.329
LIG_LIR_Apic_2 239 243 PF02991 0.679
LIG_LIR_Apic_2 52 58 PF02991 0.304
LIG_LIR_Gen_1 24 31 PF02991 0.507
LIG_LIR_Nem_3 119 123 PF02991 0.415
LIG_LIR_Nem_3 24 29 PF02991 0.507
LIG_Pex14_1 49 53 PF04695 0.421
LIG_SH2_CRK 166 170 PF00017 0.544
LIG_SH2_CRK 266 270 PF00017 0.589
LIG_SH2_NCK_1 166 170 PF00017 0.544
LIG_SH2_PTP2 194 197 PF00017 0.518
LIG_SH2_PTP2 202 205 PF00017 0.514
LIG_SH2_STAP1 75 79 PF00017 0.330
LIG_SH2_STAP1 83 87 PF00017 0.428
LIG_SH2_STAT3 210 213 PF00017 0.583
LIG_SH2_STAT3 219 222 PF00017 0.667
LIG_SH2_STAT3 253 256 PF00017 0.620
LIG_SH2_STAT3 265 268 PF00017 0.541
LIG_SH2_STAT3 274 277 PF00017 0.520
LIG_SH2_STAT3 36 39 PF00017 0.329
LIG_SH2_STAT5 100 103 PF00017 0.343
LIG_SH2_STAT5 194 197 PF00017 0.582
LIG_SH2_STAT5 202 205 PF00017 0.550
LIG_SH2_STAT5 210 213 PF00017 0.577
LIG_SH2_STAT5 219 222 PF00017 0.636
LIG_SH2_STAT5 266 269 PF00017 0.568
LIG_SH2_STAT5 83 86 PF00017 0.292
LIG_SH3_1 155 161 PF00018 0.484
LIG_SH3_1 228 234 PF00018 0.708
LIG_SH3_1 240 246 PF00018 0.659
LIG_SH3_3 155 161 PF00018 0.595
LIG_SH3_3 190 196 PF00018 0.570
LIG_SH3_3 200 206 PF00018 0.563
LIG_SH3_3 228 234 PF00018 0.719
LIG_SH3_3 239 245 PF00018 0.669
LIG_SH3_3 254 260 PF00018 0.568
LIG_SUMO_SIM_par_1 114 119 PF11976 0.549
LIG_TRAF2_1 124 127 PF00917 0.446
LIG_TYR_ITIM 200 205 PF00017 0.513
LIG_TYR_ITIM 264 269 PF00017 0.523
LIG_WW_2 233 236 PF00397 0.579
MOD_CK2_1 104 110 PF00069 0.589
MOD_GlcNHglycan 250 253 PF01048 0.598
MOD_GSK3_1 244 251 PF00069 0.544
MOD_GSK3_1 264 271 PF00069 0.515
MOD_N-GLC_2 71 73 PF02516 0.304
MOD_NEK2_1 102 107 PF00069 0.606
MOD_NEK2_2 49 54 PF00069 0.362
MOD_PIKK_1 104 110 PF00454 0.404
MOD_PIKK_1 258 264 PF00454 0.556
MOD_PIKK_1 268 274 PF00454 0.527
MOD_PIKK_1 35 41 PF00454 0.329
MOD_PIKK_1 60 66 PF00454 0.335
MOD_Plk_1 4 10 PF00069 0.329
MOD_Plk_4 236 242 PF00069 0.627
MOD_ProDKin_1 185 191 PF00069 0.535
MOD_ProDKin_1 208 214 PF00069 0.583
MOD_ProDKin_1 244 250 PF00069 0.565
MOD_SUMO_for_1 124 127 PF00179 0.434
TRG_DiLeu_BaLyEn_6 111 116 PF01217 0.398
TRG_DiLeu_BaLyEn_6 193 198 PF01217 0.528
TRG_ENDOCYTIC_2 194 197 PF00928 0.512
TRG_ENDOCYTIC_2 202 205 PF00928 0.502
TRG_ENDOCYTIC_2 266 269 PF00928 0.535
TRG_ENDOCYTIC_2 82 85 PF00928 0.352
TRG_Pf-PMV_PEXEL_1 114 119 PF00026 0.473
TRG_Pf-PMV_PEXEL_1 12 16 PF00026 0.372
TRG_Pf-PMV_PEXEL_1 143 147 PF00026 0.445

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IFD2 Leishmania donovani 99% 100%
A0A3S7X485 Leishmania donovani 34% 98%
A0A3S7X4C0 Leishmania donovani 36% 100%
A4HJ46 Leishmania braziliensis 65% 93%
A4HJ57 Leishmania braziliensis 40% 100%
A4HJ58 Leishmania braziliensis 37% 100%
A4I6H2 Leishmania infantum 36% 100%
A4I6H3 Leishmania infantum 34% 98%
E9B1L9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
E9B1N0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
Q9BHE7 Leishmania major 35% 100%
Q9BHF8 Leishmania major 87% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS