Ribosomal_L7Ae domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ribosomal protein L7Ae/L30e/S12e/Gadd45 family - putative

Species:

Leishmania infantum

UniProt:

A4I6F5_LEIIN

TriTrypDb:

LINF_310011800

Length:

559

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1
GO:0005840	ribosome	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I6F5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6F5

Function

Biological processes
Term	Name	Level	Count
GO:0001514	selenocysteine incorporation	7	1
GO:0006414	translational elongation	5	1
GO:0006417	regulation of translation	6	1
GO:0006451	translational readthrough	6	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1901576	organic substance biosynthetic process	3	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003729	mRNA binding	5	11
GO:0005488	binding	1	11
GO:0035368	selenocysteine insertion sequence binding	6	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003730	mRNA 3'-UTR binding	6	1
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0044877	protein-containing complex binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.714
CLV_C14_Caspase3-7	312	316	PF00656	0.555
CLV_NRD_NRD_1	158	160	PF00675	0.665
CLV_NRD_NRD_1	189	191	PF00675	0.518
CLV_NRD_NRD_1	199	201	PF00675	0.524
CLV_NRD_NRD_1	209	211	PF00675	0.462
CLV_NRD_NRD_1	454	456	PF00675	0.548
CLV_PCSK_FUR_1	196	200	PF00082	0.516
CLV_PCSK_FUR_1	207	211	PF00082	0.528
CLV_PCSK_KEX2_1	158	160	PF00082	0.655
CLV_PCSK_KEX2_1	189	191	PF00082	0.502
CLV_PCSK_KEX2_1	198	200	PF00082	0.466
CLV_PCSK_KEX2_1	209	211	PF00082	0.378
CLV_PCSK_KEX2_1	93	95	PF00082	0.460
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.475
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.485
CLV_PCSK_SKI1_1	210	214	PF00082	0.487
CLV_PCSK_SKI1_1	22	26	PF00082	0.760
CLV_PCSK_SKI1_1	338	342	PF00082	0.564
CLV_PCSK_SKI1_1	374	378	PF00082	0.372
CLV_PCSK_SKI1_1	399	403	PF00082	0.352
CLV_PCSK_SKI1_1	407	411	PF00082	0.349
CLV_PCSK_SKI1_1	456	460	PF00082	0.577
CLV_PCSK_SKI1_1	530	534	PF00082	0.477
CLV_PCSK_SKI1_1	541	545	PF00082	0.418
DEG_APCC_DBOX_1	404	412	PF00400	0.495
DEG_APCC_DBOX_1	529	537	PF00400	0.419
DEG_SPOP_SBC_1	130	134	PF00917	0.510
DEG_SPOP_SBC_1	28	32	PF00917	0.591
DEG_SPOP_SBC_1	323	327	PF00917	0.550
DOC_MAPK_gen_1	374	384	PF00069	0.276
DOC_MAPK_gen_1	385	394	PF00069	0.446
DOC_MAPK_gen_1	399	408	PF00069	0.536
DOC_MAPK_gen_1	514	523	PF00069	0.486
DOC_MAPK_MEF2A_6	402	410	PF00069	0.536
DOC_PP4_FxxP_1	261	264	PF00568	0.554
DOC_USP7_MATH_1	174	178	PF00917	0.469
DOC_USP7_MATH_1	220	224	PF00917	0.702
DOC_USP7_MATH_1	28	32	PF00917	0.715
DOC_USP7_MATH_1	322	326	PF00917	0.655
DOC_USP7_MATH_1	339	343	PF00917	0.559
DOC_USP7_MATH_1	430	434	PF00917	0.705
DOC_USP7_MATH_1	443	447	PF00917	0.615
DOC_USP7_MATH_1	450	454	PF00917	0.449
DOC_USP7_MATH_1	49	53	PF00917	0.646
DOC_USP7_MATH_1	513	517	PF00917	0.525
DOC_USP7_MATH_1	535	539	PF00917	0.351
DOC_USP7_MATH_1	58	62	PF00917	0.634
DOC_USP7_UBL2_3	21	25	PF12436	0.726
DOC_USP7_UBL2_3	452	456	PF12436	0.645
DOC_WW_Pin1_4	125	130	PF00397	0.612
DOC_WW_Pin1_4	29	34	PF00397	0.558
DOC_WW_Pin1_4	324	329	PF00397	0.699
DOC_WW_Pin1_4	441	446	PF00397	0.751
DOC_WW_Pin1_4	78	83	PF00397	0.607
LIG_14-3-3_CanoR_1	244	254	PF00244	0.571
LIG_14-3-3_CanoR_1	504	510	PF00244	0.535
LIG_14-3-3_CanoR_1	541	551	PF00244	0.392
LIG_BRCT_BRCA1_1	341	345	PF00533	0.519
LIG_CaM_IQ_9	201	217	PF13499	0.412
LIG_CaM_IQ_9	391	407	PF13499	0.536
LIG_FHA_1	349	355	PF00498	0.316
LIG_FHA_1	551	557	PF00498	0.543
LIG_FHA_2	155	161	PF00498	0.535
LIG_FHA_2	234	240	PF00498	0.667
LIG_FHA_2	310	316	PF00498	0.571
LIG_FHA_2	411	417	PF00498	0.496
LIG_FHA_2	459	465	PF00498	0.418
LIG_FHA_2	552	558	PF00498	0.519
LIG_LIR_Apic_2	260	264	PF02991	0.558
LIG_LIR_Gen_1	177	186	PF02991	0.401
LIG_LIR_Gen_1	360	370	PF02991	0.327
LIG_LIR_Nem_3	177	182	PF02991	0.372
LIG_LIR_Nem_3	257	261	PF02991	0.506
LIG_LIR_Nem_3	265	270	PF02991	0.484
LIG_LIR_Nem_3	283	289	PF02991	0.362
LIG_LIR_Nem_3	360	366	PF02991	0.342
LIG_LIR_Nem_3	508	512	PF02991	0.441
LIG_LIR_Nem_3	538	542	PF02991	0.359
LIG_LYPXL_yS_3	286	289	PF13949	0.473
LIG_MYND_3	119	123	PF01753	0.500
LIG_PCNA_yPIPBox_3	290	303	PF02747	0.346
LIG_SH2_NCK_1	163	167	PF00017	0.405
LIG_SH2_STAP1	163	167	PF00017	0.405
LIG_SH2_STAP1	509	513	PF00017	0.341
LIG_SH2_STAP1	539	543	PF00017	0.336
LIG_SH2_STAP1	547	551	PF00017	0.370
LIG_SH2_STAT3	370	373	PF00017	0.348
LIG_SH2_STAT5	256	259	PF00017	0.650
LIG_SH2_STAT5	349	352	PF00017	0.331
LIG_SH2_STAT5	390	393	PF00017	0.509
LIG_SH2_STAT5	542	545	PF00017	0.498
LIG_SH2_STAT5	547	550	PF00017	0.486
LIG_SH3_3	419	425	PF00018	0.663
LIG_SH3_3	426	432	PF00018	0.580
LIG_SH3_3	472	478	PF00018	0.585
LIG_SUMO_SIM_par_1	407	414	PF11976	0.518
LIG_SxIP_EBH_1	318	327	PF03271	0.421
LIG_UBA3_1	365	371	PF00899	0.456
LIG_WRC_WIRS_1	258	263	PF05994	0.627
MOD_CDK_SPxxK_3	441	448	PF00069	0.573
MOD_CK1_1	132	138	PF00069	0.720
MOD_CK1_1	233	239	PF00069	0.690
MOD_CK1_1	327	333	PF00069	0.627
MOD_CK1_1	451	457	PF00069	0.581
MOD_CK1_1	500	506	PF00069	0.420
MOD_CK2_1	134	140	PF00069	0.726
MOD_CK2_1	154	160	PF00069	0.597
MOD_CK2_1	410	416	PF00069	0.317
MOD_CK2_1	458	464	PF00069	0.434
MOD_CK2_1	551	557	PF00069	0.506
MOD_Cter_Amidation	187	190	PF01082	0.363
MOD_GlcNHglycan	114	117	PF01048	0.551
MOD_GlcNHglycan	248	251	PF01048	0.743
MOD_GlcNHglycan	275	278	PF01048	0.502
MOD_GlcNHglycan	422	425	PF01048	0.696
MOD_GlcNHglycan	445	448	PF01048	0.651
MOD_GlcNHglycan	60	63	PF01048	0.664
MOD_GSK3_1	125	132	PF00069	0.583
MOD_GSK3_1	140	147	PF00069	0.693
MOD_GSK3_1	174	181	PF00069	0.432
MOD_GSK3_1	226	233	PF00069	0.666
MOD_GSK3_1	242	249	PF00069	0.753
MOD_GSK3_1	28	35	PF00069	0.741
MOD_GSK3_1	323	330	PF00069	0.653
MOD_GSK3_1	348	355	PF00069	0.363
MOD_GSK3_1	439	446	PF00069	0.659
MOD_GSK3_1	5	12	PF00069	0.656
MOD_GSK3_1	54	61	PF00069	0.577
MOD_GSK3_1	541	548	PF00069	0.402
MOD_NEK2_1	131	136	PF00069	0.443
MOD_NEK2_1	232	237	PF00069	0.574
MOD_NEK2_1	333	338	PF00069	0.662
MOD_NEK2_1	340	345	PF00069	0.509
MOD_NEK2_1	361	366	PF00069	0.371
MOD_NEK2_1	497	502	PF00069	0.488
MOD_NEK2_1	551	556	PF00069	0.503
MOD_NEK2_1	9	14	PF00069	0.688
MOD_NEK2_2	174	179	PF00069	0.317
MOD_NEK2_2	458	463	PF00069	0.533
MOD_PIKK_1	161	167	PF00454	0.548
MOD_PIKK_1	333	339	PF00454	0.579
MOD_PIKK_1	49	55	PF00454	0.748
MOD_PKA_2	144	150	PF00069	0.493
MOD_PKA_2	226	232	PF00069	0.679
MOD_PKA_2	243	249	PF00069	0.593
MOD_PKA_2	480	486	PF00069	0.686
MOD_PKA_2	505	511	PF00069	0.533
MOD_PKA_2	54	60	PF00069	0.637
MOD_PKA_2	87	93	PF00069	0.529
MOD_Plk_1	551	557	PF00069	0.461
MOD_Plk_2-3	140	146	PF00069	0.687
MOD_Plk_2-3	309	315	PF00069	0.496
MOD_Plk_4	174	180	PF00069	0.421
MOD_Plk_4	263	269	PF00069	0.532
MOD_Plk_4	316	322	PF00069	0.616
MOD_Plk_4	340	346	PF00069	0.567
MOD_Plk_4	41	47	PF00069	0.743
MOD_Plk_4	551	557	PF00069	0.413
MOD_ProDKin_1	125	131	PF00069	0.612
MOD_ProDKin_1	29	35	PF00069	0.558
MOD_ProDKin_1	324	330	PF00069	0.703
MOD_ProDKin_1	441	447	PF00069	0.750
MOD_ProDKin_1	78	84	PF00069	0.600
TRG_DiLeu_BaEn_1	464	469	PF01217	0.419
TRG_ENDOCYTIC_2	179	182	PF00928	0.370
TRG_ENDOCYTIC_2	258	261	PF00928	0.506
TRG_ENDOCYTIC_2	286	289	PF00928	0.593
TRG_ER_diArg_1	189	191	PF00400	0.506
TRG_ER_diArg_1	199	201	PF00400	0.474
TRG_ER_diArg_1	206	209	PF00400	0.469
TRG_ER_diArg_1	387	390	PF00400	0.357
TRG_ER_diArg_1	405	408	PF00400	0.355
TRG_ER_diArg_1	504	507	PF00400	0.405
TRG_ER_diArg_1	86	89	PF00400	0.599
TRG_NLS_MonoExtN_4	196	202	PF00514	0.470
TRG_NLS_MonoExtN_4	452	459	PF00514	0.530
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMN8	Leptomonas seymouri	50%	100%
A0A1X0NJ63	Trypanosomatidae	27%	87%
A0A3R7LBH7	Trypanosoma rangeli	32%	99%
A0A3S7X464	Leishmania donovani	98%	100%
A4HJ40	Leishmania braziliensis	69%	100%
C9ZN70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B1L2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q9BHF1	Leishmania major	92%	100%
V5BDV6	Trypanosoma cruzi	28%	93%