LeishMANIAdb
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Putative C-5 sterol desaturase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative C-5 sterol desaturase
Gene product:
C-5 sterol desaturase - putative
Species:
Leishmania infantum
UniProt:
A4I6F3_LEIIN
TriTrypDb:
LINF_310011600
Length:
274

Annotations

Annotations by Jardim et al.

Sterol metabolism/biosynthesis, C-5 sterol desaturase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005789 endoplasmic reticulum membrane 4 1
GO:0016020 membrane 2 11
GO:0031090 organelle membrane 3 1
GO:0110165 cellular anatomical entity 1 11

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I6F3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6F3

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 13
GO:0008152 metabolic process 1 13
GO:0008610 lipid biosynthetic process 4 13
GO:0009058 biosynthetic process 2 13
GO:0044238 primary metabolic process 2 13
GO:0071704 organic substance metabolic process 2 13
GO:1901576 organic substance biosynthetic process 3 13
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 13
GO:0005488 binding 1 13
GO:0005506 iron ion binding 6 13
GO:0016491 oxidoreductase activity 2 13
GO:0043167 ion binding 2 13
GO:0043169 cation binding 3 13
GO:0046872 metal ion binding 4 13
GO:0046914 transition metal ion binding 5 13

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 102 106 PF00656 0.491
CLV_PCSK_SKI1_1 111 115 PF00082 0.324
CLV_PCSK_SKI1_1 268 272 PF00082 0.486
CLV_PCSK_SKI1_1 77 81 PF00082 0.336
DEG_Nend_UBRbox_2 1 3 PF02207 0.656
DOC_AGCK_PIF_2 124 129 PF00069 0.237
DOC_CYCLIN_yCln2_LP_2 104 110 PF00134 0.562
DOC_CYCLIN_yCln2_LP_2 114 120 PF00134 0.357
DOC_CYCLIN_yCln2_LP_2 220 226 PF00134 0.505
DOC_MAPK_gen_1 58 67 PF00069 0.385
DOC_MAPK_gen_1 68 75 PF00069 0.258
DOC_MAPK_MEF2A_6 111 120 PF00069 0.470
DOC_MAPK_MEF2A_6 68 75 PF00069 0.270
DOC_MAPK_NFAT4_5 111 119 PF00069 0.505
DOC_PP1_RVXF_1 109 116 PF00149 0.470
DOC_PP1_RVXF_1 237 243 PF00149 0.528
DOC_PP2B_LxvP_1 114 117 PF13499 0.411
DOC_PP2B_LxvP_1 220 223 PF13499 0.505
DOC_USP7_MATH_2 169 175 PF00917 0.318
DOC_USP7_UBL2_3 268 272 PF12436 0.686
DOC_USP7_UBL2_3 60 64 PF12436 0.390
DOC_WW_Pin1_4 14 19 PF00397 0.562
DOC_WW_Pin1_4 153 158 PF00397 0.244
DOC_WW_Pin1_4 187 192 PF00397 0.272
DOC_WW_Pin1_4 97 102 PF00397 0.564
LIG_14-3-3_CanoR_1 92 99 PF00244 0.579
LIG_BRCT_BRCA1_1 99 103 PF00533 0.561
LIG_CSK_EPIYA_1 2 6 PF00017 0.614
LIG_CSL_BTD_1 114 117 PF09270 0.318
LIG_deltaCOP1_diTrp_1 250 256 PF00928 0.456
LIG_FHA_1 160 166 PF00498 0.320
LIG_FHA_1 197 203 PF00498 0.336
LIG_FHA_2 214 220 PF00498 0.446
LIG_FHA_2 64 70 PF00498 0.283
LIG_GBD_Chelix_1 181 189 PF00786 0.518
LIG_LIR_Gen_1 128 138 PF02991 0.318
LIG_LIR_Gen_1 174 185 PF02991 0.252
LIG_LIR_Gen_1 2 13 PF02991 0.645
LIG_LIR_Gen_1 87 96 PF02991 0.418
LIG_LIR_Nem_3 112 118 PF02991 0.338
LIG_LIR_Nem_3 128 134 PF02991 0.289
LIG_LIR_Nem_3 137 143 PF02991 0.236
LIG_LIR_Nem_3 174 180 PF02991 0.271
LIG_LIR_Nem_3 250 256 PF02991 0.437
LIG_LIR_Nem_3 35 39 PF02991 0.297
LIG_LIR_Nem_3 69 75 PF02991 0.246
LIG_LIR_Nem_3 87 91 PF02991 0.386
LIG_Pex14_1 140 144 PF04695 0.246
LIG_Pex14_1 249 253 PF04695 0.446
LIG_Pex14_2 130 134 PF04695 0.290
LIG_Rb_pABgroove_1 121 129 PF01858 0.437
LIG_SH2_CRK 144 148 PF00017 0.288
LIG_SH2_CRK 39 43 PF00017 0.357
LIG_SH2_CRK 88 92 PF00017 0.418
LIG_SH2_PTP2 245 248 PF00017 0.407
LIG_SH2_STAP1 127 131 PF00017 0.294
LIG_SH2_STAP1 39 43 PF00017 0.307
LIG_SH2_STAP1 5 9 PF00017 0.670
LIG_SH2_STAT3 22 25 PF00017 0.390
LIG_SH2_STAT5 131 134 PF00017 0.289
LIG_SH2_STAT5 172 175 PF00017 0.245
LIG_SH2_STAT5 177 180 PF00017 0.246
LIG_SH2_STAT5 184 187 PF00017 0.246
LIG_SH2_STAT5 224 227 PF00017 0.459
LIG_SH2_STAT5 245 248 PF00017 0.438
LIG_SH2_STAT5 72 75 PF00017 0.314
LIG_SH3_3 115 121 PF00018 0.384
LIG_SH3_3 39 45 PF00018 0.384
LIG_SH3_4 60 67 PF00018 0.385
LIG_TRAF2_1 262 265 PF00917 0.592
LIG_WRC_WIRS_1 253 258 PF05994 0.501
LIG_WRC_WIRS_1 33 38 PF05994 0.321
LIG_WRC_WIRS_1 8 13 PF05994 0.599
LIG_WW_1 141 144 PF00397 0.270
MOD_CDC14_SPxK_1 156 159 PF00782 0.305
MOD_CDK_SPxK_1 153 159 PF00069 0.246
MOD_CDK_SPxxK_3 14 21 PF00069 0.557
MOD_CK1_1 263 269 PF00069 0.683
MOD_CK1_1 97 103 PF00069 0.543
MOD_GlcNHglycan 173 176 PF01048 0.518
MOD_GlcNHglycan 264 268 PF01048 0.481
MOD_GSK3_1 209 216 PF00069 0.336
MOD_N-GLC_1 213 218 PF02516 0.246
MOD_NEK2_1 129 134 PF00069 0.299
MOD_NEK2_1 206 211 PF00069 0.292
MOD_NEK2_1 213 218 PF00069 0.418
MOD_PKA_2 91 97 PF00069 0.581
MOD_Plk_1 213 219 PF00069 0.445
MOD_Plk_1 94 100 PF00069 0.548
MOD_Plk_2-3 63 69 PF00069 0.394
MOD_Plk_4 129 135 PF00069 0.304
MOD_Plk_4 142 148 PF00069 0.251
MOD_Plk_4 38 44 PF00069 0.374
MOD_ProDKin_1 14 20 PF00069 0.560
MOD_ProDKin_1 153 159 PF00069 0.244
MOD_ProDKin_1 187 193 PF00069 0.272
MOD_ProDKin_1 97 103 PF00069 0.568
TRG_DiLeu_BaEn_1 176 181 PF01217 0.286
TRG_ENDOCYTIC_2 127 130 PF00928 0.299
TRG_ENDOCYTIC_2 131 134 PF00928 0.280
TRG_ENDOCYTIC_2 144 147 PF00928 0.191
TRG_ENDOCYTIC_2 177 180 PF00928 0.246
TRG_ENDOCYTIC_2 245 248 PF00928 0.439
TRG_ENDOCYTIC_2 39 42 PF00928 0.302
TRG_ENDOCYTIC_2 5 8 PF00928 0.660
TRG_ENDOCYTIC_2 72 75 PF00928 0.328
TRG_ENDOCYTIC_2 88 91 PF00928 0.181
TRG_ER_diLys_1 271 274 PF00400 0.702
TRG_NES_CRM1_1 2 14 PF08389 0.638

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IA25 Leptomonas seymouri 78% 100%
A0A0S4IZK1 Bodo saltans 27% 84%
A0A0S4KFW2 Bodo saltans 57% 92%
A0A1X0NKZ9 Trypanosomatidae 54% 100%
A0A3Q8IJV0 Leishmania donovani 100% 100%
A0A3R7P157 Trypanosoma rangeli 63% 100%
A4HJ38 Leishmania braziliensis 84% 100%
C9ZN68 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 63% 100%
E9B1L0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q9BHE9 Leishmania major 95% 100%
V5DER6 Trypanosoma cruzi 68% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS