cGMP-dependent protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cyclic nucleotide-binding domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I6E9_LEIIN

TriTrypDb:

LINF_310010300

Length:

822

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I6E9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6E9

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.507
CLV_C14_Caspase3-7	459	463	PF00656	0.653
CLV_C14_Caspase3-7	643	647	PF00656	0.391
CLV_C14_Caspase3-7	734	738	PF00656	0.617
CLV_C14_Caspase3-7	81	85	PF00656	0.703
CLV_NRD_NRD_1	104	106	PF00675	0.688
CLV_NRD_NRD_1	139	141	PF00675	0.498
CLV_NRD_NRD_1	485	487	PF00675	0.709
CLV_NRD_NRD_1	517	519	PF00675	0.604
CLV_NRD_NRD_1	583	585	PF00675	0.506
CLV_NRD_NRD_1	655	657	PF00675	0.272
CLV_NRD_NRD_1	809	811	PF00675	0.329
CLV_PCSK_FUR_1	810	814	PF00082	0.420
CLV_PCSK_KEX2_1	103	105	PF00082	0.696
CLV_PCSK_KEX2_1	139	141	PF00082	0.498
CLV_PCSK_KEX2_1	210	212	PF00082	0.495
CLV_PCSK_KEX2_1	380	382	PF00082	0.586
CLV_PCSK_KEX2_1	485	487	PF00082	0.709
CLV_PCSK_KEX2_1	517	519	PF00082	0.612
CLV_PCSK_KEX2_1	655	657	PF00082	0.392
CLV_PCSK_KEX2_1	809	811	PF00082	0.409
CLV_PCSK_KEX2_1	812	814	PF00082	0.422
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.468
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.586
CLV_PCSK_PC1ET2_1	812	814	PF00082	0.434
CLV_PCSK_PC7_1	100	106	PF00082	0.684
CLV_PCSK_PC7_1	513	519	PF00082	0.463
CLV_PCSK_SKI1_1	115	119	PF00082	0.636
CLV_PCSK_SKI1_1	139	143	PF00082	0.500
CLV_PCSK_SKI1_1	277	281	PF00082	0.352
CLV_PCSK_SKI1_1	655	659	PF00082	0.312
DEG_Kelch_Keap1_1	602	607	PF01344	0.391
DEG_SPOP_SBC_1	34	38	PF00917	0.658
DEG_SPOP_SBC_1	641	645	PF00917	0.392
DOC_CYCLIN_RxL_1	272	282	PF00134	0.400
DOC_CYCLIN_yCln2_LP_2	794	800	PF00134	0.377
DOC_MAPK_gen_1	422	431	PF00069	0.514
DOC_MAPK_gen_1	809	817	PF00069	0.566
DOC_MAPK_MEF2A_6	395	404	PF00069	0.302
DOC_MAPK_MEF2A_6	796	804	PF00069	0.409
DOC_PP1_RVXF_1	801	807	PF00149	0.413
DOC_PP2B_LxvP_1	48	51	PF13499	0.557
DOC_PP2B_LxvP_1	623	626	PF13499	0.394
DOC_PP2B_LxvP_1	784	787	PF13499	0.425
DOC_PP4_FxxP_1	280	283	PF00568	0.435
DOC_PP4_FxxP_1	40	43	PF00568	0.648
DOC_USP7_MATH_1	179	183	PF00917	0.550
DOC_USP7_MATH_1	244	248	PF00917	0.624
DOC_USP7_MATH_1	35	39	PF00917	0.676
DOC_USP7_MATH_1	384	388	PF00917	0.563
DOC_USP7_MATH_1	51	55	PF00917	0.638
DOC_USP7_MATH_1	575	579	PF00917	0.685
DOC_USP7_MATH_1	580	584	PF00917	0.596
DOC_USP7_MATH_1	640	644	PF00917	0.374
DOC_USP7_MATH_1	67	71	PF00917	0.542
DOC_USP7_MATH_1	731	735	PF00917	0.493
DOC_USP7_MATH_1	787	791	PF00917	0.447
DOC_USP7_MATH_1	9	13	PF00917	0.685
DOC_WW_Pin1_4	109	114	PF00397	0.504
DOC_WW_Pin1_4	128	133	PF00397	0.403
DOC_WW_Pin1_4	175	180	PF00397	0.504
DOC_WW_Pin1_4	245	250	PF00397	0.494
DOC_WW_Pin1_4	279	284	PF00397	0.489
DOC_WW_Pin1_4	478	483	PF00397	0.676
LIG_14-3-3_CanoR_1	115	124	PF00244	0.569
LIG_14-3-3_CanoR_1	422	427	PF00244	0.597
LIG_14-3-3_CanoR_1	513	517	PF00244	0.540
LIG_14-3-3_CanoR_1	524	529	PF00244	0.433
LIG_14-3-3_CanoR_1	584	591	PF00244	0.374
LIG_14-3-3_CanoR_1	614	619	PF00244	0.391
LIG_14-3-3_CanoR_1	628	636	PF00244	0.231
LIG_14-3-3_CanoR_1	803	811	PF00244	0.423
LIG_BRCT_BRCA1_1	181	185	PF00533	0.493
LIG_BRCT_BRCA1_1	281	285	PF00533	0.436
LIG_BRCT_BRCA1_1	36	40	PF00533	0.635
LIG_Clathr_ClatBox_1	543	547	PF01394	0.474
LIG_deltaCOP1_diTrp_1	213	220	PF00928	0.476
LIG_FHA_1	250	256	PF00498	0.428
LIG_FHA_1	326	332	PF00498	0.389
LIG_FHA_1	388	394	PF00498	0.455
LIG_FHA_1	56	62	PF00498	0.695
LIG_FHA_1	631	637	PF00498	0.331
LIG_FHA_1	779	785	PF00498	0.279
LIG_FHA_1	8	14	PF00498	0.688
LIG_FHA_2	264	270	PF00498	0.542
LIG_FHA_2	615	621	PF00498	0.391
LIG_FHA_2	697	703	PF00498	0.451
LIG_Integrin_RGD_1	82	84	PF01839	0.684
LIG_IRF3_LxIS_1	321	326	PF10401	0.363
LIG_IRF3_LxIS_1	450	455	PF10401	0.508
LIG_LIR_Apic_2	37	43	PF02991	0.650
LIG_LIR_Gen_1	133	142	PF02991	0.483
LIG_LIR_Gen_1	182	193	PF02991	0.570
LIG_LIR_Gen_1	282	293	PF02991	0.409
LIG_LIR_Gen_1	319	330	PF02991	0.441
LIG_LIR_Gen_1	672	681	PF02991	0.466
LIG_LIR_Nem_3	133	138	PF02991	0.492
LIG_LIR_Nem_3	182	188	PF02991	0.560
LIG_LIR_Nem_3	282	288	PF02991	0.414
LIG_LIR_Nem_3	319	325	PF02991	0.500
LIG_LIR_Nem_3	672	676	PF02991	0.467
LIG_LIR_Nem_3	789	794	PF02991	0.454
LIG_LIR_Nem_3	808	814	PF02991	0.485
LIG_LIR_Nem_3	91	97	PF02991	0.636
LIG_PAM2_1	93	105	PF00658	0.533
LIG_PCNA_PIPBox_1	261	270	PF02747	0.393
LIG_PCNA_PIPBox_1	281	290	PF02747	0.316
LIG_PCNA_yPIPBox_3	254	268	PF02747	0.411
LIG_Pex14_1	691	695	PF04695	0.415
LIG_Pex14_2	673	677	PF04695	0.454
LIG_Pex14_2	680	684	PF04695	0.484
LIG_Pex14_2	791	795	PF04695	0.444
LIG_SH2_CRK	260	264	PF00017	0.442
LIG_SH2_CRK	811	815	PF00017	0.477
LIG_SH2_PTP2	775	778	PF00017	0.380
LIG_SH2_SRC	268	271	PF00017	0.418
LIG_SH2_STAT3	278	281	PF00017	0.512
LIG_SH2_STAT3	391	394	PF00017	0.451
LIG_SH2_STAT5	219	222	PF00017	0.434
LIG_SH2_STAT5	227	230	PF00017	0.470
LIG_SH2_STAT5	278	281	PF00017	0.475
LIG_SH2_STAT5	537	540	PF00017	0.439
LIG_SH2_STAT5	666	669	PF00017	0.365
LIG_SH2_STAT5	775	778	PF00017	0.343
LIG_SH2_STAT5	801	804	PF00017	0.386
LIG_SH3_3	225	231	PF00018	0.468
LIG_SH3_3	390	396	PF00018	0.461
LIG_SH3_3	794	800	PF00018	0.443
LIG_SUMO_SIM_anti_2	328	333	PF11976	0.397
LIG_SUMO_SIM_anti_2	362	367	PF11976	0.445
LIG_SUMO_SIM_anti_2	405	412	PF11976	0.464
LIG_SUMO_SIM_anti_2	597	605	PF11976	0.394
LIG_SUMO_SIM_par_1	405	412	PF11976	0.485
LIG_SUMO_SIM_par_1	63	70	PF11976	0.686
LIG_TRAF2_1	131	134	PF00917	0.394
LIG_TRAF2_1	370	373	PF00917	0.594
LIG_TRFH_1	227	231	PF08558	0.542
LIG_TYR_ITIM	773	778	PF00017	0.375
LIG_WRC_WIRS_1	264	269	PF05994	0.515
LIG_WRC_WIRS_1	528	533	PF05994	0.385
LIG_WRC_WIRS_1	751	756	PF05994	0.478
MOD_CDK_SPxK_1	109	115	PF00069	0.493
MOD_CDK_SPxxK_3	478	485	PF00069	0.623
MOD_CK1_1	109	115	PF00069	0.533
MOD_CK1_1	247	253	PF00069	0.534
MOD_CK1_1	38	44	PF00069	0.720
MOD_CK1_1	387	393	PF00069	0.413
MOD_CK1_1	481	487	PF00069	0.665
MOD_CK1_1	512	518	PF00069	0.438
MOD_CK1_1	527	533	PF00069	0.427
MOD_CK1_1	583	589	PF00069	0.488
MOD_CK1_1	750	756	PF00069	0.445
MOD_CK1_1	90	96	PF00069	0.641
MOD_CK2_1	128	134	PF00069	0.451
MOD_CK2_1	422	428	PF00069	0.519
MOD_CK2_1	51	57	PF00069	0.749
MOD_CK2_1	614	620	PF00069	0.394
MOD_CK2_1	696	702	PF00069	0.555
MOD_CK2_1	815	821	PF00069	0.492
MOD_GlcNHglycan	108	111	PF01048	0.719
MOD_GlcNHglycan	29	33	PF01048	0.774
MOD_GlcNHglycan	306	310	PF01048	0.636
MOD_GlcNHglycan	325	328	PF01048	0.258
MOD_GlcNHglycan	40	43	PF01048	0.720
MOD_GlcNHglycan	411	414	PF01048	0.472
MOD_GlcNHglycan	550	553	PF01048	0.449
MOD_GlcNHglycan	558	561	PF01048	0.546
MOD_GlcNHglycan	577	580	PF01048	0.633
MOD_GlcNHglycan	594	597	PF01048	0.364
MOD_GlcNHglycan	630	633	PF01048	0.487
MOD_GlcNHglycan	69	72	PF01048	0.669
MOD_GlcNHglycan	733	736	PF01048	0.603
MOD_GlcNHglycan	737	740	PF01048	0.639
MOD_GlcNHglycan	817	820	PF01048	0.443
MOD_GSK3_1	111	118	PF00069	0.566
MOD_GSK3_1	175	182	PF00069	0.641
MOD_GSK3_1	245	252	PF00069	0.528
MOD_GSK3_1	301	308	PF00069	0.504
MOD_GSK3_1	34	41	PF00069	0.742
MOD_GSK3_1	452	459	PF00069	0.576
MOD_GSK3_1	462	469	PF00069	0.623
MOD_GSK3_1	481	488	PF00069	0.622
MOD_GSK3_1	51	58	PF00069	0.638
MOD_GSK3_1	570	577	PF00069	0.717
MOD_GSK3_1	592	599	PF00069	0.394
MOD_GSK3_1	610	617	PF00069	0.277
MOD_GSK3_1	731	738	PF00069	0.572
MOD_GSK3_1	746	753	PF00069	0.476
MOD_GSK3_1	83	90	PF00069	0.666
MOD_LATS_1	418	424	PF00433	0.504
MOD_N-GLC_1	452	457	PF02516	0.571
MOD_N-GLC_1	695	700	PF02516	0.437
MOD_NEK2_1	263	268	PF00069	0.514
MOD_NEK2_1	323	328	PF00069	0.352
MOD_NEK2_1	452	457	PF00069	0.517
MOD_NEK2_1	538	543	PF00069	0.329
MOD_NEK2_1	556	561	PF00069	0.481
MOD_NEK2_1	651	656	PF00069	0.365
MOD_NEK2_1	815	820	PF00069	0.525
MOD_NMyristoyl	1	7	PF02799	0.655
MOD_PIKK_1	167	173	PF00454	0.453
MOD_PIKK_1	489	495	PF00454	0.642
MOD_PK_1	346	352	PF00069	0.359
MOD_PK_1	422	428	PF00069	0.456
MOD_PKA_1	485	491	PF00069	0.604
MOD_PKA_2	485	491	PF00069	0.604
MOD_PKA_2	512	518	PF00069	0.497
MOD_PKA_2	556	562	PF00069	0.626
MOD_PKA_2	583	589	PF00069	0.421
MOD_PKA_2	731	737	PF00069	0.685
MOD_PKB_1	420	428	PF00069	0.458
MOD_PKB_1	522	530	PF00069	0.500
MOD_Plk_1	153	159	PF00069	0.427
MOD_Plk_1	466	472	PF00069	0.716
MOD_Plk_1	500	506	PF00069	0.461
MOD_Plk_1	596	602	PF00069	0.355
MOD_Plk_1	746	752	PF00069	0.540
MOD_Plk_2-3	301	307	PF00069	0.438
MOD_Plk_2-3	460	466	PF00069	0.589
MOD_Plk_4	153	159	PF00069	0.427
MOD_Plk_4	317	323	PF00069	0.374
MOD_Plk_4	346	352	PF00069	0.362
MOD_Plk_4	466	472	PF00069	0.653
MOD_Plk_4	538	544	PF00069	0.471
MOD_Plk_4	596	602	PF00069	0.310
MOD_Plk_4	672	678	PF00069	0.402
MOD_Plk_4	717	723	PF00069	0.449
MOD_ProDKin_1	109	115	PF00069	0.509
MOD_ProDKin_1	128	134	PF00069	0.387
MOD_ProDKin_1	175	181	PF00069	0.510
MOD_ProDKin_1	245	251	PF00069	0.480
MOD_ProDKin_1	279	285	PF00069	0.483
MOD_ProDKin_1	478	484	PF00069	0.674
MOD_SUMO_rev_2	565	571	PF00179	0.552
TRG_DiLeu_BaEn_4	133	139	PF01217	0.513
TRG_DiLeu_BaLyEn_6	307	312	PF01217	0.480
TRG_DiLeu_BaLyEn_6	378	383	PF01217	0.454
TRG_ENDOCYTIC_2	260	263	PF00928	0.482
TRG_ENDOCYTIC_2	591	594	PF00928	0.391
TRG_ENDOCYTIC_2	690	693	PF00928	0.397
TRG_ENDOCYTIC_2	775	778	PF00928	0.380
TRG_ENDOCYTIC_2	801	804	PF00928	0.526
TRG_ENDOCYTIC_2	811	814	PF00928	0.419
TRG_ER_diArg_1	102	105	PF00400	0.683
TRG_ER_diArg_1	138	140	PF00400	0.499
TRG_ER_diArg_1	485	487	PF00400	0.608
TRG_ER_diArg_1	516	518	PF00400	0.492
TRG_ER_diArg_1	533	536	PF00400	0.325
TRG_ER_diArg_1	780	783	PF00400	0.393
TRG_ER_diArg_1	809	811	PF00400	0.329
TRG_Pf-PMV_PEXEL_1	257	261	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	443	447	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	485	489	PF00026	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T1	Leptomonas seymouri	41%	100%
A0A1X0NPV7	Trypanosomatidae	21%	97%
A0A3R7KL00	Trypanosoma rangeli	25%	76%
A0A3S7X491	Leishmania donovani	100%	100%
A4HJ27	Leishmania braziliensis	64%	100%
E9B1J9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q4Q6L4	Leishmania major	88%	100%